The DOI matches its Crossref record; 60 of the 62 references it cites were found in a registry or an index.
Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats
Open accessAbstract
Self-emulsifying drug delivery systems (i.e. SEDDS, SMEDDS and SNEDDS) are widely employed as solubility and bioavailability enhancing formulation strategies for poorly water-soluble drugs. Despite the capacity for SEDDS to effectively facilitate oral drug absorption, tolerability concerns exist due to the capacity for high concentrations of surfactants (typically present within SEDDS) to induce gastrointestinal toxicity and mucosal irritation. With new knowledge surrounding the role of the gut microbiota in modulating intestinal inflammation and mucosal injury, there is a clear need to determine the impact of SEDDS on the gut microbiota. The current study is the first of its kind to demonstrate the detrimental impact of SEDDS on the gut microbiota of Sprague-Dawley rats, following daily oral administration (100 mg/kg) for 21 days. SEDDS comprising a lipid phase (i.e. Type I, II and III formulations according to the Lipid Formulation Classification Scheme) induced significant changes to the composition and diversity of the gut microbiota, evidenced through a reduction in operational taxonomic units (OTUs) and alpha diversity (Shannon's index), along with statistically significant shifts in beta diversity (according to PERMANOVA of multi-dimensional Bray-Curtis plots). Key signatures of gut microbiota dysbiosis correlated with the increased expression of pro-inflammatory cytokines within the jejunum, while mucosal injury was characterised by significant reductions in plasma citrulline levels, a validated biomarker of enterocyte mass and mucosal barrier integrity. These findings have potential clinical ramifications for chronically administered drugs that are formulated with SEDDS and stresses the need for further studies that investigate dose-dependent effects of SEDDS on the gastrointestinal microenvironment in a clinical setting.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361
RetractedGut microbiome and health: mechanistic insights
de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature · doi:10.1038/nature14232 · Cited by 2,055
Extensive impact of non-antibiotic drugs on human gut bacteria
Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., et al. (2018) · Nature · doi:10.1038/nature25979 · Cited by 1,905
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
Gürsoy, R. N., & Benita, S. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2004.02.001 · Cited by 1,393
Pouton, C. W. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00167-6 · Cited by 1,232
Interaction between drugs and the gut microbiome
Weersma, R. K., Zhernakova, A., & Fu, J. (2020) · Gut · doi:10.1136/gutjnl-2019-320204 · Cited by 1,013
Pouton, C. W., & Porter, C. J. H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.010 · Cited by 908
Chassaing, B., Van de Wiele, T., De Bodt, J., Marzorati, M., & Gewirtz, A. T. (2017) · Gut · doi:10.1136/gutjnl-2016-313099 · Cited by 590
Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications
Natividad, J. M. M., & Verdu, E. F. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.007 · Cited by 525
Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms
Huang, C. B., Alimova, Y. V., Myers, T. M., & Ebersole, J. L. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.01.011 · Cited by 473
Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
Kohli, K., Chopra, S., Dhar, D., Arora, S., & Khar, R. K. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.08.007 · Cited by 426
Interactions of surfactants with lipid membranes
Heerklotz, H. H. (2008) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583508004721 · Cited by 347
Chassaing, B., Compher, C., Bonhomme, B., Liu, Q., Tian, Y., Walters, W., Nessel, L., Delaroque, C., Hao, F., Gershuni, V., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.11.006 · Cited by 347
Direct impact of commonly used dietary emulsifiers on human gut microbiota
Naimi, S., Viennois, É., Gewirtz, A. T., & Chassaing, B. (2021) · Microbiome · doi:10.1186/s40168-020-00996-6 · Cited by 329
Lipid-Based Drug Delivery Systems
Shrestha, H., Bala, R., & Arora, S. (2014) · Journal of Pharmaceutics · doi:10.1155/2014/801820 · Cited by 307
Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis
Viennois, E., Merlin, D., Gewirtz, A. T., & Chassaing, B. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1359 · Cited by 268
Self-emulsifying drug delivery systems: a novel approach to deliver drugs
Salawi, A. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2083724 · Cited by 245
Sha, X., Yan, G., Wu, Y., Li, J., & Fang, X. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.01.001 · Cited by 235
Thomas, N., Holm, R., Müllertz, A., & Rades, T. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.02.027 · Cited by 215
Surfactants: physicochemical interactions with biological macromolecules
Aguirre-Ramírez, M., Silva‐Jiménez, H., Banat, I. M., & Rienzo, M. A. D. D. (2021) · Biotechnology Letters · doi:10.1007/s10529-020-03054-1 · Cited by 213
Falk, N. A. (2019) · Journal of Surfactants and Detergents · doi:10.1002/jsde.12293 · Cited by 211
The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse
Morgan, A. P., Crowley, J. J., Nonneman, R. J., Quackenbush, C. R., Miller, C. N., Ryan, A. K., Bogue, M. A., Paredes, S. H., Yourstone, S., Carroll, I. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115225 · Cited by 197
Bancil, A. S., Sandall, A. M., Rossi, M., Chassaing, B., Lindsay, J. O., & Whelan, K. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa254 · Cited by 191
Ujhelyi, Z., Fenyvesi, F., Váradi, J., Fehér, P. S., Kiss, T., Veszelka, S., Deli, M. A., Vecsernyés, M., & Bácskay, I. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.07.005 · Cited by 190
Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective
Chen, M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.010 · Cited by 185
Saad, R., Rizkallah, M. R., & Aziz, R. K. (2012) · Gut Pathogens · doi:10.1186/1757-4749-4-16 · Cited by 168
Shilling, M., Matt, L., Rubin, E., Visitacion, M. P., Haller, N. A., Grey, S. F., & Woolverton, C. J. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0303 · Cited by 143
Viennois, É., Bretin, A., Dubé, P. E., Maue, A. C., Dauriat, C. J. G., Barnich, N., Gewirtz, A. T., & Chassaing, B. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108229 · Cited by 140
Rial, S. A., Karelis, A. D., Bergeron, K., & Mounier, C. (2016) · Nutrients · doi:10.3390/nu8050281 · Cited by 133
Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
Maji, I., Mahajan, S., Sriram, A., Medtiya, P., Vasave, R., Khatri, D. K., Kumar, R., Singh, S. B., Madan, J., & Singh, P. K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.013 · Cited by 131
Blijlevens, N., Lutgens, L. C. H. W., Schattenberg, A., & Donnelly, J. P. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704563 · Cited by 127
Synthetic surfactant food additives can cause intestinal barrier dysfunction
Csáki, K. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.01.030 · Cited by 126
Batovska, D. I., Тодорова, И., Tsvetkova, I., & Najdenski, H. M. (2009) · PubMed · Cited by 124
Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges
Joyce, P., Dening, T. J., Meola, T. R., Schultz, H. B., Holm, R., Thomas, N., & Prestidge, C. A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.11.006 · Cited by 122
Self-citationZhou, S., Wang, Y., Jacoby, J. J., Jiang, Y., Zhang, Y., & Yu, L. L. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01803 · Cited by 94
The Human Gut Microbiome in Health and Disease
Jovel, J., Dieleman, L. A., Kao, D. H., Mason, A. L., & Wine, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-102268-9.00010-0 · Cited by 83
The gut microbiome influences the bioavailability of olanzapine in rats
Cussotto, S., Walsh, J., Golubeva, A. V., Zhdanov, A. V., Strain, C., Fouhy, F., Stanton, C., Dinan, T. G., Hyland, N. P., Clarke, G. A., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103307 · Cited by 81
Tran, P., & Park, J. (2021) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-021-00516-0 · Cited by 77
Sharma, P., Vaiwala, R., Parthasarathi, S., Patil, N., Verma, A., Waskar, M., Raut, J. S., Basu, J. K., & Ayappa, K. G. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c02520 · Cited by 71
Yue, C., Li, M., Li, J., Han, X., Zhu, H., Yu, G., & Cheng, J. (2020) · Food & Function · doi:10.1039/d0fo01006e · Cited by 69
Palamakula, A., & Khan, M. A. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.12.010 · Cited by 67
Application of Lipid-Based Formulations in Drug Discovery
Chen, X., Gudmundsson, O. S., & Hageman, M. J. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3006433 · Cited by 63
Hovorková, P., Laloučková, K., & Skřivanová, E. (2018) · Czech Journal of Animal Science · doi:10.17221/70/2017-cjas · Cited by 61
Lam, H. T., Le‐Vinh, B., Phan, T. N. Q., & Bernkop‐Schnürch, A. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13021 · Cited by 61
Kamath, S., Stringer, A. M., Prestidge, C. A., & Joyce, P. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2233900 · Cited by 58
Self-citationBu, P., Narayanan, S., Dalrymple, D. M., Cheng, X., & Serajuddin, A. T. M. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.06.011 · Cited by 56
van der Velden, W. J. F. M., Herbers, A. H. E., Brüggemann, R. J. M., Feuth, T., Donnelly, J. P., & Blijlevens, N. M. A. (2013) · Bone Marrow Transplantation · doi:10.1038/bmt.2012.278 · Cited by 51
Cui, Z., Wang, X., Hou, Z., Liao, S., Qi, M., Zha, A., Yang, Z., Zuo, G., Liao, P., Chen, Y., et al. (2020) · Animals · doi:10.3390/ani10101852 · Cited by 46
The impact of common pharmaceutical excipients on the gut microbiota
Subramaniam, S., Kamath, S., Ariaee, A., Prestidge, C. A., & Joyce, P. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2223937 · Cited by 41
Self-citationBu, P., Ji, Y., Narayanan, S., Dalrymple, D. M., Cheng, X., & Serajuddin, A. T. M. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.12.018 · Cited by 41
Glynn, A. W., Igra, A. M., Sand, S., Ilbäck, N. ‐., Hellenäs, K., Rosén, J., & Aspenström-Fagerlund, B. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.068 · Cited by 35
Xu, X. L., Chen, S., Wang, H., Tu, Z., Wang, S.-H., Wang, X., Zhu, H., Wang, C., Zhu, J., & Liu, Y. (2018) · British Journal Of Nutrition · doi:10.1017/s000711451800003x · Cited by 32
Fibre-rich diet attenuates chemotherapy-related neuroinflammation in mice
Cross, C., Davies, M. R., Bateman, E. H., Crame, E. E., Joyce, P., Wignall, A. D., Ariaee, A., Gladman, M. A., Wardill, H. R., & Bowen, J. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.018 · Cited by 30
Self-citationYen, H., Lai, W., Lin, C., & Chiang, S. (2014) · Animal Science Journal · doi:10.1111/asj.12248 · Cited by 30
Pilla, R., Law, T. H., Pan, Y., Zanghi, B. M., Li, Q., Want, E. J., Lidbury, J. A., Steiner, J. M., Suchodolski, J. S., & Volk, H. A. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.541547 · Cited by 24
Hedge, O. J., Höök, F., Joyce, P., & Bergström, C. A. S. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c01689 · Cited by 16
Self-citationWardill, H. R., Ferreira, A. R. D. S., Kumar, H., Bateman, E. H., Cross, C., Bowen, J. M., Havinga, R., Harmsen, H. J. M., Knol, J., Dorresteijn, B., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05850-9 · Cited by 14
Self-citationRecent Progress in Self-Emulsifying Drug Delivery Systems: A Systematic Patent Review (2011-2020)
Ruiz, P. S. L., Serafini, M. R., Alves, I. A., & Novoa, D. M. A. (2021) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2021038490 · Cited by 14
Lai, W., Yen, H., Lin, C., & Chiang, S. (2014) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/65669/2014 · Cited by 12
Flagged first, then by citations
2 of the 62 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Betageri, 2019, Self-emulsifying drug delivery systems and their marketed products: a review, Asian Journal of Pharmaceutics (AJP), 13
- Cussotto, 2021, The gut microbiome influences the bioavailability of olanzapine in rats, EBioMedicine, 66, 10.1016/j.ebiom.2021.103307 · DOI
- Tang, 2018, Effects of different levels of dietary medium-chain triglycerides on growth performance and intestinal microflora in weaned piglets of Chuanzang black pig, Chinese, J. Anim. Sci., 54, 61
Cited by
Sorted by citations
Solubilization techniques used for poorly water-soluble drugs
Xie, B., Liu, Y., Li, X., Yang, P., & He, W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.08.027 · Cited by 241
Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers
Garbati, P., Picco, C., Magrassi, R., Signorello, P., Cacopardo, L., Serra, M. D., Faticato, M. G., Luca, M. D., Balestra, F., Scavo, M. P., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16030431 · Cited by 51
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems
Laffleur, F., Millotti, G., & Lagast, J. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2479759 · Cited by 35
Noreen, S., Maqbool, I., Saleem, A., Mahmood, H., & Rai, N. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104646 · Cited by 31
Kamath, S., Hunter, A., Collins, K., Wignall, A. D., & Joyce, P. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16507 · Cited by 30
Self-citationFine‐Shamir, N., & Dahan, A. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2298247 · Cited by 27
Meola, T. R., Elz, A. S., Wignall, A. D., Paxton, K., Hunter, A., Ariaee, A., Kamath, S., Reuter, S. E., Prestidge, C. A., & Joyce, P. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202403914 · Cited by 26
Self-citationSpinal cord injury: pathophysiology, possible treatments and the role of the gut microbiota
Pagán-Rivera, L. H., Ocasio-Rivera, S. E., Godoy‐Vitorino, F., & Miranda, J. D. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1490855 · Cited by 23
Hou, G., Xu, C., Cheng, K., Mei, S., Yu, K., Zhang, C., Shang, L., & Chen, S. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144470 · Cited by 21
A critical need for ‘gut neutrality’: mitigating adverse drug–microbiome interactions
Kamath, S., & Joyce, P. (2024) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2024.2407616 · Cited by 19
Self-citationPreeti, Sambhakar, S., Malik, R., Bhatia, S., Al‐Harrasi, A., Saharan, R., Aggarwal, G., Kumar, S. S., Sehrawat, R., & Rani, C. (2024) · International Journal of Hypertension · doi:10.1155/2024/2430147 · Cited by 15
Microbiome-driven precision medicine: advancing drug development with pharmacomicrobiomics
Ebadpour, N., Abavisani, M., & Sahebkar, A. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2509283 · Cited by 15
Saha, M., Gupta, A., Kunkalienkar, S., Dhas, N. L., Shetty, S., Gupta, A., Mutalik, S., Nandakumar, K., Hariharapura, R. C., Narasimhaswamy, N., et al. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01986-7 · Cited by 14
Patel, H. K., Trivedi, N. D., Thakkar, V. T., Patel, A. D., Trivedi, U. N., & Kapoor, D. U. (2025) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-09985-4 · Cited by 12
Meola, T. R., Kamath, S., Elz, A. S., Prestidge, C. A., Wignall, A., & Joyce, P. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114453 · Cited by 10
Self-citationLactoferrin Reduces Surfactant Content in the Self-Emulsifying Drug Delivery System
Khairnar, H., Jain, S., & Chatterjee, B. (2024) · ACS Omega · doi:10.1021/acsomega.3c06645 · Cited by 10
Nguyen, N., Hoang, T.-M., Huang, T.-Y., Nguyen, L.-D.-H., Chang, H.-H., Chang, Y., Nguyen, M. T. T., Lin, K., Chen, C.-C., & Sung, H. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.123019 · Cited by 9
Sołek, P., Różaniecka, K., Juśkiewicz, J., Fotschki, B., Stępniowska, A., & Ognik, K. (2025) · Nanotechnology Science and Applications · doi:10.2147/nsa.s494533 · Cited by 9
Bravo‐Alfaro, D. A., Ochoa-Rodríguez, L. R., Velasco‐Rodríguez, L. D. C., Vega-Guerrero, P. E., Luna‐Bárcenas, G., & Garcia, H. S. (2025) · Food Engineering Reviews · doi:10.1007/s12393-025-09429-2 · Cited by 8
Surfactant-Free Electrosprayed Alginate Beads for Oral Delivery of Hydrophobic Compounds
Jeong, H., Kim, H., Kang, S., & Choi, C. (2025) · Polymers · doi:10.3390/polym17152098 · Cited by 7
Radhakrishnan, A., Shanmukhan, N. K., & Samuel, L. C. (2025) · Medical Oncology · doi:10.1007/s12032-025-02611-w · Cited by 7
Saeed, M. D., Shah, K. U., Fahad, M., Shah, S. U., Badshah, S. F., Shah, H., Anjum, İ., Shazly, G. A., & Bourhia, M. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03494-w · Cited by 7
Ariaee, A., Wardill, H. R., Wignall, A. D., Elz, A. S., Wright, L., Prestidge, C. A., & Joyce, P. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400305 · Cited by 6
Self-citationCollins, K., Kamath, S., Meola, T. R., Wignall, A. D., & Joyce, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.17.604016 · Cited by 6
Self-citationThe gut microbiome modulates the lipase-mediated digestion of dietary lipid emulsions
Collins, K., Donnellan, L., Asif, Z., Chan, N. S. L., Subramaniam, S., Kamath, S., Ariaee, A., Abdelhafez, A., Wignall, A. D., Hoffman, P., et al. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115715 · Cited by 5
Self-citationBravo‐Núñez, Á., Berthomé, A., Sabran, C., Vairo, D., Martin, J., Alvarado‐Ramos, K., Chassaing, B., Tomas, J., & Reboul, E. (2025) · Communications Biology · doi:10.1038/s42003-025-08293-4 · Cited by 5
Sutar, Y. B., Adams, J. S., Wu, X., Bhoyarekar, V., Diaz, M. G., Wallace, J., Dave, M., Zhang, Q.-Y., & Date, A. A. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c05456 · Cited by 4
Azarkan, S. Y., Arslan, H. S., & Akçay, S. (2026) · Drug Metabolism Reviews · doi:10.1080/03602532.2026.2671428 · Cited by 4
Jin, S. G., Cho, J. H., & Choi, H. (2025) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-025-00786-y · Cited by 3
Novel liquid-based approaches for transmucosal drug delivery
van Staden, D., Lemmer, H. J. R., Liebenberg, W., & Hamman, J. H. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.12.042 · Cited by 3
The bidirectional interface between oral drug and the gut microbiome: Implications for drug delivery
Zai, K. (2026) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2026.100112 · Cited by 2
Effective Brain Targeting Using the Self-Emulsifying Drug Delivery Systems
Gawde, S., Bachhav, Y. G., & Kumar, M. S. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03398-3 · Cited by 2
Drug–microbiome interactions: What we know and why predictive translation remains elusive
Pereira, F. C., & Aidy, S. E. (2026) · Gut Microbes Reports · doi:10.1080/29933935.2026.2649166 · Cited by 2
sedeek, M., Ayoub, A., Hany, E., Bahaa, A., Bahr, A., Saher, O., & Ahmed, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1942291 · Cited by 2
Anand, K., Khawas, S., Singh, A., Kumari, R., & Sharma, N. (2023) · Journal of Pharmaceutical Technology Research and Management · doi:10.15415/jprtm.2023.112001 · Cited by 2
Lan, X., Tao, C., Zhang, L., Guo, J., Wu, Z., Li, J., Wang, D., Wei, J., Li, X., & Yang, J. (2025) · Food Chemistry X · doi:10.1016/j.fochx.2025.103429 · Cited by 1
Omer, N. A., & Noori, S. H. (2025) · Natural Product Communications · doi:10.1177/1934578x251374757 · Cited by 1
(2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26787-1.00001-1
Effect of environment of the respiratory tract on nanomedicine drug delivery
Imran, M., Chaudhary, A., Ali, M., Jha, S. K., & Mohammed, Y. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22374-7.00003-7
Ooi, A. G., Yuen, K. H., Chu, C. C., & Wong, J. W. (2026) · Lipids · doi:10.1002/lipd.70069
Hunter, A., Ariaee, A., Wignall, A. D., Paxton, K., Bremmell, K. E., Prestidge, C. A., & Joyce, P. (2026) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2026.2719683
Self-citationZhao, C., Ma, T., Zhang, B., Bian, C., Xiao, X., Li, Y., Wang, P., Li, Y., & Wang, Y. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127409
Meng, L., Wei, Y., Zhang, P., Jia, Z., Liu, Y., Shi, Z., Li, Q., Zhang, C., & Wang, Y. (2026) · RSC Advances · doi:10.1039/d6ra07386g
Nanoparticles and the gut-microbiome: a dual strategy for oral brain delivery
Negahdari, R., Pouyanfar, N., Masoudifar, R., Aftabi, P., Fendereski, F., Anvari, Z., Masoumi, N., Faizi, M., & Ghorbani‐Bidkorbeh, F. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127477
Tapadiya, S. G. (2025) · Journal of chemical health risks
The microbiota-drug delivery nexus: from pharmacomicrobiomics to live biotherapeutic delivery
Joyce, P. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115479
Self-citationSelf-emulsifying drug delivery systems (SEDDS) for anticancer agents
Szymanowska, A., & Czarnomysy, R. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.101045
Metadata
- Authors
- Subramaniam, S., Elz, A., Wignall, A., Kamath, S., Ariaee, A., Hunter, A., Newblack, T., Wardill, H. R., Prestidge, C. A., & Joyce, P.
- Affiliations
- University of South Australia (AU)
- South Australian Health and Medical Research Institute (AU)
- Corresponding author
- Joyce, Paul
- ORCID
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2023-12
- Volume
- 648
- Pages
- 123614
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W4388766960
- Cited by
- 45
- References
- 62
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 14 · 2023: 1
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Pharmaceutics (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UniSA Research Outputs Repository (University of South Australia) (submittedVersion, other-oa)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
- Funders
- Hospital Research Foundation (2022-CF-EMCR-004-25314, C-F-EMCR-007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- self-emulsifying drug delivery systems, gut microbiota, intestinal inflammation, surfactant toxicity, dysbiosis, inflammatory cytokines, mucosal injury, citrulline, enterocyte mass, mucosal integrity, poorly water-soluble drugs, oral drug absorption, alpha and beta diversity
- MeSH terms
- Gastrointestinal Microbiome, Administration, Oral, Animals, Biological Availability, Chemistry, Pharmaceutical, Pharmaceutical Preparations, Emulsions, Lipids, Solubility, Drug Delivery Systems, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
