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‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
Open accessAbstract
Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating vascular function and driving atherogenesis. Conversely, brown and beige adipose tissues utilise glucose and lipids to generate heat and are associated with improved cardiometabolic health. The cardiac and thoracic perivascular adipose tissues are now understood to be composed of brown adipose tissue in the healthy state and undergo a brown-to-white transition i.e. during obesity which may be a driving factor of cardiovascular disease. In this review we discuss the risks of excess cardiac and vascular adiposity and potential mechanisms by which restoring the brown phenotype i.e. "re-browning" could potentially be achieved in clinically relevant populations.
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“Thus, an interrelation of pericoronary fat with vasomotor function is mediated by the release of specific vasoactive factors such as leptin and adiponectin among others [41,42].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [41]
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Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Fetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 3,003
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608
A role for brown adipose tissue in diet-induced thermogenesis
Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606
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- Cannon, 2004, Brown adipose tissue: function and physiological significance, Physiol. Rev., 84, 277, 10.1152/physrev.00015.2003 · DOI · Paper page
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Items 101–147 of 147
Lacaita, P. G., Senoner, T., Bilgeri, V., Rauch, S., Barbieri, F., Kindl, B., Plank, F., Dichtl, W., Deeg, J., Widmann, G., et al. (2024) · European Radiology · doi:10.1007/s00330-024-11061-3 · Cited by 5
Wacker, J., Farpour‐Lambert, N. J., Viallon, M., Didier, D., Beghetti, M., & Maggio, A. B. R. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11120383 · Cited by 5
Chiocchi, M., Cavallo, A. U., Pugliese, L., Cesareni, M., Pasquali, D., Accardo, G., Stasio, V. D., Spiritigliozzi, L., Benelli, L., D’Errico, F., et al. (2023) · Medicina · doi:10.3390/medicina59020232 · Cited by 4
Ahmed, B., Farb, M. G., Karki, S., D'Alessandro, S., Edwards, N. M., & Gokce, N. (2023) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2023.09.104 · Cited by 4
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Yuan, M., Wu, B., Zhang, L., Wang, H., & Yang, Y. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001060 · Cited by 4
Mitochondrial respiration in thoracic perivascular adipose tissue of diabetic mice
Pinho, A. C. O., Santos, D., Baldeiras, I., Burgeiro, A., Leal, E. C., & Carvalho, E. (2022) · Journal of Endocrinology · doi:10.1530/joe-21-0446 · Cited by 4
Beňová, T. E., Sýkora, M., Andelová, K. O., Farkašová, V., Lepáček, M., Prnová, M. Š., Babál, P., Janko, D., Andelová, N., Ferko, M., et al. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01892-5 · Cited by 3
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Vargas‐Castillo, A., Torres, N., & Tovar, A. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00012-0 · Cited by 4
Hagiwara, H., Ouchi, K., Suzuki, M., Iwabuchi, Y., Okada, T., Okamoto, T., Koya, J., Komoriyama, H., Kato, Y., & Anzai, T. (2025) · Heart and Vessels · doi:10.1007/s00380-025-02635-2 · Cited by 2
Association between echocardiographic epicardial adipose tissue and E/e′ ratio in obese adults
Moreno-Galdós, L., Barba-Cosials, J., & Núñez-Córdoba, J. M. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1040-8 · Cited by 2
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Hendricks, S., Rassaf, T., & Mahabadi, A. A. (2020) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-020-9531-3 · Cited by 2
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Liu, L., Huang, X., Gao, J.-L., Guo, Y., Di, Y., Sun, S., & Cao, J. (2018) · Journal of Biomolecular Research & Therapeutics · doi:10.4172/2167-7956.1000163 · Cited by 1
Liberto, I. A. D., Pilato, G., Buccheri, S., Geraci, S., Milazzo, D., Vaccaro, G., & Caramanno, G. (2020) · Future Cardiology · doi:10.2217/fca-2020-0025 · Cited by 1
Fuss, C. (2025) · Radiology · doi:10.1148/radiol.250215 · Cited by 1
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Yin, L., Yan, C., Yang, C., Dong, H., Xu, S., Li, C., & Zeng, M.-S. (2021) · Research Square · doi:10.21203/rs.3.rs-514818/v1
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Li, F. H., Ma, K., Luo, W. F., Liu, W., Zhang, J., Zhang, W., Zhu, T., Guo, M., & Xu, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-5285851/v1
Lacaita, P. G., Bilgeri, V., Barbieri, F., Scharll, Y., Dichtl, W., Widmann, G., & Feuchtner, G. M. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12080301
Pavlova, M. G. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2025-475
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Donna, C. D., Cavallo, A. U., Picchi, E., Laudazi, M., Federici, M., Chiocchi, M., & Garaci, F. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13030113
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Dyleva, Y. A., Gruzdeva, O. V., Gorbatovskaya, E., Bogdanov, L. A., Torgunakova, E., Dolmatova, S. E., Ivanov, S. V., Fanaskova, E. V., & Barbarash, O. L. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2026-6321
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Timofeev, Y. S., Metelskaya, V. A., Rakhmonova, S., Borisova, A. L., Dzhioeva, O. N., & Drapkina, O. M. (2026) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2026-3220
Hu, X., Li, H., Yang, Z., Lv, Z., Zhang, Y., Zou, T., Tang, R., Zhang, Q., Abudula, A., & Malasadi, N. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120788
Gu, P., Zhao, X., Mao, L., Song, P., Guo, Q., Wang, W., Li, L., Xue, M., Kong, A. P.-S., Sun, W., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158345
Lan, X., Wu, Q., Zhou, J., Jiang, J., Yang, G., Yang, H., Chen, Y., Zeng, J., Han, C., & Yang, J. (2026) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70352
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Yu, H., Xiang, W., Teng, K., Ng, E. S. K., Kam, A. Y. F., Punyawatthananukool, S., Dalton, S., & Wu, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.04.735132
Bazin, H. M. L. *., Rodríguez‐Fdez, S., Baldo, F., Mali, I. D., Gupta, N., Maimaiti, M., Simonian, T. L., Campbell, M., Prasertsuk, P., Han, N., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.02.754417
Prasath, N., Senghor, K. A. A., Mohanakrishnan, V. V., Prakash, S. S., & Muralidharan, T. R. (2026) · Angiology · doi:10.1177/00033197261492072
Metadata
- Authors
- Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E.
- Affiliations
- University of Nottingham (GB)
- VA Greater Los Angeles Healthcare System (US)
- Corresponding author
- Symonds, Michael E.
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 228
- Pages
- 265-274
- ISSN
- 0167-5273 (ISSN-L)
- PMC
- PMC5236060
- OpenAlex
- W2551225596
- Cited by
- 148
- References
- 177
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 19 · 2023: 12 · 2022: 11 · 2021: 18 · 2020: 20 · 2019: 19 · 2018: 12 · 2017: 13
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Journal of Cardiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
- Funders
- British Heart Foundation (FS/15/4/31184)
- University of Nottingham
- Cardiometabolic Research Foundation, Los Angeles (CRFLAPhD2012)
- BBSRC (BBSRCBB/I016015/1)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, beige adipose tissue, cardiac adipose tissue, perivascular adipose tissue, visceral fat, cardiovascular risk, obesity, atherogenesis, cardiometabolic health, thermogenesis
- MeSH terms
- Adipose Tissue, Beige, Adipose Tissue, Brown, Cardiovascular Diseases, Coronary Artery Disease, Female, Humans, Male, Obesity, Prognosis, Body Mass Index, Risk Assessment, Intra-Abdominal Fat, Adiposity
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