Cited by 246Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases

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Andrade, Fernanda, Rafael, Diana, Videira, Mafalda, Ferreira, Domingos, Sosnik, Alejandro, Sarmento, Bruno·2013·Advanced Drug Delivery Reviews

Abstract

Used since ancient times especially for the local treatment of pulmonary diseases, lungs and airways are a versatile target route for the administration of both local and systemic drugs. Despite the existence of different platforms and devices for the pulmonary administration of drugs, only a few formulations are marketed, partly due to physiological and technological limitations. Respiratory infections represent a significant burden to health systems worldwide mainly due to intrahospital infections that more easily affect immune-compromised patients. Moreover, tuberculosis (TB) is an endemic infectious disease in many developing nations and it has resurged in the developed world associated with the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic. Currently, medicine faces the specter of antibiotic resistance. Besides the development of new anti-infectious drugs, the development of innovative and more efficient delivery systems for drugs that went off patent appears as a promising strategy pursued by the pharmaceutical industry to improve the therapeutic outcomes and to prolong the utilities of their intellectual property portfolio. In this context, nanotechnology-based drug delivery systems (nano-DDS) emerged as a promising approach to circumvent the limitations of conventional formulations and to treat drug resistance, opening the hypothesis for new developments in this area.

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Crossref · 10.1016/j.addr.2013.07.020

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  • Nanodrug delivery system reduces adverse systemic side effects and frequency of drug administration, leading to better patient compliance.

    “Furthermore, the nanodrug delivery system reduces the adverse systemic side effects and frequency of drug administration, which eventually leads to better patient compliance.196,197”

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Authors
Andrade, F., Rafael, D., Videira, M., Ferreira, D., Sosnik, A., & Sarmento, B.
Affiliations
  • Universidade do Porto (PT)
  • University of Lisbon (PT)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
  • Andrade, Fernanda
  • Sarmento, Bruno
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2013-11
Volume
65
Issue
13-14
Pages
1816-1827
ISSN
0169-409X (ISSN-L)
OpenAlex
W2010047058
Cited by
245
References
127
Citations by year
2026: 11 · 2025: 15 · 2024: 23 · 2023: 22 · 2022: 21 · 2021: 29 · 2020: 23 · 2019: 26 · 2018: 11 · 2017: 17 · 2016: 10 · 2015: 19 · 2014: 16 · 2013: 1
FWCI
2.38
Type
journal article
Language
en
Open access
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/73062/2010)
  • FCT (Portugal)/Ministry of Science, Technology and Innovation (MINCyT, Argentina)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
pulmonary drug delivery, respiratory infections, tuberculosis, HIV/AIDS, antibiotic resistance, immunocompromised patients
MeSH terms
Administration, Inhalation, Animals, Anti-Infective Agents, Chemistry, Pharmaceutical, Drug Carriers, Drug Resistance, Microbial, Equipment Design, Humans, Nebulizers and Vaporizers, Respiratory Tract Infections, Nanotechnology, Nanoparticles

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