Neurotrophic Property of Geniposide for Inducing the Neuronal Differentiation of PC12 Cells

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

During, M. J., Cao, L., Zuzga, D. S., Francis, J. S., Fitzsimons, H. L., Jiao, X., Bland, R. J., Klugmann, M., Banks, W. A., Drucker, D. J., et al. (2003) · Nature Medicine · doi:10.1038/nm919 · Cited by 851 · see citing works

Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites

Göke, R., Larsen, P. J., Mikkelsen, J. D., & Sheikh, S. P. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00650.x · Cited by 474 · see citing works

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

Greene, L. (1978) · The Journal of Cell Biology · doi:10.1083/jcb.78.3.747 · Cited by 432 · see citing works

Protection and Reversal of Excitotoxic Neuronal Damage by Glucagon-Like Peptide-1 and Exendin-4

Perry, T., Haughey, N. J., Mattson, M. P., Egan, J. M., & Greig, N. H. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.037481 · Cited by 380 · see citing works

Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures

Das, K. P., Freudenrich, T. M., & Mundy, W. R. (2004) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2004.02.006 · Cited by 328 · see citing works

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.

Perry, T., Lahiri, D., Chen, D., Zhou, J., Shaw, K., Egan, J., & Greig, N. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.958 · Cited by 306 · see citing works

Glucagon-like peptide 1 and its derivatives in the treatment of diabetes

Nauck, M. A., & Meier, J. J. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.07.014 · Cited by 179 · see citing works

Glucagon-Like Peptide-1

Doyle, M. E. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.377 · Cited by 156 · see citing works

The glucagon-like peptides: a new genre in therapeutic targets for intervention in Alzheimer's disease

Perry, T., & Greig, N. H. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4605 · Cited by 91 · see citing works

Neuritogenic Effect of Natural Iridoid Compounds on PC12h Cells and Its Possible Relation to Signaling Protein Kinases.

Yamazaki, M., Chiba, K., & Mohri, T. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.791 · Cited by 80 · see citing works

Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance

Zheng, H., Patterson, L. M., Morrison, C. D., Banfield, B. W., Randall, J. A., Browning, K. N., Travagli, R. A., & Berthoud, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.055 · Cited by 66 · see citing works

Characterization of Human and Rat Glucagon-Like Peptide-1 Receptors in the Neurointermediate Lobe: Lack of Coupling to Either Stimulation or Inhibition of Adenylyl Cyclase

Satoh, F., Beak, S. A., Small, C. J., Falzon, M., Ghatei, M. A., Bloom, S. R., & Smith, D. M. (2000) · Endocrinology · doi:10.1210/endo.141.4.7420 · Cited by 53 · see citing works

Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes

Kuo, W., Chou, F., Young, S.-C., Chang, Y., & Wang, C. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.02.013 · Cited by 53 · see citing works

Effect ofCuscuta chinensisglycoside on the neuronal differentiation of rat pheochromocytoma PC12 cells

Liu, J., Jiang, B., Yongming, B., & An, L. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00040-6 · Cited by 52 · see citing works

(−)-3,5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: through tyrosine kinase cascade signaling

Hur, J. Y., Lee, P., Kim, H., Kang, I., Lee, K. R., & Kim, S. Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.178 · Cited by 31 · see citing works

Role for calcium from the sarcoplasmic reticulum in coupling muscle activity to nicotinic acetylcholine receptor gene expression in rat

Adams, L. D., & Goldman, D. J. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19980605)35:3 · Cited by 22 · see citing works

Rat gastric somatostatin and gastrin release: Interactions of exendin-4 and truncated glucagon-like peptide-1 (GLP-1) amide

Eissele, R., Bothe, E., Göke, B., Eng, J., Arnold, R., & Koop, H. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00489-7 · Cited by 22 · see citing works

Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells

Lee, E., Williams, Z. R., GOODMAN, C., Oriaku, E. T., HARRIS, C., THOMAS, M., & Soliman, K. F. A. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.02.006 · Cited by 16 · see citing works

Nardostachys chinensis Glycoside Induces Characteristics of Neuronal Differentiation in Rat Pheochromocytoma PC12 Cells

Liu, J. H., Yin, F., & Zheng, X. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.768 · Cited by 7 · see citing works

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

Reich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248 · see citing works

Genistein: Its role in metabolic diseases and cancer

Mukund, V., Mukund, D., Sharma, V., Mannarapu, M., & Alam, A. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.09.004 · Cited by 248 · see citing works

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use

Aschner, M. (2016) · ALTEX · doi:10.14573/altex.1604201 · Cited by 152 · see citing works

Geniposide, a Novel Agonist for GLP-1 Receptor, Prevents PC12 Cells from Oxidative Damage via MAP Kinase Pathway

Liu, J., Yin, F., Zheng, X., Jing, J., & Hu, Y. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.021 · Cited by 145 · see citing works

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK 3β Pathway in Streptozotocin‐Induced A lzheimer Rat Model

Gao, C., Liu, Y., Jiang, Y., Ding, J., & Li, L. (2013) · Brain Pathology · doi:10.1111/bpa.12116 · Cited by 141 · see citing works

Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway

Liu, J., Yin, F., Guo, L., Deng, X., & Hu, Y. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2008.25 · Cited by 140 · see citing works

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides

Vrang, N., & Larsen, P. J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.07.003 · Cited by 134 · see citing works

GLP-1’s role in neuroprotection: a systematic review

Erbil, D., Eren, C. Y., Demirel, Ç., Küçüker, M. U., Solaroğlu, İ., & Eser, H. Y. (2019) · Brain Injury · doi:10.1080/02699052.2019.1587000 · Cited by 128 · see citing works

Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

Chen, Y., Zhang, Y., Li, L., & Hölscher, C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.09.029 · Cited by 111 · see citing works

In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness for Evaluating Flavonoid Bioactivity

Fang, J., Lin, C.-H., Huang, T., & Chuang, S.-Y. (2019) · Nutrients · doi:10.3390/nu11030530 · Cited by 109 · see citing works

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Qi, Y., Zhang, Q., & Zhu, H. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0277-2 · Cited by 90 · see citing works

Fructus Gardenia ( Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development

Liu, H., Chen, Y., Li, F., & Zhang, H. (2012) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2012.723203 · Cited by 90 · see citing works

Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

Omri, A. E., Han, J., Yamada, P., Kawada, K., Abderrabba, M., & Isoda, H. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.07.006 · Cited by 88 · see citing works

Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors

Gong, N., Fan, H. J., Ma, A., Xiao, Q., & Wang, Y. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.04.007 · Cited by 78 · see citing works

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Zhang, Z., Wang, X., Zhang, D., Liu, Y., & Lin, L. (2019) · Aging · doi:10.18632/aging.101759 · Cited by 75 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Geniposide Induces the Expression of Heme Oxygenase-1 via PI3K/Nrf2-Signaling to Enhance the Antioxidant Capacity in Primary Hippocampal Neurons

Yin, F., Liu, J., Zheng, X., Guo, L., & Xiao, H. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1841 · Cited by 67 · see citing works

Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells

Guo, L., Xia, Z., Gao, X. C., Yin, F., & Liu, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.146 · Cited by 61 · see citing works

Lamiophlomis rotata, an Orally Available Tibetan Herbal Painkiller, Specifically Reduces Pain Hypersensitivity States through the Activation of Spinal Glucagon-like Peptide-1 Receptors

Zhu, B., Gong, N., Fan, H. J., Peng, C., Ding, X., Jiang, Y., & Wang, Y. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000320 · Cited by 60 · see citing works

Neuroprotective effects of geniposide on Alzheimer’s disease pathology

Liu, W., Li, G., Hölscher, C., & Li, L. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0005 · Cited by 60 · see citing works

Antioxidative Property and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Diabetes Mellitus and Cardiovascular Disease

Li, N., Li, L., Wu, H., & Zhou, H. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7480512 · Cited by 59 · see citing works

Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer’s disease models: a systematic review and meta-analysis of preclinical studies

Kong, F., Wu, T., Dai, J., Zhai, Z., Cai, J., Zhu, Z., Xu, Y., & Sun, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1205207 · Cited by 54 · see citing works

Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis

Liu, J., Yin, F., Xiao, H., Guo, L., & Gao, X. C. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.07.004 · Cited by 49 · see citing works

Geniposide Attenuates Post-Ischaemic Neurovascular Damage via GluN2A/AKT/ ERK-Dependent Mechanism

Huang, B., Chen, P., Huang, L., Li, S., Zhu, R., Sheng, T., Wan, Y., Chen, Z., & Wang, T. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480657 · Cited by 49 · see citing works

Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats

Jin, X. K., Amitani, K., Zamami, Y., Takatori, S., Hobara, N., Kawamura, N., Hirata, T., Wada, A., Kitamura, Y., & Kawasaki, H. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.02.019 · Cited by 47 · see citing works

Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model

Luciani, P., Deledda, C., Benvenuti, S., Cellai, I., Squecco, R., Monici, M., Cialdai, F., Luciani, G., Danza, G., Stefano, C. D., et al. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0398-3 · Cited by 47 · see citing works

Therapeutic potential of catalpol and geniposide in Alzheimer’s and Parkinson’s diseases: A snapshot of their underlying mechanisms

Zhang, X., Liu, K., Shi, M., Xie, L., Deng, M., Chen, H., & Li, X. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.020 · Cited by 46 · see citing works

Geniposide Attenuates Insulin-Deficiency-Induced Acceleration of β-amyloidosis in an APP/PS1 Transgenic Model of Alzheimer's Disease

Zhang, Y., Yin, F., Liu, J., Liu, Z., Guo, L., Xia, Z., & Zidichouski, J. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.04.002 · Cited by 45 · see citing works

Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways

Omri, A. E., Han, J., Kawada, K., Abderrabba, M., & Isoda, H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.12.019 · Cited by 45 · see citing works

Potentials of incretin‐based therapies in dementia and stroke in type 2 diabetes mellitus

Groeneveld, O. N., Kappelle, L. J., & Biessels, G. J. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12420 · Cited by 41 · see citing works

GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells

Yin, F., Liu, J., Zheng, X., & Guo, L. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.28 · Cited by 41 · see citing works

Huang-Lian-Jie-Du-Decoction modulates glucagon-like peptide-1 secretion in diabetic rats

Yu, Y., Lu, S., Yu, S., Liu, Y.-C., Wang, P., Xie, L. Y., Wang, G., & Liu, X. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.05.027 · Cited by 40 · see citing works

Geniposide prevents H2 O2 -induced oxidative damage in melanocytes by activating the PI3K-Akt signalling pathway

Lü, W., Zhao, Y., Kong, Y., Zhang, W., Ma, W., Li, W., & Wang, K. (2018) · Clinical and Experimental Dermatology · doi:10.1111/ced.13409 · Cited by 40 · see citing works

Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology

Tramutola, A., Arena, A., Cini, C., Butterfield, D. A., & Barone, E. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1246183 · Cited by 39 · see citing works

The role of long noncoding RNA in traumatic brain injury

Li, Z., Han, K., Zhang, D., Chen, J., Xu, Z., & Hou, L. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s206624 · Cited by 38 · see citing works

Pleiotropic Effects of Isoflavones in Inflammation and Chronic Degenerative Diseases

Bernatonienė, J., Kazlauskaitė, J. A., & Kopustinskienė, D. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115656 · Cited by 37 · see citing works

Targeting amyloid-beta by glucagon-like peptide -1 (GLP-1) in Alzheimer's disease and diabetes

Bak, A. M., Egefjord, L., Gejl, M., Steffensen, C., Stecher, C. W., Smidt, K., Brock, B., & Rungby, J. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.600691 · Cited by 36 · see citing works

Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

Liu, J., Guo, L., Yin, F., Zhang, Y., Liu, Z., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078315 · Cited by 34 · see citing works

Geniposide decreases the level of Aβ1−42 in the hippocampus of streptozotocin-induced diabetic rats

Liu, J., Zhang, Y., Deng, X., & Yin, F. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt069 · Cited by 32 · see citing works

Research and application progress of Gardenia jasminoides

Yin, F., & Liu, J. (2018) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2018.09.001 · Cited by 31 · see citing works

Noninvasive observations on eyes of cats after long-term maintenance of reduced intraocular pressure by topical application of prostaglandin E2.

Bito, L. Z., Srinivasan, B., Baroody, R. A., & Schubert, H. (1983) · PubMed · Cited by 31 · see citing works

Brain microvascular endothelial cells mediate neuroprotective effects on ischemia/reperfusion neurons

Hua, Q., Qing, X., Li, P., Li, W., Hou, J., Hu, J., Hong, Q., Sun, P., & Zhu, X. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.03.024 · Cited by 29 · see citing works

Regulation of Neurogenesis and Neuronal Differentiation by Natural Compounds

Chen, B., Yang, H., An, J., Tian, D., Guo, Y., & Yan, Y. (2021) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x16666210907141447 · Cited by 30 · see citing works

The Neurotrophic Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation via the PI3K-AKT Axis

Yang, J., Lin, Y.-T., Chen, W., Yang, Y., Sun, S., & Chen, S. (2020) · Biology · doi:10.3390/biology9110348 · Cited by 28 · see citing works

Neuroprotective effects of TongLuoJiuNao in neurons exposed to oxygen and glucose deprivation

Li, X., Hou, J.-C., Sun, P., Li, P., He, R., Liu, Y. M., Zhao, L., & Hua, Q. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.03.042 · Cited by 27 · see citing works

Effects of Dietary Geniposide on Growth, Flesh Quality, and Lipid Metabolism of Grass Carp, Ctenopharyngodon idella

Sun, W., Li, X., Xu, H., Chen, J., Xu, X., & Leng, X. (2017) · Journal of the World Aquaculture Society · doi:10.1111/jwas.12412 · Cited by 26 · see citing works

Angioneural Crosstalk in Scaffolds with Oriented Microchannels for Regenerative Spinal Cord Injury Repair

Saglam, A., Perets, A., Canver, A. C., Li, H.-L., Kollins, K. M., Cohen, G., Fischer, I., Lazarovici, P., & Lelkes, P. I. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9863-9 · Cited by 25 · see citing works

Evidence that geniposide abrogates norepinephrine-induced hypopigmentation by the activation of GLP-1R-dependent c-kit receptor signaling in melanocyte

Wen-Jun, L., Hai-Yan, W., Wei, L., Ke-Yu, W., & Rui-Ming, W. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.03.021 · Cited by 25 · see citing works

Geniposide Attenuates the Level of Aβ1-42 via Enhancing Leptin Signaling in Cellular and APP/PS1 Transgenic Mice

Liu, Z., Zhang, Y., Liu, J., & Yin, F. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0875-9 · Cited by 21 · see citing works

Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis

Xue, H., Xing, H.-J., Wang, B., Fu, C., Zhang, Y., Qiao, X., Guo, C., Zhang, X., Hu, B., Zhao, X., et al. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s404055 · Cited by 21 · see citing works

Neuroprotective Effects of Geniposide in SH-SY5Y Cells and Primary Hippocampal Neurons Exposed to Aβ42

Sun, P., Ding, H., Liang, M., Li, X., Mo, W., Wang, X., Liu, Y. M., He, R., & Hua, Q. (2014) · BioMed Research International · doi:10.1155/2014/284314 · Cited by 20 · see citing works

Determination and pharmacokinetics of geniposidic acid in rat plasma after oral administration of Gardeniajasminoides fruit crude extract and Zhi‐zi‐chi decoction

Long, Z., Zhang, R., Zhao, X. D., Meng, X., Bi, K., & Chen, X. (2013) · Biomedical Chromatography · doi:10.1002/bmc.2871 · Cited by 18 · see citing works

Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons

Cui, H., Deng, M., Zhang, Y., Yin, F., & Liu, J. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2469-z · Cited by 17 · see citing works

Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review

Kioussis, B., Tuttle, C. S. L., Heard, D. S., Kennedy, B. K., Lautenschlager, N. T., & Maier, A. B. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101302 · Cited by 18 · see citing works

Evaluation of the Antidepressant Activity, Hepatotoxicity and Blood Brain Barrier Permeability of Methyl Genipin

Che, X., Wang, M., Wang, T., Fan, H., Yang, M., Wang, W., & Xu, H. Z. (2016) · Molecules · doi:10.3390/molecules21070923 · Cited by 16 · see citing works

Liraglutide Protects Neurite Outgrowth of Cortical Neurons Under Oxidative Stress though Activating the Wnt Pathway

He, W., Tian, X., Lv, M., & Wang, H. (2018) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2018.05.039 · Cited by 15 · see citing works

Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP∕PS1 mice

Zhang, Z., Gao, W., Wang, X., Zhang, D., Liu, Y., & Li, L. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134749 · Cited by 16 · see citing works

Simultaneous quantification of three iridoids in rat plasma after oral administration of Zhi‐zi‐chi decoction using LC‐MS

Long, Z., Bi, K., Huo, Y., Yan, X., Zhao, X. D., & Chen, X. (2011) · Journal of Separation Science · doi:10.1002/jssc.201100387 · Cited by 15 · see citing works

Comparison study of three compounds in Eucommia ulmoides on growth, flesh quality of grass carp ( Ctenopharyngodon idella )

Sun, W., He, M. R., Xu, X., Li, X., Pan, W., & Leng, X. (2019) · Aquaculture Nutrition · doi:10.1111/anu.12909 · Cited by 15 · see citing works

Geniposide improves insulin resistance through AMPK-mediated Txnip protein degradation in 3T3-L1 adipocytes

Zhao, W., Pu, M., Shen, S., & Yin, F. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa157 · Cited by 15 · see citing works

5′-AMP-activated protein kinase plays an essential role in geniposide-regulated glucose-stimulated insulin secretion in rat pancreatic INS-1 β cells

Hao, Y., Liu, C., Yin, F., Zhang, Y., & Liu, J. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1038-5 · Cited by 15 · see citing works

The Role of Genipin and Geniposide in Liver Diseases: A Review

Meng, S.-X., Peng, J.-H., Feng, Q., Hu, Y.-Y., & Cao, J.-M. (2013) · HAL · Cited by 14 · see citing works

Simultaneous determination of geniposide and its metabolites genipin and genipinine in culture of Aspergillus niger by HPLC

Chen, C., Han, F., Zhang, Y., Lu, J., & Shi, Y. (2008) · Biomedical Chromatography · doi:10.1002/bmc.993 · Cited by 14 · see citing works

Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells

Chen, M., Peng, C.-C., Maner, R. S., Zulkefli, N. D., Huang, S.-M., & Hsieh, C.-L. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.003 · Cited by 13 · see citing works

Quantitative Identification of Compound‐Dependent On‐Modules and Differential Allosteric Modules From Homologous Ischemic Networks

Li, B., Liu, J., Zhang, Y., Wang, P. C., Yu, Y., Kang, R., Hl, W., Xx, Z., Wang, Z., & Wang, Y. (2016) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12127 · Cited by 13 · see citing works

Geniposide prevents rotenone-induced apoptosis in primary cultured neurons

Liu, Y., Li, L., Zhao, J., Liu, K., Li, G., & Han, Y.-Q. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.167760 · Cited by 12 · see citing works

Leptin Signaling Plays a Critical Role in the Geniposide-Induced Decrease of Tau Phosphorylation

Liu, J., Liu, Z., Zhang, Y., & Yin, F. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv106 · Cited by 11 · see citing works

Geniposide protects pulmonary arterial smooth muscle cells from lipopolysaccharide‑induced injury via α7nAchR‑mediated TLR‑4/MyD88 signaling

Shen, S., Ren, L.-Q., Chen, H.-D., Zhu, H., Zhou, D.-F., Zhang, B., Tan, X., & Xie, Y. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10668 · Cited by 10 · see citing works

Overview of Therapeutic Efficacy of Mushrooms

Ramesh, S., Majrashi, M., Almaghrabi, M., Govindarajulu, M., Fahoury, E., Fadan, M., Buabeid, M. A., DeRuiter, J., Clark, R. C., Mulabagal, V., et al. (2019) · Springer eBooks · doi:10.1007/978-981-13-6382-5_3 · Cited by 10 · see citing works

Geniposide protects pancreatic INS‐1E β cells from hIAPP‐induced cell damage: Potential involvement of insulin degrading‐enzyme

Zhang, Y., Yin, F., Liu, J., & Wang, Y. (2014) · Cell Biology International · doi:10.1002/cbin.10394 · Cited by 10 · see citing works

Modulatory Effects of Natural Products on Neuronal Differentiation

An, J., Chen, B., Wang, A., Hao, D., Zhang, Q., Zhao, J., Liu, C., Zhang, L., Zhang, R., & Yang, H. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000496 · Cited by 8 · see citing works

Neurotrophic Natural Products

Fukuyama, Y., Kubo, M., & Harada, K. (2024) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-031-42422-9_1 · Cited by 7 · see citing works

The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment

Yang, K., Tan, Y. L., Wang, F., Zhang, Q., Sun, P., Zhang, Y., Yao, N., Zhao, Y., Wang, X., Fan, A., et al. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214532757 · Cited by 7 · see citing works

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use_suppl

Aschner, M. (2017) · ALTEX · doi:10.14573/altex.1604201s · Cited by 7 · see citing works

The Role of Genipin and Geniposide in Liver Diseases: A Review

Peng, S.-X. M. J.-H. (2013) · Alternative & Integrative Medicine · doi:10.4172/2327-5162.1000117 · Cited by 7 · see citing works

Gene Expression Profiling Confirms the Dosage-Dependent Additive Neuroprotective Effects of Jasminoidin in a Mouse Model of Ischemia-Reperfusion Injury

Li, H., Wang, J., Wang, P., Zhang, Y., Liu, J. H., Yu, Y., Li, B., & Wang, Z. (2018) · BioMed Research International · doi:10.1155/2018/2785636 · Cited by 5 · see citing works

Molecular Mechanisms of Geniposide and Genipin Against Alzheimer’s Disease

Liu, J., Yin, F., Guo, L., Zhang, J., & Zidichouski, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00024-2 · Cited by 3 · see citing works

Gardenia jasminoides Ellis 栀子 (Zhizi, Capejasmine)

Liu, J., & Yin, F. (2015) · Springer eBooks · doi:10.1007/978-3-211-99448-1_44 · Cited by 2 · see citing works

Scaffolds with oriented microchannels for angioneural regenerative engineering

Saglam, A., & Lelkes, P. I. (2010) · doi:10.17918/etd-3425 · Cited by 2 · see citing works

Genipin stabilized fibrin microbeads: Carrying cytokines to form niches for stem cell differentiation

Chen, Q., Hu, P., Yang, W., Xu, X., & Shao, G. (2025) · Journal of Biomaterials Applications · doi:10.1177/08853282251344394 · Cited by 1 · see citing works

Expression profile identifies novel genes involved in neuronal differentiation

Kim, J. H., Lee, T. Y., Yoo, K. H., Lee, H.-S., Cho, S. A., & Park, J. H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.2.146 · Cited by 1 · see citing works

Glucagon-like peptide-1 alleviating peripheral neuropathy in diabetic patients: advance in mechanism

Wen, X., Tang, W., & Liu, Z. (2011) · Academic Journal of Second Military Medical University · doi:10.3724/sp.j.1008.2011.00329

Geniposide inhibits glucolipotoxicity and cooperates with Txnip knockdown to potentiate cell adaption to endoplasmic reticulum stress in pancreatic beta cells

Liu, M., Liu, C., Shen, S., Liu, J., & Yin, F. (2020) · Cell Biology International · doi:10.1002/cbin.11350

mTOR-Autophagy: A Key for Geniposide Protection in APP/PS1 Transgenic Mice

Zhang, Z., Gao, W., Wang, X., Zhang, D., Liu, Y., Wang, X., & Li, L. (2020) · Vide Leaf, Hyderabad eBooks · doi:10.37247/paaging.1.2020.1

Correction: Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

Liu, J., Guo, L., Yin, F., Zhang, Y., Liu, Z., & Wang, Y. (2014) · PLoS ONE · doi:10.1371/annotation/129e1764-d44a-4b81-8b1d-ba8bce898a7b

Screening of agonist for glucagon-like peptide-1 receptor and its effect on PC12 cells

Yin, F., Xiao-hong, D., Jing, J., Xu-xu, Z., & Liu, J. (2007) · Zhōnghuá yàoxué zázhì

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.

Perry, T., Lahiri, D., Chen, D., Zhou, J., Shaw, K., Egan, J., & Greig, N. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.958 · Cited by 306 · see citing works

A Novel Neutrotrophic Property Of Glucagon‐Like Peptide 1: A Promoter Of Nerve Growth Factor‐Mediated Differentiation In PC12 Cells

Perry, T., Lahiri, D. K., Chen, D., Zhou, J., Shaw, K., Jm, E., & Greig, N. (2002) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2002.02026_3.x · Cited by 3 · see citing works

Neuritogenic Effect of Natural Iridoid Compounds on PC12h Cells and Its Possible Relation to Signaling Protein Kinases.

Yamazaki, M., Chiba, K., & Mohri, T. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.791 · Cited by 80 · see citing works

Differences in neuritogenic response to nitric oxide in PC12 and PC12h cells

Yamazaki, M., Chiba, K., & Mohri, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.068 · Cited by 21 · see citing works