Cited by 1,422T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

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Weaver, Casey T., Harrington, Laurie E., Mangan, Paul R., Gavrieli, Maya, Murphy, Kenneth M.·2006·Immunity

DOI 10.1016/j.immuni.2006.06.002

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Abstract

The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages has recently expanded with description of an IL-17-producing subset, called Th17, which develops via cytokine signals distinct from, and antagonized by, products of the Th1 and Th2 lineages. Remarkably, Th17 development depends on the pleiotropic cytokine TGF-beta, which is also linked to regulatory T cell development and function, providing a unique mechanism for matching CD4 T cell effector and regulatory lineage specification. Here, we review Th17 lineage development, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense.

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Authors: Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M.
Affiliations: University of Alabama at Birmingham (US)
Howard Hughes Medical Institute (US)
Corresponding author: Weaver, Casey T.
ORCID: Weaver, Casey T.
Harrington, Laurie E.
Murphy, Kenneth M.
Venue: Immunity
Publisher: Elsevier BV
Published: 2006-06
Volume: 24
Issue: 6
Pages: 677-688
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2006.06.002
OpenAlex: W2131678280
Cited by: 1,422
References: 105
Citations by year: 2026: 15 · 2025: 12 · 2024: 18 · 2023: 43 · 2022: 27 · 2021: 42 · 2020: 32 · 2019: 32 · 2018: 35 · 2017: 44 · 2016: 53 · 2015: 59 · 2014: 64 · 2013: 84 · 2012: 87
FWCI: 13.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2603 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI-35783, AI57956, R01AI057956)
National Institute of Diabetes and Digestive and Kidney Diseases (DK64400, R24DK064400)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: Th17 cells, CD4+ T cell differentiation, regulatory T cells, TGF-beta, IL-17, immune regulation, immune pathogenesis, host defense
MeSH terms: Animals, Autoimmune Diseases, Cell Differentiation, CD4-Positive T-Lymphocytes, Cell Lineage, Interleukin-17, T-Lymphocytes, Regulatory, Mice

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Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

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