Treatment of Men for “Low Testosterone”: A Systematic Review

Huo, Samantha; Scialli, Anthony R.; McGarvey, Sean; Hill, Elizabeth; Tügertimur, Buğra; Hogenmiller, Alycia; Hirsch, Alessandra I.; Fugh-Berman, Adriane

doi:10.1371/journal.pone.0162480

Cited by 97Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsAdrenal Hormones and Disorders

Treatment of Men for “Low Testosterone”: A Systematic Review

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Huo, Samantha, Scialli, Anthony R., McGarvey, Sean, Hill, Elizabeth, Tügertimur, Buğra, Hogenmiller, Alycia, Hirsch, Alessandra I., Fugh-Berman, Adriane·2016·PLOS ONE

DOI 10.1371/journal.pone.0162480PMC PMC5031462

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Abstract

Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of "low testosterone" (low-T) for cardiovascular health, sexual function, muscle weakness or wasting, mood and behavior, and cognition. We performed a systematic review of 156 eligible randomized controlled trials in which testosterone was compared to placebo for one or more of these conditions. We included studies in bibliographic databases between January 1, 1950 and April 9, 2016, and excluded studies involving bodybuilding, contraceptive effectiveness, or treatment of any condition in women or children. Studies with multiple relevant endpoints were included in all relevant tables. Testosterone supplementation did not show consistent benefit for cardiovascular risk, sexual function, mood and behavior, or cognition. Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo. Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido. Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function. Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality, psychological well-being, or mood. The prescription of testosterone supplementation for low-T for cardiovascular health, sexual function, physical function, mood, or cognitive function is without support from randomized clinical trials.

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A systematic review by Huo et al. showed that of 25 studies assessing the effect of testosterone on fat mass, 60% displayed a reduction in fat mass after testosterone treatment.
“A systematic review by Huo et al. reporting the effects of testosterone treatment in men with functional hypogonadism 75 showed that of the 25 studies that assessed the effect of testosterone on fat mass, 60% displayed a reduction in fat mass after testosterone treatment. 75”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [75]
Together, the majority of studies examining the effect of exogenous testosterone therapy report a modest reduction of fat mass.
“Together, the majority of studies examining the effect of exogenous testosterone therapy report a modest reduction of fat mass.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [75]

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Testosterone Replacement Therapy for Hypogonadal Men With Major Depressive Disorder
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The Effects of Growth Hormone and/or Testosterone in Healthy Elderly Men: A Randomized Controlled Trial
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Clinical Meaningfulness of the Changes in Muscle Performance and Physical Function Associated With Testosterone Administration in Older Men With Mobility Limitation
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Testosterone administration in severe burns ameliorates muscle catabolism
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Effect of testosterone cypionate on postexercise ST segment depression.
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Effects of Testosterone on Mood, Aggression, and Sexual Behavior in Young Men: A Double-Blind, Placebo-Controlled, Cross-Over Study
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Effects of Testosterone Supplementation on Whole Body and Regional Fat Mass and Distribution in Human Immunodeficiency Virus-Infected Men with Abdominal Obesity
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Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men
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A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease
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Effects of Hypogonadism and Testosterone Administration on Depression Indices in HIV-Infected Men1
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Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease
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Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men
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A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease
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Activational effects of testosterone on cognitive function in men
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Testosterone Improves Rehabilitation Outcomes in Ill Older Men
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Effects of testosterone replacement in men with opioid-induced androgen deficiency: a randomized controlled trial
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Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status
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Effect of Testosterone Administration on Sexual Behavior and Mood in Men with Erectile Dysfunction
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A Randomized, Double-Blind, Placebo-Controlled Study of Testosterone Treatment in Hypogonadal Older Men With Subthreshold Depression
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Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men
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Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging
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Randomized Study of Testosterone Gel as Adjunctive Therapy to Sildenafil in Hypogonadal Men With Erectile Dysfunction Who Do Not Respond to Sildenafil Alone
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Randomized placebo‐controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy
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Effect of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age
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Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial
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Randomized controlled trial of testosterone in myotonic dystrophy
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Testosterone and cognition in elderly men: a single testosterone injection blocks the practice effect in verbal fluency, but has no effect on spatial or verbal memory
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Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients.
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Testosterone Therapy in Men With Parkinson Disease
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Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease
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Effects of Oral Testosterone Treatment on Myocardial Perfusion and Vascular Function in Men With Low Plasma Testosterone and Coronary Heart Disease
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Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone
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Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men
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Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: A randomized, controlled trial
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Testosterone Versus Fluoxetine for Depression and Fatigue in HIV/AIDS
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The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study)
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Effects of Hypogonadism and Testosterone Administration on Depression Indices in HIV-Infected Men
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Effects of Muscle Strength Training and Testosterone in Frail Elderly Males
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Effects of Testosterone Replacement with a Nongenital, Transdermal System, Androderm, in Human Immunodeficiency Virus-Infected Men with Low Testosterone Levels
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Parallel-Group Placebo-Controlled Trial of Testosterone Gel in Men With Major Depressive Disorder Displaying an Incomplete Response to Standard Antidepressant Treatment
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Effects of Transdermal Testosterone on Lipids and Vascular Reactivity in Older Men With Low Bioavailable Testosterone Levels
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Intramuscular Testosterone Treatment in Elderly Men: Evidence of Memory Decline and Altered Brain Function
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Transdermal Androgen Therapy to Augment EPO in the Treatment of Anemia of Chronic Renal Disease
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Cerebrospinal Fluid and Behavioral Changes After Methyltestosterone Administration
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Preoperative Supraphysiological Testosterone in Older Men Undergoing Knee Replacement Surgery
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Safety and Efficacy of Testosterone Gel 1% Augmentation in Depressed Men With Partial Response to Antidepressant Therapy
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Pharmacokinetic Characteristics, Efficacy, and Safety of Buccal Testosterone in Hypogonadal Males: A Pilot Study
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A trial of testosterone therapy for HIV-associated weight loss
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Effects of testosterone and exercise on muscle leanness in eugonadal men with AIDS wasting
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Beneficial Effects of Testosterone Undecanoate on the Lipoprotein Profiles in Healthy Elderly Men. A Placebo Controlled Study.
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Testosterone Replacement in Androgen-Deficient Men With Ejaculatory Dysfunction: A Randomized Controlled Trial
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Prospective Study of Effect of Androgens on Serum Inflammatory Markers in Men
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Influence of various modes of androgen substitution on serum lipids and lipoproteins in hypogonadal men
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Testosterone Treatment of Men With Mild Cognitive Impairment and Low Testosterone Levels
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Intramuscular Testosterone Supplementation to Selective Serotonin Reuptake Inhibitor in Treatment-Resistant Depressed Men
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The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection
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Effect of Testosterone Treatment on Constitutional and Sexual Symptoms in Men With Type 2 Diabetes in a Randomized, Placebo-Controlled Clinical Trial
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Testosterone therapy increases sexual desire in ageing men with low–normal testosterone levels and symptoms of androgen deficiency
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Short-Term Testosterone Augmentation in Male Schizophrenics
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Effects of Testosterone Replacement in Middle-Aged Men With Dysthymia
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Testosterone replacement for fatigue in hypogonadal ambulatory males with advanced cancer: a preliminary double-blind placebo-controlled trial
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Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure
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Oral testosterone undecanoate (Andriol®) supplement therapy improves the quality of life for men with testosterone deficiency
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Transdermal testosterone gel increases serum testosterone levels in hypogonadal men in Taiwan with improvements in sexual function
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The effect of testosterone on health-related quality of life in elderly males - a pilot study
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Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men
Cherrier, M. M., Plymate, S. R., Mohan, S., Asthana, S., Matsumoto, A. M., Bremner, W., Peskind, E. R., Raskind, M. A., Latendresse, S. J., Haley, A. P., et al. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00136-1 · Cited by 57 · see citing works
Effects of testosterone on the Q-T Interval in older men and older women with chronic heart failure
Schwartz, J. B., Volterrani, M., Caminiti, G., Marazzi, G., Fini, M., Rosano, G. M. C., & Iellamo, F. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2011.01163.x · Cited by 56 · see citing works
Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss
Knapp, P. E., Storer, T. W., Herbst, K. L., Singh, A. B., Dzekov, C., Dzekov, J., LaValley, M. P., Zhang, A., Ulloor, J., & Bhasin, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90213.2008 · Cited by 56 · see citing works
Effects of testosterone and nandrolone on cardiac function: a randomized, placebo‐controlled study
Chung, T., Kelleher, S., Liu, P. Y., Conway, A. J., Kritharides, L., & Handelsman, D. J. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02715.x · Cited by 55 · see citing works
Double‐blind placebo‐controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism
Merza, Z., Blumsohn, A., Mah, P., Meads, D. M., McKenna, S. P., Wylie, K. R., Eastell, R., Wu, F. C. W., & Ross, R. J. M. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00612.x · Cited by 55 · see citing works
Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial
Andriole, G. L. (2008) · Yearbook of Urology · doi:10.1016/s0084-4071(08)79088-2 · Cited by 55 · see citing works
A randomized, double‐blind, placebo‐controlled trial on the effect of long‐acting testosterone treatment as assessed by the Aging Male Symptoms scale
Ho, C. C. K., Tong, S. F., Low, W. Y., Ng, C. J., Khoo, E. M., Lee, V. K. M., Zainuddin, Z. M., & Tan, H. M. (2012) · BJU International · doi:10.1111/j.1464-410x.2011.10755.x · Cited by 53 · see citing works
Testosterone Gel Replacement Improves Sexual Function in Depressed Men Taking Serotonergic Antidepressants: A Randomized, Placebo-Controlled Clinical Trial
Amiaz, R., Pope, H. G., Mahne, T., Kelly, J. F., Brennan, B. P., Kanayama, G., Weiser, M., Hudson, J. I., & Seidman, S. N. (2011) · Journal of Sex & Marital Therapy · doi:10.1080/0092623x.2011.582425 · Cited by 52 · see citing works
Impact of testosterone treatment on postprandial triglyceride metabolism in elderly men with subnormal testosterone levels
Agledahl, I., Hansen, J., & Svartberg, J. B. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510801999068 · Cited by 51 · see citing works
Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina
Smith, A. M., English, K. M., Malkin, C. J., Jones, R. D., Jones, T. H., & Channer, K. S. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01848 · Cited by 51 · see citing works
Efficacy of testosterone, trazodone and hypnotic suggestion in the treatment of non‐organic male sexual dysfunction
Aydın, S., Odabaş, Ö., Ercan, M., Kara, H., & Ağargün, M. (1996) · British Journal of Urology · doi:10.1046/j.1464-410x.1996.86316.x · Cited by 50 · see citing works
Effect of intravenous testosterone on myocardial ischemia in men with coronary artery disease
Thompson, P. D., Ahlberg, A. W., Moyna, N. M., Duncan, B. H., Ferraro-Borgida, M., White, C. M., McGill, C. C., & Heller, G. V. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120144 · Cited by 49 · see citing works
Effect of 12 month oral testosterone on testosterone deficiency symptoms in symptomatic elderly males with low-normal gonadal status
Haren, M. T. (2004) · Age and Ageing · doi:10.1093/ageing/afi003 · Cited by 47 · see citing works
No Effect of Oral Testosterone Treatment on Sexual Dysfunction in Alcoholic Cirrhotic Men
Gluud, C. N., Wantzin, P., & Eriksen, J. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80081-7 · Cited by 47 · see citing works
Chronic testosterone cypionate therapy in men with secondary impotence
Nankin, H. R., Lin, T., & Osterman, J. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49529-4 · Cited by 46 · see citing works
Androgens and sexual function: a placebo-controlled, randomized, double-blind study of testosterone<i>vs</i>. dehydroepiandrosterone in men with sexual dysfunction and androgen deficiency
Morales, A., Black, A., Emerson, L., Barkin, J., Kuzmarov, I., & Day, A. (2009) · The Aging Male · doi:10.3109/13685530903294388 · Cited by 46 · see citing works
The Sexual Effects of Testosterone Replacement in Depressed Men: Randomized, Placebo-Controlled Clinical Trial
Seidman, S. N., & Roose, S. P. (2006) · Journal of Sex & Marital Therapy · doi:10.1080/00926230600575355 · Cited by 40 · see citing works
Cognitive effects of testosterone and finasteride administration in older hypogonadal men
Borst, S. E., Yarrow, J. F., Conover, C., Ye, F., Morrow, M., Zou, B., Shuster, J. J., Fernandez, C., & Meuleman, J. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s61760 · Cited by 36 · see citing works
Oral testosterone supplementation and chronic low-grade inflammation in elderly men: A 26-week randomized, placebo-controlled trial
Nakhai-Pour, H. R., Grobbee, D. E., Emmelot‐Vonk, M. H., Bots, M. L., Verhaar, H. J. J., & van der Schouw, Y. T. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.09.001 · Cited by 34 · see citing works
The effects of short term (3 weeks) testosterone treatment on serum inflammatory markers in men undergoing coronary artery stenting
Guler, N., Batyraliev, T., Dulger, H., Ozkara, C., Tuncer, M., Aslan, S., Okut, H., & Agirbasli, M. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.06.027 · Cited by 33 · see citing works
Effect of testosterone supplementation on sexual functioning in aging men: a 6-month randomized controlled trial
Emmelot‐Vonk, M. H., Verhaar, H. J. J., Nakhai-Pour, H. R., Grobbee, D. E., & van der Schouw, Y. T. (2009) · International Journal of Impotence Research · doi:10.1038/ijir.2009.5 · Cited by 32 · see citing works
Changes in Lipoprotein-Lipid Levels in Normal Men Following Administration of Increasing Doses of Testosterone Cypionate
Kouri, E. M., Pope, H. G., & Oliva, P. S. (1996) · Clinical Journal of Sport Medicine · doi:10.1097/00042752-199607000-00003 · Cited by 31 · see citing works
Testosterone deficiency: myth, facts, and controversy.
Miner, M. M., Barkin, J., & Rosenberg, M. T. (2014) · PubMed · Cited by 27 · see citing works
Physiologic Testosterone Therapy has no Effect on Serum Levels of Tumour Necrosis Factor-α in Men with Chronic Heart Failure
Pugh, P. J., Jones, R. D., Malkin, C. J., Hall, J., Nettleship, J. E., Kerry, K., Jones, T. H., & Channer, K. S. (2005) · Endocrine Research · doi:10.1080/07435800500406205 · Cited by 25 · see citing works
Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety
Asih, P. R., Wahjoepramono, E. J., Aniwiyanti, V., Wijaya, L. K., Ruyck, K. D., Taddei, K., Fuller, S. J., Sohrabi, H. R., Dhaliwal, S. S., Verdile, G., et al. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150429112112 · Cited by 25 · see citing works
Therapeutic Effects of Nandrolone and Testosterone in Adult Male HIV Patients With AIDS Wasting Syndrome (AWS): A Randomized, Double-Blind, Placebo-Controlled Trial
Sardar, P., Jha, A., Roy, D., Majumdar, U., Guha, P., Roy, S., Banerjee, R., Banerjee, A. K., & Bandyopadhyay, D. (2010) · HIV Clinical Trials · doi:10.1310/hct1104-220 · Cited by 23 · see citing works
Osteoprotegerin Levels Decrease During Testosterone Therapy in Aging Men and are Associated with Changed Distribution of Regional Fat
Frederiksen, L., Glintborg, D., Højlund, K., HOUGAARD, D. M., Brixen, K., Rasmussen, L. M., & Andersen, M. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1323647 · Cited by 17 · see citing works
Testosterone Therapy in Obliterating Arterial Lesions in the Lower Limbs
Dohn, K., Hvidt, Nielsen, J., & Palm, L. (1968) · Angiology · doi:10.1177/000331976801900604 · Cited by 12 · see citing works
Pharmacokinetic Characteristics, Efficacy, and Safety of Buccal Testosterone in Hypogonadal Males: A Pilot Study1
Dobs, A. S., Hoover, D. R., Chen, C.-F., & Allen, R. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4505 · Cited by 11 · see citing works
EXPERIMENTAL RAISING OR LOWERING OF TESTOSTERONE LEVEL AFFECTS MOOD IN NORMAL MEN AND WOMEN
Dabbs, J. M., Karpas, A. E., Dyomina, N. V., Juechter, J., & Roberts, A. H. (2002) · Social Behavior and Personality An International Journal · doi:10.2224/sbp.2002.30.8.795 · Cited by 10 · see citing works
Testosterone in the treatment of arterial insufficiency of the lower limbs.
Hentzer, E., & Madsen, P. C. (1967) · PubMed · Cited by 9 · see citing works

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European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction
Salonia, A., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.06.007 · Cited by 858 · see citing works
Sex as a Biological Variable in Atherosclerosis
Man, J. J., Beckman, J. A., & Jaffe, I. Z. (2020) · Circulation Research · doi:10.1161/circresaha.120.315930 · Cited by 407 · see citing works
Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores
Corona, G., Rastrelli, G., Morgentaler, A., Sforza, A., Mannucci, E., & Maggi, M. (2017) · European Urology · doi:10.1016/j.eururo.2017.03.032 · Cited by 225 · see citing works
Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men
Walther, A., Breidenstein, J., & Miller, R. E. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2734 · Cited by 178 · see citing works
Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline
Newman, C. B., Blaha, M. J., Boord, J. B., Cariou, B., Chait, A., Fein, H. G., Ginsberg, H. N., Goldberg, I. J., Murad, M. H., Subramanian, S., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa674 · Cited by 180 · see citing works
The efficacy and adverse events of testosterone replacement therapy in hypogonadal men: A systematic review and meta-analysis of randomized, placebo-controlled trials
Ponce, O. J., Spencer-Bonilla, G., Alvarez-Villalobos, N., Serrano, V., Singh-Ospina, N., Rodriguez-Gutierrez, R., Salcido-Montenegro, A., Benkhadra, R., Prokop, L. J., Bhasin, S., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00404 · Cited by 148 · see citing works
Long-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces Risk of Cardiovascular Disease in Men with Hypogonadism: A Real-Life Observational Registry Study Setting Comparing Treated and Untreated (Control) Groups
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130 · see citing works
Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis
Hudson, J., Cruickshank, M., Quinton, R., Aucott, L. S., Aceves‐Martins, M., Gillies, K., Bhasin, S., Snyder, P. J., Ellenberg, S. S., Grossmann, M., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00096-4 · Cited by 114 · see citing works
Testosterone replacement therapy: for whom, when and how?
Tsametis, C. P., & Isidori, A. M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.007 · Cited by 96 · see citing works
Randomized controlled trials – mechanistic studies of testosterone and the cardiovascular system
Jones, T. H., & Kelly, D. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_6_18 · Cited by 75 · see citing works
Efficacy and Safety of Testosterone Treatment in Men: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians
Diem, S. J., Greer, N. L., MacDonald, R. H., McKenzie, L. G., Dahm, P., Ercan-Fang, N. G., Estrada, A., Hemmy, L. S., Rosebush, C. E., Fink, H. A., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m19-0830 · Cited by 72 · see citing works
Testosterone Replacement Therapy: Long-Term Safety and Efficacy
Corona, G., Sforza, A., & Maggi, M. (2017) · The World Journal of Men s Health · doi:10.5534/wjmh.2017.35.2.65 · Cited by 60 · see citing works
Therapeutic potential ofMucuna pruriens(Linn.) on ageing induced damage in dorsal nerve of the penis and its implication on erectile function: an experimental study using albino rats
Prakash, S., Muhammed, I., Mohanraj, K. G., Lakshmanan, G., Premavathy, D., Muthu, S., Shimray, K. W., & Sathyanathan, S. B. (2018) · The Aging Male · doi:10.1080/13685538.2018.1439005 · Cited by 59 · see citing works
Anabolic-androgenic steroid administration increases self-reported aggression in healthy males: a systematic review and meta-analysis of experimental studies
Chegeni, R., Pallesen, S., McVeigh, J., & Sagoe, D. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05818-7 · Cited by 54 · see citing works
Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess
Arosio, B., Ostan, R., Mari, D., Damanti, S., Ronchetti, F., Arcudi, S., Scurti, M., Franceschi, C., & Monti, D. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.02.010 · Cited by 54 · see citing works
Testosterone Therapy: Review of Clinical Applications.
Petering, R. C., & Brooks, N. A. (2017) · PubMed · Cited by 51 · see citing works
IL-1 Antagonism in Men With Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial
Ebrahimi, F., Urwyler, S. A., Straumann, S., Doerpfeld, S., Bernasconi, L., Neyer, P. J., Schüetz, P., Müeller, B., Donath, M. Y., & Christ‐Crain, M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00739 · Cited by 42 · see citing works
Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials
Tan, S., Sohrabi, H. R., Weinborn, M., Tegg, M., Bucks, R. S., Taddei, K., Carruthers, M. E., & Martins, R. N. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.05.008 · Cited by 42 · see citing works
Testosterone Replacement, Muscle Strength, and Physical Function
Nam, Y., Lee, G., Yun, J. M., & Cho, B. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.182001 · Cited by 41 · see citing works
Type 2 Diabetes and Testosterone Therapy
Hackett, G. I. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180027 · Cited by 39 · see citing works
Metabolic Effects of Testosterone Therapy in Men with Type 2 Diabetes and Metabolic Syndrome
Hackett, G. I. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.12.004 · Cited by 39 · see citing works
Testosterone and exercise: effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels
Chasland, L. C., Yeap, B. B., Maiorana, A., Chan, Y. X., Maslen, B. A., Cooke, B. R., Dembo, L. G., Naylor, L. H., & GREEN, D. J. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00010.2021 · Cited by 38 · see citing works
Effects of endocrine disorders on lipids and lipoproteins
Newman, C. B. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101667 · Cited by 37 · see citing works
Testosterone Supplementation and Cognitive Functioning in Men—A Systematic Review and Meta-Analysis
Buskbjerg, C. R., Gravholt, C. H., Dalby, H. R., Amidi, A., & Zachariae, R. H. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00119 · Cited by 33 · see citing works
EMAS position statement: Testosterone replacement therapy in older men
Kanakis, G., Pofi, R., Goulis, D. G., Isidori, A. M., Armeni, E., Erel, C. T., Fistonić, I., Hillard, T., Hirschberg, A. L., Męczekalski, B., et al. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107854 · Cited by 32 · see citing works
Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety
Asih, P. R., Wahjoepramono, E. J., Aniwiyanti, V., Wijaya, L. K., Ruyck, K. D., Taddei, K., Fuller, S. J., Sohrabi, H. R., Dhaliwal, S. S., Verdile, G., et al. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150429112112 · Cited by 25 · see citing works
Symptoms of sexual dysfunction among men from infertile couples: prevalence and association with testosterone deficiency
Kruljac, M., Finnbogadóttir, H., Bobjer, J., Giraldi, A. G. E., Fugl-Meyer, K. S., & Giwercman, A. (2019) · Andrology · doi:10.1111/andr.12678 · Cited by 25 · see citing works
Androgen abuse and the brain
Scarth, M., & Bjørnebekk, A. (2021) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000675 · Cited by 24 · see citing works
Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30‐week randomized placebo‐controlled study
Hackett, G. I., Cole, N., Saghir, A., Jones, P. W., Strange, R. C., & Ramachandran, S. (2017) · Andrology · doi:10.1111/andr.12399 · Cited by 24 · see citing works
Association of OPRK1 gene polymorphisms with opioid dependence in addicted men undergoing methadone treatment in an Iranian population
Albonaim, A., Tolami, H. F., Sharafshah, A., Omarmeli, V., Rezaei, S., Ajamian, F., & Keshavarz, P. (2017) · Journal of Addictive Diseases · doi:10.1080/10550887.2017.1361724 · Cited by 22 · see citing works
The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22 · see citing works
Libido as a motivator for starting and restarting non-prescribed anabolic androgenic steroid use among men: a mixed-methods study
Harvey, O., Parrish, M., van Teijlingen, E., & Trenoweth, S. (2021) · Drugs Education Prevention and Policy · doi:10.1080/09687637.2021.1882940 · Cited by 20 · see citing works
Management of Male Infertility with Coexisting Sexual Dysfunction: A Consensus Statement and Clinical Recommendations from the Asia-Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men’s Health and Aging (ASMHA)
Chung, E., Jiang, H., Xin, Z. C., Kim, S. W., Moon, D. G., Yuan, Y., Nagao, K., Hakim, L., Chang, H., Mak, S. K., et al. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.230180 · Cited by 21 · see citing works
The effects and safety of testosterone replacement therapy for men with hypogonadism: the TestES evidence synthesis and economic evaluation
Cruickshank, M., Hudson, J., Hernández, R. A., Aceves‐Martins, M., Quinton, R., Gillies, K., Aucott, L. S., Kennedy, C., Manson, P. D., Oliver, N. S., et al. (2024) · Health Technology Assessment · doi:10.3310/jryt3981 · Cited by 20 · see citing works
Normal Testosterone but Higher Luteinizing Hormone Plasma Levels in Men With Hypersexual Disorder
Chatzittofis, A., Boström, A. E., Öberg, K. G., Flanagan, J. N., Schiöth, H. B., Arver, S., & Jokinen, J. (2020) · Sexual Medicine · doi:10.1016/j.esxm.2020.02.005 · Cited by 18 · see citing works
Sex differences and athletic performance. Where do trans individuals fit into sports and athletics based on current research?
Oberlin, D. J. (2023) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2023.1224476 · Cited by 21 · see citing works
Sex, Energy, Well-Being and Low Testosterone: An Exploratory Survey of U.S. Men’s Experiences on Prescription Testosterone
Straftis, A. A., & Gray, P. B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16183261 · Cited by 18 · see citing works
Cognitive response to testosterone replacement added to intensive lifestyle intervention in older men with obesity and hypogonadism: prespecified secondary analyses of a randomized clinical trial
Gregori, G., Celli, A., Barnouin, Y., Paudyal, A., Armamento‐Villareal, R., Napoli, N., Qualls, C., & Villareal, D. T. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab253 · Cited by 17 · see citing works
‘Forever Young’†—Testosterone replacement therapy: a blockbuster drug despite flabby evidence and broken promises
Busnelli, A., Somigliana, E., & Vercellini, P. (2017) · Human Reproduction · doi:10.1093/humrep/dex032 · Cited by 17 · see citing works
Neurochemical and Hormonal Contributors to Compulsive Sexual Behavior Disorder
Chatzittofis, A., Boström, A. E. D., Savard, J., Öberg, K. G., Arver, S., & Jokinen, J. (2022) · Current Addiction Reports · doi:10.1007/s40429-021-00403-6 · Cited by 17 · see citing works
Statin Use in Men and New Onset of Erectile Dysfunction: A Systematic Review and Meta-Analysis
Elgendy, A. Y., Elgendy, I. Y., Mahmoud, A. N., Al‐Ani, M. A., Moussa, M., Mahmoud, A., Mojadidi, M. K., & Anderson, R. D. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.10.043 · Cited by 13 · see citing works
Emotions and Steroid Secretion in Aging Men: A Multi—Study Report
Walther, A., Waldvogel, P., Noser, E., Schoch-Ruppen, J., & Ehlert, U. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01722 · Cited by 11 · see citing works
Thinking About Pathomechanisms and Current Treatment of Erectile Dysfunction—“The Stanley Beamish Problem.” Review, Recommendations, and Proposals
Beecken, W.-D., Kersting, M., Kunert, W., Blume, G., Bacharidis, N., Cohen, D. S., Shabeeh, H., & Allen, M. S. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.11.004 · Cited by 13 · see citing works
Depression in Nonclassical Hypogonadism in Young Men
Korenman, S. G., Grotts, J. F., Bell, D. S., & Elashoff, D. A. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00137 · Cited by 12 · see citing works
Clinical significance of reproductive hormones
Manocha, A., Kankra, M., Singla, P., Sharma, A. K., Ahirwar, A. K., & Bhargava, S. (2018) · Current Medicine Research and Practice · doi:10.1016/j.cmrp.2018.05.006 · Cited by 11 · see citing works
What are the benefits and harms of testosterone therapy for male sexual dysfunction?—a systematic review
Dimitropoulos, K., Verze, P., den Broeck, T. V., Salonia, A., Yuan, C. Y., Konstantinos Hatzimouratidis, A., & Dohle, G. R. (2019) · International Journal of Impotence Research · doi:10.1038/s41443-019-0131-1 · Cited by 11 · see citing works
Hypogonadism and cancer survivorship
Faw, C. A., & Brannigan, R. E. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000583 · Cited by 11 · see citing works
Late-Onset Hypogonadism as Primary Testicular Failure
Swee, D. S., & Gan, E. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00372 · Cited by 11 · see citing works
Investigating the basis of sexual dysfunction during late-onset hypogonadism
Tharakan, T., Miah, S., Jayasena, C. N., & Minhas, S. (2019) · F1000Research · doi:10.12688/f1000research.16561.1 · Cited by 9 · see citing works
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Authors: Huo, S., Scialli, A. R., McGarvey, S., Hill, E., Tügertimur, B., Hogenmiller, A., Hirsch, A. I., & Fugh-Berman, A.
Affiliations: Tulane University (US)
Georgetown University Medical Center (US)
University of South Florida (US)
University of Illinois Chicago (US)
ORCID: Huo, Samantha
Scialli, Anthony R.
Venue: PLOS ONE
Publisher: Public Library of Science (PLoS)
Published: 2016-09-21
Volume: 11
Issue: 9
Pages: e0162480
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0162480
PMC: PMC5031462
OpenAlex: W2523479896
Cited by: 97
References: 179
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 18 · 2017: 22 · 2016: 1 · 2015: 1
FWCI: 2.55
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: George Washington University
Georgetown University
District of Columbia Department of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: testosterone supplementation, androgen deficiency, hypogonadism, testosterone replacement therapy, cardiovascular risk, sexual function, erectile dysfunction, sexual desire, muscle strength, physical function, mood, cognitive function, placebo comparison

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