Etiology of Type 1 Diabetes

CTLA-4 Control over Foxp3 + Regulatory T Cell Function

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723

Factors influencing the composition of the intestinal microbiota in early infancy

Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232

ChIP–seq: advantages and challenges of a maturing technology

Park, P. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2641 · Cited by 2,217

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Ueda, H., Howson, J. M. M., Esposito, L., Heward, J., Snook, Chamberlain, G., Rainbow, D. B., Hunter, K. M. D., Smith, A. N., Di Genova, G., et al. (2003) · Nature · doi:10.1038/nature01621 · Cited by 2,175

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921

Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A., & Soltész, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60568-7 · Cited by 1,854

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D. P., Heath, S. C., Depner, M., Berg, A. V., Bufe, A., Rietschel, E., et al. (2007) · Nature · doi:10.1038/nature06014 · Cited by 1,590

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456

Understanding mechanisms underlying human gene expression variation with RNA sequencing

Pickrell, J. K., Marioni, J. C., Pai, A. A., Degner, J. F., Engelhardt, B. E., Nkadori, E., Veyrieras, J.-B., Stephens, M., Gilad, Y., & Pritchard, J. K. (2010) · Nature · doi:10.1038/nature08872 · Cited by 1,256

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

Tobi, E. W., Lumey, L. H., Talens, R. P., Kremer, D., Putter, H., Stein, A. D., Slagboom, P. E., & Heijmans, B. T. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp353 · Cited by 1,173

Rituximab, B-lymphocyte depletion, and preservation of beta-cell function

Pescovitz, M. D., Greenbaum, C. J., Krause-Steinrauf, H., Becker, D. J., Gitelman, S. E., Goland, R., Gottlieb, P. A., Marks, J. B., McGee, P. F., Moran, A. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904452 · Cited by 1,093

Redefining Chronic Viral Infection

Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031

Multiple common variants for celiac disease influencing immune gene expression

Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G., Ádány, R., Aromaa, A. J., et al. (2010) · Nature Genetics · doi:10.1038/ng.543 · Cited by 1,027

Rare Variants of IFIH1 , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

Nejentsev, S., Walker, N., Riches, D., Egholm, M., & Todd, J. A. (2009) · Science · doi:10.1126/science.1167728 · Cited by 958

A genome-wide association study of global gene expression

Dixon, A. L., Liang, L., Moffatt, M. F., Chen, W., Heath, S. C., Wong, K., Taylor, J. C., Burnett, E. C., Gut, I. G., Farrall, M., et al. (2007) · Nature Genetics · doi:10.1038/ng2109 · Cited by 946

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

Nakayama, M., Abiru, N., Moriyama, H., Babaya, N., Liu, E., Miao, D., Yu, L.-P., Wegmann, D., Hutton, J., Elliott, J., et al. (2005) · Nature · doi:10.1038/nature03523 · Cited by 821

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium (2010) · Nature · doi:10.1038/nature08979 · Cited by 807

Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors

Hyppönen, E., & Power, C. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.860 · Cited by 756

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

Smyth, D. J., Plagnol, V., Walker, N. M., Cooper, J. D., Downes, K., Yang, J. H. M., Howson, J. M. M., Stevens, H. E., McManus, R., Wijmenga, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807917 · Cited by 750

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domainsPreprint

Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T.-P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., et al. (2010) · Genome Research · doi:10.1101/gr.103101.109 · Cited by 746

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

Tang, Q., Adams, J. Y., Penaranda, C., Melli, K., Piaggio, E., Sgouroudis, E., Piccirillo, C. A., Salomon, B. L., & Bluestone, J. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.016 · Cited by 729

Analysis of islet inflammation in human type 1 diabetes

Willcox, A., Richardson, S. J., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2008.03860.x · Cited by 712

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

Smyth, D. J., Cooper, J. D., Bailey, R., Field, S., Burren, O. S., Smink, L. J., Guja, C., Ionescu-Tirgoviste, C., Widmer, B., Dunger, D. B., et al. (2006) · Nature Genetics · doi:10.1038/ng1800 · Cited by 694

Newly identified genetic risk variants for celiac disease related to the immune response

Hunt, K. A., Zhernakova, A., Turner, G., Heap, G., Franke, L., Bruinenberg, M., Romanos, J., Dinesen, L. C., Ryan, A. W., Panesar, D., et al. (2008) · Nature Genetics · doi:10.1038/ng.102 · Cited by 685

DNA methylation profiles in monozygotic and dizygotic twins

Kaminsky, Z. A., Tang, T., Wang, S.-C., Ptak, C., Oh, G., Wong, A. H. C., Feldcamp, L. A., Virtanen, C., Halfvarson, J., Tysk, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.286 · Cited by 680

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosusPreprint

Javierre, B. M., Fernández, A. F., Richter, J., Al‐Shahrour, F., Martín-Subero, J. I., Rodríguez‐Ubreva, J., Berdasco, M., Fraga, M. F., OʼHanlon, T. P., Rider, L. G., et al. (2009) · Genome Research · doi:10.1101/gr.100289.109 · Cited by 678

Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis

Zipitis, C. S., & Akobeng, A. K. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2007.128579 · Cited by 671

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

Reveille, J. D., Jin, R., Zhou, X., Diekman, L., Sims, A. M., Danoy, P., Leo, P., Bradbury, L. A., Doan, T., Dowling, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.513 · Cited by 669

Orm family proteins mediate sphingolipid homeostasis

Breslow, D. K., Collins, S. R., Bodenmiller, B., Aebersold, R. H., Simons, K., Shevchenko, A., Ejsing, C. S., & Weissman, J. S. (2010) · Nature · doi:10.1038/nature08787 · Cited by 598

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

the IBSEN study group, Franke, A., Balschun, T. C., Karlsen, T. H., Skiecevičienė, J., Nikolaus, S., Gabriele Mayr, B., Domingues, F. S., Albrecht, M., Nothnagel, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.221 · Cited by 590

Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies

Cardwell, C. R., Stene, L. C., Joner, G., Cinek, O., Svensson, J., Goldacre, M. J., Parslow, R. C., Pozzilli, P., Brigis, G., Stoyanov, D., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-0941-z · Cited by 590

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Nejentsev, S., Howson, J. M. M., Walker, N. M., Szeszko, J. S., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M. P., King, E., Masters, J., et al. (2007) · Nature · doi:10.1038/nature06406 · Cited by 573

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

Bending, D., Peña, H. D. L., Veldhoen, M., Phillips, J. M., Uyttenhove, C., Stockinger, B., & Cooke, A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37865 · Cited by 572

Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

Dotta, F., Censini, S., van Halteren, A. G. S., Marselli, L., Masini, M., Dionisi, S., Mosca, F., Boggi, U., Muda, A. O., Prato, S. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700442104 · Cited by 569

A map of open chromatin in human pancreatic islets

Gaulton, K. J., Nammo, T., Pasquali, L., Simon, J. M., Giresi, P. G., Fogarty, M. P., Panhuis, T. M., Mieczkowski, P. A., Secchi, A., Bosco, D., et al. (2010) · Nature Genetics · doi:10.1038/ng.530 · Cited by 540

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Soranzo, N., Spector, T. D., Mangino, M., Kuehnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B. J., Chen, L., Li, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.467 · Cited by 527

Common variants at five new loci associated with early-onset inflammatory bowel disease

Imielinski, M. B., Baldassano, R. N., Griffiths, A. M., Russell, R. K., Annese, V., Dubinsky, M. C., Kugathasan, S., Bradfield, J. P., Walters, T. D., Abou‐Sleiman, P. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.489 · Cited by 484

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

Wegner, N., Lundberg, K., Kinloch, A., Fisher, B. A., Malmström, V., Feldmann, M., & Venables, P. J. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00850.x · Cited by 481

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

Lowe, C. E., Cooper, J. D., Brusko, T. M., Walker, N. M., Smyth, D. J., Bailey, R., Bourget, K., Plagnol, V., Field, S., Atkinson, M. A., et al. (2007) · Nature Genetics · doi:10.1038/ng2102 · Cited by 437

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

Näntö-Salonen, K., Kupila, A., Simell, S., Siljander, H., Salonsaari, T., Hekkala, A., Korhonen, S., Erkkola, R., Sipilä, J. I., Haavisto, L., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61309-4 · Cited by 382

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism

Senée, V., Chelala, C., Duchatelet, S., Feng, D., Blanc, H., Cossec, J., Charon, C., Nicolino, M. P., Boileau, P., Cavener, D. R., et al. (2006) · Nature Genetics · doi:10.1038/ng1802 · Cited by 375

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

Yamanouchi, J., Rainbow, D., Serra, P., Howlett, S., Hunter, K. M. D., Garner, V. E. S., González-Muñoz, A., Clark, J., Veijola, R., Cubbon, R. M., et al. (2007) · Nature Genetics · doi:10.1038/ng1958 · Cited by 367

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

Skowera, A., Ellis, R. J., Varela‐Calviño, R., Arif, S., Huang, G. C., Van-Krinks, C., Zaremba, A., Rackham, C. L., Allen, J. S., Tree, T. I. M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35449 · Cited by 361

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

Turley, S. J., Poirot, L., Hattori, M., Benoist, C. O., & Mathis, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030966 · Cited by 357

Concordance for islet autoimmunity among monozygotic twins

Redondo, M. J., Jeffrey, J., Fain, P. R., Eisenbarth, G. S., & Orban, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0805398 · Cited by 353

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

Raychaudhuri, S., Thomson, B. P., Remmers, E. F., Eyre, S., Hinks, A., Guiducci, C., Catanese, J. J., ., G. X., Stahl, E. A., Chen, R., et al. (2009) · Nature Genetics · doi:10.1038/ng.479 · Cited by 352

Role of PTPN22 in type 1 diabetes and other autoimmune diseases

Bottini, N., Vang, T., Cucca, F., & Mustelin, T. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.03.008 · Cited by 351

Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus

Waterland, R. A., Lin, J.-R., Smith, C. A., & Jirtle, R. L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi484 · Cited by 341

Chromogranin A is an autoantigen in type 1 diabetes

Stadinski, B. D., Delong, T., Reisdorph, N. A., Reisdorph, R. M., Powell, R. L., Armstrong, M., Piganelli, J. D., Barbour, G., Bradley, B., Crawford, F., et al. (2010) · Nature Immunology · doi:10.1038/ni.1844 · Cited by 339

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

Wallace, C., Smyth, D. J., Maisuria-Armer, M., Walker, N. M., Todd, J. A., & Clayton, D. G. (2009) · Nature Genetics · doi:10.1038/ng.493 · Cited by 329

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

Keymeulen, B., Walter, M., Mathieu, C., Kaufman, L., Gorus, F., Hilbrands, R., Vandemeulebroucke, E., de Velde, U. V., Crenier, L., Block, C. E. M. D., et al. (2010) · Diabetologia · doi:10.1007/s00125-009-1644-9 · Cited by 322

Tissue-mediated control of immunopathology in coeliac disease

Jabrì, B., & Sollid, L. M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2670 · Cited by 305

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease

Verlaan, D. J., Berlivet, S., Hunninghake, G. M., Madore, A.-M., Larivière, M., Moussette, S., Grundberg, E., Kwan, T., Ouimet, M., Ge, B., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.08.007 · Cited by 297

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

Long, S. A., Cerosaletti, K. M., Bollyky, P. L., Tatum, M., Shilling, H. G., Zhang, S., Zhang, Z., Pihoker, C., Sanda, S., Greenbaum, C. J., et al. (2009) · Diabetes · doi:10.2337/db09-0694 · Cited by 296

IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)

Jones, J., Phuah, C., Cox, A. L., Thompson, S. A. J., Ban, M., Shawcross, J., Walton, A., Sawcer, S. J., Compston, A., & Coles, A. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37878 · Cited by 296

Clinical Applications of Diabetes Antibody Testing

Bingley, P. J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1365 · Cited by 278

The methylome: approaches for global DNA methylation profiling

Beck, S., & Rakyan, V. K. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.01.006 · Cited by 277

The Genetics of Crohn's Disease

Limbergen, J. V., Wilson, D. C., & Satsangi, J. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082908-150013 · Cited by 275

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Dendrou, C. A., Plagnol, V., Fung, E., Yang, J. H. M., Downes, K., Cooper, J. D., Nutland, S., Coleman, G., Himsworth, M., Hardy, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.434 · Cited by 274

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

Cantero-Recasens, G., Fandos, C., Rubio-Moscardó, F., Valverde, M. A., & Vicente, R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp471 · Cited by 269

Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level

Kurreeman, F. A. S., Schonkeren, J. J. M., Heijmans, B. T., Toes, R. E. M., & Huizinga, T. W. J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh187 · Cited by 262

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

Maier, L. M., Lowe, C. E., Cooper, J. D., Downes, K., Anderson, D. E., Severson, C., Clark, P., Healy, B. C., Walker, N. M., Aubin, C., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000322 · Cited by 260

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

Clayton, D. G. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000540 · Cited by 257

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes

Wenzlau, J. M., Liu, Y., Yu, L., Moua, O., Fowler, K. T., Rangasamy, S., Walters, J., Eisenbarth, G. S., Davidson, H. W., & Hutton, J. C. (2008) · Diabetes · doi:10.2337/db08-0522 · Cited by 205

Insulin as an autoantigen in NOD/human diabetes

Zhang, L., Nakayama, M., & Eisenbarth, G. S. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.11.005 · Cited by 203

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.

Cucca, F., Lampis, R., Congia, M., Angius, E., Nutland, S., Bain, S., Barnett, A., & Todd, J. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.19.2025 · Cited by 202

Thymus‐specific deletion of insulin induces autoimmune diabetes

Fan, Y., Rudert, W., Grupillo, M., He, J., Sisino, G., & Trucco, M. (2009) · EMBO Journal · doi:10.1038/emboj.2009.212 · Cited by 201

Successful oral tolerance induction in severe peanut allergy

Clark, A. T., Islam, S., King, Y., Deighton, J., Anagnostou, A., & Ewan, P. W. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.01982.x · Cited by 200

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

Arechiga, A. F., Habib, T., He, Y., Zhang, X., Zhang, Z., Funk, A., & Buckner, J. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0713370 · Cited by 196

Humanized mouse models to study human diseases

Brehm, M. A., Shultz, L. D., & Greiner, D. L. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328337282f · Cited by 190

Interferon-α initiates type 1 diabetes in nonobese diabetic mice

Li, Q., Xu, B., Michie, S. A., Rubins, K., Schreriber, R. D., & McDevitt, H. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806439105 · Cited by 189

Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus

Svoren, B. M., Volkening, L. K., Wood, J. R., & Laffel, L. M. B. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.07.015 · Cited by 187

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

Sutherland, A. P. R., Belle, T. V., Wurster, A. L., Suto, A., Michaud, M., Zhang, D., Grusby, M. J., & von Herrath, M. (2009) · Diabetes · doi:10.2337/db08-0882 · Cited by 178

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

Mohan, J. F., Levisetti, M. G., Calderón, B., Herzog, J., Petzold, S. J., & Unanue, E. R. (2010) · Nature Immunology · doi:10.1038/ni.1850 · Cited by 177

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

Lawson, J. M., Tremble, J. M., Dayan, C. M., Beyan, H., Leslie, R. D., Peakman, M., & Tree, T. I. M. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03810.x · Cited by 175

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

Heap, G., Yang, J. H. M., Downes, K., Healy, B. C., Hunt, K. A., Bockett, N. A., Franke, L., Dubois, P. C. A., Mein, C. A., Dobson, R., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp473 · Cited by 175

Characterization of human epigenomes

Wang, Z., Schones, D. E., & Zhao, K. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.02.001 · Cited by 160

Type 1 diabetes genes and pathways shared by humans and NOD mice

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Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity

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