3D-poly (lactic acid) scaffolds coated with gelatin and mucic acid for bone tissue engineering
Abstract
Three-dimensional (3D) printing is a promising technology to fabricate the intricate biomimetic structure. The primary focus of this study was to develop the bioactive 3D-scaffolds to enhance bone regeneration. The 3D-poly (lactic acid) (PLA) scaffolds were extruded based on a computer-aided design (CAD) model and coated with gelatin (Gel) containing different concentrations of mucic acid (MA) and were investigated for their osteogenic potential. Coating the PLA scaffolds with Gel/MA improved their physicochemical properties, and the addition of MA did not alter these properties. The viability of mouse mesenchymal stem cells (mMSCs, C3H10T1/2) seeded onto the PLA/Gel/MA scaffolds remained unaffected both at metabolic and cell membrane integrity levels. Alkaline phosphatase and von Kossa staining indicated the promotion of osteoblast differentiation of mMSCs by MA in the PLA/Gel scaffolds. Inclusion of MA in PLA/Gel scaffolds also increased the expression of the master bone transcription factor, Runx2, and other osteoblastic differentiation marker genes in mMSCs. Thus, our results suggested that the 3D-printed PLA scaffolds coated with Gel/MA favor osteoblast differentiation and have potential applications in bone tissue engineering.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PLA has been increasingly utilized to construct 3D-printed bone implants.
“PLA has been increasingly utilized to construct 3D-printed bone implants [21].”
From A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties (2022) · cites this paper as [21]
Cites
Bone tissue engineering using 3D printing
Bose, S., Vahabzadeh, S., & Bandyopadhyay, A. K. (2013) · Materials Today · doi:10.1016/j.mattod.2013.11.017 · Cited by 1,873 · see citing works
Polymer surface modification for the attachment of bioactive compounds
Goddard, J. M., & Hotchkiss, J. H. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.04.002 · Cited by 1,383 · see citing works
Polymeric Scaffolds for Bone Tissue Engineering
Liu, X., & Ma, P. X. (2004) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000017544.36001.8e · Cited by 1,346 · see citing works
Mesenchymal Stem Cells for Regenerative Medicine
Han, Y., Li, X., Zhang, Y., Han, Y., Chang, F., & Ding, J. (2019) · Cells · doi:10.3390/cells8080886 · Cited by 1,093 · see citing works
Scaffolds for tissue fabrication
Ma, P. X. (2004) · Materials Today · doi:10.1016/s1369-7021(04)00233-0 · Cited by 1,081 · see citing works
Nagarajan, V., Mohanty, A. K., & Misra, M. (2016) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6b00321 · Cited by 926 · see citing works
da Silva, D., Kaduri, M., Poley, M., Adir, O., Krinsky, N., Shainsky‐Roitman, J., & Schroeder, A. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.01.010 · Cited by 872 · see citing works
Scaffold Techniques and Designs in Tissue Engineering Functions and Purposes: A Review
Eltom, A., Zhong, G., & Ameen, M. (2019) · Advances in Materials Science and Engineering · doi:10.1155/2019/3429527 · Cited by 617 · see citing works
Electrospun polymer biomaterials
Ding, J., Zhang, J. C., Li, J., Li, D., Xiao, C., Xiao, H., Yang, H., Zhuang, X., & Chen, X. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.01.002 · Cited by 605 · see citing works
Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering
Liu, X., Callahan, L. A. S., Hu, J., & Ma, P. X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.068 · Cited by 540 · see citing works
(2018) · PubMed Central · Cited by 365 · see citing works
Drug delivery from gelatin-based systems
Foox, M., & Zilberman, M. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1037272 · Cited by 361 · see citing works
Poly(dopamine) coating of 3D printed poly(lactic acid) scaffolds for bone tissue engineering
Kao, C., Lin, J. F., Chen, Y., Yeh, C.-H., Fang, H.-Y., & Shie, M. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.06.028 · Cited by 326 · see citing works
Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering
Zhang, Y., Liu, X., Zeng, L., Zhang, J. C., Zuo, J., Zou, J., Ding, J., & Chen, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201903279 · Cited by 295 · see citing works
Electrospun polymer micro/nanofibers as pharmaceutical repositories for healthcare.
Feng, X.-R., Li, J.-N., Zhang, X., Liu, T.-J., Ding, J.-X., & Chen, X.-S. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.020 · Cited by 291 · see citing works
Controlled drug release for tissue engineering
Rambhia, K. J., & Ma, P. X. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.049 · Cited by 279 · see citing works
Biomedical Applications of Poly(Lactic Acid)
Pawar, R. P., Tekale, S. U., Shisodia, S. U., Totre, J. T., & Domb, A. J. (2014) · Recent Patents on Regenerative Medicine · doi:10.2174/2210296504666140402235024 · Cited by 252 · see citing works
Chitosan and gelatin-based electrospun fibers for bone tissue engineering
Sruthi, R., Balagangadharan, K., & Selvamurugan, N. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.115 · Cited by 233 · see citing works
Self-citationYin, Y., Ye, F., Cui, J., Zhang, F., Li, X., & Yao, K. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10153 · Cited by 231 · see citing works
Cui, L., Zhang, J. C., Zou, J., Yang, X., Guo, H., Tian, H., Zhang, P., Wang, Y., Zhang, N., Zhuang, X., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119617 · Cited by 229 · see citing works
Lee, S. J., Lee, D., Yoon, T. R., Kim, H. K., Jo, H. H., Park, J. S., Lee, J. H., Kim, W. D., Kwon, I. K., & Park, S. A. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.02.006 · Cited by 221 · see citing works
Wang, M., Favi, P. M., Cheng, X., Golshan, N. H., Ziemer, K. S., Keidar, M., & Webster, T. J. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.030 · Cited by 219 · see citing works
Comparison of the Efficacy of Three Different Bone Regeneration Materials: An Animal Study
Anbu, R. T., Suresh, V., Gounder, R., & Kannan, A. (2019) · European Journal of Dentistry · doi:10.1055/s-0039-1688735 · Cited by 186 · see citing works
Kaito, T., Myoui, A., Takaoka, K., Saito, N., Nishikawa, M., Tamai, N., Ohgushi, H., & Yoshikawa, H. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.010 · Cited by 183 · see citing works
Cell adhesion and proliferation enhancement by gelatin nanofiber scaffolds
Wu, S.-C., Chang, W.-H., Dong, G., Chen, K., Chen, Y.-S., & Yao, C. (2011) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911511423563 · Cited by 182 · see citing works
Surface functionalization of 3D printed polymer scaffolds to augment stem cell response
Chakka, L. R. J., & Chatterjee, K. (2018) · Materials & Design · doi:10.1016/j.matdes.2018.11.018 · Cited by 181 · see citing works
Martin, V., Ribeiro, I. A., Alves, M. M., Gonçalves, L., Claudio, R. A., Grenho, L., Fernandes, M. H., Gomes, P., Santos, C. F., & Bettencourt, A. F. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.03.056 · Cited by 181 · see citing works
Heo, D. N., Castro, N. J., Lee, S., Noh, H., Zhu, W., & Zhang, L. G. (2017) · Nanoscale · doi:10.1039/c6nr09652b · Cited by 152 · see citing works
Chen, X., Gao, C., Jiang, J., Wu, Y., Zhu, P., & Chen, G. (2019) · Biomedical Materials · doi:10.1088/1748-605x/ab388d · Cited by 152 · see citing works
Teixeira, B. N., Aprile, P., Mendonça, R. H., Kelly, D. J., & Thiré, R. M. D. S. M. (2018) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34093 · Cited by 150 · see citing works
Chitosan scaffolds containing chicken feather keratin nanoparticles for bone tissue engineering
Sekaran, S., Sameera, D. K., Moorthi, A., & Selvamurugan, N. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.09.034 · Cited by 138 · see citing works
Self-citationAntioxidant and antiproliferative capacities of phenolics purified from Phyllanthus emblica L. fruit
Luo, W., Zhao, M., Yang, B. J., Ren, J., Shen, G., & Rao, G. H. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.018 · Cited by 138 · see citing works
A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering
Jung, Y., Kim, S.-S., Kim, Y. H., Kim, S.-H., Kim, B.-S., Kim, S., Choi, C. Y., & Kim, S. H. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.04.007 · Cited by 136 · see citing works
Choi, W. J., Hwang, K., Kwon, H. J., Lee, C., Kim, C. H., Kim, T. H., Heo, S. W., Kim, J. H., & Lee, J. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110693 · Cited by 134 · see citing works
Characterization of covalent crosslinking strategies for synthesizing DNA-based bioconjugates
Wickramathilaka, M., & Tao, B. Y. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0191-2 · Cited by 121 · see citing works
Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., & Fisher, J. P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.01.007 · Cited by 120 · see citing works
Balagangadharan, K., Trivedi, R., Vairamani, M., & Selvamurugan, N. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.04.002 · Cited by 104 · see citing works
Self-citationKhan, W. S., Rayan, F., Dhinsa, B. S., & Marsh, D. (2011) · Stem Cells International · doi:10.1155/2012/236231 · Cited by 98 · see citing works
Soundarya, S. P., Sanjay, V., Menon, A. H., Dhivya, S. M., & Selvamurugan, N. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.09.014 · Cited by 96 · see citing works
Self-citation3D printed polylactic acid nanocomposite scaffolds for tissue engineering applications
Alam, F., Varadarajan, K. M., & Kumar, S. (2019) · Polymer Testing · doi:10.1016/j.polymertesting.2019.106203 · Cited by 96 · see citing works
Velioglu, Z. B., Pulat, D., Demirbakan, B., Özcan, B., Bayrak, E., & Erişken, C. (2018) · Connective Tissue Research · doi:10.1080/03008207.2018.1499732 · Cited by 83 · see citing works
Biotechnological Production of Bioactive Compounds
(2019) · Elsevier eBooks · doi:10.1016/c2018-0-02574-8 · Cited by 83 · see citing works
Rojas, A. P., Aguilar, R., Henríquez, B., Lian, J. B., Stein, J. L., Stein, G. S., van Wijnen, A. J., van Zundert, B., Allende, M. L., & Montecino, M. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.657825 · Cited by 78 · see citing works
Chen, L., Shao, L.-P., Wang, F., Huang, Y., & Gao, F.-H. (2019) · RSC Advances · doi:10.1039/c8ra08788a · Cited by 78 · see citing works
Menon, A. H., Soundarya, S. P., Sanjay, V., Chandran, S. V., Balagangadharan, K., & Selvamurugan, N. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.04.115 · Cited by 72 · see citing works
Self-citationCai, Q., Xu, Q., Feng, Q., Cao, X., Yang, X., & Deng, X. (2011) · Applied Surface Science · doi:10.1016/j.apsusc.2011.06.157 · Cited by 69 · see citing works
Approaches for building bioactive elements into synthetic scaffolds for bone tissue engineering
Kesireddy, V., & Kasper, F. K. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00783j · Cited by 69 · see citing works
Lee, J.-M., Kim, M.-G., Byun, J., Kim, G., Ro, J. H., Hwang, D., Choi, B. B. R., Park, G.-C., & Kim, U. (2017) · Maxillofacial Plastic and Reconstructive Surgery · doi:10.1186/s40902-017-0104-6 · Cited by 69 · see citing works
Ali, D., Chen, L., Kowal, J., Okla, M., Manikandan, M., Alshehri, M., Almana, Y., AlObaidan, R. H., Alotaibi, N., Hamam, R., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115252 · Cited by 69 · see citing works
Tardajos, M. G., Cama, G., Dash, M., Misseeuw, L., Gheysens, T., Gorzelanny, C., Coenye, T., & Dubruel, P. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.02.060 · Cited by 66 · see citing works
Zafar, M. T., Maiti, S. N., & Ghosh, A. K. (2016) · RSC Advances · doi:10.1039/c6ra17894d · Cited by 64 · see citing works
Bosworth, L. A., Hu, W., Shi, Y., & Cartmell, S. H. (2019) · Journal of Nanomaterials · doi:10.1155/2019/4605092 · Cited by 64 · see citing works
Chitosan in Surface Modification for Bone Tissue Engineering Applications
Abinaya, B., Prasith, T. P., Ashwin, B., Chandran, S. V., & Selvamurugan, N. (2019) · Biotechnology Journal · doi:10.1002/biot.201900171 · Cited by 60 · see citing works
Self-citationTian, W., Yang, L., Xu, Y., Weng, S., & Wu, J. (2000) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00276-1 · Cited by 58 · see citing works
Yeh, C.-H., Chen, Y., Shie, M., & Fang, H.-Y. (2015) · Materials · doi:10.3390/ma8074299 · Cited by 57 · see citing works
Roh, H.-S., Jung, S., Kook, M.-S., & Kim, B. (2016) · Applied Surface Science · doi:10.1016/j.apsusc.2015.12.243 · Cited by 54 · see citing works
Biomechanics and Biomaterials in Orthopedics
Prever, E. M. B. D., Luigi, C., Baricco, M., C., P., & Masse', A. (2016) · Springer eBooks · doi:10.1007/978-1-84882-664-9 · Cited by 52 · see citing works
Chandran, S. V., Vairamani, M., & Selvamurugan, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-48429-1 · Cited by 44 · see citing works
Self-citationFabrication of PCL/PVP Electrospun Fibers loaded with Trans-anethole for Bone Regeneration in vitro
Shadamarshan, P., Balaji, H., Rao, H. S., Balagangadharan, K., Chandran, S. V., & Selvamurugan, N. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.08.005 · Cited by 43 · see citing works
Self-citationEffects of Graphene Nanopletelets on Poly(Lactic Acid)/Poly(Ethylene Glycol) Polymer Nanocomposites
Chieng, B. W., Azowa, I. N., Yunus, W. M. Z. W., & Hussein, M. Z. (2014) · Advanced materials research · doi:10.4028/www.scientific.net/amr.1024.136 · Cited by 38 · see citing works
Nanotechnology for enhanced bioactivity of bioactive compounds
Majumdar, M., Shivalkar, S., Pal, A., Verma, M. L., Sahoo, A. K., & Roy, D. N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64323-0.00015-1 · Cited by 38 · see citing works
Medicinal Plants and Phytocompounds: A Potential Source of Novel Antibiofilm Agents
Ahmad, I., Husain, F. M., Maheshwari, M., & Zahin, M. (2014) · Springer series on biofilms · doi:10.1007/978-3-642-53833-9_10 · Cited by 33 · see citing works
Kuo, P., Huang, Y., Chang, C., & Chang, J. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.119 · Cited by 29 · see citing works
Vázquez-Vázquez, F. C., Chanes‐Cuevas, O. A., Masuoka‐Ito, D., Arenas‐Alatorre, J., Chavarría‐Bolaños, D., Vega‐Baudrit, J. R., Serrano‐Bello, J., & Álvarez-Pérez, M. A. (2019) · Journal of Nanomaterials · doi:10.1155/2019/6105818 · Cited by 27 · see citing works
Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells
Srinaath, N., Balagangadharan, K., Pooja, V., Udayakumar, P., Adhikari, T., & Selvamurugan, N. (2019) · BioFactors · doi:10.1002/biof.1515 · Cited by 26 · see citing works
Self-citationAn osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts
Sanjeev, G., Sidharthan, D. S., Pranavkrishna, S., Adithya, S. P., Ranganathan, A., Akshaya, R. L., Balagangadharan, K., Siddabathuni, N., Srinivasan, S., & Selvamurugan, N. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127137 · Cited by 24 · see citing works
Self-citationBiocompatibility of materials and its relevance to drug delivery and tissue engineering
Chandy, T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102680-9.00012-3 · Cited by 21 · see citing works
Sterner, R. M., Kremer, K. N., Dudakovic, A., Westendorf, J. J., van Wijnen, A. J., & Hedin, K. E. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800174 · Cited by 17 · see citing works
Regulation of Histone Deacetylases by MicroRNAs in Bone
Shreya, S., Malavika, D., Priya, V. R., & Selvamurugan, N. (2018) · Current Protein and Peptide Science · doi:10.2174/1389203720666181031143129 · Cited by 16 · see citing works
Self-citationBiomaterials for Bone Tissue Engineering
Ning, C. (2016) · Springer eBooks · doi:10.1007/978-1-84882-664-9_4 · Cited by 11 · see citing works
Biocompatibility of materials and its relevance to drug delivery and tissue engineering
Chandy, T. (2010) · Elsevier eBooks · doi:10.1533/9781845699802.3.301 · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 73 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering
Collins, M. N., Ren, G., Young, K., Pina, S., Reis, R. L., & Oliveira, J. M. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010609 · Cited by 877 · see citing works
3D Printing as a Promising Tool in Personalized Medicine
Vaz, V. M., & Kumar, L. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-020-01905-8 · Cited by 413 · see citing works
Arif, Z. U., Khalid, M. Y., Noroozi, R., Sadeghianmaryan, A., Jalalvand, M., & Hossain, M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.140 · Cited by 395 · see citing works
Murugiah, K., Shin, W. Y., Suhaimi, H., & Sambudi, N. S. (2023) · Gels · doi:10.3390/gels9020100 · Cited by 334 · see citing works
3D printing of PEEK and its composite to increase biointerfaces as a biomedical material- A review
Oladapo, B. I., Zahedi, S. A., Ismail, S. O., & Omigbodun, F. T. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111726 · Cited by 172 · see citing works
Kazimierczak, P., & Przekora, A. (2020) · Coatings · doi:10.3390/coatings10100971 · Cited by 147 · see citing works
Chitosan-based 3D-printed scaffolds for bone tissue engineering
Yadav, L. R., Chandran, S. V., Lavanya, K., & Selvamurugan, N. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.215 · Cited by 125 · see citing works
Self-citationKhan, M. U. A., Razak, S. I. A., Al-Arjan, W. S., Nazir, S., Anand, T. J. S., Mehboob, H., & Amin, R. (2021) · Molecules · doi:10.3390/molecules26030619 · Cited by 123 · see citing works
3D printing of bio-instructive materials: Toward directing the cell
Zieliński, P. S., Gudeti, P. K. R., Rikmanspoel, T., & Włodarczyk‐Biegun, M. K. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.04.008 · Cited by 119 · see citing works
Fernández, I. A., Haugen, H. J., López‐Peña, M., González‐Cantalapiedra, A., & Muñoz, F. M. G. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.013 · Cited by 108 · see citing works
Phutane, P., Telange, D. R., Agrawal, S. S., Gunde, M. C., Kotkar, K., & Pethe, A. M. (2023) · Polymers · doi:10.3390/polym15051202 · Cited by 95 · see citing works
A Review of 3D Printed Bone Implants
Li, Z., Wang, Q., & Liu, G. (2022) · Micromachines · doi:10.3390/mi13040528 · Cited by 90 · see citing works
Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges
Xu, C. W., Liu, Z., Chen, X., Gao, Y., Wang, W., Zhuang, X., Zhang, H., & Dong, X. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109197 · Cited by 90 · see citing works
Oladapo, B. I., Ismail, S. O., Bowoto, O. K., Omigbodun, F. T., Olawumi, M. A., & Muhammad, M. A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.175 · Cited by 76 · see citing works
Adithya, S. P., Sidharthan, D. S., Abhinandan, R., Balagangadharan, K., & Selvamurugan, N. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.053 · Cited by 70 · see citing works
Self-citationAn overview of polyester/hydroxyapatite composites for bone tissue repairing
Fu, Z., Cui, J., Zhao, B., Shen, S. G., & Lin, K. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2021.02.005 · Cited by 69 · see citing works
Donya, H., Darwesh, R., & Ahmed, M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.073 · Cited by 63 · see citing works
RetractedA comprehensive review on nanocomposite biomaterials based on gelatin for bone tissue engineering
Abar, E. S., Vandghanooni, S., Torab, A., Jaymand, M., & Eskandani, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127556 · Cited by 58 · see citing works
Bahraminasab, M., Doostmohammadi, N., Talebi, A., Arab, S., Alizadeh, A., Ghanbari, A., & Salati, A. (2022) · BioMedical Engineering OnLine · doi:10.1186/s12938-022-01056-w · Cited by 57 · see citing works
Swarupa, S., & Thareja, P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131104 · Cited by 52 · see citing works
3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression
Shende, P. K., & Trivedi, R. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10120-2 · Cited by 50 · see citing works
Applications of poly(lactic acid) in bone tissue engineering: A review article
Alavi, M. S., Memarpour, S., Pazhohan‐Nezhad, H., Asl, A. S., Moghbeli, M., Shadmanfar, S., & Saburi, E. (2023) · Artificial Organs · doi:10.1111/aor.14612 · Cited by 52 · see citing works
Artificial bone scaffolds and bone joints by additive manufacturing: A review
Gupta, K., & Meena, K. (2023) · Bioprinting · doi:10.1016/j.bprint.2023.e00268 · Cited by 47 · see citing works
Surface Finishing of 3D-Printed Polymers with Selected Coatings
Žigon, J., Kariž, M., & Pavlič, M. (2020) · Polymers · doi:10.3390/polym12122797 · Cited by 46 · see citing works
Zhang, Y., Huo, M., Wang, Y., Xiao, L., Wu, J., Ma, Y., Zhang, D., Lang, X., & Wang, X. (2022) · Journal of Biological Engineering · doi:10.1186/s13036-022-00301-z · Cited by 43 · see citing works
Alwafi, R., Mansour, S. F., AlHammad, M. S., & Ahmed, M. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120517 · Cited by 43 · see citing works
RetractedHu, X., Lin, Z., He, J., Zhou, M., Yang, S., Wang, Y., & Li, K. (2022) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.14 · Cited by 42 · see citing works
Lavanya, K., Balagangadharan, K., Chandran, S. V., & Selvamurugan, N. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213305 · Cited by 42 · see citing works
Self-citationJeong, Y., Jeong, S., Kim, S., Kim, H. J., Jo, J., Shanmugasundaram, A., Kim, H., Choi, E., & Lee, D. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.140118 · Cited by 40 · see citing works
Loyo, C., Córdoba, A., Palza, H., Canales, D. A., Melo, F., Vivanco, J. F., Baier, R. V., Millán, C., Corrales, T., & Zapata, P. A. (2023) · Polymers · doi:10.3390/polym16010129 · Cited by 37 · see citing works
Shabankhah, M., Moghaddaszadeh, A., & Najmoddin, N. (2023) · Progress in Organic Coatings · doi:10.1016/j.porgcoat.2023.108013 · Cited by 36 · see citing works
Protein by-products: Composition, extraction, and biomedical applications
Ghaffari‐Bohlouli, P., Jafari, H., Taebnia, N., Abedi, A., Amirsadeghi, A., Niknezhad, S. V., Alimoradi, H., Jafarzadeh, S., Mirzaei, M., Nie, L., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2067829 · Cited by 35 · see citing works
Versatile 3D Printing Scaffold with Spatiotemporal Release of Multiple Drugs for Bone Regeneration
Zhu, Z., Li, C., Lin, Y., Li, L., Liu, K., Wen, W., Ding, S., Zhou, C., Lai, Y., & Luo, B. (2025) · ACS Nano · doi:10.1021/acsnano.4c13265 · Cited by 35 · see citing works
Swetha, S., Balagangadharan, K., Lavanya, K., & Selvamurugan, N. (2021) · Biotechnology Journal · doi:10.1002/biot.202100282 · Cited by 35 · see citing works
Self-citationBioengineered Living Bone Grafts—A Concise Review on Bioreactors and Production Techniques In Vitro
Kazimierczak, P., & Przekora, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031765 · Cited by 33 · see citing works
Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration
Deng, L., Liu, Y., Wu, Q., Lai, S., Yang, Q., Mu, Y., & Dong, M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04024-4 · Cited by 32 · see citing works
Liao, S., Bai, D., Jia, Y., Sun, J., Liu, H., Li, L., & Xu, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133470 · Cited by 32 · see citing works
Lai, W.-Y., Chen, Y., Lee, A. K.-X., Lin, Y.-H., Liu, Y., & Shie, M. (2021) · Biomedicines · doi:10.3390/biomedicines9070712 · Cited by 32 · see citing works
Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration
Li, X., Yang, Z., Fang, L., Ma, C. B., Zhao, Y., Liu, H., Che, S., Zvyagin, A. V., Yang, B., & Lin, Q. (2021) · Macromolecular Rapid Communications · doi:10.1002/marc.202100362 · Cited by 32 · see citing works
Influence of Gelatin-Based Coatings Crosslinked with Phenolic Acids on PLA Film Barrier Properties
Debeaufort, F., Riondet, J., Brachais, C., & Benbettaïeb, N. (2022) · Coatings · doi:10.3390/coatings12070993 · Cited by 31 · see citing works
Yan, Z., Deng, Y., Huang, L., Zeng, J., Wang, D., Tong, Z., Fan, Q., Tan, W., Yan, J., Zang, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03253-w · Cited by 31 · see citing works
3D-Printed Silk Proteins for Bone Tissue Regeneration and Associated Immunomodulation
Waidi, Y. O., Debnath, S., Datta, S., & Chatterjee, K. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00540 · Cited by 25 · see citing works
Fredericks, C. M., Kunihiro, J., Zheng, H., Waghu, N. R., & Kamkar, M. (2024) · Polymer · doi:10.1016/j.polymer.2024.127691 · Cited by 25 · see citing works
Shi, R., Zhang, J., Niu, K., Li, W., Jiang, N., Li, J., Yu, Q., & Wu, C. (2020) · Biomaterials Science · doi:10.1039/d0bm01304h · Cited by 25 · see citing works
Bharathi, R., Harini, G., Sankaranarayanan, A., Shanmugavadivu, A., Vairamani, M., & Selvamurugan, N. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127492 · Cited by 25 · see citing works
Self-citationDukle, A., & Sankar, M. R. (2024) · Materials Today Communications · doi:10.1016/j.mtcomm.2024.109776 · Cited by 24 · see citing works
Chitosan Nanocomposites as Scaffolds for Bone Tissue Regeneration
Damiri, F., Gowda, B. H. J., Andra, S., Balu, S. K., Rojekar, S. V., & Berrada, M. (2023) · Biological and medical physics, biomedical engineering · doi:10.1007/978-981-19-9646-7_16 · Cited by 24 · see citing works
Natural polymers-based surface engineering of bone scaffolds – A review
Sathiya, K., Ganesamoorthi, S., Mohan, S., Shanmugavadivu, A., & Selvamurugan, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136840 · Cited by 22 · see citing works
Self-citationYadav, L. R., Balagangadharan, K., Lavanya, K., & Selvamurugan, N. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120559 · Cited by 21 · see citing works
Self-citationBioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration
Shakoor, S., Kibble, E., & El‐Jawhari, J. J. (2022) · Bioengineering · doi:10.3390/bioengineering9050223 · Cited by 21 · see citing works
3D Bioprinting for Pancreas Engineering/Manufacturing
Xu, Y., Song, D., & Wang, X. (2022) · Polymers · doi:10.3390/polym14235143 · Cited by 21 · see citing works
Advancing strategies towards the development of tissue engineering scaffolds: a review
Pattanayak, I., Alex, Y., & Mohanty, S. (2023) · Journal of Materials Science · doi:10.1007/s10853-023-08798-5 · Cited by 19 · see citing works
Shanmugavadivu, A., & Selvamurugan, N. (2025) · Nanoscale Advances · doi:10.1039/d4na00768a · Cited by 18 · see citing works
Self-citationIranpour, S., Attari, F., Seyedjafari, E., & Nourmohammadi, J. (2022) · Polymers for Advanced Technologies · doi:10.1002/pat.5594 · Cited by 18 · see citing works
Viral and non‐viral gene therapy using 3D (bio)printing
Jahangiri, S., Rahimnejad, M., Boroujeni, N. N., Ahmadi, Z., Fath, P. M., Ahmadi, S., Safarkhani, M., & Rabiee, N. (2022) · The Journal of Gene Medicine · doi:10.1002/jgm.3458 · Cited by 19 · see citing works
Ramprasad, A., Ganesh, S. S., Victoria, V. S. S., Shanmugavadivu, A., Lavanya, K., Lekhavadhani, S., & Selvamurugan, N. (2024) · Biotechnology Journal · doi:10.1002/biot.202400288 · Cited by 18 · see citing works
Self-citationPreethi, A. M., & Bellare, J. (2021) · Frontiers in Materials · doi:10.3389/fmats.2020.594686 · Cited by 17 · see citing works
Chernozem, R. V., Pariy, I. O., Surmeneva, M. A., Shvartsman, V. V., Planckaert, G., Verduijn, J., Ghysels, S., Abalymov, A. A., Parakhonskiy, B. V., Gracey, E., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201726 · Cited by 17 · see citing works
Narrative review of gene modification: applications in three-dimensional (3D) bioprinting
Fu, B., Shen, J., Chen, Y., Wu, Y., Zhang, H., Liu, H., & Huang, W. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-2854 · Cited by 14 · see citing works
Bioactive Molecule-incorporated Polymeric Electrospun Fibers for Bone Tissue Engineering
Purushothaman, A. E., Ranganathan, A., Adithya, S. P., Sidharthan, D. S., Balagangadharan, K., & Selvamurugan, N. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220414100358 · Cited by 14 · see citing works
Self-citationZdraveva, E., Bendelja, K., Bočkor, L., Dolenec, T., & Mijović, B. (2023) · Polymers · doi:10.3390/polym15030777 · Cited by 13 · see citing works
Purushothaman, E., Shanmugavadivu, A., Balagangadharan, K., Lekhavadhani, S., Saranya, I., Babu, S., & Selvamurugan, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138518 · Cited by 12 · see citing works
Self-citationGhaffari‐Bohlouli, P., Jafari, H., Khatibi, A., Bakhtiari, M., Tavana, B., Zahedi, P., & Shavandi, A. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.04.029 · Cited by 12 · see citing works
Yang, J., Li, W., Mu, B., Xu, H., Hou, X., & Yang, Y. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.139 · Cited by 12 · see citing works
Mirzavandi, Z., Poursamar, S. A., Amiri, F., Bigham, A., & Rafienia, M. (2024) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-024-06828-5 · Cited by 11 · see citing works
Gupta, D., & Bellare, J. (2021) · Bioprinting · doi:10.1016/j.bprint.2021.e00175 · Cited by 10 · see citing works
Ma, Y., You, Y., Cao, L., Liang, B., Tian, B., Dong, J., & Lin, H. Q. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.706423 · Cited by 10 · see citing works
Direction-oriented fiber guiding with a tunable tri-layer-3D scaffold for periodontal regeneration
Abraham, S., Gupta, P., Govarthanan, K., Rao, S. R., & Santra, T. S. (2024) · RSC Advances · doi:10.1039/d4ra01459f · Cited by 9 · see citing works
Liu, Y.-C., Lo, G.-J., Shyu, V. B., Tsai, C.-H., Chen, C., & Chen, C.-T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417410 · Cited by 6 · see citing works
Ganesamoorthi, S., Sathiya, K., Mohan, S., Shanmugavadivu, A., Lekhavadhani, S., Babu, S., & Selvamurugan, N. (2025) · Chemistry - An Asian Journal · doi:10.1002/asia.202401480 · Cited by 5 · see citing works
Self-citationDesigning osteogenic interfaces on 3D-Printed thermoplastic bone scaffolds
Negi, A., Goswami, K., Diwan, H., Agrawal, G., & Murab, S. (2025) · Materials Today Chemistry · doi:10.1016/j.mtchem.2025.102635 · Cited by 5 · see citing works
Sistani, S., Asgharzade, S., Arab, S., Bahraminasab, M., & Fard, E. S. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-06166-4 · Cited by 5 · see citing works
Analysis of the influence of inner morphology on blood flow in 3D-printed bone scaffolds
Quatrano, A., Fontana, C., Rubino, F., Cappetti, N., & Carlone, P. (2022) · Procedia CIRP · doi:10.1016/j.procir.2022.06.041 · Cited by 5 · see citing works
Utility of Air Bladder-Derived Nanostructured ECM for Tissue Regeneration
Wang, J., Chen, J., Ran, Y., He, Q., Jiang, T., Li, W., & Yu, X. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.553529 · Cited by 4 · see citing works
Zhai, H., Huang, X., Qiu, L., & Zhao, Y. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.114272 · Cited by 3 · see citing works
Kommos, A. E., Magesh, P., Lattanze, S., Perros, A., Andreopoulos, F. M., Travascio, F., & Jackson, A. R. (2025) · Gels · doi:10.3390/gels11040223 · Cited by 2 · see citing works
Biopolymers/Ceramic-Based Nanocomposite Scaffolds for Drug Delivery in Bone Tissue Engineering
Lavanya, K., Swetha, S. V., & Selvamurugan, N. (2021) · Advances in material research and technology · doi:10.1007/978-3-030-70266-3_11 · Cited by 2 · see citing works
Self-citationQian, Y., Wang, X., Wang, P., Wu, J., Shen, Y., Cai, K., Bai, J., Lu, M., & Tang, C. (2024) · Journal of Biomaterials Applications · doi:10.1177/08853282241257183 · Cited by 2 · see citing works
OuYang, J., Li, B., Yang, K., Gan, W., Miao, X., Bai, B., Ling, C., Peng, J., & Zheng, X. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106401 · Cited by 2 · see citing works
Engineering scaffolds for tissue engineering and regenerative medicine
Cengiz, I. F., Reis, R. L., & Oliveira, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88524-9.00030-9 · Cited by 1 · see citing works
Composite Polylactide Materials Based on Amorphized Hydroxyapatite and Brushite for 3D Printing
Musskaya, O. N., Крутько, В. К., Shymanski, V. I., Nasan, O. A., Shumskaya, A. E., & Kulak, A. I. (2024) · Inorganic Materials Applied Research · doi:10.1134/s2075113324010180
Additive Manufacturing of Medical Solutions for Diabetic Patients
Babu, V., Muthulakshmi, L., & Hariharan, N. (2025) · Springer tracts in additive manufacturing · doi:10.1007/978-3-031-90807-1_12
Negaresh, H., Bahrami, S. H., Nazarpak, M. H., & Mehrjoo, M. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.114356
Hassanzadeh, N., & Olamaei, B. (2025) · Biomedical Materials & Devices · doi:10.1007/s44174-025-00579-9
Babu, S. S. G., Adhikari, S., Selvamurugan, N., & Rajendran, N. (2026) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2026.133165
Self-citationBieringer, E., Pütthoff, L., Zimmermann, A., Burkhanova, E., Mijačević, D., Ehrenreich, A., Liebl, W., & Weuster‐Botz, D. (2026) · BioTech · doi:10.3390/biotech15020040
Shivanee, K., Sahana, R. K., Bharathraj, A., Varsha, A., Babu, S., & Selvamurugan, N. (2026) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2026.2683525
Self-citationLekhavadhani, S., Raaju, A. L., Krishna, V. S., Hariharan, A., Patil, S., & Selvamurugan, N. (2026) · Biotechnology and Bioengineering · doi:10.1002/bit.70299
Self-citationRajan, A., Raneesh, B., Eldho, N., Gopika, S., Thomas, N. G., M, S. K., Koshy, R., Shylaja, K., & Raju, R. S. (2026) · Biomedical Materials · doi:10.1088/1748-605x/ae7fc5
Hussain, D., Basri, A. A., Basri, E. I., Sultan, M. T. H., Norrrahim, M. N. F., & Shah, A. U. M. (2026) · Next Materials · doi:10.1016/j.nxmate.2026.102813
Liu, J.-Y., Liu, X.-H., Zhong, N., Xiao, Y., Wang, G.-R., Liu, B., Yao-ting, J., & Bu, L. (2026) · Translational dental research. · doi:10.1016/j.tdr.2026.100101
- Authors
- Ashwin, B., Abinaya, B., Prasith, T. P., Chandran, S. V., Yadav, L. R., Vairamani, M., Patil, S., & Selvamurugan, N.
- Affiliations
- SRM Institute of Science and Technology (IN)
- Corresponding author
- Selvamurugan, N.
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 162
- Pages
- 523-532
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W3036229340
- Cited by
- 92
- References
- 73
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 6
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- polylactic acid scaffolds, 3D printing, gelatin coating, mucic acid, bone tissue engineering, bone regeneration, osteogenic differentiation, mesenchymal stem cells, Runx2, bioactive coatings
- MeSH terms
- Animals, Bone and Bones, Gelatin, Polyesters, Sugar Acids, Coated Materials, Biocompatible, Tissue Engineering, Mice, Tissue Scaffolds, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review