The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The JAK-STAT Pathway at Twenty
Open accessAbstract
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interferons and many other cytokines signal through similar mechanisms. This well-understood pathway now serves as a paradigm showing how information from protein-protein contacts at the cell surface can be conveyed directly to genes in the nucleus. We also review recent work on the STAT proteins showing the importance of several different posttranslational modifications, including serine phosphorylation, acetylation, methylation, and sumoylation. These remarkably proficient proteins also provide noncanonical functions in transcriptional regulation and they also function in mitochondrial respiration and chromatin organization in ways that may not involve transcription at all.
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Citations
Cites
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Self-citationVirus interference. I. the interferon
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STATs: transcriptional control and biological impact
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Function of Mitochondrial Stat3 in Cellular Respiration
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Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
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Signal Transduction and the Control of Gene Expression
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Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
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Self-citationReversible methylation of promoter-bound STAT3 by histone-modifying enzymes
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Cited by
The Molecular Signatures Database Hallmark Gene Set Collection
Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
Johnson, D. E., O'Keefe, R. A., & Grandis, J. R. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2018.8 · Cited by 3,110
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“Activated JAK phos-phorylates tyrosine residues in the cytoplasmic domain of gp130 (30, 31, 61, 62, 102, 103).”
BackgroundMechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Metadata
- Authors
- Stark, G. R., & Darnell, J. E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 36
- Issue
- 4
- Pages
- 503-514
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1973454407
- Cited by
- 1,517
- References
- 12
- FWCI
- 45.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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