Cited by 47Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmias

Risk of atrial fibrillation after atrial flutter ablation: impact of AF history, gender, and antiarrhythmic drug medication

BREMBILLA‐PERROT, BÉATRICE, GIRERD, NICOLAS, SELLAL, JEAN MARC, OLIVIER, ARNAUD, MANENTI, VLADIMIR, VILLEMIN, THIBAUT, BEURRIER, DANIEL, DE CHILLOU, CHRISTIAN +3 more·2014·Journal of Cardiovascular Electrophysiology

Abstract

INTRODUCTION: Atrial fibrillation (AF) and flutter (AFL) are frequently associated. We assessed the frequency and identified the predictors of AF occurrence after AFL ablation. METHODS AND RESULTS: A total of 1,121 patients referred for AFL ablation were followed for a mean duration of 2.1 ± 2.7 years. Antiarrhythmic drugs were stopped after ablation in patients with no AF prior to ablation, or continued otherwise. A total of 356 patients (31.7%) had a history of AF prior to AFL ablation. Patients with AF prior to ablation were more likely to be females (OR = 1.35, CI = 1.00-1.83, P = 0.05). After ablation, 260 (23.2%) patients experienced AF. In the multivariable model, AF prior to ablation (OR = 1.90, CI = 1.42-2.54, P < 0.001) and female gender (OR = 1.77, CI = 1.29-2.42, P < 0.001) were associated with a higher risk of AF after ablation. In patients without prior AF, class I antiarrhythmics and amiodarone prior to AFL ablation were independently associated with higher risk of AF after ablation (OR = 2.11, CI = 1.15-3.88, P = 0.02 and OR = 1.60, CI = 1.08-2.36, P = 0.02, respectively). In patients who experienced AF after ablation, 201/260 (77.3%) had a CHA2DS2-VASc ≥1. Two patients with AF prior to ablation had a stroke during the follow-up whereas none of the patients without AF prior to ablation had a stroke. CONCLUSIONS: AF occurrence after AFL ablation is frequent (>20%), especially in patients with a history of AF, in female patients, and in patients treated with class I antiarrythmics/amiodarone prior to AFL. Since most patients who experience AF after AFL ablation have a CHA2DS2-VASc ≥1, the decision to stop anticoagulants after ablation should be considered on an individual basis.

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Crossref · 10.1111/jce.12413

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Authors
BREMBILLA‐PERROT, B., GIRERD, N., SELLAL, J. M., OLIVIER, A., MANENTI, V., VILLEMIN, T., BEURRIER, D., DE CHILLOU, C., LOUIS, P., SELTON, O., & DE LA CHAISE, A. T.
Affiliations
  • Department of Cardiology Nancy University Hospital Vandoeuvre‐les‐Nancy France
  • Inserm (FR)
  • Centre Hospitalier Régional et Universitaire de Nancy (FR)
Venue
Journal of Cardiovascular Electrophysiology
Publisher
Wiley
Published
2014-04-21
Volume
25
Issue
8
Pages
813-820
ISSN
  • 1045-3873 (ISSN-L)
  • 1540-8167
OpenAlex
W1531976775
Cited by
47
References
34
Citations by year
2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 14 · 2015: 3 · 2014: 2
FWCI
5.03
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
atrial fibrillation, atrial flutter, catheter ablation, post-ablation atrial fibrillation, antiarrhythmic drugs, class I antiarrhythmic drugs, amiodarone, female gender, CHA2DS2-VASc score, stroke risk
MeSH terms
Aged, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Embolism, Female, France, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Time Factors, Prevalence, Multivariate Analysis, Chi-Square Distribution, Logistic Models, Odds Ratio, Treatment Outcome, Catheter Ablation, Risk Assessment, Stroke

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