Childhood Asthma Inception and Progression
Open accessAbstract
Inappropriate responses to respiratory viruses, especially rhinovirus, and early allergic sensitization are the strongest contributors to the inception and persistence of early onset asthma. The ORMDL3 asthma locus in chromosome 17q seems to exert its effects by increasing susceptibility to human rhinovirus in early life. Being raised on animal farms is highly protective against the development of asthma, and this protective effect is mediated by exposure to microbes. Two trials in high-risk young children, one to prevent wheezing lower respiratory tract illness using bacterial lyophilizates and another using anti-immunoglobulin E to prevent asthma progression, are already under way.
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In early life, a period critical for immune development, environmental microbial diversity appears protective against allergic sensitization and asthma.
“In early life, a period critical for immune development, environmental microbial diversity appears protective against allergic sensitization and asthma (77, 81, 82).”
From Indoor Allergen Interventions in Homes and Schools for Managing Asthma (2025) · cites this paper as [82]
In “Animal farming and early onset asthma” (page unavailable), the paper reports that children raised on animal farms had lower risks of early-onset asthma and allergic sensitization, and suggests that exposure to environmental bacteria and fungi may explain the protection. It discusses the timing of microbial exposure and immune maturation in “Human microbiome and the inception of early onset asthma,” but describes environmental microbial burden, not diversity specifically, as the proposed protective factor. (LLM, conf=0.84)
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Indoor Allergen Interventions in Homes and Schools for Managing Asthma
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- Authors
- Martinez, F. D.
- Venue
- Immunology and Allergy Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 39
- Issue
- 2
- Pages
- 141-150
- ISSN
- 0889-8561 (ISSN-L)
- PMC
- PMC6613822
- OpenAlex
- W2928330897
- Cited by
- 59
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 29 · 2020: 11
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology and Allergy Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- US National Heart, Lung, and Blood Institute (HL132523)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- childhood asthma, asthma progression, rhinovirus, allergen sensitization, ORMDL3, chromosome 17q, farm animal exposure, microbial exposure, wheezing, asthma prevention
- MeSH terms
- Allergens, Asthma, Child, Disease Susceptibility, Environmental Exposure, Humans, Immunization, United States, Virus Diseases, Disease Progression, Host-Pathogen Interactions, Microbiota
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