Cited by 1,586T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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Rubtsov, Yuri P., Rasmussen, Jeffrey P., Chi, Emil Y., Fontenot, Jason, Castelli, Luca, Ye, Xin, Treuting, Piper, Siewe, Lisa, Roers, Axel, Henderson, William R., Muller, Werner, Rudensky, Alexander Y.·2008·Immunity

DOI 10.1016/j.immuni.2008.02.017

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Abstract

The regulatory T (Treg) cells restrain immune responses through suppressor-function elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical role for Treg cells in maintaining lympho-myeloid homeostasis, it remains unclear whether a single mechanism or multiple mechanisms of Treg cell-mediated suppression are operating in vivo and how redundant such mechanisms might be. Here we addressed these questions by examining the role of the immunomodulatory cytokine IL-10 in Treg cell-mediated suppression. Analyses of mice in which the Treg cell-specific ablation of a conditional IL-10 allele was induced by Cre recombinase knocked into the Foxp3 gene locus showed that although IL-10 production by Treg cells was not required for the control of systemic autoimmunity, it was essential for keeping immune responses in check at environmental interfaces such as the colon and lungs. Our study suggests that Treg cells utilize multiple means to limit immune responses. Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting.

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Authors: Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., Muller, W., & Rudensky, A. Y.
Affiliations: University of Washington (US)
University of Cologne (DE)
Howard Hughes Medical Institute (US)
Corresponding author: Rudensky, Alexander Y.
ORCID: Rasmussen, Jeffrey P.
Fontenot, Jason
Castelli, Luca
Ye, Xin
Treuting, Piper
Roers, Axel
Henderson, William R.
Rudensky, Alexander Y.
Venue: Immunity
Publisher: Elsevier BV
Published: 2008-04
Volume: 28
Issue: 4
Pages: 546-558
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2008.02.017
OpenAlex: W2030284768
Cited by: 1,586
References: 55
Citations by year: 2026: 70 · 2025: 84 · 2024: 88 · 2023: 83 · 2022: 95 · 2021: 105 · 2020: 96 · 2019: 107 · 2018: 88 · 2017: 95 · 2016: 80 · 2015: 109 · 2014: 90 · 2013: 89 · 2012: 76
FWCI: 31.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1933 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Funders: Howard Hughes Medical Institute
University of Alabama
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: regulatory T cells, IL-10, Foxp3, systemic autoimmunity, intestinal inflammation, lung inflammation, environmental interfaces, suppressor mechanisms, immune homeostasis
MeSH terms: Animals, Autoimmune Diseases, Colitis, Female, Luminescent Proteins, Lung, Male, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity, Skin, Interleukin-10, Mice, Knockout, Inflammation Mediators, Integrases, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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