The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Gender Bias in Autoimmunity Is Influenced by Microbiota
Open accessAbstract
Summary Gender bias and the role of sex hormones in autoimmune diseases are well established. In specific pathogen-free (SPF) non-obese diabetic (NOD) mice, females have 1.3–4.4 times higher incidence of Type 1 diabetes (T1D). Germ-free (GF) mice lost the gender bias (female/male ratio 1.1–1.2). Gut microbiota differed in males and females, a trend reversed by male castration confirming that androgens influence gut microbiota. Colonization of GF NOD mice with defined microbiota revealed that some, but not all, lineages overrepresented in male mice supported a gender bias in T1D. Although, protection of males did not correlate with blood androgen concentration, hormone-supported expansion of selected microbial lineages may work as a positive feedback mechanism contributing to the sexual dimorphism of autoimmune diseases. Gene expression analysis suggested pathways involved in protection of males from T1D by microbiota. Our results favor a two-signal model of gender bias, in which hormones and microbes together trigger protective pathways.
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Cites
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Sex differences in immune responses
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Sex differences and hormonal effects on gut microbiota composition in mice
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Metadata
- Authors
- Yurkovetskiy, L., Burrows, M., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D., Umesaki, Y., & Chervonsky, A. V.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 39
- Issue
- 2
- Pages
- 400-412
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2007910255
- Cited by
- 913
- References
- 6
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yurkovetskiy, L., Burrows, M., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D., Umesaki, Y., & Chervonsky, A. V. (2013). Gender Bias in Autoimmunity Is Influenced by Microbiota. Immunity. https://doi.org/10.1016/j.immuni.2013.08.013
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