The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Open accessAbstract
We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, supports the differentiation of IL-17-producing T cells, a process that is amplified by IL-1beta and TNFalpha. We could not detect a role for IL-23 in the differentiation of IL-17-producing T cells but confirmed its importance for their survival and expansion. Transcription factors GATA-3 and T-bet, as well as its target Hlx, are absent in IL-17-producing T cells, and they do not express the negative regulator for TGFbeta signaling, Smad7. Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Here, we report that in addition to its key role in Th17 cell induction (3, 4), there is an absolute requirement for persistent IL-6 signaling to maintain the Th17 genetic program, and thus Th17 cells.”
From T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [3]
In the citing paper
“IL-6 together with TGFβ induces Th17 cells (Fig. 2) (164).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [164]
In the citing paper
“The produced IL-6 further induces Th17 cell differentiation through STAT3 in the presence of TGFβ, IL-1β and IL-23, all of which are rich in inflammatory lesions and tumor microenvironments (164, 166, 169–171, 174, 175).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [164]
In the citing paper
“Th17 cells were established as an independent T helper cell subset with the discovery of signature cytokines IL-17A, IL-17F, and IL-22, lineage-specific differentiation factors, and dedicated or “master” transcription factors”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [10]
In the citing paper
“In response to TGF-β in vitro as well as in vivo, many T cells co-express RORγt and Foxp3 (Veldhoen et al., 2006; Yang et al., 2008a).”
From Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 (2011) · cites this paper as Veldhoen et al., 2006
Citations
Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K. P., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00070-4 · Cited by 2,819
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,026
Nguyen, C. Q., Yin, H., Lee, B. H., Carcamo, W. C., Chiorini, J. A., & Peck, A. B. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3207 · Cited by 116
“4 distinct from, and unrelated to, either the TH1 or TH2 cell lineages [10-14].”
Omega-3 fatty acids, lipid rafts, and T cell signaling
Hou, T. Y., McMurray, D. N., & Chapkin, R. S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.091 · Cited by 119
“Based upon the essential nature of the IL-6-gp130-STAT3 signaling axis in TH17 differentiation (Veldhoen et al., 2006) and the fact that membrane modulation disrupts TH17 development (Zhu et al., 2011), Allen and colleagues hypothesized that n-3 PUFA reduce TH17 differentiation by interfering with…”
BackgroundRegulatory T Cells in Mycobacterium tuberculosis Infection
Cardona, P., & Cardona, P.-J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02139 · Cited by 113
“TGF-β induces both FoxP3 and RORγt expression; however, in order to induce Th17, TGF-β also requires the presence of IL-6, in which case the balance is tipped toward Th17 cells instead of Tregs (32).”
BackgroundThe impact of Th17 cells on transplant rejection and the induction of tolerance
Heidt, S., San, D., Chadha, R., & Wood, K. J. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32833b9bfb · Cited by 114
Emerging Role of IL-17 in Atherosclerosis
Chen, S., Crother, T. R., & Arditi, M. (2010) · Journal of Innate Immunity · doi:10.1159/000314626 · Cited by 113
Targeting the Th17 pathway in psoriasis
Elloso, M. M., Gómez-Angelats, M., & Fourie, A. M. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212101 · Cited by 113
Ruíz, L., Espinosa‐Martos, I., García-Carral, C., Manzano, S., McGuire, M. K., Meehan, C. L., McGuire, M. A., Williams, J. E., Foster, J. A., Sellen, D., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00696 · Cited by 112
Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants
Kumar, S., Sunagar, R., & Gosselin, E. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01144 · Cited by 112
Brereton, C. F., Sutton, C. E., Lalor, S. J., Lavelle, E. C., & Mills, K. H. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803851 · Cited by 115
Distinct Profiles of Effector Cytokines Mark the Different Phases of Crohn’s Disease
Zorzi, F., Monteleone, I., Sarra, M., Calabrese, E., Marafini, I., Cretella, M., Sedda, S., Biancone, L., Pallone, F., & Monteleone, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054562 · Cited by 116
Reinhardt, R. L., Hong, S., Kang, S., Wang, Z., & Locksley, R. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1618 · Cited by 113
IL-23 Receptor Regulates Unconventional IL-17–Producing T Cells That Control Bacterial Infections
Riol‐Blanco, L., Lazarevic, V., Awasthi, A., Mitsdoerffer, M., Wilson, B., Croxford, A. L., Waisman, A., Kuchroo, V. K., Glimcher, L. H., & Oukka, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902796 · Cited by 113
Zygmunt, B. M., & Veldhoen, M. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387664-5.00005-4 · Cited by 116
Interleukin-17 as a drug target in human disease
Ivanov, S., & Lindén, A. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.004 · Cited by 110
Jethwa, H., & Bowness, P. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12670 · Cited by 119
Tanaka, S., Maeda, S., Hashimoto, M., Fujimori, C., Ito, Y., Teradaira, S., Hirota, K., Yoshitomi, H., Katakai, T., Shimizu, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000848 · Cited by 111
TGFΒ-induced transcription in cancer
Cantelli, G., Crosas‐Molist, E., Georgouli, M., & Sanz‐Moreno, V. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.08.009 · Cited by 111
Li, B., Jones, L. L., & Geiger, T. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800016 · Cited by 118
Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Keulen, V. P. V., Marler, R. J., Felts, S. J., & Pease, L. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3137 · Cited by 111
RetractedDisease-association analysis of an inflammation-related feedback loop
Murakami, M., Harada, M., Kamimura, D., Ogura, H., Okuyama, Y., Kumai, N., Okuyama, A., Singh, R., Jiang, J.-J., Atsumi, T., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.028 · Cited by 110
Macrophages participate in IL‐17‐mediated inflammation
Barin, J. G., Baldeviano, G. C., Talor, M. V., Wu, L., Ong, S., Quader, F., Chen, P., Zheng, D., Caturegli, P., Rose, N. R., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201141737 · Cited by 120
“The prototypic proinflammatory cytokine of the IL17 family, IL17A, defines a novel CD4+ subset, the Th17 lineage [1, 2].”
BackgroundTH17 cells and regulatory T cells in primary immunodeficiency diseases
Ochs, H. D., Oukka, M., & Torgerson, T. R. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.030 · Cited by 110
Quintana, F. J. (2012) · Immunology · doi:10.1111/imm.12046 · Cited by 117
Corneal Allograft Rejection: Immunopathogenesis to Therapeutics
Hamrah, Y. Q. P. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.s9-006 · Cited by 113
The Single-Cell Phenotypic Identity of Human CD8+ and CD4+ T Cells
Brummelman, J., Pilipow, K., & Lugli, E. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.007 · Cited by 113
Regulation of TH17 cell differentiation by innate immune signals
Huang, G., Wang, Y., & Chi, H. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.10 · Cited by 114
Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c + cells through TLR4
Kurakevich, E., Hennet, T., Hausmann, M., Rogler, G., & Borsig, L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306322110 · Cited by 110
“Finally, 3SL stimulation resulted in increased TGF-β1 production, which is linked to induction of TH17 differentiation in the inflammatory environment (19).”
Backgroundde Paiva, C. S., Hwang, C. S., Pitcher, J. D., Pangelinan, S. B., Rahimy, E., Chen, W., Yoon, K. C., Farley, W. J., Niederkorn, J. Y., Stern, M. E., et al. (2009) · Rheumatology · doi:10.1093/rheumatology/kep357 · Cited by 109
T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease
Iclozan, C., Yu, Y., Liu, C., Liang, Y., Yi, T., Anasetti, C., & Yu, X. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.09.023 · Cited by 115
Helper T‐cell identity and evolution of differential transcriptomes and epigenomes
Vahedi, G., Poholek, A. C., Hand, T. W., Laurence, A. D. J., Kanno, Y., O’Shea, J. J., & Hirahara, K. (2013) · Immunological Reviews · doi:10.1111/imr.12037 · Cited by 112
Coquet, J. M., Middendorp, S., Horst, G., Kind, J., Veraar, E. A. M., Xiao, Y., Jacobs, H., & Borst, J. G. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.009 · Cited by 107
“, 2001), IL-4 enables Th2 cell development via GATA-3 (Zheng and Flavell, 1997), and transforming growth factor-b (TGF-b), together with the proinflammatory cytokines IL-6 (Bettelli et al., 2006; Veldhoen et al., 2006) or IL-21 (Korn et al.”
BackgroundInfluentialArcher, N. K., Harro, J. M., & Shirtliff, M. E. (2013) · Infection and Immunity · doi:10.1128/iai.00084-13 · Cited by 107
Milk-Derived Transforming Growth Factor-β and the Infant Immune Response
Penttila, I. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.11.016 · Cited by 111
Th17 cells and Tregs: unlikely allies
Chen, X., & Oppenheim, J. J. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1213633 · Cited by 111
The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
Wacleche, V. S., LANDAY, A. L., Routy, J., & Ancuța, P. (2017) · Viruses · doi:10.3390/v9100303 · Cited by 109
Horlock, C., Stott, B., Dyson, P. J., Morishita, M., Coombes, R. C., Savage, P. M., & Stebbing, J. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604963 · Cited by 107
Liu, J., Lin, F., Strainic, M. G., An, F., Miller, R. H., Altuntas, C. Z., Heeger, P. S., Tuohy, V. K., & Medof, M. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5882 · Cited by 105
The IL-23/IL-17 pathway in inflammatory bowel disease
Geremia, A., & Jewell, D. P. (2012) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.107 · Cited by 112
Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment
Hu, W., Troutman, T. D., Edukulla, R., & Pasare, C. (2011) · Immunity · doi:10.1016/j.immuni.2011.10.013 · Cited by 111
“Several studies have demonstrated that IL-6 is a master inducer of Th17 cell differentiation (Acosta-Rodriguez et al., 2007; Bettelli et al., 2006; Ivanov et al., 2006; Veldhoen et al., 2006; Zhou et al., 2007).”
BackgroundThe dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis
Kerr, E. C., Copland, D. A., Dick, A. D., & Nicholson, L. B. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.07.001 · Cited by 108
Fang, C., Zhang, X., Miwa, T., & Song, W. (2009) · Blood · doi:10.1182/blood-2009-01-198283 · Cited by 111
T Lymphocytes in Sjögren’s Syndrome: Contributors to and Regulators of Pathophysiology
Katsifis, G. E., Moutsopoulos, N. M., & Wahl, S. M. (2007) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-007-8011-8 · Cited by 110
Immune checkpoints in central nervous system autoimmunity
Joller, N., Peters, A., Anderson, A. C., & Kuchroo, V. K. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01136.x · Cited by 106
“IL-6 and TGF-b signals ultimately lead to the expression of the Th17 specific transcription factor RORct, which transactivates many Th17associated factors, including the signature cytokines IL-17A and IL-17F (45).”
BackgroundTh17 cells: positive or negative role in tumor?
Ji, Y., & Zhang, W. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0849-6 · Cited by 108
Xu, L., Gong, Y., Wang, B., Shi, K., Hou, Y., Wang, L., Lin, Z., Han, Y., Lu, L., Chen, D., et al. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12653 · Cited by 107
IL-17 in Systemic Lupus Erythematosus
Crispín, J. C., & Tsokos, G. C. (2010) · BioMed Research International · doi:10.1155/2010/943254 · Cited by 108
TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine
Bain, C. C., Montgomery, J. P., Scott, C. L., Kel, J. M., Girard-Madoux, M. J. H., Martens, L., Zangerle-Murray, T., Ober-Blöbaum, J. L., Lindenbergh-Kortleve, D. J., Samsom, J. N., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00658-6 · Cited by 105
Regulation of IL-17 production in human lymphocytes
Chen, Z., & O’Shea, J. J. (2007) · Cytokine · doi:10.1016/j.cyto.2007.09.009 · Cited by 106
Maynard, C. L., Hatton, R. D., Helms, W. S., Oliver, J. R., Stephensen, C. B., & Weaver, C. T. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20080950 · Cited by 107
From osteoimmunology to osteomicrobiology: How the microbiota and the immune system regulate bone
Hsu, E., & Pacifici, R. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0321-0 · Cited by 106
“Ovx drives differentiation of naı̈ve CD4? helper cells into mature Th17 cells [47], a process which is inhibited by estrogen binding to ERa and stimulated by cytokines such as TGFb, IL-1b, and TNF [32, 33, 48, 49].”
Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells
Sanos, S. L., Vonarbourg, C., Mortha, A., & Diefenbach, A. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03410.x · Cited by 108
Li, J., D’Amelio, P., Robinson, J. W., Walker, L. D., Vaccaro, C., Luo, T., Tyagi, A. M., Yu, M., Reott, M. A., Sassi, F., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.012 · Cited by 105
“…and osteoblasts will be necessary to conclusively confirm this hypothesis. cPTH increases the differentiation of Th17 cells via TNF and GαS signaling IL-6 and TGFβ initiate Th17 differentiation (Basu et al., 2013; Martinez et al., 2008) while TNF, IL-1, and IL-23 amplify it (Veldhoen et al., 2006).”
de, M. M., Kumar, R., Rivera, F. D. L., Amante, F. H., Sheel, M., Faleiro, R. J., Bunn, P. T., Best, S. E., Beattie, L., Ng, S. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.015 · Cited by 102
“Furthermore, IL-6, along with TGF-b, is important for IL-17 production (Bettelli et al., 2006; Mangan et al., 2006; Veldhoen et al., 2006), and the suppression of both IL-6 and IL-17 identifies amajor immunological axis regu- lated by type I IFNs during blood-stage P. falciparum infection.”
BackgroundHonardoost, M. A., Kiani‐Esfahani, A., Ghaedi, K., Etemadifar, M., & Salehi, M. (2014) · Gene · doi:10.1016/j.gene.2014.04.069 · Cited by 104
A Cytokine-Centric View of the Pathogenesis and Treatment of Autoimmune Arthritis
Astry, B., Harberts, E. M., & Moudgil, K. D. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0094 · Cited by 104
Rother, N., & van der Vlag, J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00610 · Cited by 103
“Development of Th17 cells requires TGFβ and IL-6, and they are identified by the specific transcription factor RORγt, and their characteristic production of IL-17 (56, 57).”
BackgroundYu, R., Zuo, F., Ma, H., & Chen, S. (2019) · Nutrients · doi:10.3390/nu11040782 · Cited by 108
ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer
Schumacher, N., & Rose‐John, S. (2019) · Cancers · doi:10.3390/cancers11111736 · Cited by 108
“Recently, it was found that TGFß, together with IL-6, drives the initial differentiation from naïve T-cells to pathogenic IL-17-producing T-cells (TH17 cells), which are key factors for induction of tissue damage in a variety of chronic inflammatory and autoimmune diseases [72,73].”
BackgroundThe Many Faces of CD4+ T Cells: Immunological and Structural Characteristics
Chatzileontiadou, D. S. M., Sloane, H., Nguyen, A., Gras, S., & Grant, E. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010073 · Cited by 109
TRIM28 prevents autoinflammatory T cell development in vivo
Chikuma, S., Suita, N., Okazaki, I., Shibayama, S., & Honjo, T. (2012) · Nature Immunology · doi:10.1038/ni.2293 · Cited by 105
TLR2‐activated human langerhans cells promote Th17 polarization via IL‐1β, TGF‐β and IL‐23
Aliahmadi, E., Gramlich, R., Grützkau, A., Hitzler, M., Krüger, M., Baumgrass, R., Schreiner, M., Wittig, B., Wanner, R., & Peiser, M. (2009) · European Journal of Immunology · doi:10.1002/eji.200838742 · Cited by 103
Cribbs, A. P., Terlecki-Zaniewicz, S., Philpott, M., Baardman, J., Ahern, D., Lindow, M., Obad, S., Oerum, H., Sampey, B. P., Mander, P. K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919893117 · Cited by 102
Rutitzky, L. I., Bazzone, L. E., Shainheit, M. G., Joyce-Shaikh, B., Cua, D. J., & Stadecker, M. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2486 · Cited by 105
IL‐22 and inflammation: Leukin' through a glass onion
Zenewicz, L. A., & Flavell, R. A. (2008) · European Journal of Immunology · doi:10.1002/eji.200838655 · Cited by 104
Pertussis Toxin by Inducing IL-6 Promotes the Generation of IL-17-Producing CD4 Cells
Chen, X., Howard, O. M. Z., & Oppenheim, J. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6123 · Cited by 103
TGFβ signaling in head and neck squamous cell carcinoma
White, R. A., Malkoski, S. P., & Wang, X. (2010) · Oncogene · doi:10.1038/onc.2010.306 · Cited by 104
The CD4-centered universe of human T cell subsets
Geginat, J., Paroni, M., Facciotti, F., Gruarin, P., Kastirr, I., Caprioli, F., Pagani, M., & Abrignani, S. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.012 · Cited by 112
“[76] Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.”
BackgroundInfluentialHundhausen, C., Roth, A., Whalen, E., Chen, J., Schneider, A., Long, S. A., Wei, S., Rawlings, R., Kinsman, M., Evanko, S. P., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9943 · Cited by 104
Recent advances in IBD pathogenesis: Genetics and immunobiology
Shih, D. Q., Targan, S. R., & McGovern, D. P. B. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0104-x · Cited by 105
Regulatory T cells: immune suppression and beyond
Wan, Y. Y. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.20 · Cited by 106
A Role for TGFβ Signaling in the Pathogenesis of Psoriasis
Han, G., Williams, C. A., Salter, K. D., Garl, P. J., Li, A. G., & Wang, X. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.252 · Cited by 103
Role of interleukin-22 in inflammatory bowel disease
Li, L.-J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i48.18177 · Cited by 109
Wang, B., Dileepan, T., Briscoe, S., Hyland, K. A., Kang, J., Khoruts, A., & Cleary, P. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904831107 · Cited by 102
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
Antignano, F., Burrows, K., Hughes, M. R., Han, J. M., Kron, K. J., Penrod, N. M., Oudhoff, M. J., Wang, S. K. H., Min, P. H., Gold, M. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69592 · Cited by 104
Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer
O’Mahony, C., van der Kleij, H. P. M., Bienenstock, J., Shanahan, F., & O’Mahony, L. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90904.2008 · Cited by 103
Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells
Kagami, S., Owada, T., Kanari, H., Saito, Y., Suto, A., Ikeda, K., Hirose, K., Watanabe, N., Iwamoto, I., & Nakajima, H. (2009) · International Immunology · doi:10.1093/intimm/dxp037 · Cited by 102
Bone Remodeling and the Microbiome
Pacifici, R. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031203 · Cited by 101
“…cells into mature Th17 cells (Tyagi et al. 2012a), a phenomenon driven by cytokines such as transforming growth factor b (TGF-b), IL-6, IL-1b, and TNF (Veldhoen et al. 2006; Chen et al. 2011; Sugita et al. 2012; Basu et al. 2013), factors that are all dysregulated by estrogen deficiency (Pacifici…”
BackgroundMorrison, P. J., Ballantyne, S. J., & Kullberg, M. C. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03454.x · Cited by 104
Wang, J., Ren, Z., Xu, Y., Xiao, S., Meydani, S. N., & Wu, D. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.09.007 · Cited by 103
CD28 Co-Stimulation Down Regulates Th17 Development
Bouguermouh, S., Fortin, G., Baba, N., Rubio, M., & Sarfati, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005087 · Cited by 104
Lombardi, V., Overtvelt, L. V., Horiot, S., & Moingeon, P. E. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801969 · Cited by 107
Regulation of Th17 Differentiation by Epidermal Fatty Acid-Binding Protein
Li, B., Reynolds, J. M., Stout, R. D., Bernlohr, D., & Suttles, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804192 · Cited by 100
Regulatory T‐cell immunity and its relevance to atherosclerosis
Taleb, S., Tedgui, A., & Mallat, Z. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01944.x · Cited by 107
Ohsugi, Y. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2001 · Cited by 100
Smith, E. E., Stark, M. A., Zarbock, A., Burcin, T. L., Bruce, A. C., Vaswani, D., Foley, P. L., & Ley, K. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1357 · Cited by 104
Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20100900 · Cited by 100
“In fact, various subsets of effector CD4+ T cells—for example, Th1 cells, Th2 cells, and Th17 cells, which express high levels of IFN-, IL-4, and IL-17A, respectively (Mosmann and Coffman, 1989; Glimcher and Murphy, 2000; Cua et al., 2003; Harrington et al., 2005; Park et al., 2005; Veldhoen et al., 2006; Zhu et al.,…”
Role of Circulating Lymphocytes in Patients with Sepsis
de Pablo, R., Monserrat, J., I, A. P., & Álvarez‐Mon, M. (2014) · BioMed Research International · doi:10.1155/2014/671087 · Cited by 106
Biologics for the primary care physician: Review and treatment of psoriasis
Schadler, E. D., Ortel, B. J., & Mehlis, S. L. (2018) · Disease-a-Month · doi:10.1016/j.disamonth.2018.06.001 · Cited by 101
IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice
von Vietinghoff, S., & Ley, K. F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804080 · Cited by 101
Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses
Mathers, A. R., Janelsins, B., Rubin, J. P., Tkacheva, O. A., Shufesky, W. J., Watkins, S. C., Morelli, A. E., & Larregina, A. T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.921 · Cited by 109
Animal Models of Colitis‐Associated Carcinogenesis
Kanneganti, M., Mino-Kenudson, M. A., & Mizoguchi, E. (2011) · BioMed Research International · doi:10.1155/2011/342637 · Cited by 98
“In addition, IL-6 enhances the differentiation of”
Yu, Y., Zhu, S., Li, P., Min, L., & Zhang, S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0982-2 · Cited by 103
The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A
Fu, J., Huang, Y., Bao, T., Liu, C., Liu, X., & Chen, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02446-6 · Cited by 103
Wu, C., Wang, S., Wang, F., Chen, Q., Peng, S., Zhang, Y., Qian, J., Jin, J., & Xu, H. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04011.x · Cited by 99
Lewkowich, I. P., Lajoie, S., Clark, J. R., Herman, N. S., Sproles, A. A., & Wills-Karp, M. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003879 · Cited by 99
Recent developments in the immunobiology of rheumatoid arthritis
Andersson, A. K., Li, C. L., & Brennan, F. M. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2370 · Cited by 98
Correale, J. D., & Farez, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900897 · Cited by 103
Agasing, A. M., Wu, Q., Khatri, B., Borisow, N., Ruprecht, K., Brandt, A. U., Gawde, S., Kumar, G., Quinn, J. L., Ko, R. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16625-7 · Cited by 98
Koker, S. D., Naessens, T., Geest, B. G. D., Bogaert, P., Demeester, J., Smedt, S. C. D., & Grooten, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803591 · Cited by 100
Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation
Tatara, R., Ozaki, K., Kikuchi, Y., Hatanaka, K., Oh, I., Meguro, A., Matsu, H., Sato, K., & Ozawa, K. (2010) · Cytotherapy · doi:10.3109/14653249.2010.542456 · Cited by 101
Metadata
- Authors
- Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B.
- Affiliations
- National Institute for Medical Research (GB)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stockinger, Brigitta
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 24
- Issue
- 2
- Pages
- 179-189
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2112866067
- Cited by
- 3,605
- References
- 70
- Citations by year
- 2026: 41 · 2025: 54 · 2024: 71 · 2023: 91 · 2022: 110 · 2021: 149 · 2020: 113 · 2019: 114 · 2018: 122 · 2017: 158 · 2016: 138 · 2015: 172 · 2014: 182 · 2013: 219 · 2012: 246
- FWCI
- 126.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI30663, R01AI030663)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- IL-17-producing T cells, TGF-β1, Th17 cell differentiation, regulatory T cells, interleukin-6, TLR3, TLR4, TLR9, IL-1β, TNF-α, IL-23, GATA3, T-bet, Smad7, Th1/Th2 differentiation, naive CD4+ T cells, inflammatory cytokines
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Dendritic Cells, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocytes, CD4-Positive T-Lymphocytes, Lymphocyte Subsets, Cytokines, Transforming Growth Factor beta, Receptors, Interleukin-1, Mice, Knockout, Th1 Cells, Th2 Cells, Interleukin-17, T-Lymphocytes, Regulatory, Mice, Smad7 Protein, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
