Purification, structural characterization, and cognitive improvement activity of a polysaccharides from Schisandra chinensis
Abstract
The present study aimed to evaluate structural characteristics of a polysaccharides, SCP2-1, isolated from Schisandra chinensis (Turcz.) Baill (S. chinensis) and to assess its improvement on cognitive dysfunction caused by excessive neuroinflammation. Structural characterization indicated that SCP2-1 was composed of glucose and galactose in a molar ratio of 8.78:1.23 with molecular weight of 5.388 kDa. The main linkages of the glycosidic bonds of SCP2-1were 1,4-linked-Glcp, 1,4-linked-Galp, 1-linked-Galp and 1,4,6-linked-Galp. The evaluation of behavioral pharmacology and the detection of biochemical markers exhibited that SCP2-1 could improve LPS-induced cognitive dysfunction in mice, ameliorate excessive inflammatory response. The results showed that SCP2-1 could ameliorated the animals' exploration time of novel arm in Y maze test, shortened the escape latency of mice in MWM test, and increased the exploration time of new object in NOR test. What's more, mice could improve histopathological changes induced by LPS, suppress the over-activation of glial cells, decrease the expression of proinflammatory cytokines, increase the levels of anti-inflammatory cytokines, reduce the levels of NLRP3, M-caspaes-1, which may further induce the decrease of excessive deposition of Aβ. Furthermore, SCP2-1 could inhibit the over-activation of NF-κB and the hyperphosphorylation of P38 MAPK pathway.
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From Schisandra chinensis fruit are also isolated polysaccharides, glycosides, organic acids, and vitamin E.
“From Schisandra chinensis fruit are also isolated polysaccharides, glycosides (dihydrophaseic acid-3-O--d-glucopyranoside, benzyl alcohol-O--d-glucopyranosyl (1→6)--d-glucopyranoside and benzyl alcohol-O--d-glucopyranosyl (1→2)--d-glucopyranoside), organic acids (vitamin C, malic acid, citric acid, and tartaric acid), and vitamin E. [12,87,101,102].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [101]
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Plant Adaptogens—History and Future Perspectives
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- Authors
- Xu, M., Yan, T., Gong, G., Wu, B., He, B., Du, Y., Xiao, F., & Jia, Y.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- Zunyi Medical University (CN)
- Corresponding author
- Xiao, Feng
- Jia, Ying
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 163
- Pages
- 497-507
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W3038998761
- Cited by
- 51
- References
- 36
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 8 · 2021: 7 · 2020: 1
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81573580)
- Key Laboratory of Polysaccharide Bioactivity Evaluation of TCM of Liaoning Province
- Key Techniques Study of Consistency Evaluation of Drug Quality and Therapeutic Effect (18-400-4-08)
- Distinguished Professor of Liaoning Province
- Precise Screening Technology of Chinese Traditional Medicine Anti-depressant Active Ingredients (2017LZD01)
- Doctoral Scientific Research Foundation of Liaoning Province (2019-BS-233)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Schisandra chinensis, polysaccharides, cognitive impairment, neuroinflammation, LPS-induced neuroinflammation, glycosidic linkage, spatial learning and memory, novel object recognition, glial activation, inflammatory cytokines, anti-inflammatory cytokines, NLRP3 inflammasome, amyloid-beta deposition, NF-κB, p38 MAPK, neuroprotection
- MeSH terms
- Memory and Learning Tests, Animals, Cognition, Chemical Fractionation, Hippocampus, Immunohistochemistry, Male, Molecular Weight, Monosaccharides, Magnetic Resonance Spectroscopy, Polysaccharides, Structure-Activity Relationship, Molecular Structure, Spectroscopy, Fourier Transform Infrared, Neuroprotective Agents, Maze Learning, Schisandra, Mice
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