Comparison of the impact of atrial fibrillation on the risk of stroke and cardiovascular death in women versus men (The Copenhagen City Heart Study)
Abstract
The Copenhagen City Heart Study is a population-based cohort study. Using baseline data from 3 cohort examinations (1976 to 1978, 1981 to 1983, and 1991 to 1994), we analyzed the gender-specific effect of atrial fibrillation (AF) on the risk of stroke and cardiovascular death during 5 years of follow-up. Baseline data from 29,310 subjects were included. AF was documented in 276 subjects (110 women and 166 men). During a mean follow-up of 4.7 years, 635 strokes were identified, 35 of which occurred in subjects who had AF (22 women and 13 men). After adjustment for age and co-morbidity, the effect of AF on the risk of stroke was 4.6-fold greater in women (hazard ratio 7.8, 95% confidence interval 5.8 to 14.3) than in men (hazard ratio 1.7, 95% confidence interval 1.0 to 3.0). Cardiovascular death occurred in 1,122 subjects, 63 of whom had AF (28 in women and 35 in men). The independent effect of AF on cardiovascular mortality rate was 2.5-fold greater in women (hazard ratio 4.4, 95% confidence interval 2.9 to 6.5) than in men (hazard ratio 2.2, 95% confidence interval 1.6 to 3.1). Our results indicate that AF is a much more pronounced risk factor for stroke and cardiovascular death in women than in men.
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A meta-analysis of 19 studies showed increased risk for all-cause mortality in women compared with men (women-to-men RR 1.12, 95% CI 1.07-1.17).
“However, a meta-analysis of 19 studies showed increased risk for all-cause mortality in women compared with men (women-to-men RR 1.12, 95% CI 1.07–1.17).120”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [120]
The meta-analysis included disease-based samples and the results might thus not be generalizable to the general population.
“Notably, the meta-analysis included disease-based samples and the results might thus not be generalizable to the general population.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [120]
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- Authors
- Friberg, J., Scharling, H., Gadsbøll, N., Truelsen, T., & Jensen, G. B.
- Affiliations
- Bispebjerg Hospital (DK)
- Corresponding author
- Friberg, Jens
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 94
- Issue
- 7
- Pages
- 889-894
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2154464108
- Cited by
- 257
- References
- 30
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 15 · 2019: 7 · 2018: 16 · 2017: 17 · 2016: 18 · 2015: 19 · 2014: 18 · 2013: 16 · 2012: 24
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- atrial fibrillation, stroke risk, cardiovascular mortality, sex differences, women, cardiovascular risk factors, Copenhagen City Heart Study
- MeSH terms
- Adult, Age Factors, Aged, Atrial Fibrillation, Cardiovascular Diseases, Cause of Death, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, Incidence, Multivariate Analysis, Stroke
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