Geniposide Attenuates Insulin-Deficiency-Induced Acceleration of β-amyloidosis in an APP/PS1 Transgenic Model of Alzheimer's Disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 538 · see citing works

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2011) · The Journal of Pathology · doi:10.1002/path.2912 · Cited by 505 · see citing works

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Freiherr, J., Hallschmid, M., Frey, W. H., Brünner, Y. F., Chapman, C. D., Hölscher, C., Craft, S., Felice, F. G. D., & Benedict, C. (2013) · CNS Drugs · doi:10.1007/s40263-013-0076-8 · Cited by 470 · see citing works

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

Hoyer, S. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.049 · Cited by 436 · see citing works

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ‐Degrading Enzymes in Alzheimer's Disease

Miners, J. S., Baig, S., Palmer, J. C., Palmer, L. E., Kehoe, P. G., & Love, S. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00132.x · Cited by 380 · see citing works

Common pathological processes in Alzheimer disease and type 2 diabetes: A review

Li, L., & Hölscher, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.001 · Cited by 367 · see citing works

Neurodegenerative disorders associated with diabetes mellitus

Ristow, M. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0552-1 · Cited by 350 · see citing works

Temporal memory deficits in Alzheimer’s mouse models: Rescue by genetic deletion of BACE1

Ohno, M., Chang, L., Tseng, W., Oakley, H., Citron, M., Klein, W. L., Vassar, R., & Disterhoft, J. F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04551.x · Cited by 298 · see citing works

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

Biessels, G. J., & Kappelle, L. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331041 · Cited by 266 · see citing works

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Candeias, E., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.12.063 · Cited by 195 · see citing works

Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans

Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.022 · Cited by 191 · see citing works

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes

Moreira, P. I., Santos, M. S., Seiça, R. M. F., & Oliveira, C. R. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.017 · Cited by 190 · see citing works

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease

Cole, G. M., & Frautschy, S. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.08.009 · Cited by 189 · see citing works

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

Gengler, S., Hamilton, A., & Hölscher, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009764 · Cited by 166 · see citing works

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

Beeri, M. S., Schmeidler, J., Silverman, J. M., Gandy, S., Wysocki, M., Hannigan, C. M., Purohit, D. P., Lesser, G., Grossman, H. T., & Haroutunian, V. (2008) · Neurology · doi:10.1212/01.wnl.0000324925.95210.6d · Cited by 157 · see citing works

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O’Halloran, D., Hölscher, C., & O’Neill, C. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8199-5 · Cited by 156 · see citing works

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

Devi, L., Alldred, M. J., Ginsberg, S. D., & Ohno, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032792 · Cited by 155 · see citing works

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

Hölscher, C. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390891 · Cited by 154 · see citing works

Geniposide, a Novel Agonist for GLP-1 Receptor, Prevents PC12 Cells from Oxidative Damage via MAP Kinase Pathway

Liu, J., Yin, F., Zheng, X., Jing, J., & Hu, Y. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.021 · Cited by 145 · see citing works

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK 3β Pathway in Streptozotocin‐Induced A lzheimer Rat Model

Gao, C., Liu, Y., Jiang, Y., Ding, J., & Li, L. (2013) · Brain Pathology · doi:10.1111/bpa.12116 · Cited by 141 · see citing works

Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway

Liu, J., Yin, F., Guo, L., Deng, X., & Hu, Y. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2008.25 · Cited by 140 · see citing works

Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans

Stockhorst, U., DEFRIES, D., Steingrueber, H.-J., et al. (2004) · Physiology & Behavior · doi:10.1016/s0031-9384(04)00348-8 · Cited by 127 · see citing works

Interactions Between Age, Stress and Insulin on Cognition: Implications for Alzheimer's Disease

Solas, M., Aisa, B., Mugueta, M. C., Del Río, J., Tordera, R. M., & Ramírez, M. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.13 · Cited by 124 · see citing works

Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

Hemming, M. L., Patterson, M., Reske-Nielsen, C., Lin, L., Ole Isacson, A., & Selkoe, D. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040262 · Cited by 119 · see citing works

Failures to reconsolidate memory in a mouse model of Alzheimer’s disease

Ohno, M. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.05.001 · Cited by 95 · see citing works

Neurotrophic Property of Geniposide for Inducing the Neuronal Differentiation of PC12 Cells

Liu, J., Zheng, X., Yin, F., Hu, Y., Guo, L., Deng, X., Chen, G., Jiajia, J., & Zhang, H. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2006.08.009 · Cited by 86 · see citing works

Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin

Moreira, P. I. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111127 · Cited by 81 · see citing works

Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes

Ahmad, W. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8352-z · Cited by 80 · see citing works

Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface

Biessels, G. J., Bravenboer, B., & Gispen, W. H. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.057 · Cited by 77 · see citing works

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

Stöhr, O., Schilbach, K., Moll, L., Hettich, M. M., Freude, S., Wunderlich, F. T., Ernst, M. B., Zemva, J., Brüning, J. C., Krone, W., et al. (2011) · AGE · doi:10.1007/s11357-011-9333-2 · Cited by 73 · see citing works

Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells

Guo, L., Xia, Z., Gao, X. C., Yin, F., & Liu, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.146 · Cited by 61 · see citing works

Insulin-degrading enzyme and Alzheimer disease

Bian, L., Yang, J., Guo, T., Sun, Y., Duan, S., Chen, W. Y., Pan, Y. X., Feng, G., & He, L. (2004) · Neurology · doi:10.1212/01.wnl.0000129987.70037.db · Cited by 58 · see citing works

Geniposide Attenuates Mitochondrial Dysfunction and Memory Deficits in APP/PS1 Transgenic Mice

Lv, C., Liu, X., Liu, H., Chen, T., & Zhang, W. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140618095925 · Cited by 49 · see citing works

Inhibition of staurosporine-induced neuronal cell death by bisphenol A and nonylphenol in primary cultured rat hippocampal and cortical neurons

Negishi, T., Ishii, Y., Kyuwa, S., Kuroda, Y., & Yoshikawa, Y. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.031 · Cited by 42 · see citing works

Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat

Grünblatt, E., Koutsilieri, E., Hoyer, S., & Riederer, P. F. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9305 · Cited by 38 · see citing works

Geniposide Regulates Glucose-Stimulated Insulin Secretion Possibly through Controlling Glucose Metabolism in INS-1 Cells

Liu, J., Guo, L., Yin, F., Zhang, Y., Liu, Z., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078315 · Cited by 34 · see citing works

Geniposide inhibits CoCl2-induced PC12 cells death via the mitochondrial pathway.

Guo, L., Liu, J., & Xia, Z. (2009) · PubMed · Cited by 32 · see citing works

Geniposide decreases the level of Aβ1−42 in the hippocampus of streptozotocin-induced diabetic rats

Liu, J., Zhang, Y., Deng, X., & Yin, F. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt069 · Cited by 32 · see citing works

Geniposide Regulates Insulin-Degrading Enzyme Expression to Inhibit the Cytotoxicity of Aβ1-42 in Cortical Neurons

Yin, F., Zhang, Y., Guo, L., Kong, S., & Liu, J. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311211080015 · Cited by 28 · see citing works

Insulin resistance, type 2 diabetes, and AD

Luchsinger, J. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181eee287 · Cited by 22 · see citing works

Journal of Neurochemistry special issue on Alzheimer’s disease: ‘amyloid cascade hypothesis – 20 years on’

Checler, F., & Turner, A. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07603.x · Cited by 20 · see citing works

Insulin, glucose and glycated hemoglobin in Alzheimer’s and vascular dementia with and without superimposed Type II diabetes mellitus condition

Domínguez, R. O., Marschoff, E., Guareschi, E. M., Repetto, M. G., Famulari, A. L., Pagano, M. A., Serra, J. A., & The CGSOSRA – Collaborative Group for the Study of the Oxidative Stress and Related Abnormalities (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0804-7 · Cited by 16 · see citing works

Nonviral DNA Vaccination Augments Microglial Phagocytosis of β-Amyloid Deposits as a Major Clearance Pathway in an Alzheimer Disease Mouse Model

Okura, Y., Kohyama, K., Park, I.-K., & Matsumoto, Y. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31818b48db · Cited by 15 · see citing works

The genetics of Alzheimer's disease

Tanzi, R. E. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)82529-4 · Cited by 9 · see citing works

The Genetics of Alzheimer's Disease

Brindle, N., & George‐Hyslop, P. S. (2003) · Humana Press eBooks · doi:10.1385/1-59259-195-7:23 · Cited by 8 · see citing works

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

Athauda, D., & Foltynie, T. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.013 · Cited by 383 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Geniposide Ameliorates Cognitive Deficits by Attenuating the Cholinergic Defect and Amyloidosis in Middle-Aged Alzheimer Model Mice

Zhao, C., Zhang, H., Li, H., Lv, C., Liu, X., Li, Z., Xin, W., Wang, Y., & Zhang, W. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.002 · Cited by 59 · see citing works

Iridoids and other monoterpenes in the Alzheimer’s brain: Recent development and future prospects

Habtemariam, S. (2018) · Molecules · doi:10.3390/molecules23010117 · Cited by 55 · see citing works

Geniposide Attenuates the Level of Aβ1-42 via Enhancing Leptin Signaling in Cellular and APP/PS1 Transgenic Mice

Liu, Z., Zhang, Y., Liu, J., & Yin, F. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0875-9 · Cited by 21 · see citing works

Leptin Signaling Plays a Critical Role in the Geniposide-Induced Decrease of Tau Phosphorylation

Liu, J., Liu, Z., Zhang, Y., & Yin, F. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv106 · Cited by 11 · see citing works

The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10

Hitschler, L., & Lang, T. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101911 · Cited by 11 · see citing works

Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain

Marcinkiewicz, M. M., & Seidah, N. G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752133.x · Cited by 185 · see citing works

P4–267: ADAM10 activation is required for green tea EGCG–induced alpha–secretase cleavage of amyloid precursor protein

Tan, J., Obregon, D. F., Rezai-Zadeh, K. P., et al. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.2006 · Cited by 4 · see citing works

ADAM10 Activation Is Required for Green Tea (–)-Epigallocatechin-3-gallate-induced α-Secretase Cleavage of Amyloid Precursor Protein

Obregon, D. F., Rezai-Zadeh, K. P., Bai, Y., Sun, N., Hou, H., Ehrhart, J. C., Zeng, J., Mori, T., Arendash, G. W., Shytle, D., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600617200 · Cited by 210 · see citing works

Alpha-synuclein expression influences the processing of the amyloid precursor protein

Hall‐Roberts, H. (2016) · The University of Bath Online Publications Store (The University of Bath)