Cited by 1,586T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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Rubtsov, Yuri P., Rasmussen, Jeffrey P., Chi, Emil Y., Fontenot, Jason, Castelli, Luca, Ye, Xin, Treuting, Piper, Siewe, Lisa, Roers, Axel, Henderson, William R., Muller, Werner, Rudensky, Alexander Y.·2008·Immunity

DOI 10.1016/j.immuni.2008.02.017

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Abstract

The regulatory T (Treg) cells restrain immune responses through suppressor-function elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical role for Treg cells in maintaining lympho-myeloid homeostasis, it remains unclear whether a single mechanism or multiple mechanisms of Treg cell-mediated suppression are operating in vivo and how redundant such mechanisms might be. Here we addressed these questions by examining the role of the immunomodulatory cytokine IL-10 in Treg cell-mediated suppression. Analyses of mice in which the Treg cell-specific ablation of a conditional IL-10 allele was induced by Cre recombinase knocked into the Foxp3 gene locus showed that although IL-10 production by Treg cells was not required for the control of systemic autoimmunity, it was essential for keeping immune responses in check at environmental interfaces such as the colon and lungs. Our study suggests that Treg cells utilize multiple means to limit immune responses. Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting.

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Anandagoda, N., Willis, J., Hertweck, A., Roberts, L. B., Jackson, I., Gökmen, R., Jenner, R. G., Howard, J. K., & Lord, G. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124725 · Cited by 60
IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation
Nguyen, Q. T., Jang, E., Le, H. T., Kim, S., Kim, D., Dvorina, N., Aronica, M. A., Baldwin, W. M., Asosingh, K., COMHAIR, S. A. A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123216 · Cited by 55
Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts
Rahman, T., Das, A., Abir, M. H., Nafiz, I. H., Mahmud, A. R., Sarker, M. R., Emran, T. B., & Hassan, M. M. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156268 · Cited by 62
Induction of transplantation tolerance through regulatory cells: from mice to men
Ferrer, I. R., Hester, J., Bushell, A., & Wood, K. J. (2014) · Immunological Reviews · doi:10.1111/imr.12158 · Cited by 58
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Ostmann, A., Paust, H., Panzer, U., Wegscheid, C., Kapffer, S., Huber, S., Flavell, R. A., Erhardt, A., & Tiegs, G. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012070684 · Cited by 57
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Nakanishi, Y., Ikebuchi, R., Chtanova, T., Kusumoto, Y., Okuyama, H., Moriya, T., Honda, T., Kabashima, K., Watanabe, T., Sakai, Y., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.64 · Cited by 61
Bee Venom Phospholipase A2 Protects against Acetaminophen-Induced Acute Liver Injury by Modulating Regulatory T Cells and IL-10 in Mice
Kim, H., Keum, D., Kwak, J. W., Chung, H., & Bae, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114726 · Cited by 58
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Diefenhardt, P., Nosko, A., Kluger, M. A., Richter, J. V., Wegscheid, C., Kobayashi, Y., Tiegs, G., Huber, S., Flavell, R. A., Stahl, R. A. K., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017091044 · Cited by 57
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Crotty, S. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032102 · Cited by 58
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IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation
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Rivas, M. N., Koh, Y. T., Chen, A., Nguyen, A. L., Lee, Y., Lawson, G., & Chatila, T. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci40591 · Cited by 55
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IL‐10 promotes homeostatic proliferation of human CD8 + memory T cells and, when produced by CD1c + DCs, shapes naive CD8 + T‐cell priming
Nizzoli, G., Larghi, P., Paroni, M., Crosti, M., Moro, M., Neddermann, P., Caprioli, F., Pagani, M., Francesco, R. D., Abrignani, S., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546136 · Cited by 55
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Tian, L., Altin, J. A., Makaroff, L., Franckaert, D., Cook, M., Goodnow, C. C., Dooley, J., & Liston, A. (2011) · Blood · doi:10.1182/blood-2011-04-346056 · Cited by 52
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apc min mice by inhibiting IL-10 secretion and regulatory T-cell generation
Serebrennikova, O. B., Tsatsanis, C., Mao, C., Gounaris, E. G., Ren, W., Siracusa, L. D., Eliopoulos, A. G., Khazaie, K., & Tsichlis, P. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115098109 · Cited by 54
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Burocchi, A., Pittoni, P., Gorzanelli, A., Colombo, M. P., & Piconese, S. (2011) · European Journal of Immunology · doi:10.1002/eji.201141700 · Cited by 56
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Interrelatedness between dysbiosis in the gut microbiota due to immunodeficiency and disease penetrance of colitis
Ray, A., & Dittel, B. N. (2015) · Immunology · doi:10.1111/imm.12511 · Cited by 52
Treg cell–IgA axis in maintenance of host immune homeostasis with microbiota
Feng, T., Elson, C. O., & Cong, Y. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.016 · Cited by 52
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Pelly, V. S., Coomes, S. M., Kannan, Y., Gialitakis, M., Entwistle, L. J., Perez-Lloret, J., Czieso, S., Okoye, I., Rückerl, D., Allen, J. E., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161104 · Cited by 57
Intestinal Antigen-Presenting Cells
Flannigan, K. L., Geem, D., Harusato, A., & Denning, T. L. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.02.024 · Cited by 56
CD49b defines functionally mature Treg cells that survey skin and vascular tissues
Fan, X., Moltedo, B., Mendoza, A., Davydov, A. N., Faire, M. B., Mažutis, L., Sharma, R., Pe’er, D., Chudakov, D. M., & Rudensky, A. Y. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181442 · Cited by 52
Self-citation

Authors: Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., Muller, W., & Rudensky, A. Y.
Affiliations: University of Washington (US)
University of Cologne (DE)
Howard Hughes Medical Institute (US)
Corresponding author: Rudensky, Alexander Y.
ORCID: Rasmussen, Jeffrey P.
Fontenot, Jason
Castelli, Luca
Ye, Xin
Treuting, Piper
Roers, Axel
Henderson, William R.
Rudensky, Alexander Y.
Venue: Immunity
Publisher: Elsevier BV
Published: 2008-04
Volume: 28
Issue: 4
Pages: 546-558
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2008.02.017
OpenAlex: W2030284768
Cited by: 1,586
References: 55
Citations by year: 2026: 70 · 2025: 84 · 2024: 88 · 2023: 83 · 2022: 95 · 2021: 105 · 2020: 96 · 2019: 107 · 2018: 88 · 2017: 95 · 2016: 80 · 2015: 109 · 2014: 90 · 2013: 89 · 2012: 76
FWCI: 31.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1933 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Funders: Howard Hughes Medical Institute
University of Alabama
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: regulatory T cells, IL-10, Foxp3, systemic autoimmunity, intestinal inflammation, lung inflammation, environmental interfaces, suppressor mechanisms, immune homeostasis
MeSH terms: Animals, Autoimmune Diseases, Colitis, Female, Luminescent Proteins, Lung, Male, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity, Skin, Interleukin-10, Mice, Knockout, Inflammation Mediators, Integrases, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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