Atrial fibrillation prevalence, incidence and risk of stroke and all-cause death among Chinese
Abstract
Background We investigated atrial fibrillation (AF) prevalence, incidence and the risk of stroke and all-cause death because little is known about AF risk among ethnic Chinese.Methods We conducted a community-based prospective cohort study among 3560 participants. Prevalent and incident AF was documented by using the 12-lead ECG in baseline and serial follow-ups, and the stroke and all-cause death events were ascertained.Results Overall prevalence rates of AF in the cohort were 1.4% in men and 0.7% in women. Incidence rates of AF were 1.68 per 1000 person-years for men and 0.76 per 1000 person-years for women. During a median 13.8 years' follow-up, we documented 208 cases of stroke and 776 deaths. As compared with those without AF, participants with AF had nearly 4 times the age, gender-adjusted risk of stroke (relative risk [RR], 3.87, 95% confidence interval [CI], 2.12-7.15), and twice the risk of death associated with all causes (RR, 2.23, 95% CI, 1.52-3.27). Further adjustment for body mass index, lifestyle factors, socioeconomic status and clinical diseases slightly attenuated these risks. In addition, after adjusting for echocardiographic measures, the following risks remained significant: the multivariate RRs were 2.90 (95% CI, 1.28-6.59) for risk of stroke and 2.05 (95% CI, 1.27-3.32) for risk of all-cause death among participants with AF.Conclusion Our data demonstrate that AF is a significant risk factor for stroke and all-cause death for the Chinese.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AF incidence increases disproportionately with increasing age in both women and men, reaching as high as 30.4 per 1000 person-years in women and 32.9 per 1000 person-years in men by age 85-89 years.
“AF incidence has been shown to increase disproportionately with increasing age in both women and men, reaching as high as 30.4 per 1000 person-years in women and 32.9 per 1000 person-years in men by age 85–89 years.17”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [17]
Cites
Hanley, J. A., & McNeil, B. J. (1983) · Radiology · doi:10.1148/radiology.148.3.6878708 · Cited by 7,016 · see citing works
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493 · see citing works
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205 · see citing works
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832 · see citing works
Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Devereux, R. B., & Reichek, N. (1977) · Circulation · doi:10.1161/01.cir.55.4.613 · Cited by 4,499 · see citing works
Benjamin, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510350050036 · Cited by 2,613 · see citing works
Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564 · see citing works
Ethical authorship and publishing
Coats, A. J. S. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.048 · Cited by 2,142 · see citing works
Kannel, W. B., Wolf, P. A., Benjamin, E. J., & Levy, D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00583-9 · Cited by 2,033 · see citing works
Greiner, M., Pfeiffer, D., & Smith, R. D. (2000) · Preventive Veterinary Medicine · doi:10.1016/s0167-5877(00)00115-x · Cited by 1,923 · see citing works
Ridker, P. M., Buring, J. E., Rifai, N., & Cook, N. R. (2007) · JAMA · doi:10.1001/jama.297.6.611 · Cited by 1,814 · see citing works
Krahn, A. D., Manfreda, J., TATE, R. B., Mathewson, F. A. L., & Cuddy, T. E. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80348-9 · Cited by 1,478 · see citing works
Incidence of and risk factors for atrial fibrillation in older adults
Psaty, B. M., Manolio, T. A., Kuller, L. H., Kronmal, R. A., Cushman, M., Fried, L. P., White, R., Furberg, C. D., & Rautaharju, P. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2455 · Cited by 1,462 · see citing works
Obesity and the risk of new-onset atrial fibrillation
Wang, T. J. (2004) · JAMA · doi:10.1001/jama.292.20.2471 · Cited by 1,427 · see citing works
Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley study
Stewart, S., Hart, C. L., Hole, D. J., & McMurray, J. J. V. (2001) · Heart · doi:10.1136/heart.86.5.516 · Cited by 661 · see citing works
(1999) · Choice Reviews Online · doi:10.5860/choice.36-3094 · Cited by 569 · see citing works
Atrial fibrillation and obesity—results of a meta-analysis
Wanahita, N., Messerli, F. H., Bangalore, S., Gami, A. S., Somers, V. K., & Steinberg, J. S. (2008) · American Heart Journal · doi:10.1016/j.ahj.2007.10.004 · Cited by 474 · see citing works
External correspondence: Decompositions of the mean probability score
Yates, J. (1982) · Organizational Behavior and Human Performance · doi:10.1016/0030-5073(82)90237-9 · Cited by 466 · see citing works
Fish Intake and Risk of Incident Atrial Fibrillation
Mozaffarian, D., Psaty, B. M., Rimm, E. B., Lemaitre, R. N., Burke, G. L., Lyles, M. F., Lefkowitz, D., & Siscovick, D. S. (2004) · Circulation · doi:10.1161/01.cir.0000138154.00779.a5 · Cited by 456 · see citing works
Frost, L., Hune, L. J., & Vestergaard, P. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.01.031 · Cited by 430 · see citing works
Mortality Trends in Patients Diagnosed With First Atrial Fibrillation
Miyasaka, Y., Barnes, M. E., Bailey, K. R., Cha, S. S., Gersh, B. J., Seward, J. B., & Tsang, T. S. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.062 · Cited by 411 · see citing works
New-Onset Atrial Fibrillation: Sex Differences in Presentation, Treatment, and Outcome
Humphries, K. H., Kerr, C. R., Connolly, S. J., Klein, G., Boone, J. A., Green, M., Sheldon, R., Talajic, M., Dorian, P., & Newman, D. (2001) · Circulation · doi:10.1161/01.cir.103.19.2365 · Cited by 378 · see citing works
Griffith Kathryn, E., Maurice, P., & 李永军 (2008) · doi:10.3760/cma.j.issn.1007-9742.2008.06.132 · Cited by 372 · see citing works
Pulse Pressure and Risk of New-Onset Atrial Fibrillation
Mitchell, G. F., Vasan, R. S., Keyes, M. J., Parise, H., Wang, T. J., Larson, M. G., D’Agostino, R. B., Kannel, W. B., Levy, D. A., & Benjamin, E. J. (2007) · JAMA · doi:10.1001/jama.297.7.709 · Cited by 362 · see citing works
Status of the Epidemiology of Atrial Fibrillation
Kannel, W. B., & Benjamin, E. J. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.09.002 · Cited by 359 · see citing works
Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women
Mukamal, K. J., Tolstrup, J. S., Friberg, J., Jensen, G. B., & Grønbæk, M. (2005) · Circulation · doi:10.1161/circulationaha.105.547844 · Cited by 269 · see citing works
Risk of New-Onset Atrial Fibrillation in Relation to Body Mass Index
Dublin, S. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.21.2322 · Cited by 268 · see citing works
Obesity and Risk of New-Onset Atrial Fibrillation After Cardiac Surgery
Zacharias, A., Schwann, T. A., Riordan, C. J., Durham, S. J., Shah, A. S., & Habib, R. (2005) · Circulation · doi:10.1161/circulationaha.105.553743 · Cited by 255 · see citing works
Tsang, T. S. M., Barnes, M. E., Gersh, B. J., Bailey, K. R., & Seward, J. B. (2003) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.012 · Cited by 162 · see citing works
Sex-specific increase in the prevalence of atrial fibrillation (The Copenhagen City Heart Study)
Friberg, J., Scharling, H., Gadsbøll, N., & Jensen, G. B. (2003) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.08.050 · Cited by 144 · see citing works
Epidemiology of atrial fibrillation: A current perspective
Chen, L. Y., & Shen, W.-K. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.12.018 · Cited by 140 · see citing works
Long-Term Risk Factors for Stroke
Harmsen, P., Lappas, G., Rosengren, A., & Wilhelmsen, L. (2006) · Stroke · doi:10.1161/01.str.0000226604.10877.fc · Cited by 140 · see citing works
Newly Diagnosed Atrial Fibrillation
Page, R. L. (2004) · New England Journal of Medicine · doi:10.1056/nejmcp041956 · Cited by 124 · see citing works
Lee, Y., Lin, R. S., Sung, F. C., Yang, C.-Y., Chien, K., Chen, W., Su, T., Hsu, H.-C., & Huang, Y.-C. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00198-0 · Cited by 113 · see citing works
Self-citationChien, K.-L., Hsu, H.-C., Su, T.-C., Chen, M.-F., Lee, Y.-T., & Hu, F. B. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700213-jlr200 · Cited by 109 · see citing works
Self-citationKhairallah, F. S., Ezzedine, R., Ganz, L. I., London, B., & Saba, S. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.04.068 · Cited by 101 · see citing works
[An epidemiological survey of atrial fibrillation in China].
Zhou, Z.-Q., Hu, D., Chen, J., Zhang, R.-H., Li, K., & Zhao, X. (2004) · PubMed · Cited by 75 · see citing works
Recent developments in atrial fibrillation
Iqbal, M. B., Taneja, A. K., Lip, G. Y. H., & Flather, M. D. (2005) · BMJ · doi:10.1136/bmj.330.7485.238 · Cited by 72 · see citing works
Apolipoprotein A-I and B and Stroke Events in a Community-Based Cohort in Taiwan
Chien, K., Sung, F., Hsu, H., Su, T., Lin, R. S., & Lee, Y. (2002) · Stroke · doi:10.1161/hs0102.101626 · Cited by 63 · see citing works
Self-citationOhsawa, M., Okayama, A., Okamura, T., Itai, K., Nakamura, M., Tanno, K., Kato, K., Yaegashi, Y., Onoda, T., Sakata, K., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.814 · Cited by 62 · see citing works
Kerr, C. R., & Humphries, K. H. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.07.007 · Cited by 58 · see citing works
Obesity and the risk of new-onset atrial fibrillation
Wang, T. J., Parise, H., & Levy, D. A. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2005.02.017 · Cited by 48 · see citing works
Chien, K., Hsu, H., Sung, F., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3280d94313 · Cited by 42 · see citing works
Self-citationClinical and Echocardiographic Markers of Mortality Risk in Patients With Atrial Fibrillation
Khumri, T. M., Idupulapati, M., Rader, V. J., et al. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.01.055 · Cited by 41 · see citing works
Chien, K., Hsu, H., Su, T., Sung, F., Chen, M.-F., & Lee, Y. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.090969 · Cited by 32 · see citing works
Self-citationHuang, C.-H., Chien, K., Chen, W.-J., Sung, F., Hsu, H., Su, T., & Lee, Y.-T. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.02.008 · Cited by 31 · see citing works
Self-citationElectrocardiographic manifestations of healthy residents of a tribal Himalayan village.
Kaushal, S. S., DasGupta, D. J., Prashar, B. S., & Bhardwaj, A. K. (1995) · PubMed · Cited by 30 · see citing works
Chien, K., Sung, F., Hsu, H., Su, T., & Lee, Y. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00579-7 · Cited by 17 · see citing works
Self-citationThe Epidemiology of Atrial Fibrillation
Wang, T. J., & Benjamin, E. J. (2004) · CRC Press eBooks · doi:10.3109/9780203996935-7 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Global epidemiology of atrial fibrillation
Rahman, F., Kwan, G. F., & Benjamin, E. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.118 · Cited by 731 · see citing works
Incidence and prevalence of atrial fibrillation: an analysis based on 8.3 million patients
Wilke, T., Groth, A., Mueller, S., Pfannkuche, M., Verheyen, F., Linder, R., Maywald, U., Bauersachs, R., & Breithardt, G. (2013) · Europace · doi:10.1093/europace/eus333 · Cited by 397 · see citing works
Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
Ko, D., Rahman, F., Schnabel, R. B., Yin, X., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.45 · Cited by 353 · see citing works
Prevalence, Incidence, and Lifetime Risk of Atrial Fibrillation in China
Guo, Y., Tian, Y., Wang, H., Si, Q., Wang, Y., & Lip, G. Y. H. (2015) · Chest · doi:10.1378/chest.14-0321 · Cited by 255 · see citing works
- Authors
- Chien, K.-L., Su, T.-C., Hsu, H.-C., Chang, W.-T., Chen, P.-C., Chen, M.-F., & Lee, Y.-T.
- Affiliations
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Corresponding author
- Lee, Yuan-Teh
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 139
- Issue
- 2
- Pages
- 173-180
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2157409700
- Cited by
- 146
- References
- 49
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 13 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 14 · 2015: 14 · 2014: 19 · 2013: 10 · 2012: 9
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- atrial fibrillation, prevalence, incidence, stroke risk, all-cause mortality, ethnic Chinese, sex differences, cardiovascular risk factors
- MeSH terms
- Adult, Aged, Atrial Fibrillation, Female, Humans, Life Style, Male, Middle Aged, Prospective Studies, Risk Factors, Socioeconomic Factors, Taiwan, Incidence, Prevalence, Stroke, Asian People, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
