CoChat
Sign Up
Cited by 44Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

The DOI matches its Crossref record.

An in situ catechol functionalized ε-polylysine/polyacrylamide hydrogel formed by hydrogen bonding recombination with high mechanical property for hemostasis

Man, Zhang, Sidi, Li, Xubo, Yuan, Jin, Zhao, Xin, Hou·2021·International Journal of Biological Macromolecules
DOI 10.1016/j.ijbiomac.2021.09.100
Open this paper in CoChat — free account

Abstract

In situ hydrogel has attracted widely attention in hemostasis due to its ability to match irregular defects, but its application is limited by insufficient mechanical strength and long gelation time. Although some specifical in situ chemically cross-linked hydrogels could be fast formed and exhibit high mechanical strength, they unable to absorb blood. Hence their applications were further limited in emergency hemostasis usage. In this study, a robust hydrogel formed by hydration of powders was developed using multiple hydrogen bonds crosslinking. Here, catechol groups modified ε-polylysine (PL-CAT) and polyacrylamide (PAAM) were used to construct the PL-CAT/PAAM hydrogel. This hydrogel could be formed within 7 s to adhere and seal bleeding sites. The catechol groups endowed the hydrogel outstanding adhesive strength, which was 3.5 times of fibrin glue. Besides, the mechanical performance of in-situ PL-CAT/PAAM hydrogel was explored and the results showed that the hydrogel exhibited high compressive strength (0.47 MPa at 85% strain). Most importantly, the blood loss of wound treated with PL-CAT/PAAM hydrogel powders was 1/7 of untreated group, indicating the hydrogel's excellent hemostatic effect. And the cytotoxicity studies indicated that the PL-CAT/PAAM hydrogel had low toxicity. To summarize, this hydrogel could be a potential hemostatic material in emergency situations.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ijbiomac.2021.09.100

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Using classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin, and synthetic polymers, such as PEG-based polymers.

    “Using these classic organic reactions, the catechol group has been successfully incorporated into a series of natural polymers, such as PL, HA, chitosan, SA, and gelatin (GT), and synthetic polymers, such as polyethylene glycol (PEG)-based polymers [45,47,51,52,53,54,55].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [51]

  • Interactions including hydrogen bonding, π-π stacking, cation-π interactions, electrostatic forces, and hydrophobic effects are frequently employed to create self-healable hydrogel networks.

    “Interactions, including hydrogen bonding, π-π stacking, cation-π interactions, electrostatic forces, and hydrophobic effects, are frequently employed to create self-healable hydrogel networks [3,51].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [51]

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 51

  1. Han, 2019, Mussel-inspired in situ forming adhesive hydrogels with anti-microbial and hemostatic capacities for wound healing, J. Biomater. Appl., 33, 915, 10.1177/0885328218810552 · DOI
  2. Pourshahrestani, 2020, Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing, Adv. Healthc. Mater., 9, 2000905, 10.1002/adhm.202000905 · DOI · Paper page
  3. Luo, 2020, In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis, J. Biomed. Mater. Res. B, 108, 790, 10.1002/jbm.b.34433 · DOI
  4. Behrens, 2014, Hemostatic strategies for traumatic and surgical bleeding, J. Biomed. Mater. Res. A, 102, 4182, 10.1002/jbm.a.35052 · DOI
  5. Li, 2020, Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair, ACS Appl. Mater. Int., 12, 5856
  6. Bai, 2019, A silk-based sealant with tough adhesion for instant hemostasis of bleeding tissues, Nanoscale Horiz., 4, 1333, 10.1039/C9NH00317G · DOI
  7. Huang, 2020, Degradable gelatin-based ipn cryogel hemostat for rapidly stopping deep noncompressible hemorrhage and simultaneously improving wound healing, J. Mater. Chem. C, 32, 6595, 10.1021/acs.chemmater.0c02030 · DOI
  8. Kong, 2020, Injectable in situ hydrogels containing cus nanoparticles with abilities of hemostasis, antibacterial activity, and promoting wound healing, ACS Biomater. Sci. Eng., 7, 335, 10.1021/acsbiomaterials.0c01473 · DOI
  9. Otani, 1998, Hemostatic capability of rapidly curable glues from gelatin, poly (L-glutamic acid), and carbodiimide, Biomaterials, 19, 2091, 10.1016/S0142-9612(98)00121-5 · DOI
  10. Liu, 2019, A highly efficient, in situ wet-adhesive dextran derivative sponge for rapid hemostasis, Biomaterials, 205, 23, 10.1016/j.biomaterials.2019.03.016 · DOI
  11. Li, 2021, Injectable, in situ, antibacterial, and hemostatic N, O-carboxymethyl chitosan/oxidized chondroitin sulfate composite hydrogel for wound dressing, Mater. Sci. Eng. C Mater. Biol. Appl., 118, 10.1016/j.msec.2020.111324 · DOI
  12. Wu, 2020, Exquisite design of injectable hydrogels in cartilage repair, Theranostics, 10, 9843, 10.7150/thno.46450 · DOI
  13. Zhao, 2017, Antibacterial anti-oxidant electroactive injectable hydrogel as in situ wound dressing with hemostasis and adhesiveness for cutaneous wound healing, Biomaterials, 122, 34, 10.1016/j.biomaterials.2017.01.011 · DOI
  14. Luo, 2019, In situ injectable hyaluronic acid/gelatin hydrogel for hemorrhage control, Mater. Sci. Eng. C Mater. Biol. Appl., 98, 628, 10.1016/j.msec.2019.01.034 · DOI
  15. Bu, 2016, Synthesis and properties of hemostatic and bacteria-responsive in situ hydrogels for emergency treatment in critical situations, ACS Appl. Mater. Int., 8, 12674, 10.1021/acsami.6b03235 · DOI
  16. Mannucci, 2007, Drug therapy: prevention and treatment of major blood loss, N. Engl. J. Med., 356, 2301, 10.1056/NEJMra067742 · DOI
  17. Sundaram, 2018, Bioadhesive, hemostatic, and antibacterial in situ chitin–fibrin nanocomposite gel for controlling bleeding and preventing infections at mediastinum, ACS Sustain. Chem. Eng., 6, 7826, 10.1021/acssuschemeng.8b00915 · DOI
  18. Ghorbani, 2020, Development of reinforced chitosan/pectin scaffold by using the cellulose nanocrystals as nanofillers: an injectable hydrogel for tissue engineering, Eur. Polym. J., 130, 10.1016/j.eurpolymj.2020.109697 · DOI
  19. Bi, 2020, In-situ forming thermosensitive hydroxypropyl chitin-based hydrogel crosslinked by Diels-Alder reaction for three dimensional cell culture, Carbohydr. Polym., 212, 368, 10.1016/j.carbpol.2019.02.058 · DOI
  20. Zong, 2020, Biodegradable high-strength hydrogels with injectable performance based on poly (l-glutamic acid) and gellan gum, ACS Biomater. Sci. Eng., 6, 4702, 10.1021/acsbiomaterials.0c00915 · DOI
  21. Pang, 2020, Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel, Carbohydr. Polym., 237, 10.1016/j.carbpol.2020.116138 · DOI
  22. Lin, 2019, In situ polymerization approach to cellulose–polyacrylamide interpenetrating network hydrogel with high strength and pH-responsive properties, Cellulose, 26, 1825, 10.1007/s10570-018-2171-y · DOI
  23. Hong, 2019, A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds, Nat. Commun., 10, 2060, 10.1038/s41467-019-10004-7 · DOI
  24. Xu, 2016, In situ thiolated alginate hydrogel: instant formation and its application in hemostasis, J. Biomater. Appl., 32, 721, 10.1177/0885328216661557 · DOI
  25. Hookey, 2019, Successful hemostasis of active lower GI bleeding using a hemostatic powder as monotherapy, combination therapy, or rescue therapy, Gastrointest. Endosc., 89, 865, 10.1016/j.gie.2018.10.029 · DOI
  26. Park, 2019, Novel hemostatic adhesive powder for nonvariceal upper gastrointestinal bleeding, Endosc. Int. Open, 7, E1763, 10.1055/a-0982-3194 · DOI
  27. Zhang, 2020, Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities, Biomater. Sci., 8, 1455, 10.1039/C9BM02029B · DOI
  28. Shin, 2021, Efficacy of a novel hemostatic adhesive powder in patients with upper gastrointestinal tumor bleeding, BMC Gastroenterol., 21, 40, 10.1186/s12876-021-01611-0 · DOI
  29. Bang, 2019, Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model, PLoS One, 14, 10.1371/journal.pone.0216829 · DOI
  30. Dai, 2015, A mechanically strong, highly stable, thermoplastic, and self-healable supramolecular polymer hydrogel, Adv. Mater., 27, 3566, 10.1002/adma.201500534 · DOI
  31. Huang, 2017, An intrinsically stretchable and compressible supercapacitor containing a polyacrylamide hydrogel electrolyte, Angew. Chem. Int. Ed., 56, 9141, 10.1002/anie.201705212 · DOI
  32. Wang, 2017, A biomimetic mussel-inspired epsilon-poly-l-lysine hydrogel with robust tissue-anchor and anti-infection capacity, Adv. Funct. Mater., 27, 1604894, 10.1002/adfm.201604894 · DOI · Paper page
  33. Mehdizadeh, 2012, Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure, Biomaterials, 33, 7972, 10.1016/j.biomaterials.2012.07.055 · DOI · Paper page
  34. Dos Santos, 2006, Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan, Int. J. Pharm., 310, 37, 10.1016/j.ijpharm.2005.11.019 · DOI
  35. Ye, 2015, In situ formation of adhesive hydrogels based on PL with laterally grafted catechol groups and their bonding efficacy to wet organic substrates, J. Mater. Sci. Mater. Med., 26, 273, 10.1007/s10856-015-5608-y · DOI
  36. Long, 2021, The effect of umbrella-type branching on the blood circulation and tumor targeting of star-branched PLA-PMPC copolymer micelle, Sci. China Technol. Sci., 64, 71, 10.1007/s11431-020-1645-6 · DOI
  37. Zheng, 2020, High-strength and high-toughness sodium alginate/polyacrylamide double physically crosslinked network hydrogel with superior in situ and self-recovery properties prepared by a one-pot method, Colloids. Surf. A. Physicochem. Eng. Asp., 589, 10.1016/j.colsurfa.2019.124402 · DOI
  38. Yang, 2018, Mechanically tough and recoverable hydrogels via dual physical crosslinkings, J. Polym. Sci. B Polym. Phys., 56, 1294, 10.1002/polb.24729 · DOI
  39. Li, 2020, Bioinspired double-dynamic-bond crosslinked bioadhesive enables post-wound closure care, Adv. Funct. Mater., 30, 2000130, 10.1002/adfm.202000130 · DOI · Paper page
  40. Yang, 2021, Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy, Theranostics, 11, 1543, 10.7150/thno.55978 · DOI
  41. Li, 2020, Early healing of alveolar bone promoted by microRNA-21-loaded nanoparticles combined with bio-oss particles, Chem. Eng. J., 401, 10.1016/j.cej.2020.126026 · DOI
  42. Li, 2019, Paclitaxel formulation with stable sustained-release behavior and its biological safety evaluation, Sci. China Technol. Sci., 62, 1151, 10.1007/s11431-018-9334-6 · DOI
  43. Brubaker, 2011, Enzymatically degradable mussel-inspired adhesive hydrogel, Biomacromolecules, 12, 4326, 10.1021/bm201261d · DOI
  44. Long, 2018, Salt-mediated polyampholyte hydrogels with high mechanical strength, excellent self-healing property, and satisfactory electrical conductivity, Adv. Funct. Mater., 28, 10.1002/adfm.201804416 · DOI
  45. Zhu, 2017, Graphene/cyclodextrin-based nanocomposite hydrogel with enhanced strength and thermo-responsive ability, Carbohydr. Polym., 174, 804, 10.1016/j.carbpol.2017.06.081 · DOI
  46. Lee, 2006, Single-molecule mechanics of mussel adhesion, Proc. Natl. Acad. Sci. USA, 103, 12999, 10.1073/pnas.0605552103 · DOI · Paper page
  47. Nie, 2013, Rapidly in situ forming chitosan/ε-polylysine hydrogels for adhesive sealants and hemostatic materials, Carbohydr. Polym., 96, 342, 10.1016/j.carbpol.2013.04.008 · DOI
  48. Zhu, 2020, Fast and high strength soft tissue bioadhesives based on a peptide dendrimer with antimicrobial properties and hemostatic ability, ACS Appl. Mater. Interfaces, 12, 4241, 10.1021/acsami.9b18720 · DOI
  49. Han, 2017, Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization, ACS Nano, 11, 2561, 10.1021/acsnano.6b05318 · DOI
  50. He, 2019, Bioinspired and microgel-tackified adhesive hydrogel with rapid self-healing and high stretchability, Macromolecules, 52, 72, 10.1021/acs.macromol.8b01678 · DOI
  51. Fan, 2002, Polymerization of N-acryloylsemicarbazide: a facile and versatile strategy to tailor-make highly stiff and tough hydrogels, Mater. Horiz., 7, 1160, 10.1039/C9MH01844A · DOI

Cited by

Sorted by citations

Metadata

Authors
Man, Z., Sidi, L., Xubo, Y., Jin, Z., & Xin, H.
Affiliations
Tianjin University (CN)
Corresponding author
  • Jin, Zhao
  • Xin, Hou
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2021-11
Volume
191
Pages
714-726
ISSN
0141-8130 (ISSN-L)
DOI
10.1016/j.ijbiomac.2021.09.100
OpenAlex
W3203050421
Cited by
44
References
0
Citations by year
2026: 5 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 12
FWCI
5.24
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (51673144, 51673146, 51773151)
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
in situ forming hydrogels, hemostasis, catechol functionalization, ε-polylysine, polyacrylamide, hydrogen bonding crosslinking, wound dressings, adhesion strength, compressive strength, blood loss reduction, emergency hemostasis, cytotoxicity
MeSH terms
Polyacrylamides, Acrylic Resins, Adhesives, Animals, Blood Cells, Catechols, Cell Line, Cells, Cultured, Fibroblasts, Hemostatics, Hydrogen Bonding, Polylysine, Tensile Strength, Hydrogels, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review