Hyperactive behavior in female rats in utero‐exposed to group B Streptococcus‐induced inflammation
Abstract
Abstract Group B Streptococcus (GBS) is one the most common bacterium responsible of maternal infections during pregnancy. Offspring in utero‐exposed to GBS‐induced placental inflammation displayed sex‐specific forebrain injuries. Sex differences have been reported in several neuropsychiatric disorders. Hence, we hypothesized that female rats in utero‐exposed to GBS may present sex‐specific neurobehavioral impairments. Lewis rats were injected intraperitoneally every 12 h from gestational day (G) 19 to G22 with either saline (controls) or inactivated serotype Ia GBS (109 CFU). Before puberty, no difference in terms of spontaneous motor activity, exploratory or anxiety‐related behaviors was noticed between experimental conditions. During puberty, GBS‐exposed females – but not males – performed worse than same‐sex controls in a forced motor task. During adulthood, GBS‐exposed females – but not males – displayed increased spontaneous locomotor activity and decreased inhibition. In conclusion, our findings show for the first time that adult females – but not males – in utero‐exposed to GBS‐induced inflammation presented a hyperactive and disinhibited phenotype emerging after puberty.
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Prenatal Group B Streptococcus-induced inflammation increased total distance travelled in female but not male offspring at P105-110 in elevated plus maze.
“female, and not male offspring exhibited increased total distance travelled at P105–110 in an elevated plus maze (Allard et al., 2018).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Allard et al., 2018
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Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
- Authors
- Allard, M., Brochu, M., Bergeron, J. D., & Sebire, G.
- Affiliations
- McGill University (CA)
- Université de Sherbrooke (CA)
- Department of pediatrics McGill University Montreal Quebec Canada
- ORCID
- Allard, Marie‐Julie
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2018-06-18
- Volume
- 69
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W2809033262
- Cited by
- 22
- References
- 47
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- Streptococcus agalactiae, prenatal exposure, placental inflammation, maternal infection, sex differences, hyperactivity, disinhibition, puberty, spontaneous motor activity, anxiety-like behavior, neurobehavioral impairment, Lewis rats
- MeSH terms
- Animals, Anxiety, Chorioamnionitis, Postural Balance, Female, Hyperkinesis, Inhibition, Psychological, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Inbred Lew, Sex Characteristics, Sexual Maturation, Streptococcal Infections, Streptococcus agalactiae, Rats
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