‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399

Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.

Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241

Fetal origins of coronary heart disease

Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 3,003

Brown adipose tissue activity controls triglyceride clearance

Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608

A role for brown adipose tissue in diet-induced thermogenesis

Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606

Obesity, Adipose Tissue and Vascular Dysfunction

Koenen, M., Hill, M. A., Cohen, P., & Sowers, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318093 · Cited by 979

Obesity, Hypertension, and Cardiac Dysfunction

Mouton, A. J., Li, X., Hall, M. E., & Hall, J. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.312321 · Cited by 561

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 413

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

Villarroya, F., Cereijo, R., Gavaldà‐Navarro, A., Villarroya, J., & Giralt, M. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12803 · Cited by 328

Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects

Goeller, M., Achenbach, S. S., Marwan, M., Doris, M. K., Cadet, S. J., Commandeur, F., Chen, X., Slomka, P. J., Gransar, H., Cao, J. J., et al. (2017) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2017.11.007 · Cited by 259

Epicardial adipose tissue as a metabolic transducer: Role in heart failure and coronary artery disease

Patel, V. B., Shah, S., Verma, S., & Oudit, G. Y. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9644-1 · Cited by 218

Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells

Chang, L., Garcia-Barrio, M. T., & Chen, Y. E. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.312464 · Cited by 162

Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?

Gaborit, B., Sengenès, C., Ancel, P., Jacquier, A., & Dutour, A. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160034 · Cited by 183

Inflammasome Signaling in Atrial Fibrillation

Ajoolabady, A., Nattel, S., Lip, G. Y. H., & Ren, J. T. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.03.379 · Cited by 157

Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology

Harada, M., & Nattel, S. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.11.002 · Cited by 126

Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity?

Vargas‐Castillo, A., Fuentes‐Romero, R., Rodríguez-López, L. A., Torres, N., & Tovar, A. R. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.10.002 · Cited by 101

Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease.

Liu, Z., Wang, S., Wang, Y.-Q., Zhou, N.-B., Shu, J., Stamm, C., Jiang, M., & Luo, F.-Y. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.01.033 · Cited by 84

Perivascular adipose tissue in age-related vascular disease

Queiroz, M., & Sena, C. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101040 · Cited by 92

The epicardial adipose tissue and the coronary arteries: dangerous liaisons

Madonna, R., Massaro, M., Scoditti, E., Pescetelli, I., & Caterina, R. D. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz062 · Cited by 74

Epicardial adipose tissue: an emerging biomarker of cardiovascular complications in type 2 diabetes?

Christensen, R. H., von Scholten, B. J., Lehrskov, L. L., Rossing, P. R., & Jørgensen, P. G. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820928824 · Cited by 72

Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells

Srikakulapu, P., Upadhye, A., Rosenfeld, S. M., Marshall, M. A., McSkimming, C. C., Hickman, A. W., Mauldin, I. S., Ailawadi, G., Lopes, M. B. S., Taylor, A. M., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00719 · Cited by 73

Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes

Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Rinaldi, L., Coviello, F., Di Martino, A., Albanese, G., Colantuoni, S., Medicamento, G., et al. (2022) · Biomolecules · doi:10.3390/biom12020176 · Cited by 62

Perivascular adipose tissue‐derived stromal cells contribute to vascular remodeling during aging

Pan, X., Ruan, C., Liu, X., Kong, L., Ma, Y., Wu, Q., Li, H., Sun, Y., Chen, A., Zhao, Q., et al. (2019) · Aging Cell · doi:10.1111/acel.12969 · Cited by 63

Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

Gu, P., Hui, X. H., Zheng, Q., Gao, Y., Jin, L., Jiang, W., Zhou, C., Liu, T., Huang, Y., Liu, Q., et al. (2021) · Science Advances · doi:10.1126/sciadv.abl4024 · Cited by 61

Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function

Ciccarelli, M., Dawson, D. K., Falcão‐Pires, I., Giacca, M., Hamdani, N., Heymans, S. R. B., Hooghiemstra, A. M., Leeuwis, A. E., Hermkens, D. M. A., Tocchetti, C. G., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab009 · Cited by 61

Uncovering the Role of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction

Goldman, S. A., Requena-Ibáñez, J. A., Devesa, A., Santos‐Gallego, C. G., Badimón, J. J., & Fuster, V. (2023) · JACC Advances · doi:10.1016/j.jacadv.2023.100657 · Cited by 59

Quantification of epicardial fat with cardiac CT angiography and association with cardiovascular risk factors in symptomatic patients: from the ALTER-BIO (Alternative Cardiovascular Bio-Imaging markers) registry

Milanese, G., Silva, M., Bruno, L., Goldoni, M., Benedetti, G., Rossi, E., Ferrari, C., Grutta, L. L., Maffei, E., Toia, P., et al. (2019) · Diagnostic and Interventional Radiology · doi:10.5152/dir.2018.18037 · Cited by 56

The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age

Conte, M., Martucci, M., Sandri, M., Franceschi, C., & Salvioli, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00114 · Cited by 58

Are Interactions between Epicardial Adipose Tissue, Cardiac Fibroblasts and Cardiac Myocytes Instrumental in Atrial Fibrosis and Atrial Fibrillation?

Krishnan, A., Chilton, E., Raman, J., Saxena, P., McFarlane, C., Trollope, A. F., Kinobe, R. T., & Chilton, L. (2021) · Cells · doi:10.3390/cells10092501 · Cited by 59

Hydrogen Sulfide in the Adipose Tissue—Physiology, Pathology and a Target for Pharmacotherapy

Bełtowski, J., & Jamróz-Wiśniewska, A. (2016) · Molecules · doi:10.3390/molecules22010063 · Cited by 54

Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health

Queiroz, M., & Sena, C. M. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02549-9 · Cited by 53

UCP1 expression–associated gene signatures of human epicardial adipose tissue

Chechi, K., Vijay, J., Voisine, P., Mathieu, P., Bossé, Y., Tchernof, A., Grundberg, E., & Richard, D. (2019) · JCI Insight · doi:10.1172/jci.insight.123618 · Cited by 51

Browning of Adipocytes: A Potential Therapeutic Approach to Obesity

Schirinzi, V., Poli, C., Berteotti, C., & Leone, A. (2023) · Nutrients · doi:10.3390/nu15092229 · Cited by 60

The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe

Kimura, H., Nagoshi, T., Yoshii, A., Kashiwagi, Y., Tanaka, Y., Ito, K., Yoshino, T., Tanaka, T. D., & Yoshimura, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-13563-1 · Cited by 49

The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review

Krishnan, A., Sharma, H., Yuan, D., Trollope, A. F., & Chilton, L. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9070217 · Cited by 51

Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases

Man, A. W. C., Xia, N., & Li, H. (2020) · Antioxidants · doi:10.3390/antiox9100968 · Cited by 49

Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications

Man, A. W. C., Zhou, Y., Xia, N., & Li, H. (2020) · Antioxidants · doi:10.3390/antiox9070574 · Cited by 45

Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation

Boucher, J. M., Ryzhova, L., Harrington, A. N., Davis-Knowlton, J. H., Turner, J. E., Cooper, E., Maridas, D. E., Ryzhov, S. V., Rosen, C. J., Vary, C., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314731 · Cited by 45

Developmental and functional characteristics of the thoracic aorta perivascular adipocyte

Ye, M., Ruan, C., Fu, M., Xu, L., Chen, D., Zhu, M., Zhu, D., & Gao, P. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2970-1 · Cited by 44

MicroRNA-3614 regulates inflammatory response via targeting TRAF6-mediated MAPKs and NF-κB signaling in the epicardial adipose tissue with coronary artery disease

Huang, W., Wu, X., Xue, Y., Zhou, Y., Xiang, H., Yang, W., & Wei, Y. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.09.045 · Cited by 42

Stem Cell and Obesity: Current State and Future Perspective

Payab, M., Goodarzi, P., Heravani, N. F., Hadavandkhani, M., Zarei‐Behjani, Z., Falahzadeh, K., Larijani, B. A., Rahim, F., & Arjmand, B. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_227 · Cited by 41

Cardiometabolic Risk Factors and Benign Gynecologic Disorders

AlAshqar, A., Patzkowsky, K. E., Afrin, S., Wild, R. A., Taylor, H. S., & Borahay, M. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000718 · Cited by 43

The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

Cai, M., Zhao, D., Han, X., Han, S., Zhang, W., Zang, Z., Gai, C., Rong, R., & Gao, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1271051 · Cited by 39

Inflammasome Signaling in Cardiac Arrhythmias: Linking Inflammation, Fibrosis, and Electrical Remodeling

Karakasis, P., Pamporis, K., Theofilis, P., Milaras, N., Vlachakis, P. K., Grigoriou, K., Patoulias, D., Karamitsos, T. D., Antoniadis, A. P., & Fragakis, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26135954 · Cited by 41

Epicardial fat attenuation, not volume, predicts obstructive coronary artery disease and high risk plaque features in patients with atypical chest pain

Pandey, N. N., Sharma, S., Jagia, P., & Kumar, S. (2020) · British Journal of Radiology · doi:10.1259/bjr.20200540 · Cited by 35

Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy

Fan, Y., Guan, B., Xu, J., Zhang, H., Liang, Y., & Yang, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115493 · Cited by 35

Ecklonia Cava Extract Attenuates Endothelial Cell Dysfunction by Modulation of Inflammation and Brown Adipocyte Function in Perivascular Fat Tissue

Son, M., Oh, S., Lee, H. S., Chung, D.-M., Jang, J. T., Jeon, Y., Choi, C. H., Park, K. Y., Son, K. H., & Byun, K. (2019) · Nutrients · doi:10.3390/nu11112795 · Cited by 31

Brown adipose tissue development and function and its impact on reproduction

Symonds, M. E., Aldiss, P., Dellschaft, N. S., Law, J., Fainberg, H. P., Pope, M., Sacks, H. S., & Budge, H. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0084 · Cited by 32

Adipose Tissue and Modulation of Hypertension

Das, E., Moon, J. H., Lee, J. H., Thakkar, N., Pausová, Z., & Sung, H. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0894-7 · Cited by 33

Brown and beige adipose tissue: New therapeutic targets for metabolic disorders

Magro, B. S., & Dias, D. P. M. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100148 · Cited by 34

Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging

Kim, S., Lee, E.-S., Lee, S., Kim, Y., Lee, C., Jo, D., & Kim, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902007116 · Cited by 31

Cardiometabolic implications of adipose tissue aging

Ahmed, B., Farb, M. G., & Gokce, N. (2024) · Obesity Reviews · doi:10.1111/obr.13806 · Cited by 32

Diabetic Cardiomyopathy: Role of Cell Death, Exosomes, Fibrosis and Epicardial Adipose Tissue

Galeone, A., Annicchiarico, A., Buccoliero, C., Barile, B., Luciani, G. B., Onorati, F., Nicchia, G. P., & Brunetti, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179481 · Cited by 28

The Placenta, Maternal Diet and Adipose Tissue Development in the Newborn

Symonds, M. E., Bloor, I. D., Ojha, S., & Budge, H. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000464301 · Cited by 25

Long non-coding RNAs in coronary atherosclerosis

Wang, Y., Song, X., Li, Z., & Liu, B. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.072 · Cited by 25

Epicardial, paracardial and perivascular fat quantity, genes expression and serum cytokines in coronary artery disease and diabetes

Haberka, M., Machnik, G., Kowalówka, A. R., Biedroń, M., Skudrzyk, E., Regulska−Ilow, B., Gajos, G., Manka, R., Deja, M. A., Okopień, B., et al. (2019) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.14961 · Cited by 23

Liraglutide improves lipid and carbohydrate metabolism of ovariectomized rats

Model, J. F. A., Lima, M. V., Ohlweiler, R., Vogt, É. L., Rocha, D. S., de Souza, S. K., Türck, P., Araújo, A. S. D. R., & Vinagre, A. S. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111158 · Cited by 23

Perirenal Adiposity and Other Excessive Intra- and Peri-Organ Fat Depots: What Is the Connection?

Katsiki, N., Dimitriadis, G., & Mikhailidis, D. P. (2019) · Angiology · doi:10.1177/0003319719848204 · Cited by 22

Effects of Exposure to Tobacco Cigarette, Electronic Cigarette and Heated Tobacco Product on Adipocyte Survival and Differentiation In Vitro

Zagoriti, Z., Mubarak, M. A. E., Farsalinos, K. E., & Topouzis, S. (2020) · Toxics · doi:10.3390/toxics8010009 · Cited by 22

Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2

Moon, H., Choi, J., Song, B., Kim, I.-K., Lim, S., Lee, S., Han, G., Hwang, K., & Kim, S. W. (2022) · Cells · doi:10.3390/cells11030567 · Cited by 20

Ferulic acid and protocatechuic acid alleviate atherosclerosis by promoting UCP1 expression to inhibit the NLRP3-IL-1β signaling pathway

Hong, K., Wang, J., Kang, X., Xue, H., Gao, Y., Liang, H., Huang, W., Zhan, J., & You, Y. (2024) · Food & Function · doi:10.1039/d4fo02955k · Cited by 19

Epigenetic Regulation of Fibroblasts and Crosstalk between Cardiomyocytes and Non-Myocyte Cells in Cardiac Fibrosis

Chu, L., Xie, D., & Xu, D. (2023) · Biomolecules · doi:10.3390/biom13091382 · Cited by 19

Estimating the cold-induced brown adipose tissue glucose uptake rate measured by 18F-FDG PET using infrared thermography and water-fat separated MRI

Andersson, J., Lundström, E., Engström, M., Lubberink, M., Ahlström, H. K., & Kullberg, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-48879-7 · Cited by 19

A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice

Mestres‐Arenas, A., Villarroya, J., Giralt, M., Villarroya, F., & Peyrou, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.714530 · Cited by 19

Measurement of epicardial adipose tissue using non-contrast routine chest-CT: a consideration of threshold adjustment for fatty attenuation

Yin, L., Yan, C., Yang, C., Dong, H., Xu, S., Li, C., & Zeng, M. (2022) · BMC Medical Imaging · doi:10.1186/s12880-022-00840-3 · Cited by 20

Possible Association Between Body Temperature and B-Type Natriuretic Peptide in Patients With Cardiovascular Diseases

Kang, R., Nagoshi, T., Kimura, H., Tanaka, T. D., Yoshii, A., Inoue, Y., Morimoto, S., Ogawa, K., Minai, K., Ogawa, T., et al. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.08.012 · Cited by 18

Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1

Petrosino, J. M., Longenecker, J. Z., Ramkumar, S., Xu, X., Dorn, L. E., Bratasz, A., Yu, L., Maurya, S. K., Tolstikov, V., Bussberg, V., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141799 · Cited by 18

Non-alcoholic fatty liver disease and colorectal cancer: A marker of risk or common causation?

Katsiki, N., Mikhailidis, D. P., & Mantzoros, C. S. (2018) · Metabolism · doi:10.1016/j.metabol.2018.08.003 · Cited by 18

The measurement of both carotid intima-media thickness and epicardial adipose tissue thickness in children with epilepsy receiving antiepileptic drug therapy

Çalık, M., Ozkan, H. Y., Ethemoğlu, Ö., Koca, B., Kazanasmaz, H., Karacan, N., & Dokumacı, D. Ş. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.05.042 · Cited by 16

Role of hydrogen sulfide in the regulation of lipid metabolism: Implications on cardiovascular health

Flori, L., Piragine, E., Calderone, V., & Testai, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122491 · Cited by 15

Exploring the role of epicardial adipose-tissue-derived extracellular vesicles in cardiovascular diseases

Rizzuto, A. S., Gelpi, G., Mangini, A., Carugo, S., Ruscica, M., & Macchi, C. (2024) · iScience · doi:10.1016/j.isci.2024.109359 · Cited by 17

Brown adipose tissue and alzheimer’s disease

Tayanloo-Beik, A., Nikkhah, A., Alaei, S., Goodarzi, P., Rezaei–Tavirani, M., Mafi, A. R., Larijani, B. A., Shouroki, F. F., & Arjmand, B. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01097-z · Cited by 14

Adipocyte-mediated electrophysiological remodeling of human stem cell - derived cardiomyocytes

Morrissette-McAlmon, J. B. F., Xu, W. R., Teuben, R., Boheler, K. R., & Tung, L. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.02.002 · Cited by 17

Impact of Obesity on Postoperative Outcomes following cardiac Surgery (The OPOS study): rationale and design of an investigator-initiated prospective study

Aguiar, C., MacLeod, J. B., Yip, A. M., Melville, S., Légaré, J., Pulinilkunnil, T., Kienesberger, P. C., Brunt, K. R., & Hassan, A. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-023418 · Cited by 13

Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition

Moon, H., Choi, J., Song, B., Kim, I.-K., Lim, S., Lee, S., Hwang, K., & Kim, S. W. (2020) · Molecules · doi:10.3390/molecules25235660 · Cited by 15

Microtubule affinity regulating kinase 4: A promising target in the pathogenesis of atherosclerosis

Qin, Y., Li, H., Wang, S., Wang, Z., & Tang, C. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30530 · Cited by 15

Evolution of glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes

Galstyan, G. R., Анатольевна, К. Е., & Александровна, Ю. Е. (2017) · Diabetes Mellitus · doi:10.14341/dm8804 · Cited by 17

Emerging role of the cardiac lipidome in the progression of heart failure

Flori, L., Calderone, V., & Testai, L. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118385 · Cited by 14

The role of cardiac resident macrophage in cardiac aging

Li, J., Xin, Y., Wang, Z., Li, J., Li, W., & Li, H. (2023) · Aging Cell · doi:10.1111/acel.14008 · Cited by 13

Association of Pericoronary Adipose Tissue Quality Determined by Dual-Layer Spectral Detector CT With Severity of Coronary Artery Disease: A Preliminary Study

Dang, Y., Chen, X., Ma, S., Ma, Y., Ma, Q., Zhou, K., Liu, T., Wang, K., & Hou, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.720127 · Cited by 13

Assessment of Epicardial Fat in Children: Its Role as a Cardiovascular Risk Factor and How It Is Influenced by Lifestyle Habits

Calcaterra, V., Cena, H., Garella, V., Loperfido, F., Chillemi, C., Manuelli, M. C., Mannarino, S., & Zuccotti, G. (2024) · Nutrients · doi:10.3390/nu16030420 · Cited by 12

Localization profiles of natriuretic peptides in hearts of pre-hibernating and hibernating Anatolian ground squirrels (Spermophilus xanthoprymnus)

Öztop, M., Özbek, M., Liman, N., Beyaz, F., Ergün, E., & Ergün, L. (2019) · Veterinary Research Communications · doi:10.1007/s11259-019-9745-5 · Cited by 15

Inter-software and inter-scan variability in measurement of epicardial adipose tissue: a three-way comparison of a research-specific, a freeware and a coronary application software platform

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Wang, J., Liu, S., Sun, L., Kong, Z., Chai, J., Wen, J., Tian, X., Chen, N., & Xu, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-59559-6 · Cited by 8

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Stelling, E., Ricke‐Hoch, M., Erschow, S., Hoffmann, S., Bergmann, A. K., Heimerl, M., Pietzsch, S., Battmer, K., Haase, A., Stapel, B., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000739 · Cited by 6

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