Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering
Abstract
Bone tissue engineering is an alternative strategy to generate bone utilizing a combination of biomaterials and cells. Biomaterials that mimic the structure and composition of bone tissues at nanoscale are important for the development of bone tissue engineering applications. Natural or biopolymer-based composites containing chitin, chitosan, or collagen have advantages such as biocompatibility, biodegradability that are essential for bone tissue engineering. The inclusion of nanoparticles of hydroxyapatite (one of the most widely used bioceramic materials) into the biopolymer matrix improves the mechanical properties and incorporates the nanotopographic features that mimic the nanostructure of bone. This review summarizes the recent work on the development of biocomposites containing natural polymers with hydroxyapatite particles suitable for use in bone defects/bone regeneration.
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Bone regenerative capacity is limited in large bone defects, requiring surgical procedures to prevent further degeneration.
“Even though the bone can regenerate itself, its regenerative capacity is limited in the case of large bone defects and hence, requires surgical procedures to prevent it from further degeneration [3].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [3]
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- Authors
- Swetha, M., Sahithi, K., Moorthi, A., Srinivasan, N., Ramasamy, K., & Selvamurugan, N.
- Affiliations
- SRM Institute of Science and Technology (IN)
- University of Madras (IN)
- Corresponding author
- Selvamurugan, Nagarajan
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 47
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2066518402
- Cited by
- 548
- References
- 43
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 37 · 2023: 33 · 2022: 36 · 2021: 47 · 2020: 42 · 2019: 57 · 2018: 47 · 2017: 30 · 2016: 44 · 2015: 37 · 2014: 35 · 2013: 21 · 2012: 28
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Keywords
- bone tissue engineering, biocomposites, hydroxyapatite nanoparticles, natural polymers, chitosan, chitin, collagen, biodegradable biomaterials, bone regeneration, bone defects, nanotopography, mechanical properties
- MeSH terms
- Animals, Bone Regeneration, Chitin, Collagen, Humans, Durapatite, Bone Substitutes, Tissue Engineering, Chitosan, Nanoparticles
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