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Recent advances in polymeric core–shell nanocarriers for targeted delivery of chemotherapeutic drugs

Yang, Xiuru, Xie, Yan·2021·International Journal of Pharmaceutics
DOI 10.1016/j.ijpharm.2021.121094
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Abstract

The treatment effect of chemotherapeutics is often impeded by nonspecific biodistribution and limited biocompatibility. Polymeric core-shell nanocarriers (PCS NCs) composed of a polymer core and at least one shell have been widely applied for cancer therapy and have shown great potential in selectively delivering chemotherapeutic drugs to tumor sites. These PCS NCs can effectively ameliorate the delivery efficiency and therapeutic index of anticarcinogens by prolonging drug residence in the bloodstream, enhancing tumor tissue drug penetration, facilitating cellular drug uptake, controlling the spatiotemporal release of payloads, or codelivering two or more bioactive agents. This review summarizes recently published literature on using PCS NCs to transport chemotherapeutic drugs with poor aqueous solubility and discusses their design principles, structural features, functional properties, and potential limitations.

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Cited by

Sorted by citations

Metadata

Authors
Yang, X., & Xie, Y.
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2021-10
Volume
608
Pages
121094
ISSN
0378-5173
DOI
10.1016/j.ijpharm.2021.121094
Cited by
33
References
7
Language
en
Licence
Funders
  • Program of Shanghai Academic Research Leader (19XD1423700)
  • Natural Science Foundation of Shanghai (19ZR1444200)
  • National Natural Science Foundation of China (81873198)

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