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Cited by 102Coffee research and impactsPregnancy and Medication ImpactReproductive System and Pregnancy

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy

Li, Ji, Zhao, Hong, Song, Ju‐Min, Zhang, Jing, Tang, Yin‐Lan, Xin, Chang‐Mao·2015·International Journal of Gynecology & Obstetrics
DOI 10.1016/j.ijgo.2015.03.033
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Abstract

BACKGROUND: Previous reports of the relationship between pregnancy loss and caffeine/coffee consumption have been inconsistent. OBJECTIVES: To evaluate the association between pregnancy loss and caffeine and coffee consumption. SEARCH STRATEGY: PubMed was searched for reports published before September 2014, with the keywords "caffeine," "coffee," "beverage," "miscarriage," "spontaneous abortion," and "fetal loss." SELECTION CRITERIA: Case-control and cohort studies were included when they had been reported in English, the exposure of interest was caffeine/coffee consumption during pregnancy, the outcome of interest was spontaneous abortion or fetal death, and multivariate-adjusted odds ratios (ORs) or risk ratios were provided or could be calculated. DATA COLLECTION AND ANALYSIS: Data were extracted and combined ORs calculated. MAIN RESULTS: Overall, 26 studies were included (20 of caffeine and eight of coffee). After adjustment for heterogeneity, caffeine consumption was associated with an increased risk of pregnancy loss (OR 1.32, 95% confidence interval [CI] 1.24-1.40), as was coffee consumption (OR 1.11, 95% CI 1.02-1.21). A dose-response analysis suggested that risk of pregnancy loss rose by 19% for every increase in caffeine intake of 150 mg/day and by 8% for every increase in coffee intake of two cups per day. CONCLUSIONS: Consumption of caffeine and coffee during pregnancy seems to increase the risk of pregnancy loss.

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Crossref · 10.1016/j.ijgo.2015.03.033

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Research works printed but not linked: 1

  1. Zhao N.Q., 1999, Assessment for Relative Risk RR = 1, RR > 1 and RR < 1 by Using the Results of Odds Ratio Test, J Shanghai Med Univ, 26, 425

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Metadata

Authors
Li, J., Zhao, H., Song, J., Zhang, J., Tang, Y., & Xin, C.
Affiliations
  • Anhui Medical University (CN)
  • Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
  • Kunming Medical University (CN)
  • Second Affiliated Hospital of Anhui Medical University (CN)
Corresponding author
Xin, Chang‐Mao
ORCID
Venue
International Journal of Gynecology & Obstetrics
Publisher
Wiley
Published
2015-05-14
Volume
130
Issue
2
Pages
116-122
ISSN
  • 0020-6695 (ISSN-L)
  • 0020-7292
  • 1879-3479
DOI
10.1016/j.ijgo.2015.03.033
OpenAlex
W1632849677
Cited by
102
References
42
Citations by year
2026: 3 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 5
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Gynecology & Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
caffeine consumption, coffee consumption, miscarriage, fetal death, dose-response relationship, maternal diet during pregnancy
MeSH terms
Abortion, Spontaneous, Caffeine, Coffee, Dose-Response Relationship, Drug, Female, Humans, Pregnancy, Risk

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