Cited by 491Inflammasome and immune disordersCell death mechanisms and regulationImmune Response and Inflammation

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Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

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Vince, James E., Wong, W. Wei-Lynn, Gentle, Ian, Lawlor, Kate E., Allam, Ramanjaneyulu, O'Reilly, Lorraine, Mason, Kylie, Gross, Olaf, Ma, Stephen, Guarda, Greta, Anderton, Holly, Castillo, Rosa, Häcker, Georg, Silke, John, Tschopp, Jürg·2012·Immunity

DOI 10.1016/j.immuni.2012.01.012

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Abstract

Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP. After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1β that was mediated not only by the NLRP3-caspase-1 inflammasome, but also by caspase-8 in a caspase-1-independent manner. In the absence of IAPs, rapid and full generation of active IL-1β by the NLRP3-caspase-1 inflammasome, or by caspase-8, required the kinase RIP3 and reactive oxygen species production. These results demonstrate that activation of the cell death-inducing ripoptosome platform and RIP3 can generate bioactive IL-1β and implicate them as additional targets for the treatment of pathological IL-1-driven inflammatory responses.

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Authors: Vince, J. E., Wong, W. W.-L., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., Anderton, H., Castillo, R., Häcker, G., Silke, J., & Tschopp, J.
Affiliations: University of Lausanne (CH)
The University of Melbourne (AU)
University of Freiburg (DE)
Corresponding author: Vince, James E.
ORCID: Vince, James E.
Wong, W. Wei-Lynn
Gentle, Ian
Lawlor, Kate E.
Allam, Ramanjaneyulu
Mason, Kylie
Gross, Olaf
Ma, Stephen
Guarda, Greta
Anderton, Holly
Häcker, Georg
Silke, John
Venue: Immunity
Publisher: Elsevier BV
Published: 2012-02
Volume: 36
Issue: 2
Pages: 215-227
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2012.01.012
OpenAlex: W2087968540
Cited by: 491
References: 62
Citations by year: 2026: 9 · 2025: 22 · 2024: 22 · 2023: 22 · 2022: 33 · 2021: 28 · 2020: 37 · 2019: 28 · 2018: 40 · 2017: 33 · 2016: 41 · 2015: 43 · 2014: 73 · 2013: 38 · 2012: 20
FWCI: 22.39
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 532 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
IRIS (submittedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: Australian Government
State Government of Victoria
Deutsche Krebshilfe
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: inhibitor of apoptosis proteins, caspase-8, NLRP3 inflammasome, caspase-1, IAP antagonists, cIAP1, cIAP2, XIAP, ripoptosome, reactive oxygen species, macrophages, Toll-like receptors, inflammatory cytokines
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Baculoviral IAP Repeat-Containing 3 Protein, Animals, Carrier Proteins, Macrophages, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Molecular Mimicry, Caspase 1, Mitochondrial Proteins, Ubiquitin-Protein Ligases, Apoptosis Regulatory Proteins, Inhibitor of Apoptosis Proteins, Mice, X-Linked Inhibitor of Apoptosis Protein, Receptor-Interacting Protein Serine-Threonine Kinases, Interleukin-1beta, Inflammasomes

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Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

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