The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans
Open accessAbstract
Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an elderly human. By combining in vivo kinetic labeling using deuterated water, thymectomy experiments, analysis of T cell receptor excision circles and CD31 expression, and mathematical modeling, we have quantified the contribution of thymus output and peripheral naive T cell division to the maintenance of T cells in mice and men. Aging affected naive T cell maintenance fundamentally differently in mice and men. Whereas the naive T cell pool in mice was almost exclusively sustained by thymus output throughout their lifetime, the maintenance of the adult human naive T cell pool occurred almost exclusively through peripheral T cell division. These findings put constraints on the extrapolation of insights into T cell dynamics from mouse to man and vice versa.
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“Naive murine T cells survive for only 30 days, while cell divisions from homeostatic proliferation occur only every 1 to 2 years”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as den Braber et al., 2012
In the citing paper
“T cell generation during human adult life depends on peripheral proliferation of naive T cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as den Braber et al., 2012
In the citing paper
“the number of divisions appears to be lower than what is required to generate 10,000 descendants. Frequencies of TCR excision circles (TRECs) that form during TCR-α rearrangement are more consistent with clonal sizes of around 100 cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as den Braber et al., 2012
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“These studies also showed that the while the average life span of mouse naïve T cells is only 6–10 weeks, in humans, individual naïve T cells can persist 5–10 years (den Braber et al., 2012; Vrisekoop et al., 2008).”
BackgroundHuman memory T cells: generation, compartmentalization and homeostasis
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“Conclusions for the human repertoire from animal models are unreliable because the size of the T-cell compartment and mechanisms and kinetics of T-cell homeostasis are fundamentally different in humans and mice (3).”
Background
Metadata
- Authors
- den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., Mul, E., Otto, S. A., Ruiter, A. F. C., Ackermans, M. T., Miedema, F., Borghans, J. A. M., de Boer, R. J., & Tesselaar, K.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Tesselaar, Kiki
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 36
- Issue
- 2
- Pages
- 288-297
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2069043306
- Cited by
- 572
- References
- 52
- Citations by year
- 2026: 27 · 2025: 34 · 2024: 46 · 2023: 40 · 2022: 35 · 2021: 51 · 2020: 45 · 2019: 34 · 2018: 46 · 2017: 38 · 2016: 35 · 2015: 34 · 2014: 38 · 2013: 50 · 2012: 18
- FWCI
- 19.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 532 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- Landsteiner Foundation for Blood Transfusion Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- naive T cells, T cell kinetics, T cell senescence, mouse-to-human extrapolation, thymectomy, TREC, CD31
- MeSH terms
- Adult, Aging, Animals, Child, Deuterium, Homeostasis, Humans, Infant, Newborn, Lymphopenia, Male, Mice, Inbred C57BL, Species Specificity, T-Lymphocytes, Thymus Gland, CD4-Positive T-Lymphocytes, Lymphocyte Count, Platelet Endothelial Cell Adhesion Molecule-1, Models, Animal, Cell Proliferation, Mice, Young Adult
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