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Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection
Open accessAbstract
Through genetic recombination, the adaptive immune system generates a diverse T cell repertoire allowing recognition of a vast spectrum of foreign antigens. Any given CD8+ T cell specificity is thought to be rare, but none have been directly quantified. Here, major histocompatibility complex tetramer and magnetic-bead technology were coupled to quantitate naive antigen-specific CD8+ T cells and the early response to infection. Among six specificities measured, the number of naive antigen-specific precursors ranged from approximately 80 to 1200 cells/mouse. After vesicular stomatitis virus infection, the antigen-specific CD8+ T cell response occurred in discrete phases: prolonged activation of a subset of cells over the first 72 hr followed by a rapid proliferative burst. Naive precursor frequency altered response kinetics and regulated immunodominance, as well as the time required for the responding population to shift toward CD62L(hi) memory cells. Thus, initial endogenous precursor frequencies were surprisingly diverse and not only regulated initial immune response characteristics but also controlled memory CD8+ T cell lineage decisions.
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“Increase in clonal sizes is a hallmark of immune memory; moreover, clonal dominance is quite normal for the memory T cell repertoire responding to a single peptide”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Obar et al., 2008
In the citing paper
“In mice, the TCR repertoire to an antigenic peptide follows a power law distribution involving a large number of T cell specificities, with only a few of them gaining dominance”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Obar et al., 2008
Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
T cell receptor antagonist peptides induce positive selection.
Hogquist, K., Jameson, S., Heath, W., Howard, J. L., Bevan, M., & Carbone, F. (1994) · Cell · doi:10.1016/0092-8674(94)90169-4 · Cited by 3,252
T-cell antigen receptor genes and T-cell recognition
Davis, M. M., & Bjorkman, P. J. (1988) · Nature · doi:10.1038/334395a0 · Cited by 3,202
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126
Molecular and functional profiling of memory CD8 T cell differentiation.
Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026
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Items 401–449 of 449
Homeostasis of the T cell memory compartment
Leitão, C. (2008) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
[Topographic anatomy of the Lockwood ligament].
Grusha, O. V., Grusha, Y. O., & Voropaĭ, E. V. (1998) · PubMed
Chen, W., Luciani, F., Sanders, M. T., Oveissi, S., & Pang, K. C. (2013)
Buchholz, V. R., & Busch, D. H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.08016-4
Thimme, R., Emma Gostick, D., Price, D. A., Lohmann, V., & Neumann‐Haefelin, C. (2014)
Running title: Enumeration of antigen-specific naive CD8 T cells
Alanio, C., Lemaı̂tre, F., Law, H. K., Hasan, M., & Albert, M. L. (2016)
Akram, A. (2014) · TSpace (University of Toronto)
T Cell Vaccinology: Beyond the Reflection of Infectious
Pennock, R. D., Kedl, J. D., & Kedl, R. M. (2016)
Changes of T Cell Receptor (TCR) αβ Repertoire in the Face of Aging and Persistent Infections
Smithey, M. J., & Nikolich‐Žugich, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_12-1
Milanez‐Almeida, P., Martins, A. J., Torabi‐Parizi, P., Franco, L. M., Tsang, J. S., & Germain, R. N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.27.357053
Ma, H., Tan, Y., Liu, X., Shi, X., Zheng, W., Cui, J., Zhang, L., Dou, Y., & Zhou, B. (2021) · Research Square · doi:10.21203/rs.3.rs-309275/v1
Differential Maintenance, Function, and Transcriptional Profile of CD8⁺ T cells with Age
Renkema, K. R. (2013) · UA Campus Repository (The University of Arizona)
Bousso, P., & Moreau, H. D. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717962755.793464710
Faculty Opinions recommendation of One naive T cell, multiple fates in CD8+ T cell differentiation.
Färber, D. L., & Turner, D. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.4480962.4335061
Romero, P. J., & Speiser, D. E. (2011) · Springer eBooks · doi:10.1007/978-1-61779-407-0_12
CD8 Memory Precursor Cells Generation is a Continuous ProcessPreprint
Todorov, H., Prieux, M., Laubreton, D., Bouvier, M., Wang, S., de Bernard, S., Arpin, C., Cannoodt, R., Saelens, W., Bonnaffoux, A., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4055648
Changes of T Cell Receptor (TCR) αβ Repertoire in the Face of Aging and Persistent Infections
Smithey, M. J., & Nikolich‐Žugich, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_12
Age, T Cell Homeostasis, and T Cell Diversity in Humans
Gustafson, C. E., Lamar, D. L., Weyand, C. M., & Goronzy, J. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_9-1
Woodland, D. L. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738416348.793579274
Sharma, S. K. (2023) · Springer eBooks · doi:10.1007/978-981-19-5802-1_4
Swain, A. C. (2023) · doi:10.33540/1850
Cai, C., Keoshkerian, E., Wing, K., Samir, J., Effenberger, M. J. P., Schober, K., Bull, R. A., Lloyd, A. R., Busch, D. H., & Luciani, F. (2024) · Immunology and Cell Biology · doi:10.1111/imcb.12791
Witney, M. J., Croft, N. P., Wong, Y. C., Smith, S. A., Flesch, I. E. A., Keller, E., Gruta, N. L. L., Purcell, A. W., & Tscharke, D. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.18.624047
The Development of Activated CD8 T Cells During Transition From Effector to Memory Phases
Albao, D. S., Nagaraja, S., & Pipkin, M. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00279-9
Kalia, V., Ahmed, R., & Sarkar, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00292-1
Wei, L., Chen, R., Zhang, K., Guo, T., Li, P., & Zhang, C. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1771474
Rôle des lymphocytes cytotoxiques dans les hypersensibilités retardées cutanées
Nosbaum, A. (2013) · theses.fr (ABES) · doi:10.70675/08df0469z5fdbz4f7bz9dbdz857258a2c88d
Espinosa-Carrasco, G. (2016) · theses.fr (ABES) · doi:10.70675/f4c31cbcz110ez48dbza3eaz9a7512ef00fe
Alexandre, Y. O. (2014) · theses.fr (ABES) · doi:10.70675/23671955zcb88z4239z9792z55d7b9341fb0
Rôle des cellules dendritiques conventionnelles de type 1 dans l'immunosurveillance des cancers
Mattiuz, R. (2019) · theses.fr (ABES) · doi:10.70675/2685bed4zde26z40eezad12zdac1c487379e
Structure learning to unravel mechanisms of the immune system
Todorov, H. (2020) · theses.fr (ABES) · doi:10.70675/69543fb0zccf0z4c4dzbd34z6aa4482b1101
Prieux, M. (2023) · theses.fr (ABES) · doi:10.70675/60e19408z260bz435ezaba8zc9581068c165
Limited adaptability of virtual memory CD8 T cells to chronic viral infection
Sajiki, Y., Huang, Y.-C., Perkins, C. M., Ando, S., & Araki, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1804320
A stochastic agent-based model for naive CD8+ T cell recirculation dynamics in mice
Elrefaei, N., Christian, D. A., & Adams, T. A. (2026) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2026.112577
Immunity, Pathogenesis, and Prevention of Poxvirus Infections: A Dissertation
Seedhom, M. O. (2010) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/trbs-0z56
Leger, S., & James, A. T. (2012) · D-Scholarship@Pitt (University of Pittsburgh)
Persaud, S. P. (2015) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k75h7ddz
Salman, A. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Obar, J. J., Khanna, K. M., & Lefrançois, L.
- Affiliations
- UConn Health (US)
- Corresponding author
- Lefrançois, Leo
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 28
- Issue
- 6
- Pages
- 859-869
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC2836785
- OpenAlex
- W2027434623
- Cited by
- 449
- References
- 62
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 7 · 2023: 19 · 2022: 14 · 2021: 18 · 2020: 20 · 2019: 13 · 2018: 21 · 2017: 14 · 2016: 17 · 2015: 29 · 2014: 36 · 2013: 57 · 2012: 51
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1872 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AI41576, F32AI074277)
- Damon Runyon Cancer Research Foundation (DRG-1886-05)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- naive CD8+ T cells, T cell precursor frequency, antigen-specific T cells, primary immune response, memory T cells, immunodominance, L-selectin, T cell proliferation, MHC tetramers, magnetic bead separation
- MeSH terms
- Animals, Immunologic Memory, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Transgenic, RNA, Messenger, Vesicular stomatitis Indiana virus, Histocompatibility Antigens Class I, Rhabdoviridae Infections, CD8-Positive T-Lymphocytes, Lymphocyte Count, L-Selectin, Cell Proliferation, Mice, Precursor Cells, T-Lymphoid
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