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Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells

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Antioxidative Property and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Diabetes Mellitus and Cardiovascular Disease

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Geniposide inhibits high glucose-induced cell adhesion through the NF-κB signaling pathway in human umbilical vein endothelial cells

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Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice

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A Review of Plant Extracts and Plant-Derived Natural Compounds in the Prevention/Treatment of Neonatal Hypoxic-Ischemic Brain Injury

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Geniposide Attenuates Insulin-Deficiency-Induced Acceleration of β-amyloidosis in an APP/PS1 Transgenic Model of Alzheimer's Disease

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Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage

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Therapeutic potential of catalpol and geniposide in Alzheimer’s and Parkinson’s diseases: A snapshot of their underlying mechanisms

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The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review

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Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique

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GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells

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Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway

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Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology

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Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window

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Targeting amyloid-beta by glucagon-like peptide -1 (GLP-1) in Alzheimer's disease and diabetes

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Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin‐deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

Zhang, Y., Yin, F., Liu, J., & Liu, Z. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12673 · Cited by 34 · see citing works

Geniposide inhibited endothelial-mesenchymal transition via the mTOR signaling pathway in a bleomycin-induced scleroderma mouse model.

Qi, Q., Mao, Y., Tian, Y., Zhu, K., Cha, X., Wu, M., & Zhou, X. (2017) · PubMed Central · Cited by 35 · see citing works

Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components

Tian, M., Li, Y., Liu, S., Zhu, C., Lan, X., Du, J., Ma, L., Yang, J., Zheng, P., Yu, J., et al. (2021) · Molecules · doi:10.3390/molecules27010255 · Cited by 34 · see citing works

Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

Liu, J., Guo, L., Yin, F., Zhang, Y., Liu, Z., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078315 · Cited by 34 · see citing works

Neuroprotective Effects of Brain-Gut Peptides: A Potential Therapy for Parkinson’s Disease

Dong, D., Xie, J.-X., & Wang, J. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00407-3 · Cited by 34 · see citing works

Epidermal Growth Factor Receptor Transactivation Is Necessary for Glucagon-Like Peptide-1 to Protect PC12 Cells from Apoptosis

Kimura, R., Okouchi, M., Kato, T., Imaeda, K., Okayama, N., Asai, K., & Joh, T. (2012) · Neuroendocrinology · doi:10.1159/000345529 · Cited by 33 · see citing works

Geniposide Suppresses Hepatic Glucose Production via AMPK in HepG2 Cells

Guo, L., Zheng, X., Liu, J., & Yin, Z. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00591 · Cited by 33 · see citing works

The effects of glucagon-like peptide-1 receptor agonists and dipeptydilpeptidase-4 inhibitors on blood pressure and cardiovascular complications in diabetes

Yaribeygi, H., Farrokhi, F. R., Abdalla, M. A., Sathyapalan, T., Banach, M., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/6518221 · Cited by 31 · see citing works

Geniposide decreases the level of Aβ1−42 in the hippocampus of streptozotocin-induced diabetic rats

Liu, J., Zhang, Y., Deng, X., & Yin, F. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt069 · Cited by 32 · see citing works

Anti-hyperuricemic and nephroprotective effect of geniposide in chronic hyperuricemia mice

Liu, C., Zhou, H.-N., Zhang, R., Wang, X., He, S., Zhang, J., Guo, X., Wang, Q., & Sun, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.05.011 · Cited by 32 · see citing works

Early Intranasal Insulin Therapy Halts Progression of Neurodegeneration: Progress in Alzheimer’s Disease Therapeutics

de la Monte, S. M. (2012) · Aging Health · doi:10.2217/ahe.11.89 · Cited by 31 · see citing works

Research and application progress of Gardenia jasminoides

Yin, F., & Liu, J. (2018) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2018.09.001 · Cited by 31 · see citing works

Geniposide alleviates lipopolysaccharide-caused apoptosis of murine kidney podocytes by activating Ras/Raf/MEK/ERK-mediated cell autophagy

Li, X., Ma, A., & Liu, K. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1601630 · Cited by 30 · see citing works

Profiling of components and validated determination of iridoids in Gardenia Jasminoides Ellis fruit by a high-performance-thin-layer- chromatography/mass spectrometry approach

Coran, S. A., Mulas, S., & Vasconi, A. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.12.001 · Cited by 30 · see citing works

Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration

Mehan, S., Bhalla, S., Siddiqui, E. M., Sharma, N., Shandilya, A., & Khan, A. (2022) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s247153 · Cited by 29 · see citing works

Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis

Li, J., Ge, H., Xu, Y., Xie, J., Yan, F., & Chen, W. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c03856 · Cited by 26 · see citing works

Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy

Wang, Z., Jing, Z., Zhou, C., Zhang, L., Cheng, J., Zhang, Z., Liu, J. H., Xu, C., Li, P.-T., & Wang, Y.-Y. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.046 · Cited by 26 · see citing works

Synergistic neuroprotective effects of Geniposide and ursodeoxycholic acid in hypoxia‑reoxygenation injury in SH‑SY5Y cells

Cheng, F., Ma, C., Sun, L., Zhang, X., Zhai, C., Li, C., Zhang, S., Ren, B., Liu, S., Liu, S., et al. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5395 · Cited by 25 · see citing works

Japanese traditional Kampo medicine bofutsushosan improves body mass index in participants with obesity: A systematic review and meta-analysis

Uneda, K., Kawai, Y., Yamada, T., Kaneko, A., Saito, R., Chen, L., Ishigami, T., Namiki, T., & MITSUMA, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266917 · Cited by 25 · see citing works

DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects

Zhang, G., Kim, S., Gu, X., Yu, S. P., & Wei, L. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00446-w · Cited by 25 · see citing works

Regulation of insulin secretion by geniposide: possible involvement of phosphatidylinositol 3-phosphate kinase.

Lx, G., Liu, H., & Yin, F. (2014) · PubMed · Cited by 24 · see citing works

Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice

Kobayashi, S., Kawasaki, Y., Takahashi, T., Maeno, H., & Nomura, M. (2017) · Chinese Medicine · doi:10.1186/s13020-017-0129-x · Cited by 24 · see citing works

Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β-cells

Liu, C.-Y., Hao, Y., Yin, F., Zhang, Y. L., & Liu, J. H. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0591-9 · Cited by 24 · see citing works

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

Kim, H. I., Hong, S. H., Ku, J. M., Kim, M.-J., Ju, S. W., Chang, S. W., Cheon, C., & Ko, S. (2020) · Nutrients · doi:10.3390/nu12010196 · Cited by 22 · see citing works

A Mechanism for the Temporal Potentiation of Genipin to the Cytotoxicity of Cisplatin in Colon Cancer Cells

Wang, R., MoYung, K. C., Yj, Z., & Poon, K. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.15449 · Cited by 22 · see citing works

Geniposide Attenuates the Level of Aβ1-42 via Enhancing Leptin Signaling in Cellular and APP/PS1 Transgenic Mice

Liu, Z., Zhang, Y., Liu, J., & Yin, F. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0875-9 · Cited by 21 · see citing works

Neonatal Exendin-4 Leads to Protection from Reperfusion Injury and Reduced Rates of Oxidative Phosphorylation in the Adult Rat Heart

Brown, S. B., Libonati, J. R., Selak, M. A., Shannon, R. P., & Simmons, R. A. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6242-z · Cited by 20 · see citing works

Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells

Guo, L., Liu, J. H., Zheng, X. X., Yin, Z., Kosaraju, J., & Tam, K. Y. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.03.038 · Cited by 20 · see citing works

Geniposide effectively safeguards HT22 cells against Aβ-induced damage by activating mitophagy via the PINK1/Parkin signaling pathway

Ye, J., Wu, J., Ai, L., Zhu, M., Li, Y., Yin, D., & Huang, Q. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116296 · Cited by 19 · see citing works

Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase

Liu, C., Hao, Y., Yin, F., Zhang, Y., & Liu, J. (2017) · Cell Biology International · doi:10.1002/cbin.10758 · Cited by 18 · see citing works

Bcl-2 or bcl-XL gene therapy increases neural plasticity proteins nestin and c-fos expression in PC12 cells

Gál, A., Pentelényi, K., Reményi, V., Wappler-Guzzetta, E. A., Sáfrány, G., Skopál, J., & Nagy, Z. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.04.003 · Cited by 18 · see citing works

Differential crosstalk between P2X7 and arachidonic acid in activation of mitogen-activated protein kinases

Barbieri, R., Alloisio, S., Ferroni, S., & Nobile, M. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.05.001 · Cited by 18 · see citing works

Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis

Koudouna, E., Huertas-Bello, M., Rodriguez, C. N., Riveros, S. C. H., Navarrete, M. L., & Avila, M. Y. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.9.31 · Cited by 17 · see citing works

Role of glucagon-like peptide- 1 in vascular endothelial dysfunction.

Goyal, S., Kumar, S., Bijjem, K. R. V., & Singh, M. (2010) · PubMed · Cited by 17 · see citing works

Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons

Cui, H., Deng, M., Zhang, Y., Yin, F., & Liu, J. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2469-z · Cited by 17 · see citing works

Aβ1-42 increases the expression of neural KATP subunits Kir6.2/SUR1 via the NF-κB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons

Li, Y., Ba, M., Du, Y., Xia, C., Tan, S., Ng, K. P., & Ma, G. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119833742 · Cited by 17 · see citing works

Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review

Kioussis, B., Tuttle, C. S. L., Heard, D. S., Kennedy, B. K., Lautenschlager, N. T., & Maier, A. B. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101302 · Cited by 18 · see citing works

Geniposide reverses multidrug resistance in vitro and in vivo by inhibiting the efflux function and expression of P-glycoprotein

Huang, H., Zhang, X., Huang, Z., Zhang, Y., & Zhou, Z. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.4011 · Cited by 17 · see citing works

Evaluation of the Antidepressant Activity, Hepatotoxicity and Blood Brain Barrier Permeability of Methyl Genipin

Che, X., Wang, M., Wang, T., Fan, H., Yang, M., Wang, W., & Xu, H. Z. (2016) · Molecules · doi:10.3390/molecules21070923 · Cited by 16 · see citing works

Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway

Liu, J., Yin, F., Guo, L., Deng, X., & Hu, Y. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2008.25 · Cited by 140 · see citing works

Screening of agonist for glucagon-like peptide-1 receptor and its effect on PC12 cells

Yin, F., Xiao-hong, D., Jing, J., Xu-xu, Z., & Liu, J. (2007) · Zhōnghuá yàoxué zázhì

Neurotrophic Property of Geniposide for Inducing the Neuronal Differentiation of PC12 Cells

Liu, J., Zheng, X., Yin, F., Hu, Y., Guo, L., Deng, X., Chen, G., Jiajia, J., & Zhang, H. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2006.08.009 · Cited by 86 · see citing works

Geniposide Prevents PC12 Cells from Peroxynitrite via the Mitogen-Activated Protein Kinase Signaling Pathway

Yin, F., Liu, J., Xiao, H., & Kong, S. (2010) · Eisei kagaku · doi:10.1248/jhs.56.195 · Cited by 3 · see citing works

GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1–42-treated PC12 cells

Li, H., Cao, L., Ren, Y., Jiang, Y., Xie, W., & Li, D. (2017) · Bioscience Reports · doi:10.1042/bsr20171284 · Cited by 20 · see citing works