The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family
Open accessAbstract
The T cell immunoglobulin mucin (TIM) receptors are involved in the regulation of immune responses, autoimmunity, and allergy. Structures of the N-terminal ligand binding domain of the murine mTIM-1 and mTIM-2 receptors revealed an immunoglobulin (Ig) fold, with four Cys residues bridging a distinctive CC′ loop to the GFC β-sheet. The structures showed two ligand-recognition modes in the TIM family. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding. Biochemical, mutational, and cell adhesion analyses confirmed the divergent ligand-binding modes revealed by the structures. Structural features characteristic of mTIM-1 appear conserved in human TIM-1, which also mediated homophilic interactions. The extracellular mucin domain enhanced binding through the Ig domain, modulating TIM receptor functions. These results explain the divergent immune functions described for the murine receptors and the role of TIM-1 as a cell adhesion receptor in renal regeneration and cancer.
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Cites
Protein Structure Comparison by Alignment of Distance Matrices
Holm, L., & Sander, C. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1489 · Cited by 3,984 · cited 1×
“The structures revealed an Ig domain belonging to the V set (IgV), related to the N-terminal domains of the CD4 and CAR (coxsackievirus and adenovirus receptor) cellular receptors (highest Z score in DALI search) (Holm and Sander, 1993).”
BackgroundIdentification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T., & DeKruyff, R. H. (2001) · Nature Immunology · doi:10.1038/ni739 · Cited by 501
The TIM gene family: emerging roles in immunity and disease
Kuchroo, V. K., Umetsu, D. T., DeKruyff, R. H., & Freeman, G. J. (2003) · Nature Reviews Immunology · doi:10.1038/nri1111 · Cited by 388
Cited by
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
Anderson, A. C., Joller, N., & Kuchroo, V. K. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.001 · Cited by 2,096
Tim‐3 and its role in regulating anti‐tumor immunity
Das, M., Zhu, C., & Kuchroo, V. K. (2017) · Immunological Reviews · doi:10.1111/imr.12520 · Cited by 856
Patterns of Positive Selection in Six Mammalian Genomes
Kosiol, C., Vinař, T., da Fonseca, R. R., Hubisz, M. J., Bustamante, C. D., Nielsen, R., & Siepel, A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000144 · Cited by 576
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane
Bevers, E. M., & Williamson, P. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00020.2015 · Cited by 447
Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry
Moller-Tank, S., Kondratowicz, A. S., Davey, R. A., Rennert, P. D., & Maury, W. (2013) · Journal of Virology · doi:10.1128/jvi.01025-13 · Cited by 285
Metadata
- Authors
- Santiago, C., Ballesteros, A., Tami, C., Martínez-Muñoz, L., Kaplan, G. G., & Casasnovas, J. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 26
- Issue
- 3
- Pages
- 299-310
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2007610160
- Cited by
- 164
- References
- 3
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Santiago, C., Ballesteros, A., Tami, C., Martínez-Muñoz, L., Kaplan, G. G., & Casasnovas, J. M. (2007). Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family. Immunity. https://doi.org/10.1016/j.immuni.2007.01.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
