Etiology of Type 1 Diabetes

CTLA-4 Control over Foxp3 + Regulatory T Cell Function

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723

Factors influencing the composition of the intestinal microbiota in early infancy

Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232

ChIP–seq: advantages and challenges of a maturing technology

Park, P. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2641 · Cited by 2,217

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Ueda, H., Howson, J. M. M., Esposito, L., Heward, J., Snook, Chamberlain, G., Rainbow, D. B., Hunter, K. M. D., Smith, A. N., Di Genova, G., et al. (2003) · Nature · doi:10.1038/nature01621 · Cited by 2,175

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921

Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A., & Soltész, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60568-7 · Cited by 1,854

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D. P., Heath, S. C., Depner, M., Berg, A. V., Bufe, A., Rietschel, E., et al. (2007) · Nature · doi:10.1038/nature06014 · Cited by 1,590

Immune interventions to preserve β cell function in type 1 diabetes

Ehlers, M. R. (2015) · Journal of Investigative Medicine · doi:10.1097/jim.0000000000000227 · Cited by 28

First application of a transcutaneous optical single-port glucose monitoring device in patients with type 1 diabetes mellitus

Rumpler, M., Mader, J. K., Fischer, J., Thar, R., Granger, J., Deliane, F., Klimant, I., Aberer, F., Sinner, F. M., Pieber, T. R., et al. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.039 · Cited by 25

Preparation and Characterization of Hypoglycemic Nanoparticles for Oral Insulin Delivery

Zhang, L., Zhang, Y., Qiu, J.-N., Li, J., Chen, W., & Guan, Y. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01322 · Cited by 25

The gut microbiota perspective for interventions in MS

Żołędziewska, M. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.016 · Cited by 25

High meat consumption is associated with type 1 diabetes mellitus in a Sardinian case–control study

Muntoni, S., Mereu, R., Atzori, L., Mereu, A., Galassi, S., Corda, S., Frongia, P., Angius, E., Contu, P., Contu, P., et al. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0385-2 · Cited by 27

A cognitive behavioural model of the bidirectional relationship between disordered eating and diabetes self care in people with type 1 diabetes mellitus

Harrison, A., Zaremba, N., Brown, J., Allan, J., Konstantara, E., Hopkins, D., Treasure, J. L., Ismail, K., & Stadler, M. (2021) · Diabetic Medicine · doi:10.1111/dme.14578 · Cited by 24

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved

Giusti, L., Tesi, M., Ciregia, F., Marselli, L., Zallocco, L., Suleiman, M., Luca, C. D., Guerra, S. D., Zuccarini, M., Trerotola, M., et al. (2022) · Cells · doi:10.3390/cells11152465 · Cited by 22

Applications of Genome-Editing Technologies for Type 1 Diabetes

Nahas, R. E., Al‐Aghbar, M. A., Herrero, L., van Panhuys, N., & Espino‐Guarch, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010344 · Cited by 27

Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

Lo, B., Swafford, A. D.-E., Shafer-Weaver, K., Jerome, L. F., Rakhlin, L., Mathern, D. R., Callahan, C. A., Jiang, P. D., Davison, L. J., Stevens, H. E., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-203 · Cited by 26

Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes

Żurawek, M., Fichna, M., Fichna, P., Skowrońska, B., Dzikiewicz‐Krawczyk, A., Januszkiewicz, D., & Nowak, J. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.11.008 · Cited by 24

Strategies for clinical trials in type 1 diabetes

Ehlers, M. R. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.03.008 · Cited by 25

The recent rise in the frequency of type 1 diabetes: Who pulled the trigger?

Hasham, A., & Tomer, Y. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.04.001 · Cited by 24

Towards Safe and Robust Closed-Loop Artificial Pancreas Using Improved PID-Based Control Strategies

Alshalalfah, A.-L., Hamad, G. B., & Mohamed, O. A. (2021) · IEEE Transactions on Circuits and Systems I Regular Papers · doi:10.1109/tcsi.2021.3058355 · Cited by 24

Mechanisms and therapeutic strategies of immune checkpoint molecules and regulators in type 1 diabetes

Ding, J., Yang, K., Lin, K.-L., Cao, Y.-K., & Zou, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1090842 · Cited by 25

Autoimmunity and inflammation: murine models and translational studies

Hall, S. W., & Cooke, A. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9338-2 · Cited by 23

Decreased dendritic cell numbers but increased TLR9-mediated interferon-alpha production in first degree relatives of type 1 diabetes patients

Kayserová, J., Včeláková, J., Štechová, K., Dudkova, E., Hromádková, H., Šumnı́k, Z., Koloušková, S., Špíšek, R., & Šedivá, A. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.03.018 · Cited by 23

HLA-DQB1* alleles and genetic susceptibility to type 1 diabetes mellitus

Mosaad, Y. M. (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i8.149 · Cited by 25

Anti‐ CD 25 monoclonal antibody Fc variants differentially impact regulatory T cells and immune homeostasis

Huss, D. J., Pellerin, A., Collette, B., Kannan, A., Peng, L., Datta, A., Wipke, B. T., & Fontenot, J. D. (2016) · Immunology · doi:10.1111/imm.12609 · Cited by 23

Guts, Germs, and Meals: The Origin of Type 1 Diabetes

Beyan, H., Li, W., & Leslie, R. D. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0298-z · Cited by 22

Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study

Rose, K., Penna-Martinez, M., Klahold, E., Kärger, D., Shoghi, F., Kahles, H., Bayer, M., Hintermann, E., Pfeilschifter, J. M., Badenhoop, K. W. J., et al. (2012) · Clinical & Experimental Immunology · doi:10.1111/cei.12013 · Cited by 22

Pancreatic Beta Cell Survival and Signaling Pathways: Effects of Type 1 Diabetes-Associated Genetic Variants

Santín, I., dos Santos, R. S., & Eizirik, D. L. (2015) · Methods in molecular biology · doi:10.1007/7651_2015_291 · Cited by 20

The association between Type 1 diabetes mellitus and periodontal diseases

Sun, K., Chen, S.-C., Lin, C., Hsu, J.-T., Chen, I.-A., Wu, I., Palanisamy, K., Shen, T., & Li, C. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.10.012 · Cited by 22

Reduction of Connexin36 Content by ICER-1 Contributes to Insulin-Secreting Cells Apoptosis Induced by Oxidized LDL Particles

Haefliger, J., Martin, D. J., Favre, D., Petremand, Y., Mazzolai, L., Abderrahmani, A., Meda, P., Waeber, G., & Allagnat, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055198 · Cited by 22

Follicular Helper T Cells in Autoimmunity

Scherm, M. G., Ott, V. B., & Daniel, C. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0770-2 · Cited by 23

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

Truman, L. A., Pękalski, M. Ł., Kareclas, P., Evangelou, M., Walker, N. M., Howlett, J., Mander, A., Kennet, J., Wicker, L. S., Bond, S. J., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009799 · Cited by 20

MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance

Blum, S. I., Taylor, J. P., Barra, J. M., Burg, A. R., Shang, Q., Qiu, S., Shechter, O., Hayes, A. R., Green, T. J., Geurts, A. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.157929 · Cited by 20

Using epigenetic mechanisms to understand the impact of common disease causing alleles

Leung, A., Schones, D. E., & Natarajan, R. D. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.07.004 · Cited by 21

T regulatory lymphocytes in type 1 diabetes: Impaired CD25 expression and IL-2 induced STAT5 phosphorylation in pediatric patients

Paračková, Z., Kayserová, J., Dáňová, K., Šišmová, K., Dudkova, E., Šumnı́k, Z., Koloušková, S., Lebl, J., Štechová, K., & Šedivá, A. (2016) · Autoimmunity · doi:10.1080/08916934.2016.1217998 · Cited by 20

Modeling Glucagon Action in Patients With Type 1 Diabetes

Emami, A., Youssef, J. E., Rabasa-Lhoret, R., Pineau, J., Castle, J. R., & Haidar, A. (2017) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2016.2593630 · Cited by 20

Predictors of progression to Type 1 diabetes: preparing for immune interventions in the preclinical disease phase

Gorus, F., Keymeulen, B., Veld, P. I. '., & PIPELEERS, D. G. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.856757 · Cited by 20

A Model-Based Insulin Dose Optimization Algorithm for People With Type 1 Diabetes on Multiple Daily Injections Therapy

Fathi, A. E., Kearney, R. E., Palisaitis, E., Boulet, B., & Haidar, A. (2020) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2020.3023555 · Cited by 21

Genetic Determinants of Enterovirus Infections: Polymorphisms in Type 1 Diabetes and Innate Immune Genes in the MIDIA Study

Witsø, E., Cinek, O., Tapia, G., Brorsson, C., Stene, L. C., Gjessing, H. K., Rasmussen, T., Bergholdt, R., Pociot, F., & Rønningen, K. S. (2015) · Viral Immunology · doi:10.1089/vim.2015.0067 · Cited by 20

A study of type-1 diabetes associated autoantibodies in schizophrenia

Hallford, P., Clair, D. S., Halley, L., Mustard, C. J., & Wei, J. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.07.020 · Cited by 20

Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery

Hotta-Iwamura, C., Benck, C. J., Coley, W., Liu, Y., Zhao, Y., Quiel, J. A., & Tarbell, K. V. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.01.005 · Cited by 20

Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds

Denyer, A. L., Massey, J., Davison, L. J., Ollier, W., Catchpole, B., & Kennedy, L. J. (2020) · Canine Medicine and Genetics · doi:10.1186/s40575-020-00093-9 · Cited by 23

Modelling glucose dynamics during moderate exercise in individuals with type 1 diabetes

Alkhateeb, H., Fathi, A. E., Ghanbari, M., & Haidar, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248280 · Cited by 20

Systemic Levels of CCL 2, CCL 3, CCL 4 and CXCL 8 Differ According to Age, Time Period and Season among Children Newly Diagnosed with type 1 Diabetes and their Healthy Siblings

Thorsen, S. U., Eising, S., Mortensen, H. B., Skogstrand, K., Pociot, F., Johannesen, J., Svensson, J., & the Danish Childhood Diabetes Registry (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12240 · Cited by 19

Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)

Akbar, T., McGurnaghan, S. J., Palmer, C. N. A., Livingstone, S. J., Petrie, J. R., Chalmers, J., Lindsay, R. S., McKnight, J. A., Pearson, D. W. M., Patrick, A. W., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw152 · Cited by 20

Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes

Lu, F., Wu, B., & Wang, Y. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01575-y · Cited by 20

IL-2Rβ–Dependent Signaling and CD103 Functionally Cooperate To Maintain Tolerance in the Gut Mucosa

Yuan, X., Dee, M. J., Altman, N. H., & Malek, T. R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400955 · Cited by 21

A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes

Awata, T., Yamashita, H., Kurihara, S., Morita‐Ohkubo, T., Miyashita, Y., Katayama, S., Kawasaki, E., Tanaka, S. A., Ikegami, H., Maruyama, T., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.102 · Cited by 19

B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice

Leeth, C. M., Racine, J. J., Chapman, H. D., Arpa, B., Carrillo, J., Carrascal, J., Wang, Q., Ratiu, J. J., Egia‐Mendikute, L., Rosell‐Mases, E., et al. (2016) · Diabetes · doi:10.2337/db15-1606 · Cited by 19

Islet-on-a-chip for the study of pancreatic β-cell function

Rodríguez‐Comas, J., & Ramón‐Azcón, J. (2021) · In vitro models · doi:10.1007/s44164-021-00005-6 · Cited by 20

Strategies for the prevention of autoimmune Type 1 diabetes

Todd, J. A., Knip, M., & Mathieu, C. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03400.x · Cited by 18

Epigenetics of autoimmune diabetes

Jayaraman, S. (2011) · Epigenomics · doi:10.2217/epi.11.78 · Cited by 19

Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies

Maziarz, M., Hagopian, W., Palmer, J. P., Sanjeevi, C. B., Kockum, I. S., Breslow, N. E., Lernmark, Å., Graham, J., MacNeney, B., Arnqvist, H. J., et al. (2015) · Genes and Immunity · doi:10.1038/gene.2015.43 · Cited by 19

Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation

Sun, C., Xue, L., Zhu, Z., Zhang, F., Yang, R., Yuan, X., Jia, Z., & Liu, Q. (2016) · Mediators of Inflammation · doi:10.1155/2016/9275106 · Cited by 18

Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)

He, X., Han, W., Hu, S., Zhang, M., Hua, J., & Peng, S. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2220-x · Cited by 18

Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms

Yu, Z., Li, C. F., Mkhikian, H., Zhou, R. W., Newton, B. L., & Demetriou, M. (2014) · Genes and Immunity · doi:10.1038/gene.2014.7 · Cited by 18

Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes

Lipes, M. A., & Galderisi, A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0598-1 · Cited by 18

Chitosan-coated rectangular DNA nanospheres for better outcomes of anti-diabetic drug

Baig, M. M. F. A., Naveed, M., Abbas, M., Kassim, S. A., Khan, G. J., Ullah, S., Sohail, M., Nawaz, W., Younis, M. R., & Ansari, M. T. (2019) · Journal of Nanoparticle Research · doi:10.1007/s11051-019-4534-1 · Cited by 17

Altered Metabolic Signature in Pre-Diabetic NOD Mice

Madsen, R. B., Banday, V. S., Möritz, T., Trygg, J., & Lejon, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035445 · Cited by 17

T-cell receptor repertoire analysis in monozygotic twins concordant and discordant for type 1 diabetes

Fozza, C., Contini, S., Corda, G., Virdis, P., Galleu, A., Bonfigli, S., Pacifico, A., Maioli, M., Mastinu, F., Pitzalis, M., et al. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.01.002 · Cited by 17

Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 Diabetes

Elmaoğulları, S., Uçaktürk, S. A., Elbeğ, Ş., Döğer, E., Tayfun, M., Gürbüz, F., & Bıdecı, A. (2017) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.5020 · Cited by 17

Shared genetic factors and their causality in autoimmune diseases

Yamamoto, K., & Okada, Y. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215099 · Cited by 17

The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes

Inoue, R., Nishiyama, K., Li, J., Miyashita, D., Ono, M., Terauchi, Y., & Shirakawa, J. (2021) · Cells · doi:10.3390/cells10071589 · Cited by 20

GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus

Duarte, G. C. K., Assmann, T. S., Dieter, C., de Souza, B. M., & Crispim, D. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1009-7 · Cited by 18

Restoration of the type I IFN–IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice

Rahman, M. J., Rodrigues, K. B., Quiel, J. A., Liu, Y., Bhargava, V., Zhao, Y., Hotta-Iwamura, C., Shih, H., Lau-Kilby, A. W., Malloy, A. M. W., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97843 · Cited by 17

Three-dimensional bioprinting of functional β-islet-like constructs

Parvaneh, S., Kemény, L. V., Ghaffarinia, A., Yarani, R., & Veréb, Z. (2023) · International Journal of Bioprinting · doi:10.18063/ijb.v9i2.665 · Cited by 18

Elevated systemic glutamic acid level in the non‐obese diabetic mouse is Idd linked and induces beta cell apoptosis

Banday, V. S., & Lejon, K. (2016) · Immunology · doi:10.1111/imm.12674 · Cited by 16

An Unannounced Meal Detection Module for Artificial Pancreas Control Systems

Fathi, A. E., Palisaitis, E., Boulet, B., Legault, L., & Haidar, A. (2019) · Proceedings of the ... American Control Conference/Proceedings of the American Control Conference · doi:10.23919/acc.2019.8814932 · Cited by 16

Pancreatectomy, Islet Cell Transplantation, and Nutrition Considerations

Narayanan, S., Bhutiani, N., Adamson, D. T., & Jones, C. M. (2020) · Nutrition in Clinical Practice · doi:10.1002/ncp.10578 · Cited by 16

Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets

Tran, D. T., Pottekat, A., Lee, K., Raghunathan, M., Loguercio, S., Mir, S. A., Paton, A. W., Paton, J. C., Arvan, P., Kaufman, R. J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac493 · Cited by 13

Genetics of Type 1 Diabetes

Zemunik, T., & Borask, V. (2011) · InTech eBooks · doi:10.5772/21880 · Cited by 18

Association analysis of PTPN22 , CTLA4 and IFIH1 genes with type 1 diabetes in C olombian families在哥伦比亚家族中进行的PTPN22、CTLA4以及IFIH1基因与1型糖尿病的相关性分析

Rodríguez, A. M., Alfaro, J. M. E., Balthazar, V., & Pineda-Trujillo, N. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12192 · Cited by 16

First reported case of diabetes mellitus type 1 as a possible secondary autoimmune disease following alemtuzumab treatment in MS

Malmeström, C., Andersson, B. A., & Lycke, J. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7448-y · Cited by 16

Noninsulin pharmacological management of type 1 diabetes mellitus

Garg, V. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.83053 · Cited by 18

FUT 2 non‐secretor status is associated with Type 1 diabetes susceptibility in Japanese children

Ihara, K., Fukano, C., Abe, Y., Fukami, M., Ogata, T., Kawamura, T., Urakami, T., Kikuchi, N., Yokota, I., Takemoto, K., et al. (2016) · Diabetic Medicine · doi:10.1111/dme.13288 · Cited by 16

Pesticides Residues in Egyptian Diabetic Children: A Preliminary Study

Morsi, D. A. E. (2012) · Journal of Clinical Toxicology · doi:10.4172/2161-0495.1000138 · Cited by 16

Incidence trend of type 1 diabetes mellitus in Serbia

Ciric, V. M., Rancic, N. K., Pešić, M., Slobodan, A., Kocić, R., Danijela, R., & Radenković, S. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-0504-y · Cited by 15

A Reproducible Bioimpedance Transducer for Insulin Noninvasive Measurement

Arpaïa, P., Mancino, F., & Moccaldi, N. (2023) · IEEE Transactions on Instrumentation and Measurement · doi:10.1109/tim.2023.3264037 · Cited by 16

Advances in the Pathogenesis and Treatment Strategies for Type 1 Diabetes Mellitus

Du, M., Li, S., Jiang, J., Ma, X., Liu, L., Wang, T., Zhang, J., & Niu, D. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114185 · Cited by 18

Targeting the trimolecular complex

Michels, A. W. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.02.020 · Cited by 16

RNA-seq methods for identifying differentially expressed gene in human pancreatic islet cells treated with pro-inflammatory cytokines

Li, B., Bi, C. L., Lang, N., Li, Y. Z., Xu, C., Zhang, Y. Q., Zhai, A. X., & Cheng, Z. F. (2014) · Molecular Biology Reports · doi:10.1007/s11033-013-3016-2 · Cited by 15

The Efficacy of Basal Rate and Carbohydrate Ratio Learning Algorithm for Closed-Loop Insulin Delivery (Artificial Pancreas) in Youth with Type 1 Diabetes in a Diabetes Camp

Palisaitis, E., Fathi, A. E., Oettingen, J. E. V., Krishnamoorthy, P., Kearney, R. E., Jacobs, P. G., Rutkowski, J., Legault, L., & Haidar, A. (2019) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2019.0270 · Cited by 15

Efficacy of Stem Cell Application in Diabetes Mellitus: Promising Future Therapy for Diabetes and Its Complications

Hamad, F. R. B., Rahat, N., Shankar, K., & Tsouklidis, N. (2021) · Cureus · doi:10.7759/cureus.13563 · Cited by 18

I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes

Stadinski, B. D., Cleveland, S. B., Brehm, M. A., Greiner, D. L., Huseby, P. G., & Huseby, E. S. (2023) · Nature Immunology · doi:10.1038/s41590-023-01441-0 · Cited by 15

Vitamin D status and the predictors of circulating T helper 1‐type immunoglobulin levels in Iranian subjects with type 1 diabetes and their siblings: a case‐control study

Ghandchi, Z., Neyestani, T. R., Saboor-Yaraghi, A. A., Eshraghian, M. R., Gharavi, A., Shariátzadeh, N., Kalayi, A., & Houshiarrad, A. (2012) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2012.01228.x · Cited by 15

Seed storage proteins of the globulin family are cleaved post-translationally in wheat embryos

Koziol, A. G., Loit, E., McNulty, M. S., MacFarlane, A. J., Scott, F. W., & Altosaar, I. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-385 · Cited by 15

A systematic review of non‐genetic predictors and genetic factors of glycated haemoglobin in type 1 diabetes one year after diagnosis

Gloaguen, E., Bendelac, N., Nicolino, M. P., Julier, C., & Mathieu, F. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3051 · Cited by 18

Basal insulin requirement in patients with type 1 diabetes depends on the age and body mass index

Mitsui, Y., Kuroda, A., Ishizu, M., Mori, H., Kurahashi, K., Kondo, T., Yoshida, S., Akehi, Y., Aihara, K., Endo, I., et al. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13547 · Cited by 13

Effect of 48 Months of Closed-Loop Insulin Delivery on Residual C-Peptide Secretion and Glycemic Control in Newly Diagnosed Youth With Type 1 Diabetes: A Randomized Trial

Ware, J., Boughton, C. K., Allen, J. M., Wilinska, M. E., Hartnell, S., Thankamony, A., Randell, T. L., Ghatak, A., Besser, R. E. J., Elleri, D., et al. (2024) · Diabetes Care · doi:10.2337/dc24-0360 · Cited by 19

On the future of HLA

Thorsby, E. (2011) · Tissue Antigens · doi:10.1111/j.1399-0039.2011.01770.x · Cited by 14

D'oh! Genes and Environment Cause Crohn's Disease

Todd, J. A. (2010) · Cell · doi:10.1016/j.cell.2010.06.015 · Cited by 14

Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes

Creusot, R. J., Battaglia, M., Roncarolo, M., & Fathman, C. G. (2016) · Stem Cells · doi:10.1002/stem.2290 · Cited by 14

Association between interferon-induced helicase (IFIH1 ) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus

Jermendy, Á., Szatmári, I., Körner, A., Szabo, A. J., Tóth‐Heyn, P., & Hermann, R. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12569 · Cited by 14

Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population

Fichna, M., Żurawek, M., Fichna, P., Januszkiewicz, D., & Nowak, J. (2011) · Tissue Antigens · doi:10.1111/j.1399-0039.2011.01828.x · Cited by 14

Collective effects of common single nucleotide polymorphisms and genetic risk prediction in type 1 diabetes

Gui, Y., Lei, X., & Huang, S. (2017) · Clinical Genetics · doi:10.1111/cge.13193 · Cited by 13

Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia

He, X., Kang, Y., Fei, X., Chen, L., Li, X., Ma, Y.-Q., Hu, Q., Qu, S., Wang, H.-Z., Shao, X., et al. (2022) · Purinergic Signalling · doi:10.1007/s11302-021-09829-z · Cited by 13

Subcongenic Analyses Reveal Complex Interactions between Distal Chromosome 4 Genes Controlling Diabetogenic B Cells and CD4 T Cells in Nonobese Diabetic Mice

Stolp, J., Chen, Y., Cox, S. L., Henck, V., Zhang, W., Tsaih, S., Chapman, H. D., Stearns, T. M., SERREZE, D. V., & Silveira, P. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200120 · Cited by 13

Physiopathologie du diabète

Tenenbaum, M., Bonnefond, A., Froguel, P., & Abderrahmani, A. (2018) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(18)30145-x · Cited by 13

Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs

Haider, M. Z., Rasoul, M. A., Al-Mahdi, M., Alkandari, H., & Dhaunsi, G. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198652 · Cited by 13

A pilot non‐inferiority randomized controlled trial to assess automatic adjustments of insulin doses in adolescents with type 1 diabetes on multiple daily injections therapy

Fathi, A. E., Palisaitis, E., Oettingen, J. E. V., Krishnamoorthy, P., Kearney, R. E., Legault, L., & Haidar, A. (2020) · Pediatric Diabetes · doi:10.1111/pedi.13052 · Cited by 13

Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?

Makam, A. A., Biswas, A., Kothegala, L., & Gandasi, N. R. (2022) · Biomedicines · doi:10.3390/biomedicines10112695 · Cited by 14

Redefining disease

Bell, J. I. (2010) · Clinical Medicine · doi:10.7861/clinmedicine.10-6-584 · Cited by 12

Case report: type 1 diabetes in monozygotic quadruplets

Štechová, K., Halbhuber, Z., Hubackova, M., Kayserová, J., Petruželková, L., Včeláková, J., Koloušková, S., Ulmannová, T., Faresjö, M., Neuwirth, A., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.212 · Cited by 12

Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study): an open-label, multicentre, multinational, randomised cross-over study protocol

Fuchs, J., Allen, J. M., Boughton, C. K., Wilinska, M. E., Thankamony, A., de Beaufort, C. E., Campbell, F., Yong, J., Froehlich‐Reiterer, E., Mader, J. K., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-042790 · Cited by 12

An implementation framework and a feasibility evaluation of a clinical decision support system for diabetes management in secondary mental healthcare using CogStack

Patel, D., Msosa, Y. J., Wang, T., Mustafa, O. G., Gee, S., Williams, J., Roberts, A., Dobson, R., & Gaughran, F. (2022) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-022-01842-5 · Cited by 12

Interferon induced with helicase C domain 1 (IFIH1): Trends on helicase domain and type 1 diabetes onset

de Moura, R. R., Araújo, J., Guimarães, R. L., Crovella, S., & Brandão, L. A. C. (2012) · Gene · doi:10.1016/j.gene.2012.11.066 · Cited by 12

The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes

Nakayasu, E. S., Qian, W., Evans‐Molina, C., Mirmira, R. G., Eizirik, D. L., & Metz, T. (2019) · Expert Review of Proteomics · doi:10.1080/14789450.2019.1634548 · Cited by 14

Genetic and Epigenetic Etiologies of Type 1 Diabetes Mellitus

Yahaya, T., Obaroh, I. O., Magaji, U. F., Obadiah, C. D., Anyebe, D., & Shemishere, U. B. (2024) · Iranian journal of diabetes and obesity · doi:10.18502/ijdo.v16i2.15712

An insight into the genetics of type 1 Diabetes

Espino-Paisán, L., Urcelay, E., & Santiago, J. L. (2009) · Inmunología · doi:10.1016/s0213-9626(09)70040-x · Cited by 4

Beyond Genetics: What Causes Type 1 Diabetes

Wang, Z., Xie, Z., Lu, Q., Chang, C., & Zhou, Z. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8592-1 · Cited by 112

Genes predisposing to type 1 diabetes mellitus and pathophysiology: a narrative review

Yahaya, T., & Salisu, T. F. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2101.06680

Implication of epigenetic factors in the pathogenesis of type 1 diabetes

Zhang, J., Chen, L., Zou, Y., Zhang, S., Xiong, F., & Wang, C. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001450 · Cited by 19