Cited by 201Immunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersCell death mechanisms and regulation

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

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Adkins, Irena, Fucikova, Jitka, Garg, Abhishek D, Agostinis, Patrizia, Špíšek, Radek·2014·OncoImmunology

Abstract

The concept of immunogenic cancer cell death (ICD), as originally observed during the treatment with several chemotherapeutics or ionizing irradiation, has revolutionized the view on the development of new anticancer therapies. ICD is defined by endoplasmic reticulum (ER) stress response, reactive oxygen species (ROS) generation, emission of danger-associated molecular patterns and induction of antitumor immunity. Here we describe known and emerging cancer cell death-inducing physical modalities, such as ionizing irradiation, ultraviolet C light, Photodynamic Therapy (PDT) with Hypericin, high hydrostatic pressure (HHP) and hyperthermia (HT), which have been shown to elicit effective antitumor immunity. We discuss the evidence of ICD induced by these modalities in cancer patients together with their applicability in immunotherapeutic protocols and anticancer vaccine development.

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Crossref · 10.4161/21624011.2014.968434

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  • ICD can be initiated by viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy.

    “ICD can be initiated by a relatively restricted set of stimuli, including viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy [854–861].”

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1 of the 127 references couldn’t be matched to a known paper.

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  1. [89]Fucikova J, Moserova I, Truxova I, Hermanova I, Vancurova I, Partlova S, Sojka L, Cartron PF, Houska M, Rob L et al. Article title: high hydrostatic pressure induces immunogenic cell death in human tumor cells. Int J Cancer 2014; 135: 1165- 77; PMID:; http://dx.doi.org/ 10.1002/ijc.28766 24500981 · DOI

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Authors
Adkins, I., Fucikova, J., Garg, A. D., Agostinis, P., & Špíšek, R.
Affiliations
  • Charles University (CZ)
  • KU Leuven (BE)
Corresponding author
  • Adkins, Irena
  • Špíšek, Radek
Venue
OncoImmunology
Published
2014-11-03
Volume
3
Issue
12
Pages
e968434
ISSN
  • 2162-4011 (ISSN-L)
  • 2162-402X
OpenAlex
W2081035306
Cited by
200
References
127
Citations by year
2026: 8 · 2025: 16 · 2024: 12 · 2023: 20 · 2022: 17 · 2021: 19 · 2020: 24 · 2019: 17 · 2018: 15 · 2017: 18 · 2016: 22 · 2015: 11 · 2013: 1
FWCI
1.66
Type
journal article
Language
en
Open access
Locations
  • OncoImmunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
immunogenic cancer cell death, physical agents, ionizing irradiation, ultraviolet C light, photodynamic therapy, hypericin, high hydrostatic pressure, hyperthermia, endoplasmic reticulum stress, reactive oxygen species, damage-associated molecular patterns, antitumor immunity, cancer immunotherapy, cancer vaccines

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