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Cited by 186Hepatitis B Virus StudiesT-cell and B-cell ImmunologyLiver physiology and pathology

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Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver

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Isogawa, Masanori, Furuichi, Yoshihiro, Chisari, Francis V.·2005·Immunity
DOI 10.1016/j.immuni.2005.05.005
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Abstract

When hepatitis B virus (HBV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) are adoptively transferred into HBV transgenic mice, they enter the liver, recognize antigen, secrete interferon gamma (IFNgamma), inhibit viral replication, and kill their target cells, causing hepatitis. In the current study, we examined the impact of antigen recognition on the evolution of the activation phenotype, antiviral effector functions, expansion and contraction kinetics, and compartmentalization of the transferred CTLs. The results reveal that noncytolytic and cytolytic effector functions and expansion-contraction kinetics of the CTLs are regulated asynchronously and in an oscillatory manner as a consequence of antigen recognition in the liver and in association with PD-1 upregulation. We suggest that such oscillations maximize viral clearance and minimize tissue injury during HBV infection and that poor coordination of these events could lead to viral persistence and chronic liver disease.

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Research works printed but not linked: 42

  1. Ando, 1993, Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis, J. Exp. Med., 178, 1541, 10.1084/jem.178.5.1541 · DOI
  2. Barry, 2002, Cytotoxic T lymphocytes: all roads lead to death, Nat. Rev. Immunol., 2, 401, 10.1038/nri819 · DOI
  3. Berke, 1995, The CTL’s kiss of death, Cell, 81, 9, 10.1016/0092-8674(95)90365-8 · DOI
  4. Castellanos, 1997, Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1, J. Immunol., 159, 5463, 10.4049/jimmunol.159.11.5463 · DOI
  5. Chisari, 2000, Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B, Am. J. Pathol., 156, 1117, 10.1016/S0002-9440(10)64980-2 · DOI
  6. D’Souza, 2003, IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion, J. Immunol., 171, 5727, 10.4049/jimmunol.171.11.5727 · DOI
  7. D’Souza, 2002, Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses, J. Immunol., 168, 5566, 10.4049/jimmunol.168.11.5566 · DOI
  8. Depper, 1985, Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene, Proc. Natl. Acad. Sci. USA, 82, 4230, 10.1073/pnas.82.12.4230 · DOI
  9. Flynn, 1998, Virus-specific CD8+ T cells in primary and secondary influenza pneumonia, Immunity, 8, 683, 10.1016/S1074-7613(00)80573-7 · DOI
  10. Freeman, 2000, Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J. Exp. Med., 192, 1027, 10.1084/jem.192.7.1027 · DOI · Paper page
  11. Fuller, 2004, Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections, J. Immunol., 172, 4204, 10.4049/jimmunol.172.7.4204 · DOI
  12. Guidotti, 1995, High-level hepatitis B virus replication in transgenic mice, J. Virol., 69, 6158, 10.1128/jvi.69.10.6158-6169.1995 · DOI
  13. Guidotti, 1996, Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes, Immunity, 4, 25, 10.1016/S1074-7613(00)80295-2 · DOI
  14. Guidotti, 1999, Viral clearance without destruction of infected cells during acute HBV infection, Science, 284, 825, 10.1126/science.284.5415.825 · DOI · Paper page
  15. Harty, 2000, CD8+ T cell effector mechanisms in resistance to infection, Annu. Rev. Immunol., 18, 275, 10.1146/annurev.immunol.18.1.275 · DOI
  16. Ishikawa, 1998, Polyclonality and multispecificity of the CTL response to a single viral epitope, J. Immunol., 161, 5842, 10.4049/jimmunol.161.11.5842 · DOI
  17. Iwai, 2002, Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade, Proc. Natl. Acad. Sci. USA, 99, 12293, 10.1073/pnas.192461099 · DOI
  18. Judge, 2002, Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells, J. Exp. Med., 196, 935, 10.1084/jem.20020772 · DOI
  19. Kakimi, 2000, Natural killer T cell activation inhibits hepatitis B virus replication in vivo, J. Exp. Med., 192, 921, 10.1084/jem.192.7.921 · DOI
  20. Kakimi, 2002, Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections, J. Virol., 76, 8609, 10.1128/JVI.76.17.8609-8620.2002 · DOI
  21. Kim, 2002, The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements, EMBO J., 21, 3051, 10.1093/emboj/cdf321 · DOI
  22. Kuhrober, 1997, DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes, Int. Immunol., 9, 1203, 10.1093/intimm/9.8.1203 · DOI
  23. Lalvani, 1997, Rapid effector function in CD8+ memory T cells, J. Exp. Med., 186, 859, 10.1084/jem.186.6.859 · DOI
  24. Lechner, 2000, Analysis of successful immune responses in persons infected with hepatitis C virus, J. Exp. Med., 191, 1499, 10.1084/jem.191.9.1499 · DOI
  25. Leonard, 1982, A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor, Nature, 300, 267, 10.1038/300267a0 · DOI
  26. Masopust, 2001, Preferential localization of effector memory cells in nonlymphoid tissue, Science, 291, 2413, 10.1126/science.1058867 · DOI · Paper page
  27. McClary, 2000, Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines, J. Virol., 74, 2255, 10.1128/JVI.74.5.2255-2264.2000 · DOI
  28. Moriyama, 1990, Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice, Science, 248, 361, 10.1126/science.1691527 · DOI
  29. Murali-Krishna, 1998, Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection, Immunity, 8, 177, 10.1016/S1074-7613(00)80470-7 · DOI
  30. Pien, 2002, A unique mechanism for innate cytokine promotion of T cell responses to viral infections, J. Immunol., 169, 5827, 10.4049/jimmunol.169.10.5827 · DOI
  31. Schirmbeck, 2003, Different immunogenicity of H-2 Kb-restricted epitopes in natural variants of the hepatitis B surface antigen, Eur. J. Immunol., 33, 2429, 10.1002/eji.200324125 · DOI
  32. Sette, 2001, Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice, J. Immunol., 166, 1389, 10.4049/jimmunol.166.2.1389 · DOI
  33. Slifka, 2000, Antigen-specific regulation of T cell-mediated cytokine production, Immunity, 12, 451, 10.1016/S1074-7613(00)80197-1 · DOI
  34. Slifka, 1999, Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells, Nature, 401, 76, 10.1038/43454 · DOI · Paper page
  35. Testi, 1989, T cell activation via Leu-23 (CD69), J. Immunol., 143, 1123, 10.4049/jimmunol.143.4.1123 · DOI
  36. Thimme, 2001, Determinants of viral clearance and persistence during acute hepatitis C virus infection, J. Exp. Med., 194, 1395, 10.1084/jem.194.10.1395 · DOI
  37. Thimme, 2003, CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection, J. Virol., 77, 68, 10.1128/JVI.77.1.68-76.2003 · DOI · Paper page
  38. Wherry, 2003, Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment, J. Virol., 77, 4911, 10.1128/JVI.77.8.4911-4927.2003 · DOI
  39. Wieland, 2004, Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees, Proc. Natl. Acad. Sci. USA, 101, 2129, 10.1073/pnas.0308478100 · DOI
  40. Wolint, 2004, Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells, J. Exp. Med., 199, 925, 10.1084/jem.20031799 · DOI
  41. Zhang, 1998, Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15, Immunity, 8, 591, 10.1016/S1074-7613(00)80564-6 · DOI
  42. Zhou, 2004, Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection, J. Virol., 78, 3578, 10.1128/JVI.78.7.3578-3600.2004 · DOI

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Metadata

Authors
Isogawa, M., Furuichi, Y., & Chisari, F. V.
Affiliations
Scripps Research Institute (US)
Corresponding author
Chisari, Francis V.
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
2005-07
Volume
23
Issue
1
Pages
53-63
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2005.05.005
OpenAlex
W2047908014
Cited by
186
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 11
FWCI
10.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA40489)
Topics
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
hepatitis B virus, CD8+ cytotoxic T lymphocytes, antigen recognition, PD-1, interferon-gamma, viral clearance, liver, chronic hepatitis B, viral persistence, chronic liver disease, HBV transgenic mice
MeSH terms
Animals, Hepatitis B, Hepatitis B Surface Antigens, Immunologic Memory, Interferon-gamma, Liver, Mice, Transgenic, Receptors, Antigen, T-Cell, Serine Endopeptidases, Spleen, T-Lymphocytes, Cytotoxic, Viral Envelope Proteins, Adoptive Transfer, Mice, Granzymes

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