SOCS3 and its role in associated diseases

Cell Signaling by Receptor Tyrosine Kinases

Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929 · see citing works

Regulation of JAK–STAT signalling in the immune system

Shuai, K., & Liu, B. (2003) · Nature reviews. Immunology · doi:10.1038/nri1226 · Cited by 1,379 · see citing works

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer

Lesina, M., Kurkowski, M. U., Ludes, K., Rose-John, S., Treiber, M., Klöppel, G., Yoshimura, A., Reindl, W., Sipos, B., Akira, S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.009 · Cited by 862 · see citing works

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651 · see citing works

SOCS regulation of the JAK/STAT signalling pathway

Croker, B. A., Kiu, H., & Nicholson, S. E. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.010 · Cited by 610 · see citing works

Rheumatoid Arthritis: Diagnosis and Management

Majithia, V., & Geraci, S. A. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.04.005 · Cited by 524 · see citing works

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490 · see citing works

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

Taleb, S., Romain, M., Ramkhelawon, B., Uyttenhove, C., Pasterkamp, G., Herbin, O., Esposito, B., Pérez, N., Yasukawa, H., Snick, J. V., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090545 · Cited by 409 · see citing works

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

Shouda, T., Yoshida, T., Hanada, T., Wakioka, T., Oishi, M., Miyoshi, K., Komiya, S., Kosai, K.-I., Hanakawa, Y., Hashimoto, K., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13568 · Cited by 394 · see citing works

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A. Y., Costello, J. F., McCormick, F., & Jablons, D. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232790100 · Cited by 380 · see citing works

SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses

Seki, Y.-I., Inoue, H., Nagata, N., Hayashi, K., Fukuyama, S., Matsumoto, K., Komine, O., Hamano, S., Himeno, K., Inagaki‐Ohara, K., et al. (2003) · Nature Medicine · doi:10.1038/nm896 · Cited by 361 · see citing works

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Niemand, C., Nimmesgern, A., Haan, S., Fischer, P., Schaper, F., Rossaint, R., Heinrich, P. C., & Müller-Newen, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3263 · Cited by 357 · see citing works

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

Hu, B., Elinav, E., Huber, S., Strowig, T., Hao, L., Hafemann, A., Jin, C., Wunderlich, C. M., Wunderlich, T., Eisenbarth, S. C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307575110 · Cited by 325 · see citing works

Cytokine receptor signaling through the Jak–Stat–Socs pathway in disease

O’Sullivan, L. A., Liongue, C., Lewis, R. S., Stephenson, S. E. M., & Ward, A. C. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.11.025 · Cited by 308 · see citing works

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., et al. (2005) · Nature Medicine · doi:10.1038/nm1282 · Cited by 308 · see citing works

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2519 · Cited by 301 · see citing works

Activation of SOCS-3 by Resistin

Steppan, C. M., Wang, J., Whiteman, E. L., Birnbaum, M. J., & Lazar, M. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1569-1575.2005 · Cited by 280 · see citing works

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

Pauli, E.-K., Schmolke, M., Wolff, T., Viemann, D., Roth, J., Bode, J. G., & Ludwig, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000196 · Cited by 274 · see citing works

Suppressor of Cytokine Signaling (SOCS) Proteins Indirectly Regulate Toll-like Receptor Signaling in Innate Immune Cells

Baetz, A., Frey, M., Heeg, K. M., & Dalpke, A. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410992200 · Cited by 270 · see citing works

Involvement of Suppressor of Cytokine Signaling-3 as a Mediator of the Inhibitory Effects of IL-10 on Lipopolysaccharide-Induced Macrophage Activation

Berlato, C., Cassatella, M. A., Kinjyo, I., Gatto, L., Yoshimura, A., & Bazzoni, F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6404 · Cited by 267 · see citing works

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., Lee, C. E., Elmquist, J. K., Yoshimura, A., & Flier, J. S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.010 · Cited by 242 · see citing works

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

Kinjyo, I., Inoue, H., Hamano, S., Fukuyama, S., Yoshimura, T., Koga, K., Takaki, H., Himeno, K., Takaesu, G., Kobayashi, T., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052333 · Cited by 225 · see citing works

Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling

Shi, H., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403886200 · Cited by 223 · see citing works

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis

Wong, P. K. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25660 · Cited by 215 · see citing works

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

Zhang, X., Jin, J., Peng, X., Ramgolam, V. S., & Markovic‐Plese, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6988 · Cited by 201 · see citing works

Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

Lovato, P., Brender, C., Agnholt, J. S., Kelsen, J., Kaltoft, K., Svejgaard, A., Eriksen, K. W., Woetmann, A., & Ødum, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207999200 · Cited by 199 · see citing works

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells

Sawa, S.-I., Kamimura, D., Jin, G.-H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K., Murakami, M., & Hirano, T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052187 · Cited by 176 · see citing works

The many faces of the SOCS box

Piessevaux, J., Lavens, D., Peelman, F., & Tavernier, J. H. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.006 · Cited by 176 · see citing works

Expression of IL-24, an Activator of the JAK1/STAT3/SOCS3 Cascade, Is Enhanced in Inflammatory Bowel Disease

Andoh, A., Shioya, M., Nishida, A., Bamba, S., Tsujikawa, T., Kim‐Mitsuyama, S., & Fujiyama, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804169 · Cited by 156 · see citing works

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon

Rigby, R. J., Simmons, J. G., Greenhalgh, C. J., Alexander, W. S., & Lund, P. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210286 · Cited by 153 · see citing works

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Jørgensen, S. B., O’Neill, H. M., Sylow, L., Honeyman, J. E., Hewitt, K. A., Palanivel, R., Fullerton, M. D., Öberg, L., Balendran, A., Galić, S., et al. (2012) · Diabetes · doi:10.2337/db12-0443 · Cited by 148 · see citing works

The role of leptin resistance in the lipid abnormalities of aging

WANG, Z.-W., Pan, W., Lee, Y., Kakuma, T., ZHOU, Y.-T., & Unger, R. H. (2001) · The FASEB Journal · doi:10.1096/fj.00-0310com · Cited by 146 · see citing works

Dendritic Cells Transduced with SOCS-3 Exhibit a Tolerogenic/DC2 Phenotype That Directs Type 2 Th Cell Differentiation In Vitro and In Vivo

Li, Y., Chu, N., Rostami, A. M., & Zhang, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1679 · Cited by 141 · see citing works

pSTAT1, pSTAT3, and T‐bet expression in peripheral blood mononuclear cells from relapsing‐remitting multiple sclerosis patients correlates with disease activity

Frisullo, G., Angelucci, F., Caggiula, M., Nociti, V., Iorio, R., Patanella, A. K., Sancricca, C., Massimiliano Mirabella, A., Tonali, P. A., & Batocchi, A. P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20995 · Cited by 138 · see citing works

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

Olofsson, L. E., Unger, E. K., Cheung, C. C., & Xu, A. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218284110 · Cited by 137 · see citing works

Expression and Functional Significance of SOCS-1 and SOCS-3 in Astrocytes

Qin, H., Niyongere, S., Lee, S. J., Baker, B. J., & Benveniste, E. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3167 · Cited by 129 · see citing works

Regulation of the immune system by SOCS family adaptor proteins

Ilangumaran, S., Ramanathan, S., & Rottapel, R. K. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.08.015 · Cited by 127 · see citing works

Suppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis

Ortiz-Muñoz, G., Martı́n-Ventura, J. L., Hernández-Vargas, P., Mallavia, B., López-Parra, V., López‐Franco, Ó., Muñoz‐García, B., Fernández‐Vizarra, P., Ortega, L. M., Egido, J., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.173781 · Cited by 123 · see citing works

Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance

Shi, H., Cave, B. J., Inouye, K., Bjørbæk, C., & Flier, J. S. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0841 · Cited by 117 · see citing works

JAK/STAT/SOCS SIGNALING CIRCUITS AND ASSOCIATED CYTOKINE-MEDIATED INFLAMMATION AND HYPERTROPHY IN THE HEART

Terrell, A. M., Crisostomo, P. R., Wairiuko, G. M., Wang, M., Morrell, E. D., & Meldrum, D. R. (2006) · Shock · doi:10.1097/01.shk.0000226341.32786.b9 · Cited by 114 · see citing works

The dual function of hepatic SOCS3 in insulin resistance in vivo

Torisu, T., Sato, N., Yoshiga, D., Kobayashi, T., Yoshioka, T., Mori, H., Iida, M., & Yoshimura, A. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01044.x · Cited by 111 · see citing works

The Control of Allergic Conjunctivitis by Suppressor of Cytokine Signaling (SOCS)3 and SOCS5 in a Murine Model

Ozaki, A., Seki, Y.-I., Fukushima, A., & Kubo, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5489 · Cited by 109 · see citing works

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

Babon, J. J., Sabo, J. K., Soetopo, A., Yao, S., Bailey, M. F., Zhang, J., Nicola, N. A., & Norton, R. S. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.06.038 · Cited by 103 · see citing works

IL-10 Inhibits Lipopolysaccharide-Induced CD40 Gene Expression through Induction of Suppressor of Cytokine Signaling-3

Qin, H., Wilson, C. A., Roberts, K. L., Baker, B. J., Zhao, X., & Benveniste, E. N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7761 · Cited by 103 · see citing works

p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation

Fahmi, A., Smart, N., Punn, A., Jabr, R. I., Marber, M. S., & Heads, R. J. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.12.008 · Cited by 94 · see citing works

The immunopathogenesis of Crohn's disease: a three-stage model

Sewell, G. W., Marks, D. J., & Segal, A. W. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.06.003 · Cited by 92 · see citing works

Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)

Yang, Z., Hulver, M., McMillan, R. P., Cai, L., Kershaw, E. E., Yu, L., Xue, B., & Shi, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047493 · Cited by 90 · see citing works

SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced InflammationIn Vivo

de Souza, J. A. C., Nogueira, A. V. B., de Souza, P. P. C., Kim, Y. J., Lobo, C. S., de Oliveira, G. J. P. L., Cirelli, J. A., Garlet, G. P., & Rossa, C. (2013) · Mediators of Inflammation · doi:10.1155/2013/650812 · Cited by 88 · see citing works

Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways

Puhr, M., Santer, F. R., Neuwirt, H., Susani, M., Nemeth, J. A., Hobisch, A., Kenner, L., & Čulig, Z. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0806 · Cited by 84 · see citing works

Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNα

Brender, C., Lovato, P., Sommer, V. H., Woetmann, A., Mathiesen, A.-M., Geisler, C., Wasik, M. A., & Ødum, N. (2004) · Leukemia · doi:10.1038/sj.leu.2403610 · Cited by 78 · see citing works

Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction

Hiwatashi, K., Tamiya, T., Hasegawa, E., Fukaya, T., Hashimoto, M., Kakoi, K., Kashiwagi, I., Kimura, A., Inoue, N., Morita, R., et al. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.04.024 · Cited by 73 · see citing works

Roles of Stat3 and ERK in G‐CSF Signaling

Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Kakumitsu, H., Yoshie, M., Yamamoto, M., Takeda, K., Matsuda, T., Akira, S., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0173a · Cited by 65 · see citing works

Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice

Inagaki-Ohara, K., Mayuzumi, H., Kato, S., Minokoshi, Y., Otsubo, T., Kawamura, Y. I., Dohi, T., Matsuzaki, G., & Yoshimura, A. (2012) · Oncogene · doi:10.1038/onc.2012.540 · Cited by 64 · see citing works

Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes

Jeppesen, P. L., Christensen, G. L., Schneider, M., Nossent, A. Y., Brønnum, H., Andersen, D. C., Eskildsen, T. V., Gammeltoft, S., Hansen, J. L., & Sheikh, S. P. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01375.x · Cited by 61 · see citing works

Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer

Bellezza, I., Neuwirt, H., Nemes, C., Cavarretta, I. T. R., Puhr, M., Steiner, H., Minelli, A., Bartsch, G. C., Offner, F. A., Hobisch, A., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060171 · Cited by 59 · see citing works

Hepatitis B virus overexpresses suppressor of cytokine signaling-3 (SOCS3) thereby contributing to severity of inflammation in the liver

Koeberlein, B., Hausen, A. Z., Bektas, N., Zentgraf, H., Chin, R. A. D., Toàn, N. L., Kandolf, R., Torresi, J., & Bock, C. –. (2009) · Virus Research · doi:10.1016/j.virusres.2009.12.003 · Cited by 59 · see citing works

Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation

White, G. E., Cotterill, A., Addley, M. R., Soilleux, E. J., & Greaves, D. R. (2011) · Journal of Molecular Histology · doi:10.1007/s10735-011-9317-7 · Cited by 56 · see citing works

Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis

Arakawa, S., Hatano, Y., & Katagiri, K. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02405.x · Cited by 53 · see citing works

Defective Leukocyte GM-CSF Receptor (CD116) Expression and Function in Inflammatory Bowel Disease

Goldstein, J. I., Kominsky, D. J., Jacobson, N. E., Bowers, B., Regalia, K. A., Austin, G. L., Yousefi, M., Falta, M. T., Fontenot, A. P., Gerich, M. E., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.060 · Cited by 53 · see citing works

Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines

Uto-Konomi, A., Miyauchi, K., Ozaki, N., Motomura, Y., Suzuki, Y., Yoshimura, A., Suzuki, S., Cua, D., & Kubo, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040343 · Cited by 52 · see citing works

Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression.

Oguro, T., Ishibashi, K., Sugino, T., Hashimoto, K., Tomita, S., Takahashi, N., Yanagida, T., Haga, N., Aikawa, K., Suzutani, T., et al. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2012.11.038 · Cited by 51 · see citing works

Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice

Zafra, M. P., Mazzeo, C., Gámez, C., Marco, A. R., de Zulueta, A., Sanz, V., Bilbao, I., Ruı́z-Cabello, J., Zubeldia, J. M., & del Pozo, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091996 · Cited by 46 · see citing works

Suppressor of Cytokine Signaling 3 Is Induced by Angiotensin II in Heart and Isolated Cardiomyocytes, and Participates in Desensitization

Calegari, V. C., Bezerra, R. M. N., Torsoni, M. A., Torsoni, A. S., Franchini, K. G., Saad, M. J. A., & Velloso, L. A. (2003) · Endocrinology · doi:10.1210/en.2003-0046 · Cited by 42 · see citing works

Suppressor of Cytokine Signaling 3 Inhibits LPS-induced IL-6 Expression in Osteoblasts by Suppressing CCAAT/Enhancer-binding Protein β Activity

Yan, C., Cao, J., Wu, M., Zhang, W., Jiang, T., Yoshimura, A., & Gao, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132084 · Cited by 40 · see citing works

The essential role of p38 MAPK in mediating the interplay of oxLDL and IL-10 in regulating endothelial cell apoptosis

Yin, Y., Liu, W., Ji, G. H., & Dai, Y. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.01.001 · Cited by 40 · see citing works

Regulation of Suppressor of Cytokine Signaling 3 (SOC3) by Growth Hormone in Pro-B Cells

Barclay, J. L., Anderson, S. T., Waters, M. J., & Curlewis, J. D. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0498 · Cited by 36 · see citing works

T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma

Moriwaki, A., Inoue, H., Nakano, T., Matsunaga, Y., Matsuno, Y., Matsumoto, T., Fukuyama, S., Kan‐o, K., Matsumoto, K., Tsuda, M., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0051oc · Cited by 33 · see citing works

Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-γ-induced vascular smooth muscle cells

Xiang, S., Dong, N.-G., Liu, J.-P., Wang, Y., Shi, J.-W., Wei, Z., Hu, X., & Gong, L. (2013) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-013-1168-x · Cited by 33 · see citing works

Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance

You, J., Yu, Y., Jiang, L., Li, W., Yu, X., Gonzalez, L., Yang, G., Ke, Z., Li, W., Cai, L., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01307-09 · Cited by 31 · see citing works

SOCS3 and SOCS6 are required for the risperidone-mediated inhibition of insulin and leptin signaling in neuroblastoma cells

Piao, L., Park, J., Li, Y., Shin, S., Shin, S., Kong, G., SHRESTHA, R., Tran, Q., Hur, G. M., Kim, J. L., et al. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1693 · Cited by 25 · see citing works

Nox2/ROS-dependent human antigen R translocation contributes to TNF-α-induced SOCS-3 expression in human tracheal smooth muscle cells

Hsu, C.-K., Lee, I., Lin, C., Hsiao, L., & Yang, C. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00274.2013 · Cited by 22 · see citing works

Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative colitis

Miyanaka, Y. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i21.2939 · Cited by 21 · see citing works

Statins and Demyelination

Weber, M. S., & Zamvil, S. S. (2007) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-73677-6_12 · Cited by 17 · see citing works

Ghrelin Restoration of Function In Vitro in Somatotropes from Male Mice Lacking the Janus Kinase (JAK)-Binding Site of the Leptin Receptor

Syed, M., Cozart, M. A., Haney, A. C., Akhter, N., Odle, A. K., Allensworth‐James, M. L., Crane, C., Syed, F. M., & Childs, G. V. (2013) · Endocrinology · doi:10.1210/en.2012-2254 · Cited by 16 · see citing works

Nuclear Factor κB Mediates the Inhibitory Effects of Interleukin-1 on Growth Hormone-Inducible Gene Expression

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Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/Thrombocythemia

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Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis

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Occurrence and Ecotoxicological Effects of Free, Conjugated, and Halogenated Steroids Including 17α-Hydroxypregnanolone and Pregnanediol in Swiss Wastewater and Surface Water

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Hypoxic Conditioned Medium From Human Adipose-Derived Stem Cells Promotes Mouse Liver Regeneration Through JAK/STAT3 Signaling

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Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5

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Lidocaine Potentiates SOCS3 to Attenuate Inflammation in Microglia and Suppress Neuropathic Pain

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Inhibition of MAPK and STAT3-SOCS3 by Sakuranetin Attenuated Chronic Allergic Airway Inflammation in Mice

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Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

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EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice

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Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth

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Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer’s Disease

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Prognostic significance of SOCS3 and its biological function in colorectal cancer

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Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis

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Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response

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SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation

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SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells

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Ginsenoside Rg1 relieves experimental colitis by regulating balanced differentiation of Tfh/Treg cells

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SOCS1 and its Potential Clinical Role in Tumor

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Olfactory Ensheathing Cells Grafted Into the Retina of RCS Rats Suppress Inflammation by Down-Regulating the JAK/STAT Pathway

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Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

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Multi-omics reveals microbiome, host gene expression, and immune landscape in gastric carcinogenesis

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Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis

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MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression

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MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling

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miR-26a Inhibits Feline Herpesvirus 1 Replication by Targeting SOCS5 and Promoting Type I Interferon Signaling

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Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3

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Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

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Genomic Landscapes of Epstein-Barr Virus in Pulmonary Lymphoepithelioma-Like Carcinoma

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Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease

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Ex vivo perfusion induces a time- and perfusate-dependent molecular repair response in explanted porcine lungs

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PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells

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Compound heterozygous mutation of the ASXL3 gene causes autosomal recessive congenital heart disease

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MiR-125b participates in the occurrence of preeclampsia by regulating the migration and invasion of extravillous trophoblastic cells through STAT3 signaling pathway

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The Functional SOCS3 RS115785973 Variant Regulated by MiR-4308 Promotes Gastric Cancer Development in Chinese Population

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Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation

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PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation

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SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration

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Endothelial Recovery in Bare Metal Stents and Drug-Eluting Stents on a Single-Cell Level

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Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats

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SOCS3 acts as a potential negative regulator in the antiviral response of large yellow croaker (Larimichthys crocea) by interacting with STAT1

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Retinal regeneration mechanisms linked to multiple cancer molecules: A therapeutic conundrum

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Curcumin exerts beneficial role on insulin resistance through modulation of SOCS3 and Rac-1 pathways in type 2 diabetic rats

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An in vitro model of the macrophage-endothelial interface to characterize CAR T-cell induced cytokine storm

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Knockdown of miR-92a suppresses the stemness of colorectal cancer cells via mediating SOCS3

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Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats

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A meta‑analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma

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Suppressors of cytokine signaling (SOCS) proteins in inflammatory bone disorders

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The prognostic role of BORIS and SOCS3 in human hepatocellular carcinoma

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Viability and Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells Are Maintained After Incubation With Porphyromonas gingivalis Protein Extract

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Age-Dependent Effects of Butyl Benzyl Phthalate Exposure on Lipid Metabolism and Hepatic Fibrosis in Mice

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The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus

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The Role of Phthalocyanine-Gold Nanoconjugates (Pc-Au NCs) in Ameliorating the Hepatic and Renal Toxicity-Induced by Silver Nanoparticles (Ag NPs) in Male Rats

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Verbascoside alleviates renal fibrosis in unilateral ureteral obstruction rats by inhibiting macrophage infiltration.

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The Novel Synthetic Peptide AESIS-1 Exerts a Preventive Effect on Collagen-Induced Arthritis Mouse Model via STAT3 Suppression

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Suppressor of cytokine signaling-3 expression and its regulation in relation to inflammation in Chronic Obstructive Pulmonary Disease

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The Rise of Molecules Able To Regenerate the Central Nervous System

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Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation

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The multifaceted roles of COL4A4 in lung adenocarcinoma: An integrated bioinformatics and experimental study

Zheng, T., Zheng, Z., Zhou, H., Guo, Y., & Li, S. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107896 · Cited by 9 · see citing works

Low-intensity exercise in the prevention of cardiac insulin resistance-related inflammation and disturbances in NOS and MMP-9 regulation in fructose-fed ovariectomized rats

Stanišić, J., Korićanac, G., Kostić, M., Stojiljković, M., Ćulafić, T., Romić, S., & Tepavčević, S. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0785 · Cited by 9 · see citing works

Low SOCS3 expression in CD4+ T cells from pemphigus vulgaris patients enhanced Th1- and Th17-cell differentiation and exacerbated acantholysis via STAT activation

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Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures

Tylek, K., Trojan, E., Leśkiewicz, M., Francavilla, F., Lacivita, E., Leopoldo, M., & Basta‐Kaim, A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00525 · Cited by 8 · see citing works

COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein

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Insights into gene expression profiles induced by Socs3 depletion in keratinocytes

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E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression

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Identifying differentially expressed genes in goat mammary epithelial cells induced by overexpression of SOCS3 gene using RNA sequencing

Song, N., Ma, C., Guo, Y., Cui, S., Chen, S., Chen, Z., Ling, Y., Zhang, Y., & Liu, H. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1392152 · Cited by 7 · see citing works

The role of suppressor of cytokine signaling 3 in inflammatory bowel disease and its associated colorectal cancer

Zhang, P., Pei, B., Yi, C., Akanyibah, F. A., & Mao, F. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167578 · Cited by 7 · see citing works

Expression of suppressor of cytokine signaling 3 (SOCS3) and interleukin-6 (-174-G/C) polymorphism in atopic conditions

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Advances in Amino Acid-Based Chemistry

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Up-regulation of SOCS4 promotes cell proliferation and migration in esophageal squamous cell carcinoma

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Research Advances on Suppressor of Cytokine Signaling 3 (SOCS3) in Animal Carbohydrate and Lipid Metabolism Processes

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Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases

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Role of the suppressor of cytokine signaling-3 in the pathogenesis of Graves’ orbitopathy

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The hepatic transcriptome of the turkey poult (Meleagris gallopavo) is minimally altered by high inorganic dietary selenium

Taylor, R. M., Mendoza, K. M., Abrahante, J. E., Reed, K. M., & Sunde, R. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232160 · Cited by 5 · see citing works

Fucoidan Alleviates Chemotherapy-Induced Peripheral Neuropathy via Activating the Gas6/MerTK Signaling Pathway to Reduce Neuroinflammation

Yang, Y., Ma, X., Ni, X., Ruan, S., Tang, L. P., Ju, Z., Wang, M., Jia, R., Chen, Y., Liu, W., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09429 · Cited by 4 · see citing works

Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages

Long, K., Xiang, K., Zeng, Q., & Dong, W. (2025) · European Journal of Histochemistry · doi:10.4081/ejh.2025.4176 · Cited by 4 · see citing works

Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome

Dexheimer, P. J., Hass, M. R., Edsall, L., Diouf, A. A., Jones, S. H., Donmez, O., Yin, C., Dunn, K. A., Forney, C. R., Hesse, H. K., et al. (2026) · Cell Genomics · doi:10.1016/j.xgen.2026.101303 · Cited by 4 · see citing works

Maternal Socs3 knockdown attenuates postnatal obesity caused by an early life environment of maternal obesity and intrauterine overnutrition in progeny mice

Zhu, F. Y., Zhang, D., Shen, F., Xu, K., Huang, X. S., Liu, J., Zhang, J., & Teng, Y. (2021) · IUBMB Life · doi:10.1002/iub.2526 · Cited by 4 · see citing works

Effects of antidiabetics and exercise therapy on suppressors of cytokine signaling-1, suppressors of cytokine signaling-3, and insulin receptor substrate-1 molecules in diabetes and obesity

Akarsu, E., Sayıner, Z. A., Balcı, S. O., Demirel, C., Bozdağ, Z., Korkmaz, M., & Yilmaz, İ. (2023) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.20220856 · Cited by 4 · see citing works

A consensus single-cell transcriptomic atlas of dermal fibroblast heterogeneityPreprint

Ascensión, A. M., & Izeta, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.05.611379 · Cited by 4 · see citing works

GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-MYC pathway in hepatocellular carcinoma

Zhang, L., Yang, W., Yang, J., & Sun, F. (2023) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-125 · Cited by 3 · see citing works

Unfolding the pathogenesis of systemic sclerosis through epigenomics

Jia, X., Cheng, H., & Xiao, Y. (2020) · STEMedicine · doi:10.37175/stemedicine.v1i1.5 · Cited by 3 · see citing works

MicroRNA-155 acts as a potential prognostic and diagnostic factor in patients with ankylosing spondylitis by modulating SOCS3

Jahangir, M., Kahrizi, M. S., Natami, M., Pour, R. M., Ghoreishizadeh, S., Hemmatzadeh, M., Mohammadi, H., Shomali, N., & Shotorbani, S. S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08033-5 · Cited by 3 · see citing works

Moderate exercise relieves heart failure-induced skeletal muscle atrophy through the inhibition of MAPK/SOCS3 signaling

Zhao, Y., Zhang, Y., Song, R., He, Y., & Yao, L. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155982 · Cited by 2 · see citing works

Psoralen promotes SOCS5 to inhibit JAK/STAT3 to alleviate cartilage degeneration in knee osteoarthritis

Zhang, J., Tian, J., Weiyang, W., Yang, Y., Li, Y., Ye, X., Huang, D., & Xu, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157643 · Cited by 2 · see citing works

M6A methylation in thyroid cancer: Functions, mechanisms, and clinical significance

Huang, D., Xie, Z., Zhang, S., Su, Y., Liu, C., & Chen, W. (2026) · Cancer Genetics · doi:10.1016/j.cancergen.2026.01.005 · Cited by 2 · see citing works

COMMD8 changes expression during initial phase of wasp venom immunotherapy

Kempiński, K., Romantowski, J., Maciejewska, A., Pawłowski, R., Chełmińska, M., Jassem, E., & Niedoszytko, M. (2020) · The Journal of Gene Medicine · doi:10.1002/jgm.3243 · Cited by 2 · see citing works

Identification of Hit Compounds Using Artificial Intelligence for the Management of Allergic Diseases

Byun, J., Tai, J., Kim, B., Kim, J., Jung, S., Lee, J., Song, Y. W., Shin, J., & Kim, T. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042280 · Cited by 1 · see citing works

Socs3a is Dispensable for Zebrafish Hematopoiesis and is Required for Neuromast Formation

Sobah, M. L., Liongue, C., & Ward, A. C. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl36537 · Cited by 1 · see citing works

Sex-dependent epigenomic and transcriptomic reprogramming links maternal obesity to cardiac remodeling in adult offspring

Wilson, T. D., Phillips, E. A., Alharithi, Y. J., Broberg, C., Vanderpool, J., Rakshe, S. K., Fei, S. S., Davis, B. A., Koch, S. E., Zhu, Z., et al. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00507.2026 · Cited by 1 · see citing works

Involvement of IL‐6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate

Ali, G. F., Hassanein, E. H. M., Abdel‐Reheim, M. A., Arafa, E. A., & Mohamed, W. R. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70339 · Cited by 2 · see citing works

Locally constrained xylene-based cyclic mimetics of SOCS3 protein

Cugudda, A., Manna, S. L., Cozzolino, F., Tolbatov, I., Marrone, A., & Marasco, D. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118210 · Cited by 1 · see citing works

SOCS, Inflammation, and Autoimmunity

Yoshimura, A., Suzuki, M., Sakaguchi, R., Hanada, T., & Yasukawa, H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00020 · Cited by 254 · see citing works

doi: 10.3389/fimmu.2014.00058 SOCS3, a major regulator of infection and inflammation

Carow, B., Rottenberg, M. E., Yamazaki, T., Carow, B., & Rottenberg, M. E. (2014)

SOCS3, a Major Regulator of Infection and Inflammation

Carow, B., & Rottenberg, M. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00058 · Cited by 555 · see citing works

SOCS3 revisited: a broad regulator of disease, now ready for therapeutic use?

Mahony, R., Ahmed, S., Diskin, C., & Stevenson, N. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2234-x · Cited by 92 · see citing works

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways

Tamiya, T., Kashiwagi, I., Takahashi, R., Yasukawa, H., & Yoshimura, A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207464 · Cited by 323 · see citing works