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Plasticity of CD4+ T Cell Lineage Differentiation

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Zhou, Liang, Chong, Mark M.W., Littman, Dan R.·2009·Immunity

DOI 10.1016/j.immuni.2009.05.001

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Abstract

The differentiation of naive CD4(+) T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-gamma, whereas Th2 cells express IL-4. The discovery and investigation of two other CD4(+) T cell subsets, induced regulatory T (iTreg) cells and Th17 cells, has led to a rethinking of the notion that helper T cell subsets represent irreversibly differentiated endpoints. Accumulating evidence suggests that CD4(+) T cells, particularly iTreg and Th17 cells, are more plastic than previously appreciated. It appears that expression of Foxp3 by iTreg cells or IL-17 by Th17 cells may not be stable and that there is a great degree of flexibility in their differentiation options. Here, we will discuss recent findings that demonstrate the plasticity of CD4(+) T cell differentiation and the biological implications of this flexibility.

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Authors: Zhou, L., Chong, M. M. W., & Littman, D. R.
Affiliations: Howard Hughes Medical Institute (US)
New York University (US)
Corresponding author: Littman, Dan R.
ORCID: Zhou, Liang
Chong, Mark M.W.
Littman, Dan R.
Venue: Immunity
Publisher: Elsevier BV
Published: 2009-05
Volume: 30
Issue: 5
Pages: 646-655
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2009.05.001
OpenAlex: W2016827757
Cited by: 1,551
References: 101
Citations by year: 2026: 33 · 2025: 48 · 2024: 51 · 2023: 61 · 2022: 73 · 2021: 96 · 2020: 73 · 2019: 61 · 2018: 68 · 2017: 77 · 2016: 90 · 2015: 99 · 2014: 110 · 2013: 145 · 2012: 134
FWCI: 11.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1574 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: CD4+ T cell differentiation, T cell plasticity, Th1 cells, Th2 cells, induced regulatory T cells, Th17 cells, Foxp3, IL-17, T helper cell subsets
MeSH terms: Animals, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, T-Lymphocyte Subsets, Cytokines, Cell Lineage, T-Lymphocytes, Regulatory, Forkhead Transcription Factors

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Plasticity of CD4+ T Cell Lineage Differentiation

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