Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery

Mechanisms underlying inflammation in neurodegeneration

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How neuroinflammation contributes to neurodegeneration

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Curcumin: From ancient medicine to current clinical trials

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Role of ROS and RNS Sources in Physiological and Pathological Conditions

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Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy

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Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice

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Evaluation of intranasal delivery route of drug administration for brain targeting

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Neuroinflammation and psychiatric illness

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Mechanism of intranasal drug delivery directly to the brain

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Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells

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Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease

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Inflammation in neurodegenerative diseases—An update

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Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

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LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

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Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

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Unravelling the Interplay between Extracellular Acidosis and Immune Cells

Díaz, F. A. E., Dantas, E., & Geffner, J. R. (2018) · Mediators of Inflammation · doi:10.1155/2018/1218297 · Cited by 273 · see citing works

Are NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment?

Imbimbo, B. P. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00019 · Cited by 240 · see citing works

Expression of P-selectin on Endothelial Cells is Upregulated by LPS and TNF-α in Vivo

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Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs

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Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies

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Determination of baseline human nasal pH and the effect of intranasally administered buffers

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Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways

Meng, Z., Yan, C., Deng, Q., Gao, D., & Niu, X. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.24 · Cited by 196 · see citing works

Chitosan Schiff base: an environmentally benign biological macromolecule as a new corrosion inhibitor for oil & gas industries

Ansari, K. R., Chauhan, D. S., Quraishi, M. A., Mazumder, M. A. J., & Singh, A. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.106 · Cited by 186 · see citing works

Coating with chitosan-based edible films for mechanical/biological protection of strawberries

Pavinatto, A., Mattos, A. V. D. A., Granato, A. C., Okura, M. H., Balogh, D. T., & Sanfelice, R. C. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.076 · Cited by 181 · see citing works

Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends

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The depolymerization mechanism of chitosan by hydrogen peroxide

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Low Molecular-Weight Chitosan as a pH-Sensitive Stealth Coating for Tumor-Specific Drug Delivery

Amoozgar, Z., Park, J., Lin, Q., & Yeo, Y. (2012) · Molecular Pharmaceutics · doi:10.1021/mp2005615 · Cited by 159 · see citing works

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

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O-carboxymethyl chitosan/fucoidan nanoparticles increase cellular curcumin uptake

Huang, Y., & Kuo, T.-H. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2015.02.006 · Cited by 146 · see citing works

Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles

Huang, Y., & Liu, T.-J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.12.009 · Cited by 129 · see citing works

Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery

Huang, Y., Li, R., Chen, J.-Y., & Chen, J. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.11.072 · Cited by 123 · see citing works

Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E

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Preparation and Characterization of Antioxidant Nanoparticles Composed of Chitosan and Fucoidan for Antibiotics Delivery

Huang, Y., & Li, R. (2014) · Marine Drugs · doi:10.3390/md12084379 · Cited by 119 · see citing works

Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy

Jafari, M., Sriram, V., Xu, Z., Harris, G. M., & Lee, J. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116837 · Cited by 117 · see citing works

Recruitment of Neutrophils across the Blood–Brain Barrier: The Role of E- and P-selectins

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Curcumin Prevents Acute Neuroinflammation and Long-Term Memory Impairment Induced by Systemic Lipopolysaccharide in Mice

Sorrenti, V., Contarini, G., Sut, S., Dall’Acqua, S., Confortin, F., Pagetta, A., Giusti, P., & Zusso, M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00183 · Cited by 113 · see citing works

The emerging value of P-selectin as a disease marker

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Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays

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Development and Characterization of Eucalyptol Microemulsions for Topic Delivery of Curcumin

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Dual-Targeting Glycol Chitosan/Heparin-Decorated Polypyrrole Nanoparticle for Augmented Photothermal Thrombolytic Therapy

Lu, T.-Y., Chiang, C.-Y., Fan, Y., Jheng, P., Quiñones, E. D., Liu, K., Kuo, S.-H., Hsieh, H., Tseng, C., Yu, J., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c20940 · Cited by 89 · see citing works

Soluble eggshell membrane protein-loaded chitosan/fucoidan nanoparticles for treatment of defective intestinal epithelial cells

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Chitosan-mediated in situ biomolecule assembly in completely packaged microfluidic devices

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Effect of basic fibroblast growth factor released from chitosan-fucoidan nanoparticles on neurite extension

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Genipin-crosslinked carboxymethyl chitosan nanogel for lung-targeted delivery of isoniazid and rifampin

Wu, T., Liao, W., Wang, W., Zhou, J., Tan, W., Xiang, W., Zhang, J., Guo, L., Chen, T., Ma, D., et al. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.06.034 · Cited by 79 · see citing works

Imaging of intranasal drug delivery to the brain.

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Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Ιnhibition by ST1926

Dong, Z., & Yuan, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3574 · Cited by 71 · see citing works

Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

Setthacheewakul, S., Kedjinda, W., Maneenuan, D., & Wiwattanapatapee, R. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9568-8 · Cited by 67 · see citing works

Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles

Lu, K.-Y., Jheng, P., Lu, L., Rethi, L., Mi, F., & Chuang, E. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.091 · Cited by 65 · see citing works

Targeting P-Selectin Adhesion Molecule in Molecular Imaging: P-Selectin Expression as a Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease

Perkins, L. A., Anderson, C. J., & Novelli, E. M. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.225169 · Cited by 58 · see citing works

A review on factors affecting the design of nasal drug delivery system

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A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells

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Efficacy of Some Plant Extracts as Storage Protectants against Callosobruchus maculatus

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Two-photon autofluorescence microscopy and spectroscopy of Antarctic fungus: New approach for studying effects of UV-B irradiation

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Emerging Trends in Nanomaterials for Antibacterial Applications

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Chitosan Based Materials in Cosmetic Applications: A Review

Kulka, K., & Sionkowska, A. (2023) · Molecules · doi:10.3390/molecules28041817 · Cited by 157 · see citing works

Functionalized chitosan for cancer nano drug delivery

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Chitosan Nanoparticles for Intranasal Drug Delivery

Omidian, H., Gill, E. J., Chowdhury, S. D., & Cubeddu, L. X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060746 · Cited by 98 · see citing works

Transdermal Delivery of Curcumin-Loaded Solid Lipid Nanoparticles as Microneedle Patch: an In Vitro and In Vivo Study

Prabhu, A., Jose, J., Kumar, L., Salwa, S., Kumar, M. V., & Nabavi, S. (2022) · AAPS PharmSciTech · doi:10.1208/s12249-021-02186-5 · Cited by 69 · see citing works

Polysaccharides-based nanocarriers enhance the anti-inflammatory effect of curcumin

Luo, W. H., Bai, L., Zhang, J., Li, Z., Liu, Y., Tang, X., Xia, P., Xu, M., Shi, A., Liu, X., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120718 · Cited by 80 · see citing works

Fucoidan-based nanoparticles: Preparations and applications

Venkatesan, J., Murugan, S. S., & Seong, G. H. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.068 · Cited by 79 · see citing works

The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, Including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumins

Shahrajabian, M. H., & Sun, W. (2023) · Current Organic Synthesis · doi:10.2174/1570179420666230607124949 · Cited by 77 · see citing works

Evaluation of photodynamic therapy on nanoparticles and films loaded-nanoparticles based on chitosan/alginate for curcumin delivery in oral biofilms

Silvestre, A. L. P., dos Santos, A. M., de Oliveira, A. B., Ferrisse, T. M., Brighenti, F. L., Meneguin, A. B., & Chorilli, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124489 · Cited by 69 · see citing works

Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases

Khalil, A., Barras, A., Boukherroub, R., Tseng, C., Devos, D., Burnouf, T. P. R., Neuhaus, W., & Szunerits, S. (2023) · Nanoscale Horizons · doi:10.1039/d3nh00306j · Cited by 62 · see citing works

Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights

Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

Witika, B. A., Makoni, P. A., Matafwali, S. K., Mweetwa, L. L., Shandele, G. C., & Walker, R. B. (2021) · Molecules · doi:10.3390/molecules26144244 · Cited by 57 · see citing works

Algal Polysaccharides‐Based Nanoparticles for Targeted Drug Delivery Applications

Zhang, S., Qamar, S. A., Junaid, M., Munir, B., Badar, Q., & Bilal, M. (2022) · Starch - Stärke · doi:10.1002/star.202200014 · Cited by 51 · see citing works

Nano-Sized Fucoidan Interpolyelectrolyte Complexes: Recent Advances in Design and Prospects for Biomedical Applications

Dubashynskaya, N. V., Gasilova, E. R., & Skorik, Y. А. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032615 · Cited by 46 · see citing works

Biomaterial strategies for regulating the neuroinflammatory response

Galindo, A. N., Rubio, D. A. F., & Hettiaratchi, M. H. (2024) · Materials Advances · doi:10.1039/d3ma00736g · Cited by 46 · see citing works

Marine biomaterials in biomedical nano/micro-systems

Wang, Y., Chen, L., Wang, X., Wang, X., Qian, D., Yan, J., Sun, Z., Cui, P., Yu, L., Wu, J., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02112-w · Cited by 47 · see citing works

Cancer-targeted fucoidan‑iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress

Ho, T.-L., Mutalik, C., Rethi, L., Nguyen, H.-N. T., Jheng, P., Wong, C.-C., Yang, T., Nguyen, T. T. D., Mansel, B. W., Wang, C.-A., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123821 · Cited by 42 · see citing works

Fucoidan-mediated targeted delivery of dasatinib-loaded nanoparticles amplifies apoptosis and endows cytotoxic potential in triple-negative breast cancer

Saren, B. N., Mahajan, S., Aalhate, M., Kumar, R., Chatterjee, E., Maji, I., Gupta, U., Guru, S. K., & Singh, P. K. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113631 · Cited by 42 · see citing works

Unraveling the role of chitosan for nasal drug delivery systems: A review

Kaur, G., Goyal, J., Behera, P. K., Devi, S., Singh, S. K., Garg, V., & Mittal, N. (2023) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2023.100316 · Cited by 33 · see citing works

Bioactive Carbohydrate Polymers—Between Myth and Reality

Drira, M., Hentati, F., Babich, O., Sukhikh, S., Larina, V., Sharifian, S., Homaei, A. A., Fendri, I., Lemos, M. F. L., Félix, C., et al. (2021) · Molecules · doi:10.3390/molecules26237068 · Cited by 34 · see citing works

An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders

Lamanna‐Rama, N., Romero‐Miguel, D., Desco, M., & Soto‐Montenegro, M. L. (2022) · Antioxidants · doi:10.3390/antiox11020353 · Cited by 33 · see citing works

Construction of quercetin-fucoidan nanoparticles and their application in cancer chemo-immunotherapy treatment

Lin, Z., Liu, Y., Gong, X., Nie, F., Xu, J., & Guo, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128057 · Cited by 32 · see citing works

Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector

Teixeira, L. M., Reis, C. P., & Pacheco, R. (2025) · Marine Drugs · doi:10.3390/md23050207 · Cited by 26 · see citing works

Targeting pulmonary vascular endothelial cells for the treatment of respiratory diseases

Li, Y., Wang, H., Li, J., Jin, J.-B., Hu, J., & Yang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.983816 · Cited by 26 · see citing works

Intranasal administration nanosystems for brain-targeted drug delivery

Jiang, Y., Pan, X., Yu, T., & Wang, H. (2023) · Nano Research · doi:10.1007/s12274-023-6026-y · Cited by 25 · see citing works

Structural characterization of a P-selectin and EGFR dual-targeting fucoidan from Sargassum fusiforme

Liu, X., Liu, X. B., Игоревич, К. М., Zhang, M., Bai, X., Cui, T., Shi, Y., Liu, C., & Jia, A. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.12.135 · Cited by 24 · see citing works

Curcumin-Encapsulated Chitosan-Coated Nanoformulation as an Improved Otoprotective Strategy for Ototoxic Hearing Loss

Chen, X., Zhang, H., Wang, C., Su, Y., Xiong, M., Feng, X., Chen, D., Ke, Z., Wen, L., & Chen, G. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00067 · Cited by 23 · see citing works

Neuroprotective Potential of Intranasally Delivered Sulforaphane-Loaded Iron Oxide Nanoparticles Against Cisplatin-Induced Neurotoxicity

Fouad, G. I., El-Sayed, S. A. M., Mabrouk, M., Ahmed, K. A., & Beherei, H. (2022) · Neurotoxicity research · doi:10.1007/s12640-022-00555-x · Cited by 19 · see citing works

Bioinspired and self-restorable alginate-tyramine hydrogels with plasma reinforcement for arthritis treatment

Chen, Y., Wong, C.-C., Weng, P.-W., Chiang, C., Lin, P.-Y., Lee, P.-W., Jheng, P., Hao, P.-C., Chen, Y., Cho, E.-C., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126105 · Cited by 22 · see citing works

Fucoidans: Exploring its neuroprotective mechanisms and therapeutic applications in brain disorders

Batista, P., Cunha, S. A., Ribeiro, T. B., Borges, S., Baptista-Silva, S., Oliveira‐Silva, P., & Pintado, M. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104300 · Cited by 21 · see citing works

Improved camptothecin encapsulation and efficacy by environmentally sensitive block copolymer/chitosan/fucoidan nanoparticles for targeting lung cancer cells

Don, T., Hong, Y., Jheng, P., Chuang, E., & Huang, Y.-C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133901 · Cited by 21 · see citing works

The innovative design of a delivery and real-time tracer system for anti-encephalitis drugs that can penetrate the blood-brain barrier

Wang, X., Song, B., Wang, Z., Qin, L., & Liang, W. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.043 · Cited by 18 · see citing works

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

Hou, L., Zhang, L., Yu, C., Chen, J., Ye, X., Zhang, F., Linhardt, R. J., Chen, S., & Pan, H. (2023) · Foods · doi:10.3390/foods12081623 · Cited by 16 · see citing works

Antimicrobial peptide-fucoidan nanoplexes: A novel multifunctional biomimetic nanocarrier for enhanced vancomycin delivery against bacterial infections and sepsis

Gafar, M. A., Omolo, C. A., Ibrahim, U. H., Peters, X. Q., Ismail, E. A., Khan, R. B., & Govender, T. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125344 · Cited by 13 · see citing works

Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery

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Physicochemical properties of bacterial cellulose/phototherapeutic polypyrrole/antibacterial chitosan composite membranes and their evaluation as chronic wound dressings

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