The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii
Open accessAbstract
SUMMARY Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii-infected mice. However, TLR11 only modestly affects survival of T. gondii-challenged mice. We report that TLR12, a previously uncharacterized TLR, also recognized TgPRF. TLR12 was sufficient for recognition of TgPRF by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 were both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection. TLR12-dependent induction of IL-12 and IFN-α in pDCs led to production of IFN-γ by NK cells. Consistent with this observation, the partial resistance of Tlr11−/− mice is lost upon pDC or NK cell depletion. Thus, TLR12 is critical for the innate immune response to T. gondii, and this TLR may promote host resistance by triggering pDC and NK cell function.
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Cites
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“…TLR4, TLR5, TLR9, and TLR11), viruses (by TLR3, TLR7, TLR8, and TLR9), fungi (TLR2, TLR4), and parasites (TLR9 and TLR11) (Akira et al., 2006; Alexopoulou et al., 2001; Hayashi et al., 2001; Heil et al., 2004; Hemmi et al., 2000; Medzhitov et al., 1997; Takeuchi et al., 2000; Zhang et al., 2004).”
Self-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
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Self-citationInterleukin-12 and the regulation of innate resistance and adaptive immunity
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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
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Self-citationInterferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii
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Cited by
Toll-Like Receptor Signaling Pathways
Kawasaki, T., & Kawai, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00461 · Cited by 3,233
The history of toll-like receptors - redefining innate immunity
O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3446 · Cited by 1,765
Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
Kawai, T., Ikegawa, M., Ori, D., & Akira, S. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.004 · Cited by 528
Self-citationInnate immunity to Toxoplasma gondii infection
Yarovinsky, F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3598 · Cited by 462
Newly described pattern recognition receptors team up against intracellular pathogens
Broz, P., & Monack, D. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3479 · Cited by 462
Metadata
- Authors
- Koblansky, A. A., Jankovic, D., Oh, H., Hieny, S., Sungnak, W., Mathur, R., Hayden, M. S., Akira, S., Sher, A., & Ghosh, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 38
- Issue
- 1
- Pages
- 119-130
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2009521410
- Cited by
- 342
- References
- 37
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Koblansky, A. A., Jankovic, D., Oh, H., Hieny, S., Sungnak, W., Mathur, R., Hayden, M. S., Akira, S., Sher, A., & Ghosh, S. (2013). Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii. Immunity. https://doi.org/10.1016/j.immuni.2012.09.016
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