Nanoparticle-Induced Controlled Drug Delivery Using Chitosan-Based Hydrogel and Scaffold: Application to Bone Regeneration
Abstract
The novel chitosan nanohybrid hydrogel and scaffold have been developed with high mechanical strength and tailor the drug release ability for their applications in the biomedical arena. Nanohybrid hydrogels are prepared in dilute acetic acid medium using two different types of two-dimensional-layered nanoparticles. Scaffolds are prepared through lyophilization of hydrogels. Highly porous, open, and 3D interconnected morphologies are observed in the nanohybrid scaffolds, as opposed to the thick wall, smaller pore dimension in pure chitosan. The interaction between the nanoparticles and chitosan chains are elucidated using different spectroscopic techniques, which in turn are responsible for the uniform distribution of the nanoparticle in the chitosan matrix. Nanohybrids are found to be highly mechanically stable in both states (hydrogel and scaffold), as compared to pure chitosan because of the good reinforcing ability of 2D nanoparticles. Sustained drug release has been achieved in nanohybrid in vitro, as compared to the pure chitosan hydrogel/scaffold, mainly due to greater interactions between the components and the better barrier effect of 2D nanoparticles. Cytotoxicity of the nanohybrids is verified using NIH 3T3 mouse embryonic fibroblast cells for their possible use as controlled drug delivery vehicles. Nanohybrids are found to be nontoxic in nature and more biocompatible as compared to pure chitosan, as observed through cell viability and cell imaging studies. Interestingly, cell growth occurs within the pores of the nanohybrid scaffold, vis-à-vis the surface proliferation noticed in the pure chitosan scaffold. Better biocompatibility, hydrophilic nature, and sustained delivery with location specific cell growth make this nanohybrid hydrogel unique for biomedical uses. The bone regeneration rate is found to be significantly higher for the nanohybrid scaffold as compared to blank/pure chitosan without any side effect, suggesting nanohybrid systems are superior biomaterials.
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Highly porous, 3D-interconnected nanohybrid scaffolds/hydrogels controlled drug release and were biocompatible.
“Highly porous, 3D-interconnected nanohybrid scaffolds/hydrogels controlled drug release and were biocompatible as well.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [252]
Chitosan nanohybrid scaffolds with enhanced mechanical properties have been reported as drug carriers for biomedical applications.
“In another approach, chitosan nanohybrid scaffolds with enhanced mechanical properties have been reported as drug carriers for biomedical applications.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [252]
The scaffold was found to be safe and very effective in bone regeneration compared to pure chitosan.
“The scaffold has been found to be safe and very effective in bone regeneration compared to pure chitosan.252”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [252]
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From Nature to Nanocarriers: Advancements in Natural Polymer Drug Delivery Systems
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- Authors
- Mahanta, A. K., Senapati, S., Paliwal, P., Krishnamurthy, S., Hemalatha, S., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Corresponding author
- Maiti, Pralay
- ORCID
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-11-16
- Volume
- 16
- Issue
- 1
- Pages
- 327-338
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2901097670
- Cited by
- 81
- References
- 51
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 14 · 2021: 9 · 2020: 9 · 2019: 7
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research (02(0074)/12/EMR-II)
- Science and Engineering Research Board (R&D/SERB/LT/SMST/16/17/06)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- chitosan scaffolds, controlled drug delivery, sustained drug release, bone regeneration, mechanical reinforcement, 3D porous scaffolds, biocompatibility, cytotoxicity, NIH3T3 cells
- MeSH terms
- Animals, Bone Regeneration, Drug Delivery Systems, Hydrogels, NIH 3T3 Cells, Chitosan, Mice, Nanoparticles, Tissue Scaffolds
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