Fabrication and in vitro characterization of HPMC-g-poly (AMPS) hydrogels loaded with loxoprofen sodium
Abstract
The aim of this study was to prepare hydroxypropyl-methyl cellulose (HPMC)-K15 based hydrogels via free radical polymerization using 2‑acrylamido-2‑methyl propane sulphonic acid (AMPS) as a monomer and N,N'-methylene bisacrylamide (MBAAm) as a crosslinker. Loxoprofen sodium was chosen as a model drug and successfully loaded in hydrogel discs. Sol-gel, porosity, loading efficiency, and the in vitro drug release analysis were carried out to evaluate its drug delivery potential. HMPC-g-poly(AMPS) hydrogels were characterized by using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) approaches. Maximum swelling and drug release were observed at pH 7.4. Kinetic modelling suggested that drug release followed first-order kinetics with the non-Fickian mechanism. FTIR and DSC confirmed the formation of new hydrogels. SEM micrographs confirmed uneven, rough, and partially porous type of surface. These results suggested that HMPC-g-poly(AMPS) hydrogels can be a prospective pH-responsive carrier for delivery of water-soluble drugs, such as loxoprofen sodium.
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High porosity offers more water permeation, leading to more swelling and greater drug loading/releasing capacity.
“High porosity offers more water permeation leading to more swelling, and drug loading/releasing capacity (Khanum et al., 2018).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Khanum et al., 2018
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“High porosity offers more water permeation leading to more swelling, and drug loading/releasing capacity (Khanum et al., 2018).”
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- Authors
- Khanum, H., Ullah, K., Murtaza, G., & Khan, S. A.
- Affiliations
- COMSATS University Islamabad (PK)
- Corresponding author
- Murtaza, Ghulam
- Khan, Shujaat Ali
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 120
- Issue
- Pt B
- Pages
- 1624-1631
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2895734086
- Cited by
- 104
- References
- 33
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 10 · 2023: 24 · 2022: 26 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 1
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Polymer-Based Agricultural Enhancements
- Keywords
- hydroxypropyl methylcellulose, 2-acrylamido-2-methylpropane sulfonic acid, loxoprofen sodium, drug delivery, pH-responsive hydrogels, radical polymerization, N,N'-methylenebisacrylamide crosslinker, in vitro drug release, non-Fickian release kinetics, swelling behavior, porosity, water-soluble drugs
- MeSH terms
- Drug Carriers, Hydrogen-Ion Concentration, Kinetics, Phenylpropionates, Temperature, Porosity, Hydrogels, Hypromellose Derivatives, Drug Liberation
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