Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy
Open accessAbstract
The concept of immunogenic cancer cell death (ICD), as originally observed during the treatment with several chemotherapeutics or ionizing irradiation, has revolutionized the view on the development of new anticancer therapies. ICD is defined by endoplasmic reticulum (ER) stress response, reactive oxygen species (ROS) generation, emission of danger-associated molecular patterns and induction of antitumor immunity. Here we describe known and emerging cancer cell death-inducing physical modalities, such as ionizing irradiation, ultraviolet C light, Photodynamic Therapy (PDT) with Hypericin, high hydrostatic pressure (HHP) and hyperthermia (HT), which have been shown to elicit effective antitumor immunity. We discuss the evidence of ICD induced by these modalities in cancer patients together with their applicability in immunotherapeutic protocols and anticancer vaccine development.
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ICD can be initiated by viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy.
“ICD can be initiated by a relatively restricted set of stimuli, including viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy [854–861].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [857]
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Self-citation
- Authors
- Adkins, I., Fucikova, J., Garg, A. D., Agostinis, P., & Špíšek, R.
- Affiliations
- Charles University (CZ)
- KU Leuven (BE)
- Corresponding author
- Adkins, Irena
- Špíšek, Radek
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2014-11-03
- Volume
- 3
- Issue
- 12
- Pages
- e968434
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC4352954
- OpenAlex
- W2081035306
- Cited by
- 200
- References
- 127
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 12 · 2023: 20 · 2022: 17 · 2021: 19 · 2020: 24 · 2019: 17 · 2018: 15 · 2017: 18 · 2016: 22 · 2015: 11 · 2013: 1
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- OncoImmunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- immunogenic cancer cell death, physical agents, ionizing irradiation, ultraviolet C light, photodynamic therapy, hypericin, high hydrostatic pressure, hyperthermia, endoplasmic reticulum stress, reactive oxygen species, damage-associated molecular patterns, antitumor immunity, cancer immunotherapy, cancer vaccines
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