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An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

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Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA)

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Use of Transgenic Parasites and Host Reporters To Dissect Events That Promote Interleukin-12 Production during Toxoplasmosis

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The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages

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Interferon regulatory factors: critical mediators of human lupus

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Specificity and Function of IRF Family Transcription Factors: Insights from Genomics

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The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics

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Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro

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Immunomodulatory effects of a polysaccharide from Solanum nigrum Linne through TLR4-MyD88 signaling pathway

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Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

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Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome

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Immune Disease-Associated Variants in Gene Enhancers Point to BET Epigenetic Mechanisms for Therapeutic Intervention

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Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

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Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response

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Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function

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Immunomodulation effect of polysaccharides from liquid fermentation of Monascus purpureus 40269 via membrane TLR-4 to activate the MAPK and NF-κB signaling pathways

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IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo

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Making sense of IL‐6 signalling cues in pathophysiology

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Time-dependent recruitment of GAF, ISGF3 and IRF1 complexes shapes IFNα and IFNγ-activated transcriptional responses and explains mechanistic and functional overlap

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Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitors

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Mouse B2 SINE elements function as IFN-inducible enhancers

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Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond

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Preparing the First Responders: Building the Inflammatory Transcriptome from the Ground Up

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The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

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Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages

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IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter

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The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage

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Epigenetic‐modifying therapies: An emerging avenue for the treatment of inflammatory skin diseases

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IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation

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Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages

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Myeloid Cell-Mediated Trained Innate Immunity in Mucosal AIDS Vaccine Development

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Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy

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Inflammatory tissue priming: novel insights and therapeutic opportunities for inflammatory rheumatic diseases

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The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

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Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesis

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Human Endoderm Stem Cells Reverse Acute Liver Failure Through Cystatin SN-Mediated Inhibition of Interferon Signaling

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Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?

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IL-10 regulates Aicda expression through miR-155

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Epigenetic Control of IFN-γ Host Responses During Infection With Toxoplasma gondii

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The Ground State of Innate Immune Responsiveness Is Determined at the Interface of Genetic, Epigenetic, and Environmental Influences

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Tilianin attenuates HDM-induced allergic asthma by suppressing Th2-immune responses via downregulation of IRF4 in dendritic cells

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Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes

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Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell Lymphoma

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Control of IFN-γ production and regulatory function by the inducible nuclear protein IκB-ζ in T cells

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Selected β-Glucans Act as Immune-Training Agents by Improving Anti-Mycobacterial Activity in Human Macrophages: A Pilot Study

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Effects of Sparassis latifolia neutral polysaccharide on immune activity via TLR4-mediated MyD88-dependent and independent signaling pathways in RAW264.7 macrophages

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Remembering foods and foes: emerging principles of transcriptional memory

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Lactobacillus plantarum L‐137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice

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Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS

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IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages

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Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis

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Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation

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Immunomodulatory effect of intracellular polysaccharide from mycelia of Agaricus bitorquis (QuéL.) Sacc. Chaidam by TLR4-mediated MyD88 dependent signaling pathway

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Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis

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Developmental Control of NRAMP1 (SLC11A1) Expression in Professional Phagocytes

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Epigenetic modulations of immune cells: from normal development to tumor progression

Xu, Y., He, Z., Du, J., Chen, K., Creemers, J. W. M., Wang, B., Fan, L., & Wang, Y. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.88327 · Cited by 21

Brief Report: Expression of Interferon‐γ Receptor Genes in Peripheral Blood Mononuclear Cells Is Associated With Rheumatoid Arthritis and Its Radiographic Severity in African Americans

Tang, Q., Danila, M. I., Cui, X., Parks, L. M., Baker, B. J., Reynolds, R. J., Raman, C., Wanseck, K. C., Redden, D. T., Johnson, M. R., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39056 · Cited by 17

Monocytes undergo multi-step differentiation in mice during oral infection by Toxoplasma gondii

Detavernier, A., Azouz, A., Shehade, H., Splittgerber, M., Maele, L. V., Nguyen, M., Thomas, S., Achouri, Y., Švec, D., Calonne, E., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0718-6 · Cited by 17

Born to be wild: utilizing natural microbiota for reliable biomedical research

Bruno, P., Schüler, T., & Rosshart, S. P. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.11.013 · Cited by 19

Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases

Panousis, N. I., Garwany, O. E., Knights, A. J., Rop, J., Kumasaka, N., Imaz, M., Vilarino, L. B., Tsingene, A., Tokolyi, A., Barnett, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61670-9 · Cited by 15

Activated Phosphorylated STAT1 Levels as a Biologically Relevant Immune Signal in Schizophrenia

Sharma, R. P., Rosen, C., Melbourne, J. K., Feiner, B., & Chase, K. A. (2016) · NeuroImmunoModulation · doi:10.1159/000450581 · Cited by 16

When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection

Pacis, A., Nédélec, Y., & Barreiro, L. B. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.002 · Cited by 19

Epigenetics of Aberrant Cardiac Wound Healing

Russell‐Hallinan, A., Watson, C. J., & Baugh, J. A. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170029 · Cited by 17

The pathogenesis of multiple sclerosis: a series of unfortunate events

van Noort, J. M., Baker, D., Kipp, M., & Amor, S. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad075 · Cited by 17

IFNγ-Induced Bcl3, PD-L1 and IL-8 Signaling in Ovarian Cancer: Mechanisms and Clinical Significance

Reddy, S. P., Sadia, F. Z., Vančura, A., & Vancurova, I. (2024) · Cancers · doi:10.3390/cancers16152676 · Cited by 16

Dose- and sex-dependent effects of phlebotomy-induced anemia on the neonatal mouse hippocampal transcriptome

Singh, G., Wallin, D. J., Abrahante, J. E., Tran, P. V., Feldman, H. A., Georgieff, M., & Gisslen, T. A. (2021) · Pediatric Research · doi:10.1038/s41390-021-01832-9 · Cited by 15

Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways

Ho, C., Fan, C., Wu, C., Yu, H., Liu, H.-T., Chen, K., Liu, S., & Cheng, P.-C. (2019) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2019.05.008 · Cited by 15

Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune responsePreprint

Alasoo, K., Rodrigues, J., Mukhopadhyay, S., Knights, A. J., Mann, A. L., Kundu, K., Hale, C., Dougan, G., & Gaffney, D. J. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/102392 · Cited by 15

SNX10 deficiency impairs sensitivity to anti-HER2 antibody–drug conjugates via altering HER2 trafficking in HER2-positive breast cancer

Chen, Y.-F., Zhang, Q., Zhang, Z., Zhou, Y.-J., Liu, C., Shao, Z.-M., & Yu, K. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417586122 · Cited by 16

The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages

Domokos, A., Varga, Z., Jambrovics, K., Caballero-Sánchez, N., Szabó, E. V., Nagy, G., Scholtz, B., Halász, L., Váradi, E., Bene, K., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1168635 · Cited by 14

Type I interferon pathway in pediatric systemic lupus erythematosus

Zhou, Y., & Song, H. (2024) · World Journal of Pediatrics · doi:10.1007/s12519-024-00811-4 · Cited by 16

Interferon-γ stimulates human follicular dendritic cell-like cells to produce prostaglandins via the JAK-STAT pathway

Kim, J., Yoon, Y., Jeoung, D., Kim, Y., & Choe, J. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.003 · Cited by 14

Synergistic Proinflammatory Responses by IL-17A and Toll-Like Receptor 3 in Human Airway Epithelial Cells

Mori, K., Fujisawa, T., Kusagaya, H., Yamanaka, K., Hashimoto, D., Enomoto, N., Inui, N., Nakamura, Y., Maekawa, M., & Suda, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139491 · Cited by 14

Interferon-γ Protects from Staphylococcal Alpha Toxin-Induced Keratinocyte Death through Apolipoprotein L1

Brauweiler, A. M., Goleva, E., & Leung, D. Y. M. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.12.006 · Cited by 14

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

Peeters, J. G. C., Boltjes, A., Scholman, R. C., Vervoort, S. J., Coffer, P. J., Mokrý, M., Vastert, S. J., van Wijk, F., & van Loosdregt, J. (2023) · Lara D. Veeken · doi:10.1093/rheumatology/kead001 · Cited by 13

Priming of regulatory DNA elements activates inflammatory cytokine genes synergistically with TLR signaling to increase transcription (P1230)

Qiao, Y., Γιαννοπούλου, Ε., Elemento, O., & Ivashkiv, L. B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.138.13

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Ivashkiv, L. B. (2013) · Cytokine · doi:10.1016/j.cyto.2013.06.132

Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1Preprint

Mishra, B., Wingert, C. K., Bachu, M., & Ivashkiv, L. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.26.625557 · Cited by 2

A Distal Locus Element Mediates IFN-γ Priming of Lipopolysaccharide-Stimulated TNF Gene Expression

Chow, N. A., Jasenosky, L. D., & Goldfeld, A. E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.011 · Cited by 26

IFN-γ synergistically activates IL23A gene in LPS-stimulated macrophages

You, C., & Kang, K. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.204.supp.152.20