Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects
Abstract
Background Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction. Aims To determine if 7weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men. Methods 16 subjects were examined during 40-h TSD, both before and after 7weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) and pulse wave velocity (PWV), blood pressure and heart rate (HR) were assessed before TSD (controlday), during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones were measured from morning blood samples. Results Before training, ACh-, insulin- and heat-induced vasodilatations were significantly decreased during TSD and recovery as compared with the control day, with no difference after training. Training prevented the decrease of ACh-induced vasodilation related to TSD after sleep recovery, as well as the PWV increase after TSD. A global lowering effect of training was found on HR values during TSD, but not on blood pressure. Training induces the decrease of TNF-α concentration after TSD and prevents the increase of MCP-1 after sleep recovery. Before training, IL-6 concentrations increased. Cortisol and testosterone decreased after TSD as compared with the control day, while insulin and E-selectin increased after sleep recovery. No effect of TSD or training was found on CRP and sICAM-1. Conclusions In healthy young men, a moderate to high-intensity interval training is effective at improving aerobic fitness and limiting vascular dysfunction induced by TSD, possibly through pro-inflammatory cytokine responses.(ClinicalTrial:NCT02820649).
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Sleep loss and lower sleep duration are associated with lower morning, afternoon, and 24-h testosterone.
“When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosterone; as well as higher afternoon, but not morning or 24-h cortisol.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [47]
All in-laboratory studies when collectively examined show that sleep restriction decreases testosterone.
“All studies when collectively examined show that sleep restriction decreases testosterone.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [47]
Cites
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works
Autonomic Recovery after Exercise in Trained Athletes: Intensity and Duration Effects
SEILER, S., HAUGEN, O., & KUFFEL, E. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318060f17d · Cited by 407 · see citing works
Effect of acute sleep deprivation on vascular function in healthy subjects
Sauvet, F., Leftheriotis, G., Gomez-Merino, D., Langrume, C., Drogou, C., Van Beers, P., Bourrilhon, C., Florence, G., & Chennaoui, M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00851.2009 · Cited by 268 · see citing works
Cardiovascular effects of partial sleep deprivation in healthy volunteers
Dettoni, J. L., Consolim-Colombo, F. M., Drager, L. F., Rubira, M. C., Cavasin de Souza, S. B. P., Irigoyen, M. C., Mostarda, C., Borile, S., Krieger, E. M., Moreno, H., et al. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01604.2011 · Cited by 245 · see citing works
Cocks, M., Shaw, C. S., Shepherd, S. O., Fisher, J. P., Ranasinghe, A. M., Barker, T. A., Tipton, K. D., & Wagenmakers, A. J. M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.239566 · Cited by 226 · see citing works
Exercise Interventions and Peripheral Arterial Function: Implications for Cardio-Metabolic Disease
Phillips, S. A., Mahmoud, A. M., Brown, M. D., & Haus, J. M. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.12.005 · Cited by 78 · see citing works
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Liang, Y. Y., Feng, H., Chen, Y., Jin, X., Xue, H., Zhou, M., Ma, H., Ai, S., Wing, Y.-K., Geng, Q., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad060 · Cited by 102 · see citing works
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80 · see citing works
Liu, P. Y., Takahashi, P. Y., Yang, R. J., Iranmanesh, A., & Veldhuis, J. D. (2020) · SLEEP · doi:10.1093/sleep/zsaa008 · Cited by 22 · see citing works
- Authors
- Sauvet, F., Arnal, P. J., Tardo-Dino, P. E., Drogou, C., Van Beers, P., Bougard, C., Rabat, A., Dispersyn, G., Malgoyre, A., Leger, D., Gomez-Merino, D., & Chennaoui, M.
- Affiliations
- Université Paris Descartes (FR)
- Université de Lyon (FR)
- Corresponding author
- Sauvet, Fabien
- ORCID
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 232
- Pages
- 76-85
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2571372697
- Cited by
- 32
- References
- 6
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- exercise training, interval training, total sleep deprivation, endothelial dysfunction, vascular function, vasodilation, pulse wave velocity, sleep recovery, TNF-α, MCP-1, interleukin-6, inflammation, cortisol, testosterone, E-selectin, cardiovascular risk
- MeSH terms
- Adult, Cardiovascular Diseases, Electrocardiography, Endothelium, Vascular, Female, Follow-Up Studies, Humans, Inflammation, Male, Regional Blood Flow, Sleep Deprivation, Time Factors, Vasodilation, Exercise, Cytokines, Laser-Doppler Flowmetry, Pulse Wave Analysis, Healthy Volunteers
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