The effects of short term (3 weeks) testosterone treatment on serum inflammatory markers in men undergoing coronary artery stenting
Open accessAbstract
Objective Inflammation markers can predict restenosis after successful intracoronary stenting. There is evidence that testosterone suppresses the expression of the inflammatory cytokines. We hypothesized that testosterone therapy after coronary stenting can reduce the inflammation markers.Methods We selected 41 men with coronary artery disease who underwent successful stent implantation for a >70% diameter stenosis of a major coronary artery. Patients, who had stable angina and positive exercise test results, were recruited after diagnostic coronary angiography. Twenty-five men were treated with 3 doses of i.m. testosterone administration once a week for 3 weeks following diagnostic angiography. Sixteen patients were recruited as a control group and they received standard therapy. First venous blood samples were obtained after angiography. Stents were implanted 3 weeks after diagnostic angiography. Second venous blood samples were taken 24 h after the coronary stenting.Results Baseline biochemical or hematological parameters were similar between the control and treatment groups. After coronary stenting, free testosterone, total testosterone, and sex hormone binding globulin were significantly elevated in the testosterone group (P<0.0001, P<0.0001 and P=0.02; respectively). After coronary stent implantation, there was a significant increase in IL-6 and CRP levels in the control group only (P=0.02 and P=0.038), while TNF-alpha levels were increased significantly in both groups (P=0.016 and P=0.014; respectively). Statistical analysis revealed that testosterone treatment prior to stent implantation attenuated IL-6 and hs-CRP levels significantly (P=0.042 and P=0.043; respectively).Conclusions The present study shows that 3 weeks testosterone treatment prior to intracoronary stenting results in a significant suppression in hs-CRP and IL-6 levels after the stent implantation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Effects of testosterone on inflammation occur within 3-12 weeks.
“Effects on inflammation occur within 3–12 weeks.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [63]
Testosterone administration decreases C-reactive protein after 3 weeks and after 3 months.
“A decrease in C-reactive protein (CRP) was observed after 3 weeks (63) and in other studies after 3 months (32, 43).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [63]
Testosterone administration decreases IL6 after 3 weeks and after 16 weeks.
“Already after 3 weeks of testosterone administration, a decline was noted in IL6 (63) and in another study after 16 weeks (64).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [63]
Cites
Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., Orazem, J., Magorien, R. D., O'Shaughnessy, C., & Ganz, P. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042000 · Cited by 1,325 · see citing works
Kornowski, R., Hong, M. K., Tio, F. O., Bramwell, O., Wu, H., & Leon, M. B. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00450-6 · Cited by 842 · see citing works
Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731 · see citing works
Morphological Predictors of Restenosis After Coronary Stenting in Humans
Farb, A. A., Weber, D. K., Kolodgie, F. D., BURKE, A. P., & Virmani, R. (2002) · Circulation · doi:10.1161/01.cir.0000019071.72887.bd · Cited by 592 · see citing works
English, K. M., Steeds, R. P., Jones, T. H., Diver, M. J., & Channer, K. S. (2000) · Circulation · doi:10.1161/01.cir.102.16.1906 · Cited by 582 · see citing works
Hak, A. E., Witteman, J. C. M., de Jong, F. H., Geerlings, M. I., Albert Hofman, D., & Pols, H. A. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.8.3632 · Cited by 480 · see citing works
English, K. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1873 · Cited by 350 · see citing works
Natural Androgens Inhibit Male Atherosclerosis
Alexandersen, P., Haarbo, J., Byrjalsen, I., Lawaetz, H., & Christiansen, C. (1999) · Circulation Research · doi:10.1161/01.res.84.7.813 · Cited by 251 · see citing works
Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis
Whitsel, E. A., Boyko, E. J., Matsumoto, A. M., Anawalt, B. D., & Siscovick, D. S. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00833-6 · Cited by 240 · see citing works
Anderson, J. L., Carlquist, J. F., Muhlestein, J. B., Horne, B. D., & Elmer, S. P. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00203-4 · Cited by 229 · see citing works
Androgen replacement therapy in male patients with rheumatoid arthritis
Cutolo, M., Balleari, E., Giusti, M., Intra, E., & Accardo, S. (1991) · Arthritis & Rheumatism · doi:10.1002/art.1780340102 · Cited by 209 · see citing works
Gaspardone, A., Crea, F., Versaci, F., et al. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00370-1 · Cited by 209 · see citing works
Lincoff, A. M., Kereiakes, D. J., Mascelli, M. A., Deckelbaum, L. I., Barnathan, E. S., Patel, K. K., Frederick, B., Nakada, M. T., & Topol, E. J. (2001) · Circulation · doi:10.1161/01.cir.104.2.163 · Cited by 196 · see citing works
Increased Carotid Atherosclerosis in Andropausal Middle-Aged Men
Mäkinen, J. I., Järvisalo, M. J., Pöllänen, P., Perheentupa, A. H., Irjala, K. M. A., Koskenvuo, M. J., Mäkinen, J., Huhtaniemi, I. T., & Raitakari, O. T. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.052 · Cited by 164 · see citing works
Malkin, C. J., Pugh, P., Jones, R., Jones, T. H., & Channer, K. S. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780373 · Cited by 163 · see citing works
Hanke, H., Lenz, C., Hess, B., et al. (2001) · Circulation · doi:10.1161/01.cir.103.10.1382 · Cited by 141 · see citing works
Fukui, M., Kitagawa, Y., Nakamura, N., Kadono, M., Mogami, S.-I., Hirata, C., Ichio, N., Wada, K., Hasegawa, G., & Yoshikawa, T. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1869 · Cited by 114 · see citing works
Prospective Study of Effect of Androgens on Serum Inflammatory Markers in Men
Ng, M., Liu, P. Y., Williams, A. J., Nakhla, S., Ly, L. P., Handelsman, D. J., & Celermajer, D. S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000022167.80130.a6 · Cited by 73 · see citing works
Administration of Testosterone Is Associated with a Reduced Susceptibility to Myocardial Ischemia
Callies, F., Strömer, H., Schwinger, R. H. G., Bölck, B., Hu, K., Frantz, S., Leupold, A., Beer, S., Allolio, B., & Bonz, A. W. (2003) · Endocrinology · doi:10.1210/en.2003-0058 · Cited by 63 · see citing works
The association of low plasma testosterone level with coronary artery disease in Chinese men
Zhao, S., & Li, X.-P. (1998) · International Journal of Cardiology · doi:10.1016/s0167-5273(97)00295-7 · Cited by 59 · see citing works
C-reactive protein and coronary events following percutaneous coronary angioplasty
de Winter, R. J., Koch, K. T., van Straalen, J. P., Heyde, G., Bax, M., Schotborgh, C. E., Mulder, K., Sanders, G. T., Fischer, J., Tijssen, J. G. P., et al. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00238-9 · Cited by 59 · see citing works
Kabakçı, G., Yı́ldı́rı́r, A., Can, İ., Ünsal, İ., & Erbaş, B. (1999) · Cardiology · doi:10.1159/000006977 · Cited by 46 · see citing works
The association of lower testosterone level with coronary artery disease in postmenopausal women
Kaczmarek, A., Reczuch, K. W., Majda, J., Banasiak, W., & Ponikowski, P. P. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00203-6 · Cited by 46 · see citing works
Dobrzycki, S., Serwatka, W., Nadlewski, S., et al. (2003) · PubMed · Cited by 37 · see citing works
Patti, G., Sciascio, G. D., D’Ambrosio, A., et al. (2002) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.10201 · Cited by 23 · see citing works
Grander, W., Dichtl, W., Prokop, W., et al. (2004) · Clinical Cardiology · doi:10.1002/clc.4960270407 · Cited by 10 · see citing works
Interleukin 6 but not interleukin 10 is associated with restenosis after coronary stenting
Владиславович, Е. М. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00130-8 · Cited by 9 · see citing works
The Effects of Cardiopulmonary Bypass on Androgen Hormones in Coronary Artery Bypass Surgery
Canbaz, S., Ege, T., Sunar, H., et al. (2002) · Journal of International Medical Research · doi:10.1177/147323000203000102 · Cited by 8 · see citing works
[Apathetic form of thyrotoxicosis].
Gs, Z., Lebedev, V. V., Mirzoiants, G. G., et al. (1986) · PubMed · Cited by 2 · see citing works
[Use of androgens in the complex treatment of men with systemic lupus erythematosus].
MIu, F. (1986) · PubMed · Cited by 2 · see citing works
[Use of androgens in the complex treatment of men with systemic lupus erythematosus].
Folomeev, M., & IuV, P. (1987) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232 · see citing works
Treatment of Men for “Low Testosterone”: A Systematic Review
Huo, S., Scialli, A. R., McGarvey, S., Hill, E., Tügertimur, B., Hogenmiller, A., Hirsch, A. I., & Fugh-Berman, A. (2016) · PLOS ONE · doi:10.1371/journal.pone.0162480 · Cited by 97 · see citing works
- Authors
- Guler, N., Batyraliev, T., Dulger, H., Ozkara, C., Tuncer, M., Aslan, S., Okut, H., & Agirbasli, M.
- Affiliations
- Van Yüzüncü Yıl Üniversitesi (TR)
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 109
- Issue
- 3
- Pages
- 339-343
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2097212705
- Cited by
- 33
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Van Yüzüncü Yıl University Academic Data Management System (submittedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- testosterone replacement therapy, coronary stenting, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, restenosis, coronary artery disease, sex hormone-binding globulin, inflammatory cytokines
- MeSH terms
- Adult, Aged, C-Reactive Protein, Coronary Disease, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Tumor Necrosis Factor-alpha, Stents, Interleukin-6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
