The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
Open accessAbstract
SUMMARY There is a discrepancy between the in vitro anergic state of CD4+CD25hiFoxP3+ regulatory T (Treg) cells and their in vivo proliferative capability. The underlying mechanism of this paradox is unknown. Here we show that the anergic state of Treg cells depends on the elevated activity of the mammalian target of rapamycin-(mTOR)-pathway induced by leptin: a transient inhibition of mTOR with rapamycin, before T-cell-receptor-(TCR)-stimulation, made Treg cells highly proliferative in the absence of exogenous interleukin-2 (IL-2). This was a dynamic and oscillatory phenomenon characterized by an early downregulation of the leptin-mTOR-pathway followed by an increase in mTOR activation necessary for Treg cell expansion to occur. These data suggest that energy metabolism, through the leptin-mTOR-axis, sets responsiveness of Treg cells that use this information to control immune tolerance and autoimmunity.
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Cites
Regulatory T Cells and Immune Tolerance
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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
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mTOR regulates memory CD8 T-cell differentiation
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Normalization of obesity-associated insulin resistance through immunotherapy
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The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
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Hypothalamic mTOR Signaling Regulates Food Intake
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Cited by
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588
Mitochondrial ROS Signaling in Organismal Homeostasis
Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353
Self-citationMetabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Regulation and function of mTOR signalling in T cell fate decisions
Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035
Regulation of Immune Responses by mTOR
Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836
Metadata
- Authors
- Procaccini, C., De Rosa, V., Galgani, M., Abanni, L., Calì, G., Porcellini, A., Carbone, F., Fontana, S., Horvath, T. L., La Cava, A., & Matarese, G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 33
- Issue
- 6
- Pages
- 929-941
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1991263620
- Cited by
- 368
- References
- 41
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Procaccini, C., De Rosa, V., Galgani, M., Abanni, L., Calì, G., Porcellini, A., Carbone, F., Fontana, S., Horvath, T. L., La Cava, A., & Matarese, G. (2010). An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness. Immunity. https://doi.org/10.1016/j.immuni.2010.11.024
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