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Cited by 60Thermoregulation and physiological responsesClimate Change and Health ImpactsEffects of Environmental Stressors on Livestock

Global warming, heat-related illnesses, and the dermatologist

Open access
Williams, Mary L.·2021·International Journal of Women's Dermatology
DOI 10.1016/j.ijwd.2020.08.007PMC PMC7838243
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Abstract

Global warming, provoked by the greenhouse effect of high levels of atmospheric gases (most notably carbon dioxide and methane), directly threatens human health and survival. Individuals vary in their capacity to tolerate episodes of extreme heat. Because skin is the organ tasked with heat dissipation, it is important for dermatologists to be versed in the physiology of cutaneous heat dissipation and cognizant of clinical settings in which the skin's thermoregulatory responses may be impaired. When the external temperature is lower than that of the skin, the skin releases internal heat through direct thermal exchange with the environment, a process that is aided by an expansion of cutaneous blood flow and eccrine sweating. Cooling through the evaporation of sweat is effective even when the external temperature exceeds that of skin. Many factors, including environmental and physiological (e.g., age and sex), and pathological (e.g., preexisting illnesses, disorders of eccrine function, and medications) considerations, affect the skin's capacity to thermoregulate. Identification of individuals at increased risk for heat-related morbidity and mortality will become increasingly important in the care of patients.

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  • Elevated ambient temperatures and more frequent heatwaves can increase sweat gland activity and vasodilation which can aggravate inflammatory dermatoses such as atopic dermatitis.

    “Elevated ambient temperatures and more frequent heatwaves can increase sweat gland activity and vasodilation which can aggravate inflammatory dermatoses such as atopic dermatitis [43,44].”

    From The Environmental Determinants of Skin Health: Linking Climate Change, Air Pollution, and the Dermatologic Disease Burden (2025) · cites this paper as [43]

    The Abstract (page unavailable) describes sweating and increased cutaneous blood flow as responses involved in heat dissipation. The 'Acquired disorders with impaired sweating' section (page unavailable) links sweating with pruritus in atopic dermatitis, but does not say that heatwaves or vasodilation aggravate the dermatitis; it chiefly discusses how dermatitis can impair sweating and increase heat-related risk. (LLM, conf=0.86)

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Research works printed but not linked: 137

  1. Adelman S. Taylor C.R. Heglund N.C. Sweating on paws and palms: What is its function? Am J Physiol 229 5 1975 1400 1402 1200160
  2. Akosa A.B. Lampert I.A. The sweat gland in graft versus host disease J Pathol 161 3 1990 261 266 1697340
  3. Anderson G.S. Human morphology and temperature regulation Int J Biometeorol 43 3 1999 99 109 10639901
  4. Avalos L.A. Chen H. Li D.K. Basu R. The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study Environ Health 16 1 2017 5 28143601 PMC5286689
  5. Baker L.B. Physiology of sweat gland function: the roles of sweating and sweat composition in human health Temperature (Austin) 6 3 2019 211 259 31608304 PMC6773238
  6. Balmain B.N. Sabapathy S. Jay O. Adsett J. Stewart G.M. Jayasinghe R. Heart failure and thermoregulatory control: can patients with heart failure handle the heat? J Card Fail 23 8 2017 621 627 28408306
  7. Basu R. Pearson D. Sie L. Broadwin R. A case-crossover study of temperature and infant mortality in California Paediatr Perinat Epidemiol 29 5 2015 407 415 26154414
  8. Ben-Zeev B. Watemberg N. Augarten A. Brand N. Yahav Y. Efrati O. Oligohydrosis and hyperthermia: pilot study of a novel topiramate adverse effect J Child Neurol 18 4 2003 254 257 12760427
  9. Bergeron M.F. Training and competing in the heat in youth sports: no sweat? Br J Sports Med 49 13 2015 837 839 26084522
  10. Best A. Lieberman D.E. Kamilar J.M. Diversity and evolution of human eccrine sweat gland density J Therm Biol 84 2019 331 338 31466771
  11. Bongers K.S. Salahudeen M.S. Peterson G.M. Drug-associated non-pyrogenic hyperthermia: a narrative review Eur J Clin Pharmacol 76 1 2020 9 16 31642960
  12. Bruning R.S. Santhanam L. Stanhewicz A.E. Smith C.J. Berkowitz D.E. Kenney W.L. Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin J Appl Physiol (1985) 112 12 2012 2019 2026 22500004 PMC3378394
  13. Budd G.M. Wet-bulb globe temperature (WBGT)–Its history and its limitations J Sci Med Sport 11 1 2008 20 32 17765661
  14. Bytomski J.R. Squire D.L. Heat illness in children Curr Sports Med Rep 2 6 2003 320 324 14583161
  15. Carod-Artal F.J. Infectious diseases causing autonomic dysfunction Clin Auton Res 28 1 2018 67 81 28730326
  16. Caterina M.J. Pang Z. TRP channels in skin biology and pathophysiology Pharmaceuticals (Basel) 9 4 2016 PMC5198052 27983625
  17. Cerminara C. Seri S. Bombardieri R. Pinci M. Curatolo P. Hypohidrosis during topiramate treatment: a rare and reversible side effect Pediatr Neurol 34 5 2006 392 394 16648001
  18. Cheshire W.P. Fealey R.D. Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management Drug Saf 31 2 2008 109 126 18217788
  19. Chow D. Nakamoto B.K. Sullivan K. Sletten D.M. Fujii S. Umekawa S. Symptoms of autonomic dysfunction in human immunodeficiency virus Open Forum Infect Dis 2 3 2015 ofv103 PMC4531222 26269797
  20. Cil G. Cameron T.A. Potential climate change health risks from increases in heat waves: abnormal birth outcomes and adverse maternal health conditions Risk Anal 37 11 2017 2066 2079 28230268
  21. Coates S.J. Davis M.D.P. Andersen L.K. Temperature and humidity affect the incidence of hand, foot, and mouth disease: a systematic review of the literature - a report from the International Society of Dermatology Climate Change Committee Int J Dermatol 58 4 2019 388 399 30187452
  22. Concepcion A.R. Vaeth M. Wagner L.E. 2nd Eckstein M. Hecht L. Yang J. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function J Clin Invest 126 11 2016 4303 4318 27721237 PMC5096923
  23. Coon E.A. Fealey R.D. Sletten D.M. Mandrekar J.N. Benarroch E.E. Sandroni P. Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction Mov Disord 32 3 2017 397 404 27859565 PMC5483990
  24. Csosz E. Emri G. Kallo G. Tsaprailis G. Tozser J. Highly abundant defense proteins in human sweat as revealed by targeted proteomics and label-free quantification mass spectrometry J Eur Acad Dermatol Venereol 29 10 2015 2024 2031 26307449 PMC4583350
  25. Dai X. Okazaki H. Hanakawa Y. Murakami M. Tohyama M. Shirakata Y. Eccrine sweat contains IL-1alpha, IL-1beta and IL-31 and activates epidermal keratinocytes as a danger signal PLoS One 8 7 2013 e67666 PMC3708933 23874436
  26. de Seze J. Dubucquoi S. Fauchais A.L. Hachulla E. Matthias T. Lefranc D. Autoantibodies against alpha-fodrin in Sjogren's syndrome with neurological manifestations J Rheumatol 31 3 2004 500 503 14994394
  27. Duran C.E. Acermai M. Vander Stichele R.H. Systematic review of anticholinergic risk scales in older adults Eur J Clin Pharmacol 69 2013 1485 1496 10.1007/s00228-013-1499-3 23529548 · DOI
  28. Elias P.M. Wakefield J.S. Man M.Q. Moisturizers versus current and next-generation barrier repair therapy for the management of atopic dermatitis Skin Pharmacol Physiol 32 1 2019 1 7 30336483
  29. Epstein Y. Roberts W.O. The pathopysiology of heat stroke: an integrative view of the final common pathway Scand J Med Sci Sports 21 6 2011 742 748 21635561
  30. Facer P. Mathur R. Pandya S.S. Ladiwala U. Singhal B.S. Anand P. Correlation of quantitative tests of nerve and target organ dysfunction with skin immunohistology in leprosy Brain 121 Pt 12 1998 2239 2247 9874477
  31. Falk B. Effects of thermal stress during rest and exercise in the paediatric population Sports Med 25 4 1998 221 240 9587181
  32. Folk G.E. Jr Semken H.A. Jr. The evolution of sweat glands Int J Biometeorol 35 3 1991 180 186 1778649
  33. Foster K.G. Hey E.N. Katz G. The response of the sweat glands of the newborn baby to thermal stimuli and to intradermal acetylcholine J Physiol 203 1 1969 13 29 5821864 PMC1351510
  34. Foster K.G. Hey E.N. O'Connell B. Sweat function in babies with defects of the central nervous system Arch Dis Child 46 248 1971 444 451 4935620 PMC1647778
  35. Fujita K. Hatta K. Acquired generalized anhidrosis: review of the literature and report of a case with lymphocytic hidradenitis and sialadenitis successfully treated with cyclosporine Dermatology 227 3 2013 270 277 24191980
  36. Gagnon D. Crandall C.G. Sweating as a heat loss thermoeffector Handb Clin Neurol 156 2018 211 232 30454591
  37. Gagnon D. Crandall C.G. Kenny G.P. Sex differences in postsynaptic sweating and cutaneous vasodilation J Appl Physiol (1985) 114 3 2013 394 401 23154992 PMC3568872
  38. Gagnon D. Kenny G.P. Sex differences in thermoeffector responses during exercise at fixed requirements for heat loss J Appl Physiol (1985) 113 5 2012 746 757 22797311
  39. Gifford R.M. Todisco T. Stacey M. Fujisawa T. Allerhand M. Woods D.R. Risk of heat illness in men and women: a systematic review and meta-analysis Environ Res 171 2019 24 35 30641370
  40. Goldstein D.S. Holmes C. Imrich R. Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: preliminary observations Auton Neurosci 146 1–2 2009 18 21 19155193 PMC4164394
  41. Goto H. Matsuo H. Fukudome T. Shibuya N. Ohnishi A. Nakamura H. Chronic autonomic neuropathy in a patient with primary Sjogren's syndrome J Neurol Neurosurg Psychiatry 69 1 2000 135 PMC1736990 10864625
  42. Green H. Gilbert J. James R. Byard R.W. An analysis of factors contributing to a series of deaths caused by exposure to high environmental temperatures Am J Forensic Med Pathol 22 2 2001 196 199 11394759
  43. Haga R. Sugimoto K. Nishijima H. Miki Y. Suzuki C. Wakabayashi K. Clinical utility of skin biopsy in differentiating between Parkinson's disease and multiple system atrophy Parkinsons Dis 2015 2015 167038 PMC4402568 25945280
  44. Hajat S. O'Connor M. Kosatsky T. Health effects of hot weather: from awareness of risk factors to effective health protection Lancet 375 9717 2010 856 863 20153519
  45. Hanna E.G. Tait P.W. Limitations to thermoregulation and acclimatization challenge human adaptation to global warming Int J Environ Res Public Health 12 7 2015 8034 8074 26184272 PMC4515708
  46. Haque M.S. Hailu T. Pritchett E. Cusack C.A. Allen H.B. The oldest new finding in atopic dermatitis: subclinical miliaria as an origin JAMA Dermatol 149 4 2013 436 438 23715198
  47. Holowatz L.A. Houghton B.L. Wong B.J. Wilkins B.W. Harding A.W. Kenney W.L. Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin Am J Physiol Heart Circ Physiol 284 5 2003 H1662 H1667 12505876
  48. Iizuka M. Tsuboi H. Asashima H. Hirota T. Kondo Y. Matsui M. M3 muscarinic acetylcholine receptor reactive IL-17 producing T cells promotes development of Sjogren's syndrome like sialadenitis Mod Rheumatol 25 1 2015 158 160 24593169
  49. Illigens B.M.W. Gibbons C.H. Autonomic testing, methods and techniques Handb Clin Neurol 160 2019 419 433 31277866
  50. Imrich R. Alevizos I. Bebris L. Goldstein D.S. Holmes C.S. Illei G.G. Predominant glandular cholinergic dysautonomia in patients with primary Sjogren's syndrome Arthritis Rheumatol 67 5 2015 1345 1352 25622919 PMC4414824
  51. Inoue R. New findings on the mechanism of perspiration including aquaporin-5 water channel Curr Probl Dermatol 51 2016 11 21 27584958
  52. Itin P. Bree A. Sybert V.P. Ectodermal dysplasias 2017 Elsevier Bolognia 1046 1056
  53. Jablonski N.G. Skin: a natural history 2006 University of California Press Berkeley
  54. Jamshidi N. Dawson A. The hot patient: acute drug-induced hyperthermia Aust Prescr 42 1 2019 24 28 30765906 PMC6370613
  55. Jhun I. Mata D.A. Nordio F. Lee M. Schwartz J. Zanobetti A. Ambient temperature and sudden infant death syndrome in the United States Epidemiology 28 5 2017 728 734 28661937 PMC5552234
  56. Johnson J.M. Minson C.T. Kellogg D.L. Jr. Cutaneous vasodilator and vasoconstrictor mechanisms in temperature regulation Compr Physiol 4 1 2014 33 89 24692134
  57. Johnson R.S. Titze J. Weller R. Cutaneous control of blood pressure Curr Opin Nephrol Hypertens 25 1 2016 11 15 26625865 PMC5432654
  58. Kalisch Ellett L.M. Pratt N.L. Le Blanc V.T. Westaway K. Roughead E.E. Increased risk of hospital admission for dehydration or heat-related illness after initiation of medicines: a sequence symmetry analysis J Clin Pharm Ther 41 5 2016 503 507 27378245
  59. Kamberov Y.G. Guhan S.M. DeMarchis A. Jiang J. Wright S.S. Morgan B.A. Comparative evidence for the independent evolution of hair and sweat gland traits in primates J Hum Evol 125 2018 99 105 30502901 PMC6289065
  60. Kaminska E.C. Larson R.A. Petronic-Rosic V. Amelanocytic anhidrotic alopecia areata-like phenotype after allogeneic hematopoietic cell transplant Arch Dermatol 148 8 2012 931 934 22911189
  61. Katayama I. Dry skin manifestations in Sjogren syndrome and atopic dermatitis related to aberrant sudomotor function in inflammatory allergic skin diseases Allergol Int 67 4 2018 448 454 30104151
  62. Katayama I. Yokozeki H. Nishioka K. Impaired sweating as an exocrine manifestation in Sjogren's syndrome Br J Dermatol 133 5 1995 716 720 8555022
  63. Kazman J.B. Purvis D.L. Heled Y. Lisman P. Atias D. Van Arsdale S. Women and exertional heat illness: Identification of gender specific risk factors US Army Med Dep J Apr–Jun 2015 58 66 26101907
  64. Keller R.C. Fatal isolation, the devastating Paris heat wave of 2003 2015 University of Chicago Press Chicago
  65. Kenney W.L. Hodgson J.L. Heat tolerance, thermoregulation and ageing Sports Med 4 6 1987 446 456 3324259
  66. Kenny G.P. Yardley J. Brown C. Sigal R.J. Jay O. Heat stress in older individuals and patients with common chronic diseases CMAJ 182 10 2010 1053 1060 19703915 PMC2900329
  67. Khalifian S. Rosenbach M. Dermatology, climate change, and the perils of attacks on expertise J Am Acad Dermatol 79 2 2018 397 399 29499291
  68. Kihara M. Opfer-Gehrking T.L. Low P.A. Comparison of directly stimulated with axon-reflex-mediated sudomotor responses in human subjects and in patients with diabetes Muscle Nerve 16 6 1993 655 660 8502263
  69. Klar J. Hisatsune C. Baig S.M. Tariq M. Johansson A.C. Rasool M. Abolished InsP3R2 function inhibits sweat secretion in both humans and mice J Clin Invest 124 11 2014 4773 4780 25329695 PMC4347256
  70. Klar J. Piontek J. Milatz S. Tariq M. Jameel M. Breiderhoff T. Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage PLoS Genet 13 7 2017 e1006897 PMC5521874 28686597
  71. Knudsen J.F. Thambi L.R. Kapcala L.P. Racoosin J.A. Oligohydrosis and fever in pediatric patients treated with zonisamide Pediatr Neurol 28 3 2003 184 189 12770670
  72. Kondo T. Inoue H. Usui T. Mimori T. Tomimoto H. Vernino S. Autoimmune autonomic ganglionopathy with Sjogren's syndrome: significance of ganglionic acetylcholine receptor antibody and therapeutic approach Auton Neurosci 146 1–2 2009 33 35 19097826
  73. Kovats R.S. Hajat S. Heat stress and public health: a critical review Annu Rev Public Health 29 2008 41 55 18031221
  74. Kuehn L. McCormick S. Heat exposure and maternal health in the face of climate change Int J Environ Res Public Health 14 8 2017 PMC5580557 28758917
  75. Lacruz R.S. Feske S. Diseases caused by mutations in ORAI1 and STIM1 Ann N Y Acad Sci 1356 2015 45 79 26469693 PMC4692058
  76. Larose J. Boulay P. Sigal R.J. Wright H.E. Kenny G.P. Age-related decrements in heat dissipation during physical activity occur as early as the age of 40 PLoS One 8 12 2013 e83148 PMC3861480 24349447
  77. Lee J.B. Kim J.H. Murota H. Perspiration functions in different ethnic, age, and sex populations: modification of sudomotor function Curr Probl Dermatol 51 2016 109 119 27584970
  78. Lee J.B. Lee I.H. Shin Y.O. Min Y.K. Yang H.M. Age- and sex-related differences in sudomotor function evaluated by the quantitative sudomotor axon reflex test (QSART) in healthy humans Clin Exp Pharmacol Physiol 41 6 2014 392 399 24684442
  79. Levy B.S. Sidel V.W. Patz J.A. Climate change and collective violence Annu Rev Public Health 38 2017 241 257 28125385 PMC6098709
  80. Levine M. LoVecchio F. Ruha A.-M. Chu G. Roque P. Influence of drug use on morbidity and mortality in heatstroke J Med Toxicol 8 2012 252 257 10.1007/s13181-012-0222-6 22447633 PMC3550168 · DOI
  81. Lidove O. Kaminsky P. Hachulla E. Leguy-Seguin V. Lavigne C. Marie I. Fabry disease 'The New Great Imposter': results of the French Observatoire in Internal Medicine Departments (FIMeD) Clin Genet 81 6 2012 571 577 21623772
  82. Lim J.H. Choo W. Chang J.H. Tey H.L. Chong W.S. Application of iodinated starch powder using an atomizer spray gun - a new and effective tool to evaluate hypohidrosis Skin Res Technol 22 3 2016 370 374 26452436
  83. Lim J.H. Kok W.L. Bin Ali N. Chong W.S. Tey H.L. Hypohidrosis in individuals with exertional heat injury: a prospective open cohort study Dermatology 232 1 2016 50 56 26402230
  84. Lisman P. Kazman J.B. O'Connor F.G. Heled Y. Deuster P.A. Heat tolerance testing: association between heat intolerance and anthropometric and fitness measurements Mil Med 179 11 2014 1339 1346 25373064
  85. Lockwood A.H. Heat advisory, protecting health on a warming planet 2016 MIT Press Cambridge, MA
  86. Low P.A. Opfer-Gehrking T.L. Kihara M. In vivo studies on receptor pharmacology of the human eccrine sweat gland Clin Auton Res 2 1 1992 29 34 1638102
  87. Luo K.R. Chao C.C. Hsieh P.C. Lue J.H. Hsieh S.T. Effect of glycemic control on sudomotor denervation in type 2 diabetes Diabetes Care 35 3 2012 612 616 22301122 PMC3322711
  88. Mancini A.J. Lawley L. Structure and function of newborn skin Eichenfield L.F. Frieden I.J. Neonatal and infant dermatology 2015 Elsevier London 14 23
  89. Mangus C.W. Canares T.L. Heat-related illness in children in an era of extreme temperatures Pediatr Rev 40 3 2019 97 107 30824495
  90. McAllen R.M. McKinley M.J. Efferent thermoregulatory pathways regulating cutaneous blood flow and sweating Handb Clin Neurol 156 2018 305 316 30454597
  91. Michenot F. Sommet A. Bagheri H. Lapeyre-Mestre M. Montastruc J.L. French Network of PharmacoVigilance Centres. Adverse drug reactions in patients older than 70 years during the heat wave occurred in France in summer 2003: A study from the French PharmacoVigilance Database Pharmacoepidemiol Drug Saf 15 10 2006 735 740 16924603
  92. Moore J. Northway S. Wells N. Woolf E. Buono M.J. Local inhibition of carbonic anhydrase does not decrease sweat rate J Basic Clin Physiol Pharmacol 30 1 2018 47 50 30099410
  93. Morimoto T. Slabochova Z. Naman K. Sargent F. Sex differences in physiological reactions to thermal stress Physiology 22 3 1967 526 532 6020238
  94. Mukaino A. Nakane S. Higuchi O. Nakamura H. Miyagi T. Shiroma K. Insights from the ganglionic acetylcholine receptor autoantibodies in patients with Sjogren's syndrome Mod Rheumatol 26 5 2016 708 715 26873295
  95. Munetsugu T. Fujimoto T. Oshima Y. Sano K. Murota H. Satoh T. Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan J Dermatol 44 4 2017 394 400 27774633
  96. Murota H. Old and new approaches for assessing sweating Yokozeki H. Murota H. Katayama I. Perspiration research 2016 Karger Basel, Swizterland 22 29
  97. Nitschke M. Tucker G.R. Bi P. Morbidity and mortality during heatwaves in metropolitan Adelaide Med J Aust 187 11–12 2007 662 665 18072911
  98. Nitschke M. Tucker G.R. Hansen A.L. Williams S. Zhang Y. Bi P. Impact of two recent extreme heat episodes on morbidity and mortality in Adelaide, South Australia: a case-series analysis Environ Health 10 2011 42 21592410 PMC3116460
  99. Nolano M. Provitera V. Perretti A. Stancanelli A. Saltalamacchia A.M. Donadio V. Ross syndrome: a rare or a misknown disorder of thermoregulation? A skin innervation study on 12 subjects Brain 129 Pt 8 2006 2119 2131 16837483
  100. Nordon C. Martin-Latry K. de Roquefeuil L. Latry P. Begaud B. Falissard B. Risk of death related to psychotropic drug use in older people during the European 2003 heatwave: a population-based case-control study Am J Geriatr Psychiatry 17 12 2009 1059 1067 20104062
  101. Noronha M.J. Vas C.J. Aziz H. Autonomic dysfunction (sweating responses) in multiple sclerosis J Neurol Neurosurg Psychiatry 31 1 1968 19 22 5644926 PMC496280
  102. Ootsuka Y. Tanaka M. Control of cutaneous blood flow by central nervous system Temperature (Austin) 2 3 2015 392 405 27227053 PMC4843916
  103. Orteu C.H. Jansen T. Lidove O. Jaussaud R. Hughes D.A. Pintos-Morell G. Fabry disease and the skin: data from FOS, the Fabry outcome survey Br J Dermatol 157 2 2007 331 337 17573884
  104. Page L.A. Hajat S. Kovats R.S. Relationship between daily suicide counts and temperature in England and Wales Br J Psychiatry 191 2007 106 112 17666493
  105. Panda S. Verma D. Budania A. Bharti J.N. Sharma R.K. Clinical and laboratory correlates of selective autonomic dysfunction due to Ross syndrome J Family Med Prim Care 8 4 2019 1500 1503 31143750 PMC6510077
  106. Pandolf K.B. Gange R.W. Latzka W.A. Blank I.H. Kraning K.K. 2nd Gonzalez R.R. Human thermoregulatory responses during heat exposure after artificially induced sunburn Am J Physiol 262 4 Pt 2 1992 R610 R616 1566925
  107. Papa C.M. Kligman A.M. Mechanisms of eccrine anidrosis. I. High level blockade J Invest Dermatol 47 1 1966 1 9 25622342
  108. Periard J.D. Racinais S. Sawka M.N. Adaptations and mechanisms of human heat acclimation: applications for competitive athletes and sports Scand J Med Sci Sports 25 Suppl 1 2015 20 38 25943654
  109. Pryor R.R. Roth R.N. Suyama J. Hostler D. Exertional heat illness: emerging concepts and advances in prehospital care Prehosp Disaster Med 30 3 2015 297 305 25860637
  110. Rieg S. Steffen H. Seeber S. Humeny A. Kalbacher H. Dietz K. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo J Immunol 174 12 2005 8003 8010 15944307
  111. Roskind J.L. Petrofsky J. Lind A.R. Paletta F.X. Quantitation of thermoregulatory impairment in patients with healed burns Ann Plast Surg 1 2 1978 172 176 365049
  112. Saari A. Tolonen U. Paakko E. Suominen K. Pyhtinen J. Sotaniemi K.A. Sympathetic skin responses in multiple sclerosis Acta Neurol Scand 118 4 2008 226 231 18355393
  113. Sahuc P. Chiche L. Dussol B. Pouget J. Franques J. Sudoscan as a noninvasive tool to assess sudomotor dysfunction in patients with Fabry disease: results from a case-control study Ther Clin Risk Manag 12 2016 135 138 26893567 PMC4745837
  114. Sato K. Kang W.H. Saga K. Sato K.T. Biology of sweat glands and their disorders. I. Normal sweat gland function J Am Acad Dermatol 20 4 1989 537 563 2654204
  115. Schwartz J. Who is sensitive to extremes of temperature? A case-only analysis Epidemiology 16 1 2005 67 72 15613947
  116. Shibasaki M. Davis S.L. Cui J. Low D.A. Keller D.M. Crandall C.G. Botulinum toxin abolishes sweating via impaired sweat gland responsiveness to exogenous acetylcholine Br J Dermatol. 161 4 2009 757 761 10.1111/j.1365-2133.2009.09248.x 19538183 PMC2866124 · DOI
  117. Shatzky S. Moses S. Levy J. Pinsk V. Hershkovitz E. Herzog L. Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical finds, and results of nerve conduction studies Am J Med Genet 92 5 2020 353 360 10861667
  118. Sherwood S.C. Huber M. An adaptability limit to climate change due to heat stress Proc Natl Acad Sci U S A 107 21 2010 9552 9555 20439769 PMC2906879
  119. Shin Y.O. Lee J.B. Kim J.H. Seasonal acclimation in sudomotor function evaluated by QSART in healthy humans Korean J Physiol Pharmacol 20 5 2016 499 505 27610036 PMC5014996
  120. Skorvanek M. Bhatia K.P. The skin and Parkinson's disease: review of clinical, diagnostic, and therapeutic issues Mov Disord Clin Pract 4 1 2017 21 31 30363435 PMC6174479
  121. Smith A.G. Lessard M. Reyna S. Doudova M. Singleton J.R. The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathy J Diabetes Complications 28 4 2014 511 516 24661818 PMC4219320
  122. Smith C.J. Pediatric thermoregulation: considerations in the face of global climate change Nutrients 11 9 2019 PMC6770410 31454933
  123. Sommer C. Lindenlaub T. Zillikens D. Toyka K.V. Naumann M. Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome Ann Neurol 52 2 2002 247 250 12210801
  124. Strand L.B. Barnett A.G. Tong S. Maternal exposure to ambient temperature and the risks of preterm birth and stillbirth in Brisbane, Australia Am J Epidemiol 175 2 2012 99 107 22167749
  125. Takahashi A. Tani S. Murota H. Katayama I. Histamine modulates sweating and affects clinical manifestations of atopic dermatitis Curr Probl Dermatol 51 2016 50 56 27584962
  126. Tey H.L. Tay E.Y. Cao T. In vivo imaging of miliaria profunda using high-definition optical coherence tomography: diagnosis, pathogenesis, and treatment JAMA Dermatol 151 3 2015 346 348 25390622
  127. Thoenes M.M. Heat-related illness risk with methylphenidate use J Pediatr Health Care 25 2 2011 127 132 21320685
  128. Tyler C.J. Reeve T. Hodges G.J. Cheung S.S. The effects of heat adaptation on physiology, perception and exercise performance in the heat: a meta-analysis Sports Med 46 11 2016 1699 1724 27106556
  129. Wang Q. Guo S. Duan G. Xiang G. Ying Y. Zhang Y. Novel and novel de novo mutations in NTRK1 associated with congenital insensitivity to pain with anhidrosis: a case report Medicine (Baltimore) 94 19 2015 e871 PMC4602583 25984678
  130. Wataya-Kaneda M. Genetic disorders with dyshidrosis: ectodermal dysplasia, incontinentia pigmenti, Fabry disease, and congenital insensitivity to pain with anhidrosis Curr Probl Dermatol 51 2016 42 49 27584961
  131. Watts N. Amann M. Arnell N. Ayeb-Karlsson S. Belesova K. Boykoff M. The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate Lancet 394 10211 2019 1836 1878 31733928 PMC7616843
  132. Wells J.C. Thermal environment and human birth weight J Theor Biol 214 3 2002 413 425 11846599
  133. Westaway K. Frank O. Husband A. McClure A. Shute R. Edwards S. Medicines can affect thermoregulation and accentuate the risk of dehydration and heat-related illness during hot weather J Clin Pharm Ther 40 4 2015 363 367 26073686
  134. Wexler R.K. Evaluation and treatment of heat-related illnesses Am Fam Physician 65 11 2002 2307 2314 12074531
  135. Yamaga K. Murota H. Tamura A. Miyata H. Ohmi M. Kikuta J. Claudin-3 loss causes leakage of sweat from the sweat gland to contribute to the pathogenesis of atopic dermatitis J Invest Dermatol 138 6 2018 1279 1287 29277540
  136. Yard E.E. Gilchrist J. Haileyesus T. Murphy M. Collins C. McIlvain N. Heat illness among high school athletes–United States, 2005–2009 J Safety Res 41 6 2010 471 474 21134511
  137. Yardley J.E. Stapleton J.M. Sigal R.J. Kenny G.P. Do heat events pose a greater health risk for individuals with type 2 diabetes? Diabetes Technol Ther 15 6 2013 520 529 23530578

Cited by

Sorted by citations

Authors
Williams, M. L.
Affiliations
University of California, San Francisco (US)
Corresponding author
Williams, Mary L.
ORCID
Williams, Mary L.
Venue
International Journal of Women's Dermatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021-01
Volume
7
Issue
1
Pages
70-84
ISSN
2352-6475 (ISSN-L)
DOI
10.1016/j.ijwd.2020.08.007
PMC
PMC7838243
OpenAlex
W3084312169
Cited by
60
References
10
Citations by year
2026: 10 · 2025: 16 · 2024: 11 · 2023: 10 · 2022: 7 · 2021: 5 · 2020: 1
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Women’s Dermatology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
Keywords
global warming, heat-related illness, heat dissipation, eccrine sweating, skin blood flow, risk factors, dermatology

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