The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Open accessAbstract
The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages has recently expanded with description of an IL-17-producing subset, called Th17, which develops via cytokine signals distinct from, and antagonized by, products of the Th1 and Th2 lineages. Remarkably, Th17 development depends on the pleiotropic cytokine TGF-beta, which is also linked to regulatory T cell development and function, providing a unique mechanism for matching CD4 T cell effector and regulatory lineage specification. Here, we review Th17 lineage development, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense.
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In the citing paper
“draws a further parallel between Th17 cells and Treg cells (62).”
From T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [62]
In the citing paper
“The well-established pathological actions of Th17 cells in other diseases (45–47)”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [47]
In the citing paper
“IL-17 is not only the master cytokine of Th17 cells but is also produced by CD8+ T cells and innate lymphocytes, such as γδ T cells, NK cells, and NKT cells.73”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [73]
Citations
Cites
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Cited by
Sorted by citations
Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,928
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
Self-citation
Metadata
- Authors
- Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M.
- Affiliations
- University of Alabama at Birmingham (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Weaver, Casey T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 24
- Issue
- 6
- Pages
- 677-688
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2131678280
- Cited by
- 1,422
- References
- 105
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 18 · 2023: 43 · 2022: 27 · 2021: 42 · 2020: 32 · 2019: 32 · 2018: 35 · 2017: 44 · 2016: 53 · 2015: 59 · 2014: 64 · 2013: 84 · 2012: 87
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2603 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI-35783, AI57956, R01AI057956)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK64400, R24DK064400)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th17 cells, CD4+ T cell differentiation, regulatory T cells, TGF-beta, IL-17, immune regulation, immune pathogenesis, host defense
- MeSH terms
- Animals, Autoimmune Diseases, Cell Differentiation, CD4-Positive T-Lymphocytes, Cell Lineage, Interleukin-17, T-Lymphocytes, Regulatory, Mice
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