Cited by 94Gut microbiota and healthFatty Acid Research and HealthDiet and metabolism studies

Effects of medium- and long-chain triacylglycerols on lipid metabolism and gut microbiota composition in C57BL/6J mice

Zhou, Shengmin, Wang, Yueqiang, Jacoby, Jörg J., Jiang, Yuanrong, Zhang, Yaqiong, Yu, Liangli Lucy·2017·Journal of Agricultural and Food Chemistry

Abstract

Obesity is related to an increasing risk of chronic diseases. Medium- and long-chain triacylglycerols (MLCT) have been recognized as a promising choice to reduce body weight. In this study, three MLCT with different contents of medium-chain fatty acids (MCFA) (10-30%, w/w) were prepared, and their effects on lipid metabolism and fecal gut microbiota composition of C57BL/6J mice were systematically investigated. MLCT with 30% (w/w) MCFA showed the best performance in decreasing body weight gain as well as optimizing serum lipid parameters and liver triacylglycerol content. The expression levels of genes encoding enzymes for fatty acid degradation increased markedly and expression levels of genes encoding enzymes for de novo fatty acid biosynthesis decreased significantly in the liver of mice treated with MLCT containing 30% (w/w) MCFA. Interestingly, the dietary intake of a high fat diet containing MLCT did significantly decrease the ratio of Firmicutes to Bacteroidetes and down-regulate the relative abundance of Proteobacteria that may attribute to weight loss. Furthermore, we found a notable increase in the total short-chain fatty acid (SCFA) content in feces of mice on a MLCT containing diet. All these results may be concomitantly responsible for the antiobesity effect of MLCT with relatively high contents of MCFA.

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Crossref · 10.1021/acs.jafc.7b01803

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  • Medium-chain fatty acids increase the abundance of Bifidobacterium, Bacteroides, and Prevotella and decrease the abundance of Clostridium histolyticum or Helicobacter in animal studies.

    “Results from animal studies show that medium-chain fatty acids (7-12 carbons) increase the abundance of Bifidobacterium, Bacteroides, and Prevotella and decrease the abundance of Clostridium histolyticum or Helicobacter (119, 124-126).”

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Authors
Zhou, S., Wang, Y., Jacoby, J. J., Jiang, Y., Zhang, Y., & Yu, L. L.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd., Shanghai, 200137, China
  • University of Maryland, College Park (US)
Corresponding author
Yu, Liangli Lucy
Venue
Journal of Agricultural and Food Chemistry
Published
2017-07-26
Volume
65
Issue
31
Pages
6599-6607
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2734566240
Cited by
94
References
66
Citations by year
2026: 8 · 2025: 7 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 6 · 2018: 7 · 2017: 1
FWCI
2.90
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Science and Technology of the People's Republic of China (2013AA102202, 2013AA102207)
  • Ministry of Agriculture of the People's Republic of China (201203069)
  • Wilmar (Shanghai) Biotechnology Research & Development Center Co.,Ltd.
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
medium-chain fatty acids, anti-obesity, lipid metabolism, gut microbiota, Firmicutes/Bacteroidetes ratio, short-chain fatty acids, liver triacylglycerol, fatty acid degradation, de novo lipogenesis, high-fat diet, weight gain, C57BL/6J mice
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteria, Male, Mice, Inbred C57BL, Triglycerides, Gastrointestinal Tract, Lipid Metabolism, Mice

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