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Cited by 1,093Mesenchymal stem cell researchPeriodontal Regeneration and TreatmentsBone Tissue Engineering Materials

Mesenchymal Stem Cells for Regenerative Medicine

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Han, Yu, Li, Xuezhou, Zhang, Yanbo, Han, Yuping, Chang, Fei, Ding, Jianxun·2019·Cells
DOI 10.3390/cells8080886PMC PMC6721852
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Abstract

In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We present a brief overview of MSC extraction methods and subsequent potential for differentiation, and a comprehensive overview of their preclinical and clinical applications in regenerative medicine, and discuss future challenges.

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  • Neurotrophin-3-transfected BM-MSCs-CM reduces the apoptosis of motor neurons in an animal model of spinal cord injury.

    “In the neurological field, neurotrophin-3-transfected BM-MSCs-CM has shown to reduce the apoptosis of motor neurons in an animal model of spinal cord injury (SCI) [152], [153].”

    From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [152]

    Section 4.4 (Central Nervous System Rebuilding; page unavailable) reports improved neuronal differentiation in vivo with neurotrophin-3-modified BMSCs and discusses MSC therapy in animal models of spinal cord injury. It does not report that conditioned medium from those cells reduced motor-neuron apoptosis. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Han, Y., Li, X., Zhang, Y., Han, Y., Chang, F., & Ding, J.
Affiliations
  • Jilin University (CN)
  • Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, China
  • Department of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
  • Chinese Academy of Sciences (CN)
Corresponding author
Han, Yuping
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2019-08-13
Volume
8
Issue
8
Pages
886
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells8080886
PMC
PMC6721852
OpenAlex
W2968810602
Cited by
1,093
References
6
Citations by year
2026: 58 · 2025: 125 · 2024: 172 · 2023: 205 · 2022: 217 · 2021: 177 · 2020: 125 · 2019: 10 · 2018: 4
FWCI
16.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (51873207, 51803006, 81701811, 51673190, and 81671804)
  • Development and Reform Commission of Jilin Province (2018C052-4)
  • Health and Family Planning Commission of Jilin Province (20165061)
  • Science and Technology Development Project of Jilin Province (20190201068JC)
  • Youth Talents Promotion Project of Jilin Province (181909)
  • Youth Innovation Promotion Association of Chinese Academy of Science (2019005)
  • Natural Science Foundation of Shandong Province (ZR2018BH008)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
mesenchymal stem cells, regenerative medicine, tissue engineering, stem cell differentiation, bone marrow, adipose tissue, synovium, graft rejection, immune tolerance, clinical application, preclinical applications
MeSH terms
Animals, Cell Differentiation, Humans, Tissue Engineering, Regenerative Medicine, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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