Cited by 114Wound Healing and TreatmentsNanocomposite Films for Food PackagingAdvanced Drug Delivery Systems

Nitric oxide-releasing chitosan film for enhanced antibacterial and in vivo wound-healing efficacy

Kim, Jong Oh, Noh, Jin-Ki, Thapa, Raj Kumar, Hasan, Nurhasni, Choi, Moonjeong, Kim, Jeong Hwan, Lee, Joon-Hee, Ku, Sae Kwang +1 more·2015·International Journal of Biological Macromolecules

Abstract

Nitric oxide (NO) is a promising therapeutic agent with antibacterial and wound-healing properties. However, the gaseous state and short half-life of NO necessitate a formulation that can control its storage and release. In this study, we developed NO-releasing films (CS/NO film) composed of chitosan (CS) and S-nitrosoglutathione (GSNO) as a NO donor. Thermal analysis demonstrated molecular dispersion of GSNO in the films. In vitro release study revealed that NO release from CS/NO films followed Korsmeyer-Peppas model with Fickian diffusion kinetics. Moreover, the CS/NO film showed a stronger antibacterial activity against Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) than the CS film. Further, the CS/NO film accelerated wound healing and epithelialization in a rat model of full-thickness wounds as compared to the CS film. Histopathological studies revealed that CS/NO films favorably enhanced the re-epithelialization and reconstruction of wounded skin. Therefore, our results suggest that CS/NO films could be a suitable formulation for treating full-thickness wounds.

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Crossref · 10.1016/j.ijbiomac.2015.04.073

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Authors
Kim, J. O., Noh, J.-K., Thapa, R. K., Hasan, N., Choi, M., Kim, J. H., Lee, J.-H., Ku, S. K., & Yoo, J.-W.
Affiliations
  • Yeungnam University (KR)
  • Pusan National University (KR)
  • Daegu Haany University (KR)
Corresponding author
Yoo, Jin-Wook
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2015-08
Volume
79
Pages
217-225
ISSN
0141-8130 (ISSN-L)
OpenAlex
W289801092
Cited by
114
References
42
Citations by year
2026: 2 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 19 · 2021: 20 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 1
FWCI
7.06
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education (NRF-2014R1A1A4A01007808)
  • Ministry of Health and Welfare (HI12C0529010013)
  • National Research Foundation of Korea
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
nitric oxide release, chitosan films, S-nitrosoglutathione, nitric oxide donors, antibacterial activity, wound healing, full-thickness wounds, re-epithelialization, Pseudomonas aeruginosa, Staphylococcus aureus, controlled release, Fickian diffusion, wound dressings
MeSH terms
Animals, Anti-Bacterial Agents, Bandages, Diffusion, Kinetics, Male, Membranes, Artificial, Nitric Oxide, Pseudomonas aeruginosa, Staphylococcus aureus, Wound Healing, Rats, Sprague-Dawley, Nitric Oxide Donors, S-Nitrosoglutathione, Chitosan, Rats, Disk Diffusion Antimicrobial Tests, Drug Liberation

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