Gender-related differences in presentation, treatment and long-term outcome in patients with first-diagnosed atrial fibrillation and structurally normal heart: The Belgrade atrial fibrillation study
Abstract
Background Several studies have investigated gender-related differences in atrial fibrillation (AF), but limited data are available in relation to gender-related differences in presentation, treatment and long-term outcomes of patients with first-diagnosed AF and structurally normal heart.Objective To compare gender-related clinical characteristics, presentation, treatment and long-term outcomes in a cohort of patients with first-diagnosed non-valvular AF and a structurally normal heart, following a 10-year follow-up.Methods Observational cohort study of patients with AF between 1992 and 2007.Results Of 862 patients (mean age 52.2±12.1 years), 315 (36.5%) were female. Paroxysmal AF and hypertension were significantly more prevalent in females, while persistent AF was more common amongst males (all p<0.001). Female patients were more symptomatic (p=0.002). After a mean follow-up of 10.1±6.1 years, more male patients developed tachycardiomyopathy (6.0% vs. 1.9%, p=0.02). In multivariate analysis, male gender remained significantly associated with tachycardiomyopathy (HR 3.1, 95% CI: 1.3-7.4, p=0.012). The rate of transition to permanent AF, thromboembolism, hemorrhage, all-cause mortality, cardiovascular and sudden death did not significantly differ between male and female patients.Conclusions Gender differences are evident in AF. Male patients were less asymptomatic or more frequently developed persistent AF. Male patients were also at higher risk of tachycardiomyopathy, suggesting that these patients require more attention to rate control during follow-up.
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In studies from North America, Europe, and Australia, women with AF are, on average, older than men.
“However, in studies from North America,5 Europe,34,35 and Australia,11 women with AF are, on average, older than men.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [35]
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- Authors
- Potpara, T. S., Marinkovic, J. M., Polovina, M. M., Stankovic, G. R., Seferovic, P. M., Ostojic, M. C., & Lip, G. Y. H.
- Affiliations
- Univerzitetski Klinički Centar Srbije (RS)
- Birmingham City Hospital (GB)
- Corresponding author
- Potpara, Tatjana S.
- Lip, Gregory Y.H.
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 161
- Issue
- 1
- Pages
- 39-44
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2044898585
- Cited by
- 71
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 4 · 2014: 2 · 2013: 10 · 2012: 6
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- atrial fibrillation, sex differences, non-valvular atrial fibrillation, structurally normal heart, tachycardia-induced cardiomyopathy, paroxysmal atrial fibrillation, persistent atrial fibrillation, rate control, thromboembolism, all-cause mortality, sudden death, long-term outcomes
- MeSH terms
- Adult, Aged, Atrial Fibrillation, Diagnosis, Differential, Electric Countershock, Female, Follow-Up Studies, Heart, Humans, Longitudinal Studies, Male, Middle Aged, Sex Characteristics, Time Factors, Treatment Outcome, Serbia
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