Cellular Specificity of NF-κB Function in the Nervous System

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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Parkinson's Disease

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Shared Principles in NF-κB Signaling

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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<i>TREM2</i> Variants in Alzheimer's Disease

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Molecular Architecture of the Mouse Nervous System

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

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Suppression of TNF-α-Induced Apoptosis by NF-κB

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The Cellular Phase of Alzheimer’s Disease

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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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NF-κB, the first quarter-century: remarkable progress and outstanding questions

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Huntington disease

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Mutations of optineurin in amyotrophic lateral sclerosis

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

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NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of <i>Drosophila</i> Pink1 is rescued by Parkin

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The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x L

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosisPreprint

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NF-κB functions in synaptic signaling and behavior

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Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

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Microglia contact induces synapse formation in developing somatosensory cortex

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Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

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Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury

Brambilla, R., Bracchi-Ricard, V. C., Hu, W.-H., Frydel, B. R., Bramwell, A., Karmally, S., Green, E. J., & Bethea, J. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041918 · Cited by 589 · see citing works

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

Wang, C.-Y., D, D. C. G., Mayo, M. W., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.5923 · Cited by 586 · see citing works

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

Tamatani, M., Ho, Y., Matsuzaki, H., Ogawa, S., Okado, H., Miyake, S., Mizuno, T., & Tohyama, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8531 · Cited by 549 · see citing works

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

Trushina, E., Dyer, R. B., Badger, J. D., Ure, D., Eide, L., Tran, D. D., Vrieze, B. T., Legendre-Guillemin, V., McPherson, P. S., Mandavilli, B. S., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8195-8209.2004 · Cited by 520 · see citing works

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

Srinivasan, R., Lu, T.-Y., Chai, H., Xu, J., Huang, B. S., Golshani, P., Coppola, G., & Khakh, B. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.030 · Cited by 443 · see citing works

Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

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TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosisPreprint

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Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

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Huntingtin facilitates dynein/dynactin-mediated vesicle transport

Caviston, J. P., Ross, J. L., Antony, S. M., Tokito, M. K., & Holzbaur, E. L. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610628104 · Cited by 334 · see citing works

Genes associated with Alzheimer&amp;#39;s disease: an overview and current status

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Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival

Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310 · see citing works

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

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Physiological functions for brain NF-κB

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Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.

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From Calcium to NF-κB Signaling Pathways in Neurons

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A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

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The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories

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NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling

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NF-κB activity in transgenic mice: developmental regulation and tissue specificity

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A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

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Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity

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Brain synapses contain inducible forms of the transcription factor NF-κB

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Regulation of Cu/Zn-Superoxide Dismutase Expression via the Phosphatidylinositol 3 Kinase/Akt Pathway and Nuclear Factor-κB

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Gene expression of the transcription factor NF-κ B in hippocampus: regulation by synaptic activity

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Parkin Mediates Neuroprotection through Activation of IκB Kinase/Nuclear Factor-κB Signaling

Henn, I. H., Bouman, L., Schlehe, J. S., Schlierf, A., Schramm, J. E., Wegener, E., Nakaso, K., Culmsee, C., Berninger, B., Krappmann, D., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5537-06.2007 · Cited by 188 · see citing works

Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-κB

Ling, H., Gray, C. B. B., Zambon, A. C., Grimm, M. F., Gu, Y., Dalton, N. D., Purcell, N. H., Peterson, K. L., & Brown, J. H. (2013) · Circulation Research · doi:10.1161/circresaha.112.276915 · Cited by 184 · see citing works

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

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The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

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A Bioinformatics Analysis of Memory Consolidation Reveals Involvement of the Transcription Factor c-Rel

Levenson, J. M., Choi, S., Lee, S.-Y., Cao, Y. A., Ahn, H. J., Worley, K. C., Pizzi, M., Liou, H.-C., & Sweatt, J. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5646-03.2004 · Cited by 170 · see citing works

A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis

Boersma, M. C. H., Dresselhaus, E. C., De Biase, L. M., Mihalas, A. B., Bergles, D. E., & Meffert, M. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2456-10.2011 · Cited by 168 · see citing works

Forebrain-Specific Neuronal Inhibition of Nuclear Factor-κB Activity Leads to Loss of Neuroprotection

Fridmacher, V., Kaltschmidt, B., Goudeau, B., Ndiaye, D., Rossi, F. M., Pfeiffer, J., Kaltschmidt, C., Israël, A., & Mémet, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09403.2003 · Cited by 167 · see citing works

Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight

Zhang, Y., Reichel, J. M., Han, C., Zuniga-Hertz, J. P., & Cai, D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.002 · Cited by 164 · see citing works

Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease

Snow, W. M., & Albensi, B. C. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00118 · Cited by 157 · see citing works

NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

Alami, N. O., Schurr, C., Heuvel, F. O., Tang, L., Li, Q., Tasdogan, A., Kimbara, A., Nettekoven, M. H., Ottaviani, G., Raposo, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798697 · Cited by 157 · see citing works

Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

Cho, I., Hong, J., Suh, E. C., Kim, J. H., Lee, H., Lee, J. E., Lee, S., Kim, C., Kim, D. W., Jo, E., et al. (2008) · Brain · doi:10.1093/brain/awn230 · Cited by 156 · see citing works

Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells

Carrasco, D. R., Ryseck, R.-P., & Bravo, R. (1993) · Development · doi:10.1242/dev.118.4.1221 · Cited by 148 · see citing works

c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formationPreprint

Ahn, H. J., Hernandez, C. M., Levenson, J. M., Lubin, F. D., Liou, H.-C., & Sweatt, J. D. (2008) · Learning & Memory · doi:10.1101/lm.866408 · Cited by 144 · see citing works

Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway

Simmons, L. J., Surles-Zeigler, M. C., Li, Y., Ford, G. D., Newman, G. W., & Ford, B. D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0703-7 · Cited by 144 · see citing works

IκB Kinase/Nuclear Factor κB-Dependent Insulin-Like Growth Factor 2 (Igf2) Expression Regulates Synapse Formation and Spine Maturation via Igf2 Receptor Signaling

Schmeißer, M. J., Baumann, B., Johannsen, S., Vindedal, G. F., Jensen, V., Hvalby, Ø., Sprengel, R., Seither, J., Maqbool, A., Magnutzki, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0111-12.2012 · Cited by 137 · see citing works

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

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NFκB Activation Is Required for the Neuroprotective Effects of Pigment Epithelium-derived Factor (PEDF) on Cerebellar Granule Neurons

Yabe, T., Wilson, D., & Schwartz, J. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107831200 · Cited by 134 · see citing works

Transgenic inhibition of astroglial NF‐κB leads to increased axonal sparing and sprouting following spinal cord injury

Brambilla, R., Hurtado, A., Persaud, T., Esham, K., Pearse, D. D., Oudega, M., & Bethea, J. R. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06190.x · Cited by 130 · see citing works

Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans

Jones, S. V., & Kounatidis, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01805 · Cited by 128 · see citing works

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

Chami, L., Buggia-Prévot, V., Duplan, E., Delprete, D., Chami, M., Peyron, J., & Checler, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333054 · Cited by 120 · see citing works

NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain

Kaltschmidt, B., & Kaltschmidt, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00069 · Cited by 117 · see citing works

Regulation of Nuclear Factor κB in the Hippocampus by Group I Metabotropic Glutamate Receptors

O’Riordan, K. J., Huang, I.-C., Pizzi, M., Spano, P., Boroni, F., Egli, R. E., Desai, P., Fitch, O., Malone, L. M., Ahn, H. J., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4527-05.2006 · Cited by 112 · see citing works

NF-κB/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity

O'Mahony, A., Raber, J., Montano, M., Foehr, E., Han, V., Lu, S.-M., Kwon, H., LeFevour, A., Chakraborty-Sett, S., & Greene, W. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00510-06 · Cited by 110 · see citing works

Transcription Factor NF-κB Is Transported to the Nucleus via Cytoplasmic Dynein/Dynactin Motor Complex in Hippocampal Neurons

Mikenberg, I., Widera, D., Kaus, A., Kaltschmidt, B., & Kaltschmidt, C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000589 · Cited by 107 · see citing works

Calmodulin-dependent Kinase II Mediates T Cell Receptor/CD3- and Phorbol Ester-induced Activation of IκB Kinase

Hughes, K. A., Edin, S., Antonsson, Å., & Grundström, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106125200 · Cited by 106 · see citing works

Lack of NF-κB p50 Exacerbates Degeneration of Hippocampal Neurons after Chemical Exposure and Impairs Learning

Kassed, C. A., Willing, A. E., Garbuzova-Davis, S., Sanberg, P. R., & Pennypacker, K. R. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7967 · Cited by 103 · see citing works

NF-κB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid β-peptide toxicity

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NF-κB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety

Kassed, C. A., & Herkenham, M. A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.03.026 · Cited by 99 · see citing works

The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus

Marcora, E. M., & Kennedy, M. B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq358 · Cited by 99 · see citing works

Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

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TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies

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